ATE319297T1 - Zusammensetzungen und verfahren für taxol- biosynthese - Google Patents

Zusammensetzungen und verfahren für taxol- biosynthese

Info

Publication number: ATE319297T1
Authority: AT; Austria
Prior art keywords: compositions; methods; taxol biosynthesis; cloned; synthase gene
Prior art date: 1996-04-15

Application number

AT97923414T

Other languages

English (en)

Inventor

Mark R Wildung

Rodney B Croteau

Original Assignee

Univ Washington

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-04-15

Filing date

1997-04-15

Publication date

2006-03-15

1997-04-15 Application filed by Univ Washington filed Critical Univ Washington

2006-03-15 Application granted granted Critical

2006-03-15 Publication of ATE319297T1 publication Critical patent/ATE319297T1/de

Links

229930012538 Paclitaxel Natural products 0.000 title 1
230000015572 biosynthetic process Effects 0.000 title 1
239000000203 mixture Substances 0.000 title 1
229960001592 paclitaxel Drugs 0.000 title 1
RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 title 1
230000014509 gene expression Effects 0.000 abstract 2
108090000765 processed proteins & peptides Chemical group 0.000 abstract 2
108010014539 taxa-4(5),11(12)-diene synthase Proteins 0.000 abstract 2
241000588724 Escherichia coli Species 0.000 abstract 1
241000015728 Taxus canadensis Species 0.000 abstract 1
108020004707 nucleic acids Proteins 0.000 abstract 1
102000039446 nucleic acids Human genes 0.000 abstract 1
150000007523 nucleic acids Chemical group 0.000 abstract 1
229920001184 polypeptide Chemical group 0.000 abstract 1
102000004196 processed proteins & peptides Human genes 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/90—Isomerases (5.)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Genetics & Genomics (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Wood Science & Technology (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Zoology (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Molecular Biology (AREA)
Microbiology (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Physics & Mathematics (AREA)
Cell Biology (AREA)
Nutrition Science (AREA)
Biophysics (AREA)
Plant Pathology (AREA)
Enzymes And Modification Thereof (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Epoxy Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Peptides Or Proteins (AREA)

AT97923414T 1996-04-15 1997-04-15 Zusammensetzungen und verfahren für taxol- biosynthese ATE319297T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US1599396P	1996-04-15	1996-04-15

Publications (1)

Publication Number	Publication Date
ATE319297T1 true ATE319297T1 (de)	2006-03-15

Family

ID=21774770

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT97923414T ATE319297T1 (de)	1996-04-15	1997-04-15	Zusammensetzungen und verfahren für taxol- biosynthese

Country Status (9)

