ATE321754T1 - 2-substituierte 1,2,3,4-tetrahydrochinoline und derivate davon, zusammensetzungen und verfahren - Google Patents
2-substituierte 1,2,3,4-tetrahydrochinoline und derivate davon, zusammensetzungen und verfahrenInfo
- Publication number
- ATE321754T1 ATE321754T1 AT02746308T AT02746308T ATE321754T1 AT E321754 T1 ATE321754 T1 AT E321754T1 AT 02746308 T AT02746308 T AT 02746308T AT 02746308 T AT02746308 T AT 02746308T AT E321754 T1 ATE321754 T1 AT E321754T1
- Authority
- AT
- Austria
- Prior art keywords
- methods
- derivatives
- substituted
- compositions
- tetrahydrocinolines
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title 1
- 239000000262 estrogen Substances 0.000 abstract 3
- 229940011871 estrogen Drugs 0.000 abstract 3
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 230000002401 inhibitory effect Effects 0.000 abstract 2
- -1 2-substituted 1,2,3,4-tetrahydroquinolin-6-ols Chemical class 0.000 abstract 1
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical class C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 abstract 1
- 230000001594 aberrant effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000006461 physiological response Effects 0.000 abstract 1
- 239000000583 progesterone congener Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Endocrinology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Reproductive Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Quinoline Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29270401P | 2001-05-22 | 2001-05-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE321754T1 true ATE321754T1 (de) | 2006-04-15 |
Family
ID=23125830
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02746308T ATE321754T1 (de) | 2001-05-22 | 2002-05-09 | 2-substituierte 1,2,3,4-tetrahydrochinoline und derivate davon, zusammensetzungen und verfahren |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7056931B2 (de) |
| EP (1) | EP1395563B1 (de) |
| JP (1) | JP2004531562A (de) |
| AT (1) | ATE321754T1 (de) |
| DE (1) | DE60210283T2 (de) |
| ES (1) | ES2259376T3 (de) |
| WO (1) | WO2002094788A1 (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0224557D0 (en) | 2002-10-22 | 2002-11-27 | Glaxo Group Ltd | Novel compounds |
| CL2004000985A1 (es) * | 2003-05-16 | 2005-01-14 | Wyeth Corp | Compuestos derivados de fenilquinolinas; composicion farmaceutica, proceso de preparacion; y uso para tratar osteoporosis, enfermedad de paget, dano vascular, osteoartritis, cancer oseo, cancer ovarico, cancer prostatico, hipercolesterolemia, aterosc |
| JP2007523952A (ja) | 2004-02-25 | 2007-08-23 | スミスクライン ビーチャム コーポレーション | 選択的エストロゲンレセプターモジュレーターとして使用するための置換キノリン化合物 |
| JP2008509999A (ja) * | 2004-08-17 | 2008-04-03 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 選択的なエストロゲン受容体モジュレーターとしてのベンズオキサゼピン誘導体 |
| DE102005027168A1 (de) * | 2005-06-13 | 2006-12-14 | Merck Patent Gmbh | Tetrahydrochinoline |
| CA3105491C (en) * | 2018-07-12 | 2023-09-05 | Eli Lilly And Company | Selective estrogen receptor degraders |
| TWI702219B (zh) * | 2018-07-12 | 2020-08-21 | 美商美國禮來大藥廠 | 選擇性雌激素受體降解劑 |
Family Cites Families (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3819637A (en) * | 1971-06-23 | 1974-06-25 | Sterling Drug Inc | 1,2-diphenyl-1,2,3,4-tetrahydroquinolines |
| US3994902A (en) * | 1971-06-23 | 1976-11-30 | Sterling Drug Inc. | Certain 1,2-diphenyl-1,2,3,4-tetrahydroquinoline compounds |
| US4133814A (en) * | 1975-10-28 | 1979-01-09 | Eli Lilly And Company | 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents |
| AU509682B2 (en) * | 1975-10-28 | 1980-05-22 | Eli Lilly And Company | 2-Aroyl-3-Phenylbenzothiophene Derivatives |
| US4230862A (en) * | 1975-10-28 | 1980-10-28 | Eli Lilly And Company | Antifertility compounds |
