ATE317850T1 - 2-((n-(2-amino-3-(heteroaryl- oder - aryl)propionyl)aminoacyl)amino)- alkylboronsäurederivate - Google Patents

2-((n-(2-amino-3-(heteroaryl- oder - aryl)propionyl)aminoacyl)amino)- alkylboronsäurederivate

Info

Publication number
ATE317850T1
ATE317850T1 AT02743128T AT02743128T ATE317850T1 AT E317850 T1 ATE317850 T1 AT E317850T1 AT 02743128 T AT02743128 T AT 02743128T AT 02743128 T AT02743128 T AT 02743128T AT E317850 T1 ATE317850 T1 AT E317850T1
Authority
AT
Austria
Prior art keywords
amino
aminoacyl
propionyl
heteroaryl
aryl
Prior art date
Application number
AT02743128T
Other languages
English (en)
Inventor
Pascal Furet
Vito Guagnano
Patricia Imbach
Marc Lang
Original Assignee
Novartis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0113096A external-priority patent/GB0113096D0/en
Priority claimed from GB0129394A external-priority patent/GB0129394D0/en
Application filed by Novartis Pharma Gmbh filed Critical Novartis Pharma Gmbh
Application granted granted Critical
Publication of ATE317850T1 publication Critical patent/ATE317850T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT02743128T 2001-05-30 2002-05-29 2-((n-(2-amino-3-(heteroaryl- oder - aryl)propionyl)aminoacyl)amino)- alkylboronsäurederivate ATE317850T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0113096A GB0113096D0 (en) 2001-05-30 2001-05-30 Organic compounds
GB0129394A GB0129394D0 (en) 2001-12-07 2001-12-07 Organic compounds

Publications (1)

Publication Number Publication Date
ATE317850T1 true ATE317850T1 (de) 2006-03-15

Family

ID=26246132

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02743128T ATE317850T1 (de) 2001-05-30 2002-05-29 2-((n-(2-amino-3-(heteroaryl- oder - aryl)propionyl)aminoacyl)amino)- alkylboronsäurederivate

Country Status (11)

Country Link
US (2) US6933290B2 (de)
EP (1) EP1399468B1 (de)
JP (1) JP4416501B2 (de)
CN (1) CN100415770C (de)
AT (1) ATE317850T1 (de)
BR (1) BR0210112A (de)
CA (1) CA2446282A1 (de)
DE (1) DE60209227T2 (de)
ES (1) ES2258149T3 (de)
PT (1) PT1399468E (de)
WO (1) WO2002096933A1 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE317850T1 (de) * 2001-05-30 2006-03-15 Novartis Pharma Gmbh 2-((n-(2-amino-3-(heteroaryl- oder - aryl)propionyl)aminoacyl)amino)- alkylboronsäurederivate
WO2003059898A2 (en) * 2002-01-08 2003-07-24 Eisai Co. Ltd. Eponemycin and epoxomicin analogs and uses thereof
PL376993A1 (pl) * 2002-11-11 2006-01-23 Bayer Healthcare Ag Pochodne fenylo- lub heteroarylo-aminoalkanów jako antagoniści receptora IP
US7223745B2 (en) 2003-08-14 2007-05-29 Cephalon, Inc. Proteasome inhibitors and methods of using the same
US7576206B2 (en) 2003-08-14 2009-08-18 Cephalon, Inc. Proteasome inhibitors and methods of using the same
US7468383B2 (en) 2005-02-11 2008-12-23 Cephalon, Inc. Proteasome inhibitors and methods of using the same
EP1940843A4 (de) 2005-08-11 2010-09-15 Ariad Pharma Inc Ungesättigte heterocyclische derivate
US20070185150A1 (en) 2005-11-14 2007-08-09 Bedrosian Camille L Therapeutic methods
ES2403206T3 (es) 2005-12-23 2013-05-16 Ariad Pharmaceuticals, Inc. Compuestos bicíclicos de heteroarilo
PT2178888E (pt) 2007-08-06 2012-10-04 Millennium Pharm Inc Inibidores do proteassoma
WO2009143389A1 (en) 2008-05-21 2009-11-26 Ariad Pharmaceuticals, Inc. Phosphorous derivatives as kinase inhibitors
BR122014008754A2 (pt) 2008-06-17 2015-11-03 Millennium Pharm Inc processos para a geração de compostos de éster boronato e ditos compostos
AR075090A1 (es) 2008-09-29 2011-03-09 Millennium Pharm Inc Derivados de acido 1-amino-2-ciclobutiletilboronico inhibidores de proteosoma,utiles como agentes anticancerigenos, y composiciones farmaceuticas que los comprenden.
AU2009314631B2 (en) 2008-11-12 2014-07-31 Takeda Pharmaceutical Company Limited Pyrazinopyrazines and derivatives as kinase inhibitors
WO2010096574A1 (en) 2009-02-20 2010-08-26 Lisanti Michael P A method of diagnosis or prognosis of a neoplasm comprising determining the level of expression of a protein in stromal cells adjacent to the neoplasm
CA2785300A1 (en) 2009-12-22 2011-07-21 Cephalon, Inc. Proteasome inhibitors and processes for their preparation, purification and use
CA2791651C (en) * 2010-03-01 2019-08-20 Onyx Therapeutics, Inc. Compounds for immunoproteasome inhibition
EP2560647B1 (de) 2010-04-19 2016-04-13 Niiki Pharma Inc. Kombinationstherapie mit einem proteasomhemmer und einem galliumkomplex
US10085987B2 (en) 2012-01-27 2018-10-02 Thomas Jefferson University MCT protein inhibitor-related prognostic and therapeutic methods
CN103421032B (zh) * 2012-05-17 2016-01-20 上海创诺制药有限公司 一种硼替佐米中间体及其制备方法和应用
WO2014172627A1 (en) 2013-04-19 2014-10-23 Thomas Jefferson University Caveolin-1 related methods for treating glioblastoma with temozolomide
UA121389C2 (uk) 2014-05-20 2020-05-25 Мілленніум Фармасьютікалз, Інк. Борвмісні інгібітори протеасом для застосування після первинної протиракової терапії
GEP20197011B (en) 2014-06-19 2019-08-12 Ariad Pharma Inc Heteroaryl compounds for kinase inhibition
MA41505A (fr) 2015-02-11 2017-12-19 Millennium Pharm Inc Nouvelle forme cristalline d'un inhibiteur de protéasome
EP3472151A4 (de) 2016-06-21 2020-03-04 Orion Ophthalmology LLC Carbocyclische prolinamidderivate
KR102595723B1 (ko) 2016-06-21 2023-10-27 오리온 옵탈몰로지 엘엘씨 헤테로시클릭 프롤린아미드 유도체

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4499082A (en) 1983-12-05 1985-02-12 E. I. Du Pont De Nemours And Company α-Aminoboronic acid peptides
EP0315574A3 (de) 1987-11-05 1990-08-22 Hoechst Aktiengesellschaft Renin-Inhibitoren
US5106948A (en) * 1988-05-27 1992-04-21 Mao Foundation For Medical Education And Research Cytotoxic boronic acid peptide analogs
GB9017694D0 (en) 1990-08-13 1990-09-26 Sandoz Ltd Improvements in or relating to organic chemistry
US5384410A (en) 1993-03-24 1995-01-24 The Du Pont Merck Pharmaceutical Company Removal of boronic acid protecting groups by transesterification
US5658885A (en) 1993-04-27 1997-08-19 The Dupont Merck Pharmaceutical Company Amidino and guanidino substituted boronic acid inhibitors of trypsin-like enzymes
IL109319A0 (en) 1993-04-27 1994-07-31 Du Pont Merck Pharma Amidino and guanidino substituted boronic acid compounds
FR2721611B1 (fr) * 1994-06-22 1996-09-27 Adir Nouveaux dérivés peptidiques de l'acide boronique, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent .
US6083903A (en) * 1994-10-28 2000-07-04 Leukosite, Inc. Boronic ester and acid compounds, synthesis and uses
US5550262A (en) 1994-11-14 1996-08-27 Cephalon, Inc. Multicatalytic protease inhibitors
US5614649A (en) 1994-11-14 1997-03-25 Cephalon, Inc. Multicatalytic protease inhibitors
CN1282242A (zh) 1997-12-16 2001-01-31 赛福伦公司 多相催化蛋白酶抑制剂用作抗肿瘤剂
ATE317850T1 (de) * 2001-05-30 2006-03-15 Novartis Pharma Gmbh 2-((n-(2-amino-3-(heteroaryl- oder - aryl)propionyl)aminoacyl)amino)- alkylboronsäurederivate

Also Published As

Publication number Publication date
PT1399468E (pt) 2006-05-31
US20050239716A1 (en) 2005-10-27
US6933290B2 (en) 2005-08-23
DE60209227D1 (de) 2006-04-20
ES2258149T3 (es) 2006-08-16
JP4416501B2 (ja) 2010-02-17
WO2002096933A1 (en) 2002-12-05
CN1512999A (zh) 2004-07-14
EP1399468B1 (de) 2006-02-15
CN100415770C (zh) 2008-09-03
BR0210112A (pt) 2004-06-08
CA2446282A1 (en) 2002-12-05
DE60209227T2 (de) 2006-08-17
US20040167337A1 (en) 2004-08-26
JP2005501005A (ja) 2005-01-13
EP1399468A1 (de) 2004-03-24

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