Country	Link
US (3)	US5994114A (de)
EP (1)	EP0907312B1 (de)
JP (1)	JP2000508902A (de)
AT (1)	ATE319297T1 (de)
AU (1)	AU710405B2 (de)
CA (1)	CA2250693C (de)
DE (1)	DE69735419T2 (de)
ES (1)	ES2259190T3 (de)
WO (1)	WO1997038571A1 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US8106260B2 (en)	1996-04-12	2012-01-31	The Board Of Trustees Of The University Of Kentucky	Chimeric isoprenoid synthases and uses thereof
US6265639B1 (en) *	1998-01-22	2001-07-24	Washington State University Foundation	Gymnosperm nucleic acid molecules encoding sesquiterpene synthases and methods of use
US6342380B1 (en) *	1998-02-02	2002-01-29	The Regents Of The University Of California	Germacrene C synthase gene of Lycopersicon esculentum
AU4968599A (en) *	1998-07-02	2000-01-24	Research And Development Institute, Inc.	Taxol production via generation of extrachromosomal dnas in the fungus (pestalotiopsis)
AR022383A1 (es)	1998-09-18	2002-09-04	Univ Kentucky Res Found	Sintasas
AU2001278098A1 (en)	2000-07-31	2002-02-13	Frederick M. Hahn	Manipulation of genes of the mevalonate and isoprenoid pathways to create novel traits in transgenic organisms
WO2002040694A2 (en) *	2000-11-17	2002-05-23	Novozymes A/S	Heterologous expression of taxanes
US7405057B2 (en)	2001-03-09	2008-07-29	Board Of Trustees Of The University Of Kentucky	Cytochrome P450s and uses thereof
ES2201933B1 (es) *	2001-08-23	2005-02-01	Sociedad Española De Carburos Metalicos, S.A.	Utilizacion de co2 para incrementar la concentracion de metabolitos secundarios en plantas.
US7192751B2 (en) *	2001-12-06	2007-03-20	The Regents Of The University Of California	Biosynthesis of amorpha-4,11-diene
US7172886B2 (en) *	2001-12-06	2007-02-06	The Regents Of The University Of California	Biosynthesis of isopentenyl pyrophosphate
TW200304947A (en) *	2002-02-08	2003-10-16	Bristol Myers Squibb Co	Compositions and methods for latering biosynthesis of taxanes and taxane-related compounds
GB0403847D0 (en) *	2004-02-20	2004-03-24	Plant Bioscience Ltd	Methods and means
US20090004715A1 (en)	2007-06-01	2009-01-01	Solazyme, Inc.	Glycerol Feedstock Utilization for Oil-Based Fuel Manufacturing
AU2009319722B2 (en)	2008-11-28	2016-08-04	Corbion Biotech, Inc.	Production of tailored oils in heterotrophic microorganisms
EP2594648B1 (de)	2009-11-10	2016-03-16	Massachusetts Institute of Technology	Mikrobielles Engineering zur Herstellung von chemischen und pharmazeutischen Produkten aus dem Isoprenoid-Signalweg
US8927241B2 (en)	2009-11-10	2015-01-06	Massachusetts Institute Of Technology	Microbial engineering for the production of chemical and pharmaceutical products from the isoprenoid pathway
US8592188B2 (en)	2010-05-28	2013-11-26	Solazyme, Inc.	Tailored oils produced from recombinant heterotrophic microorganisms
CA2819253A1 (en)	2010-11-30	2012-06-07	Massachusetts Institute Of Technology	Microbial production of natural sweeteners, diterpenoid steviol glycosides
KR101964965B1 (ko)	2011-02-02	2019-04-03	테라비아 홀딩스 인코포레이티드	재조합 유지성 미생물로부터 생산된 맞춤 오일
CN103146728B (zh) *	2013-02-28	2015-05-20	天津大学	一种生产紫杉二烯的酵母菌及构建方法
WO2017047651A1 (ja) *	2015-09-18	2017-03-23	神戸天然物化学株式会社	形質転換体、およびテルペノイドの製造方法
WO2019118701A1 (en) *	2017-12-13	2019-06-20	Purdue Research Foundation	Tunable transcriptional regulators reponsive to environmental triggers

1997
- 1997-04-15 AU AU29225/97A patent/AU710405B2/en not_active Ceased
- 1997-04-15 AT AT97923414T patent/ATE319297T1/de not_active IP Right Cessation
- 1997-04-15 JP JP9537339A patent/JP2000508902A/ja active Pending
- 1997-04-15 CA CA002250693A patent/CA2250693C/en not_active Expired - Fee Related
- 1997-04-15 US US08/843,363 patent/US5994114A/en not_active Expired - Lifetime
- 1997-04-15 ES ES97923414T patent/ES2259190T3/es not_active Expired - Lifetime
- 1997-04-15 DE DE69735419T patent/DE69735419T2/de not_active Expired - Fee Related
- 1997-04-15 WO PCT/US1997/006320 patent/WO1997038571A1/en not_active Ceased
- 1997-04-15 EP EP97923414A patent/EP0907312B1/de not_active Expired - Lifetime
1999
- 1999-05-20 US US09/315,861 patent/US6114160A/en not_active Expired - Lifetime
2000
- 2000-06-13 US US09/593,253 patent/US6610527B1/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
JP2000508902A (ja)	2000-07-18
EP0907312A1 (de)	1999-04-14
US6610527B1 (en)	2003-08-26
EP0907312B1 (de)	2006-03-08
WO1997038571A1 (en)	1997-10-23
AU710405B2 (en)	1999-09-16
US6114160A (en)	2000-09-05
ES2259190T3 (es)	2006-09-16
CA2250693A1 (en)	1997-10-23
US5994114A (en)	1999-11-30
EP0907312A4 (de)	2001-06-06
DE69735419D1 (de)	2006-05-04
AU2922597A (en)	1997-11-07
CA2250693C (en)	2005-09-06
DE69735419T2 (de)	2006-11-09