| US4418068A (en) * | 1981-04-03 | 1983-11-29 | Eli Lilly And Company | Antiestrogenic and antiandrugenic benzothiophenes |
| JPS59124889A (ja) * | 1982-12-30 | 1984-07-19 | インタ−ナショナル ビジネス マシ−ンズ コ−ポレ−ション | 放電記録材 |
| US5395842A (en) * | 1988-10-31 | 1995-03-07 | Endorecherche Inc. | Anti-estrogenic compounds and compositions |
| US5686465A (en) * | 1988-10-31 | 1997-11-11 | Endorecherche Inc. | Sex steroid activity inhibitors |
| JPH04316557A (ja) | 1991-04-16 | 1992-11-06 | Kyorin Pharmaceut Co Ltd | ６−アリール環状アントラニル酸誘導体 |
| TW366342B (en) * | 1992-07-28 | 1999-08-11 | Lilly Co Eli | The use of 2-phenyl-3-aroylbenzothiophenes in inhibiting bone loss |
| US5403847A (en) * | 1992-11-13 | 1995-04-04 | Synaptic Pharmaceutical Corporation | Use of α1C specific compounds to treat benign prostatic hyperlasia |
| US5508306A (en) * | 1992-11-13 | 1996-04-16 | Synaptic Pharmaceutical Corporation | Aromatic amine derivatives |
| US5482949A (en) * | 1993-03-19 | 1996-01-09 | Eli Lilly And Company | Sulfonate derivatives of 3-aroylbenzo[b]thiophenes |
| US6756388B1 (en) | 1993-10-12 | 2004-06-29 | Pfizer Inc. | Benzothiophenes and related compounds as estrogen agonists |
| US5457116A (en) * | 1993-10-15 | 1995-10-10 | Eli Lilly And Company | Methods of inhibiting uterine fibrosis |
| US5461065A (en) * | 1993-10-15 | 1995-10-24 | Eli Lilly And Company | Methods for inhibiting endometriosis |
| AU1339795A (en) | 1993-12-21 | 1995-07-10 | Eli Lilly And Company | Non-peptide tachykinin receptor antagonists |
| US5446053A (en) * | 1993-12-21 | 1995-08-29 | Eli Lilly And Company | Methods of inhibiting dysfunctional uterine bleeding |
| US7501441B1 (en) | 1994-09-20 | 2009-03-10 | Eli Lilly And Company | Naphthyl compounds, intermediates, processes, compositions, and methods |
| US5492921A (en) | 1994-09-20 | 1996-02-20 | Eli Lilly And Company | Benzothiophene compounds, compositions, and methods for inhibiting aortal smooth muscle proliferation |
| US5510357A (en) * | 1995-02-28 | 1996-04-23 | Eli Lilly And Company | Benzothiophene compounds as anti-estrogenic agents |
| US6479517B1 (en) | 1995-02-28 | 2002-11-12 | Eli Lilly And Company | Phosphorous-containing benzothiophenes |
| US5998401A (en) | 1995-02-28 | 1999-12-07 | Eli Lilly And Company | Naphthyl compounds, intermediates, compositions, and methods |
| US6391892B1 (en) | 1995-03-10 | 2002-05-21 | Eli Lilly And Company | Naphthyl pharmaceutical compounds |
| US6417199B1 (en) | 1995-03-10 | 2002-07-09 | Eli Lilly And Company | 3-benzyl-benzothiophenes |
| US6384053B1 (en) | 1995-03-10 | 2002-05-07 | Eli Lilly And Company | α-substituted-1-benzyl-napthyls |
| US6395755B1 (en) | 1995-03-10 | 2002-05-28 | Eli Lilly And Company | Benzothiophene pharmaceutical compounds |
| US5523309A (en) * | 1995-03-10 | 1996-06-04 | Eli Lilly And Company | Benzofuran pharmaceutical compounds |
| CA2215902A1 (en) | 1995-04-21 | 1996-10-24 | Charles David Jones | Benzothiophenes with novel basic side chains |
| US6608090B1 (en) | 1995-04-21 | 2003-08-19 | Eli Lilly And Company | Benzothiophenes with novel basic side chains |
| US6444688B1 (en) | 1995-06-07 | 2002-09-03 | Eli Lilly And Company | Compounds and compositions with nitrogen-containing non-basic side chains |
| US5567828A (en) | 1995-06-07 | 1996-10-22 | Eli Lilly And Company | Compounds and compositions with nitrogen-containing non-basic side |
| DE69600709T2 (de) | 1995-06-07 | 1999-03-18 | Eli Lilly And Co., Indianapolis, Ind. | Verbindungen mit N-Acyliertem Piperidin in der Seitenkette und Zusammensetzungen |
| ATE198477T1 (de) | 1995-06-26 | 2001-01-15 | Lilly Co Eli | Benzothiophenderivate |
| US5811421A (en) * | 1995-07-31 | 1998-09-22 | Eli Lilly And Company | Naphthyl and dihydronaphthyl intermediates, compounds, compositions, and methods |
| US5728724A (en) * | 1995-08-17 | 1998-03-17 | Eli Lilly And Company | Benzothiophene compounds |
| US5726168A (en) * | 1995-10-12 | 1998-03-10 | Eli Lilly And Company | Lipophilic benzothiophenes |
| ES2233982T3 (es) | 1995-10-31 | 2005-06-16 | Eli Lilly And Company | Diaminas antitromboticas. |
| EP0773217A1 (de) | 1995-11-07 | 1997-05-14 | Eli Lilly And Company | Benzothiophenederivate zur Behandlung von resistenten Tumoren |
| US6432982B1 (en) | 1996-02-21 | 2002-08-13 | Eli Lilly And Company | Benzothiophenes, and formulations and methods using same |
| US5688796A (en) | 1996-03-12 | 1997-11-18 | Eli Lilly And Company | Heterocyclic substituted benzothiophenes, compositions, and methods |
| TW397821B (en) | 1996-04-19 | 2000-07-11 | American Home Produits Corp | 3-[4-(2-phenyl-indole-1-ylmethyl)-phenyl]-acrylamides and 2-phenyl-1-[4-(amino-1-yl-alk-1-ynyl)-benzyl]-1H-indol-5-ol as well as pharmaceutical compositions of estrogenic agents thereof |
| DK0802183T3 (da) | 1996-04-19 | 2002-02-04 | American Home Prod | Østrogenforbindelser |
| CA2206752A1 (en) | 1996-07-02 | 1998-01-02 | George Joseph Cullinan | Benzothiophene compounds, intermediates, processes, and methods of use |
| CA2207141A1 (en) * | 1996-07-15 | 1998-01-15 | David Thompson Berg | Benzothiophene compounds, and uses and formulations thereof |
| ID19392A (id) | 1996-08-29 | 1998-07-09 | Lilly Co Eli | Senyawa naftil dan bahan pertengahan serta komposisi dan metode penggunaan |
| CA2213810C (en) | 1996-08-29 | 2006-06-06 | Lewis Dale Pennington | Benzo¬b|thiophene compounds, intermediates, processes, compositions and methods |
| CA2214072C (en) * | 1996-08-29 | 2006-11-14 | Eli Lilly And Company | Benzo [b] thiophene compounds, intermediates, processes, compositions, and methods |
| CA2214070C (en) * | 1996-08-29 | 2006-03-14 | Eli Lilly And Company | Dihydronaphthalene and naphthalene compounds, intermediates, formulations, and methods |
| US6599920B2 (en) | 1996-08-29 | 2003-07-29 | Eli Lilly And Company | Naphthalene compounds, intermediates, formulations, and methods |
| CA2214919A1 (en) * | 1996-09-24 | 1998-03-24 | Kenneth Lee Hauser | Benzothiophene compounds, intermediates, processes, compositions, and methods |
| CA2214922A1 (en) | 1996-09-27 | 1998-03-27 | Eli Lilly And Company | Benzothiophene compounds, compositions, and methods |
| US5958969A (en) * | 1996-10-10 | 1999-09-28 | Eli Lilly And Company | Benzo b!thiophene compounds, intermediates, formulations, and methods |
| US5948796A (en) * | 1996-10-10 | 1999-09-07 | Eli Lilly And Company | Benzo B!thiophene compounds, intermediates, formulations, and methods |
| US5916916A (en) | 1996-10-10 | 1999-06-29 | Eli Lilly And Company | 1-aryloxy-2-arylnaphthyl compounds, intermediates, compositions, and methods |
| CA2216592C (en) | 1996-10-24 | 2006-07-18 | Brian Stephen Muehl | Benzothiophene compounds, intermediates, compositions, and methods |
| JPH10204082A (ja) | 1996-10-25 | 1998-08-04 | Eli Lilly & Co | 選択的エストロゲンレセプターモジュレーターとしての活性を有する置換されたベンゾ［ｂ］チオフェン化合物 |
| CZ341297A3 (cs) | 1996-10-30 | 1998-05-13 | Eli Lilly And Company | Způsob zlepšení léčby nebo profylaxe rakoviny prsu |
| AU7261498A (en) | 1997-04-30 | 1998-11-24 | Eli Lilly And Company | Intermediates and processes for preparing benzo{b}thiophenes |
| CA2298651A1 (en) | 1997-08-07 | 1999-02-18 | Jeffrey Alan Dodge | 1-¬4-(substituted alkoxy)benzyl|naphthalene compounds having estrogen inhibitory activity |
| US6090843A (en) | 1997-08-11 | 2000-07-18 | Eli Lilly And Company | Benzothiophenes compounds which have useful pharmaceutical activity |
| US6017914A (en) | 1997-09-03 | 2000-01-25 | Eli Lilly And Company | Benzo[b]thiophene compounds, intermediates, formulations, and methods |