Legal Events

Date	Code	Title	Description
2006-09-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE69735419D1 (de)	2006-05-04	Zusammensetzungen und verfahren für taxol-biosynthese
TR200100705T2 (tr)	2001-10-22	Bitkilerde enzim ve asetil'in değiştirilmesi için yöntemler.
MY120693A (en)	2005-11-30	Human bikunin
AR056723A2 (es)	2007-10-17	Polipeptido purificado metodo para producirlo , metodo para identificarlo y/ o aislarlo composicion farmaceutica que lo comprende, secuencia de acidos nucleicos aislada que codifica dicho polipeptido, vector que contiene a dicha secuencia celula huesped transfectada por dicho vector, sonda nucleotid
BR0108959A (pt)	2003-10-14	Composições de poloxmero ou poloxamina melhoradas para distribuição de ácido nucléico
FI953867A0 (fi)	1995-08-16	Rehun entsyymilisäaine ja sitä sisältävä eläinrehu
EP1005540A4 (de)	2003-04-02	Ikk-beta proteines, nukleinsäuren und verfahren
ATE227739T1 (de)	2002-11-15	Hybridprotein zur hemmung der mastzelldegranulation und dessen verwendung
MY135913A (en)	2008-07-31	Fsh and fsh variant formulations comprising benzyl alcohol as a preservative
DE60024659D1 (de)	2006-01-12	Vektoren und verfahren für rekombinante proteinexpression
ATE275956T1 (de)	2004-10-15	Veränderung der dns methyltransferase durch kombinationstherapie
Boulikas et al.	1990	Increase in histone poly (ADP-ribosylation) in mitogen-activated lymphoid cells
DE69623786D1 (de)	2002-10-24	Mch2, EINE APOPTOTISCHE CYSTEIN-PROTEASE, ZUSAMMENSETZUNGEN FÜR IHRE PRÄPARATION UND METHODEN FÜR IHRE VERWENDUNG
ATE294856T1 (de)	2005-05-15	Lunasin peptide
DE69504808D1 (de)	1998-10-22	Corticotropin freisetzende rezeptoren des faktor 2
DE60319369D1 (de)	2008-04-10	Nukleinsäuren, polypeptide und verfahren zur modulierung von apoptosis
HUP9900750A2 (hu)	1999-06-28	Gén kifejezésére szolgáló promóterek
NO960965D0 (no)	1996-03-08	Genet Grb3-3 med varianter derav samt deres anvendelse
BR9912519A (pt)	2001-05-02	Variantes estabilizadas de inibidor de subtilisina de streptomyces
BRPI0415431A (pt)	2006-12-05	processos e composições para alteração de fenótipos de sementes
DE59904870D1 (de)	2003-05-08	Antisense-sequenzen für die hemmung der expression des adhäsionsmoleküls icam-1
HUP0101393A1 (hu)	2001-08-28	Redukáló körülményekre érzékeny transzfektáló kompozíciók, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
SG161106A1 (en)	2010-05-27	Inhibitor proteins of a protease and use thereof
ATE205538T1 (de)	2001-09-15	Genregulatorische sequenzen von cd4, welche spezifisch in reifen t-zellen exprimiert werden
AU2589002A (en)	2002-06-18	Transcriptional regulator nucleic acids, polypeptides and methods of use thereof