| US5929090A (en) * | 1997-09-12 | 1999-07-27 | Eli Lilly And Company | 2-aryl-3-aminoaryloxynaphthy1 compounds, intermediates, compositions and methods |
| EA003937B1 (ru) | 1997-10-15 | 2003-10-30 | Уайт | Новые арилоксиалкилдиалкиламины |
| WO1999059969A1 (en) | 1998-05-15 | 1999-11-25 | American Home Products Corporation | Compositions comprising 2-phenyl-indole compounds and estrogen formulations |
| US6060488A (en) | 1998-09-22 | 2000-05-09 | Eli Lilly And Company | Benzothiophenes for treating estrogen deficiency |
| EP1113007A1 (de) | 1999-12-24 | 2001-07-04 | Pfizer Inc. | Tetrahydroisochinolin-Verbindungen zur Verwendung als Östrogen-Agonisten/-Antagonisten |
-
2002
- 2002-05-09 ES ES02746308T patent/ES2259376T3/es not_active Expired - Lifetime
- 2002-05-09 JP JP2002591461A patent/JP2004531562A/ja not_active Withdrawn
- 2002-05-09 AT AT02746308T patent/ATE321754T1/de not_active IP Right Cessation
- 2002-05-09 WO PCT/US2002/011878 patent/WO2002094788A1/en not_active Ceased
- 2002-05-09 US US10/475,593 patent/US7056931B2/en not_active Expired - Fee Related
- 2002-05-09 EP EP02746308A patent/EP1395563B1/de not_active Expired - Lifetime
- 2002-05-09 DE DE60210283T patent/DE60210283T2/de not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP2004531562A (ja) | 2004-10-14 |
| DE60210283T2 (de) | 2006-11-09 |
| US7056931B2 (en) | 2006-06-06 |
| US20040215018A1 (en) | 2004-10-28 |
| DE60210283D1 (de) | 2006-05-18 |
| EP1395563A1 (de) | 2004-03-10 |
| WO2002094788A1 (en) | 2002-11-28 |
| EP1395563B1 (de) | 2006-03-29 |
| ES2259376T3 (es) | 2006-10-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE388958T1 (de) | 4'-c-substituierte 2-haloadenosinderivate | |
| CY1106522T1 (el) | Ετepοκυκλικη ενωση και αντικαρκινικο μεσο που πepιεχει την ιδια ως δραστικο συστατικο | |
| HRP20090281T1 (hr) | 1,2,3,4-tetrasubstituirani indol za liječenje respiratornih bolesti | |
| CY1105386T1 (el) | Βενζοϋλοσουλφοναμιδια και σουλφονυλβενζαμιδινες για χρηση σαν παραγοντες κατα του ογκου | |
| NO20042596L (no) | Inbibitorer av 11-beta-hydroksy steroid dehydrogenase type 1 | |
| ID27178A (id) | Senyawa aminosikloheksil eter dan penggunaannya | |
| MA27040A1 (fr) | Nucleosides substitues en 4' | |
| BRPI0407922A (pt) | derivados de isoquinolina e métodos de uso destes | |
| BR9914044A (pt) | ésteres tetrahidropirido | |
| BR9902086A (pt) | Formulações farmacêuticas. | |
| BR0105563A (pt) | Derivados e análogos de galantamina | |
| DE60121461D1 (de) | Kondensierte pyridoindolderivate | |
| DE60324544D1 (de) | Muskarin antagonisten | |
| TR200402529T4 (tr) | Yeni Fenalliloksi fenil türevleri. | |
| ATE316962T1 (de) | Pyrimidin-derivate als selective inhibitoren von cox-2 | |
| NO20043016L (no) | 6-aminomorfinan-derivater, fremgangsmate for fremstilling og anvendelse derav | |
| NO20024597D0 (no) | Alkylerte imidazopyridinderivater | |
| MXPA05006889A (es) | Compuestos aromaticos como agentes anti-inflamatorios, inmunomoduladores y anti-proliferativos. | |
| ATE311389T1 (de) | Wirkstoffvorläufer von imidazopyridin-derivaten | |
| MXPA05009282A (es) | Derivados de anilina sustituidos. | |
| MXPA04003611A (es) | Piperidina- y piperazinacetaminas como inhibidores de la 17 beta-hidroxiesteroide deshidrogenasa tipo 3 para el tratamiento de enfermedades androgeno-dependientes. | |
| BR0104358A (pt) | Formulações de taxana tendo solubilidade aperfeiçoada | |
| DE60112960D1 (de) | Kondensierte pyridoindolderivate | |
| ATE321754T1 (de) | 2-substituierte 1,2,3,4-tetrahydrochinoline und derivate davon, zusammensetzungen und verfahren | |
| CY1109950T1 (el) | Νεα παραγωγα 4,4-διθειοδις-(3-αμινοβουτανιο-1-σουλφονικων) και συνθεσεις που τα περιεχουν |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |