ATE321781T1 - Verfahren zur herstellung einer proteinhaltigen fraktion, mit beta-tgf in aktivierter form bereichert, sowie die so erhaltene fraktion und deren therapeutische verwendungen - Google Patents

Verfahren zur herstellung einer proteinhaltigen fraktion, mit beta-tgf in aktivierter form bereichert, sowie die so erhaltene fraktion und deren therapeutische verwendungen

Info

Publication number: ATE321781T1
Authority: AT; Austria
Prior art keywords: tgf; beta; fraction; solution; activated form
Prior art date: 2001-07-13

Application number

AT02764984T

Other languages

English (en)

Inventor

Jean-Louis Maubois

Jacques Fauquant

Pierre Jouan

Michel Bourtourault

Original Assignee

Pierre Jouan Biotechnologies Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-07-13

Filing date

2002-07-12

Publication date

2006-04-15

2002-07-12 Application filed by Pierre Jouan Biotechnologies Sa filed Critical Pierre Jouan Biotechnologies Sa

2006-04-15 Application granted granted Critical

2006-04-15 Publication of ATE321781T1 publication Critical patent/ATE321781T1/de

Links

108090000623 proteins and genes Proteins 0.000 title abstract 4
102000004169 proteins and genes Human genes 0.000 title abstract 4
238000004519 manufacturing process Methods 0.000 title 1
230000001225 therapeutic effect Effects 0.000 title 1
238000001471 micro-filtration Methods 0.000 abstract 4
102000004887 Transforming Growth Factor beta Human genes 0.000 abstract 3
108090001012 Transforming Growth Factor beta Proteins 0.000 abstract 3
235000018102 proteins Nutrition 0.000 abstract 3
239000012465 retentate Substances 0.000 abstract 3
108010046377 Whey Proteins Proteins 0.000 abstract 2
238000011026 diafiltration Methods 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 abstract 2
239000005862 Whey Substances 0.000 abstract 1
102000007544 Whey Proteins Human genes 0.000 abstract 1
230000002378 acidificating effect Effects 0.000 abstract 1
239000008346 aqueous phase Substances 0.000 abstract 1
238000001035 drying Methods 0.000 abstract 1
239000006193 liquid solution Substances 0.000 abstract 1
235000013336 milk Nutrition 0.000 abstract 1
239000008267 milk Substances 0.000 abstract 1
210000004080 milk Anatomy 0.000 abstract 1
239000000843 powder Substances 0.000 abstract 1
230000001376 precipitating effect Effects 0.000 abstract 1
235000021119 whey protein Nutrition 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/20—Milk; Whey; Colostrum
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
- A23J1/00—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites
- A23J1/20—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites from milk, e.g. casein; from whey
- A23J1/205—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites from milk, e.g. casein; from whey from whey, e.g. lactalbumine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1841—Transforming growth factor [TGF]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/495—Transforming growth factor [TGF]
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/12—Growth hormone, growth factor other than t-cell or b-cell growth factor, and growth hormone releasing factor; related peptides

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Organic Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Zoology (AREA)
Physical Education & Sports Medicine (AREA)
Biochemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Epidemiology (AREA)
Rheumatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Developmental Biology & Embryology (AREA)
Toxicology (AREA)
Genetics & Genomics (AREA)
Food Science & Technology (AREA)
Polymers & Plastics (AREA)
Biophysics (AREA)
Virology (AREA)
Molecular Biology (AREA)
Cell Biology (AREA)
Biotechnology (AREA)
Biomedical Technology (AREA)
Dermatology (AREA)
Neurology (AREA)
Transplantation (AREA)
Pain & Pain Management (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AT02764984T 2001-07-13 2002-07-12 Verfahren zur herstellung einer proteinhaltigen fraktion, mit beta-tgf in aktivierter form bereichert, sowie die so erhaltene fraktion und deren therapeutische verwendungen ATE321781T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR0109390A FR2827290B1 (fr)	2001-07-13	2001-07-13	Procede d'obtention d'une fraction proteique enrichie en tgf-beta sous forme activee, fraction proteique et applications therapeutiques

Publications (1)

Publication Number	Publication Date
ATE321781T1 true ATE321781T1 (de)	2006-04-15

Family

ID=8865500

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02764984T ATE321781T1 (de)	2001-07-13	2002-07-12	Verfahren zur herstellung einer proteinhaltigen fraktion, mit beta-tgf in aktivierter form bereichert, sowie die so erhaltene fraktion und deren therapeutische verwendungen

Country Status (13)

Country	Link
US (3)	US7141262B2 (de)
EP (1)	EP1409539B1 (de)
JP (1)	JP4688092B2 (de)
AT (1)	ATE321781T1 (de)
AU (1)	AU2002329364B8 (de)
CA (1)	CA2434303C (de)
DE (1)	DE60210304T2 (de)
DK (1)	DK1409539T3 (de)
ES (1)	ES2258154T3 (de)
FR (1)	FR2827290B1 (de)
GB (1)	GB0324873D0 (de)
NZ (1)	NZ529180A (de)
WO (1)	WO2003006500A1 (de)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2827290B1 (fr) *	2001-07-13	2004-07-09	Pierre Jouan Biotechnologies Sa	Procede d'obtention d'une fraction proteique enrichie en tgf-beta sous forme activee, fraction proteique et applications therapeutiques
US7622562B2 (en)	2002-06-26	2009-11-24	Zimmer Orthobiologics, Inc.	Rapid isolation of osteoinductive protein mixtures from mammalian bone tissue
AU2003235874A1 (en) *	2003-05-07	2004-11-26	Snow Brand Milk Products Co., Ltd.	Skin collagen production promoter
ES2314152T3 (es) *	2003-09-12	2009-03-16	Nestec S.A.	Fracciones de leche y preparaciones de leche para el tratamiento y/o prevencion de enfermedades inducidas por la cox-2.
EP2335650B1 (de)	2003-12-11	2012-10-03	Isto Technologies Inc.	Teilchenförmiges Knorpelsystem
TW200533299A (en) *	2004-03-31	2005-10-16	Calpis Co Ltd	Functional food for improving endogenous rhythm of melatonin secretion, and functional food for improving circadian rhythm
GB0423352D0 (en) *	2004-10-21	2004-11-24	Hannah Res Inst	"Control of mammary cell number"
EP1817347B1 (de) *	2004-11-24	2017-05-17	Albumedix A/S	Verfahren zur vernetzung von hyaluronsäure mit divinylsulfon
EP1669086A1 (de) *	2004-12-09	2006-06-14	Advitech Solutions Inc.	Zusammensetzung enthaltend TGF-beta und Proteine zur Behandlung von Schuppenflechte
US20060127493A1 (en) *	2004-12-09	2006-06-15	Yves Pouliot	Composition for treating psoriasis
US7763257B2 (en) *	2004-12-09	2010-07-27	Christina Juneau	Compositions comprising transforming growth factor (TGF)-β1 and TGF-β2 in admixture of proteins obtained from dairy products
US7572474B2 (en)	2005-06-01	2009-08-11	Mead Johnson Nutrition Company	Method for simulating the functional attributes of human milk oligosaccharides in formula-fed infants
US8075934B2 (en) *	2008-10-24	2011-12-13	Mead Johnson Nutrition Company	Nutritional composition with improved digestibility
JP5292533B2 (ja)	2005-08-26	2013-09-18	ジンマー・インコーポレイテッド	インプラントおよび関節疾患の治療、置換および治療方法
NZ567126A (en) *	2005-10-04	2010-09-30	Advitech Inc	A dairy derived composition comprising beta-lactoglobulin, IGF and TGF-beta for use in treating chronic intestinal inflammatory disease
US20080154233A1 (en) *	2006-12-20	2008-06-26	Zimmer Orthobiologics, Inc.	Apparatus for delivering a biocompatible material to a surgical site and method of using same
US8163549B2 (en)	2006-12-20	2012-04-24	Zimmer Orthobiologics, Inc.	Method of obtaining viable small tissue particles and use for tissue repair
US20100119614A1 (en) *	2007-04-03	2010-05-13	Christina Juneau	Process for the manufacture of a dairy-based anti-inflammatory composition
EP2134297B1 (de)	2007-04-12	2017-03-08	Zimmer, Inc.	Vorrichtung zur gewebereparatur
US20080293159A1 (en) *	2007-05-24	2008-11-27	Murray Goulburn Co-Operative Co. Ltd.	Validation Process
CA2687123A1 (en) *	2007-06-11	2008-12-18	Advitech Inc.	Method for the treatment of atopic eczema
RU2359684C1 (ru) *	2008-01-23	2009-06-27	Закрытое акционерное общество "СКАЙ ЛТД"	Способ лечения эндометриоза
WO2010028432A1 (en) *	2008-09-11	2010-03-18	Healthlinx Limited	Protocols for treating bone disorders
US8986769B2 (en) *	2008-10-24	2015-03-24	Mead Johnson Nutrition Company	Methods for preserving endogenous TGF-β
US8367354B2 (en) *	2008-10-24	2013-02-05	Mead Johnson Nutrition Company	Methods for determining the levels of TGF-β in a composition
US8350006B2 (en) *	2008-10-24	2013-01-08	Mead Johnson Nutrition Company	Methods for determining the bioactivity of TGF-β in a composition
US9055752B2 (en)	2008-11-06	2015-06-16	Intercontinental Great Brands Llc	Shelf-stable concentrated dairy liquids and methods of forming thereof
KR20120089725A (ko) *	2009-10-16	2012-08-13	우먼'스 앤드 칠드런'스 헬스 리서치 인스티튜트	산 처리 수성 유청 단백질 추출물을 사용하는 알레르기 치료 방법
UA112972C2 (uk)	2010-09-08	2016-11-25	Інтерконтінентал Грейт Брендс ЛЛС	Рідкий молочний концентрат з високим вмістом сухих речовин
US20140178343A1 (en)	2012-12-21	2014-06-26	Jian Q. Yao	Supports and methods for promoting integration of cartilage tissue explants
EP3247343A1 (de) *	2015-01-23	2017-11-29	Nestec S.A.	Ernährungszusammensetzung zur behandlung von patienten mit entzündlichen darmerkrankungen
US10094030B2 (en)	2015-02-03	2018-10-09	Tipul Biotechnology, LLC	Devices and methods for electrolytic production of disinfectant solution from salt solution in a container
EP3969019A4 (de) *	2019-05-14	2023-06-07	Hadasit Medical Research Services and Development Ltd.	Von milch abgeleitete extrazelluläre vesikel zur verwendung bei der behandlung von entzündlichen darmerkrankungen
TWI751551B (zh) *	2020-05-11	2022-01-01	中化合成生技股份有限公司	一種將化合物溶液除水並進行共軛酸轉換之方法
FR3115037B1 (fr) *	2020-10-12	2025-02-21	Cie Laitiere Europeenne	Procédé de purification de fraction de protéines cationiques et fraction ainsi obtenue
FR3159096A1 (fr)	2024-02-08	2025-08-15	Compagnie Laitiere Europeenne	Utilisation de TGF-β pour la prévention et le traitement des manifestations névralgiques

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3791283A (en) *	1970-08-28	1974-02-12	Gen Foods Corp	Method for producing heat and acid stable whey protein material
BE786588A (fr) *	1971-07-20	1973-01-22	Unilever Nv	Compositions alimentaires
CH556143A (fr) *	1972-09-11	1974-11-29	Nestle Sa	Procede de preparation d'une fraction soluble des proteines du petit lait.
US3883448A (en) *	1973-04-23	1975-05-13	Miles Lab	Recovery and purification of protein
US3997447A (en) *	1974-06-07	1976-12-14	Composite Sciences, Inc.	Fluid processing apparatus
US3992375A (en) *	1974-08-12	1976-11-16	G. D. Searle & Co.	Dibenzoxazepine N-carboxylic acid hydrazines and derivatives
SE396017B (sv) *	1974-12-23	1977-09-05	Alfa Laval Ab	Filtreringsforfarande, serskilt for ultrafiltrering
US4029825A (en) *	1975-05-30	1977-06-14	Stauffer Chemical Company	Production of egg white substitute from whey
GB1591609A (en) *	1976-09-24	1981-06-24	Unilever Ltd	Fat
DE3164983D1 (en) *	1980-04-17	1984-08-30	Bridel Laiteries	Decationized milk, process for treating milk by a cation exchange resin for the manufacture of decationized milk and use of the decationized milk in the manufacture of curdled milk casein for cheeses and lactoserum
US4462989A (en) *	1981-05-04	1984-07-31	Evreka, Inc.	Method and agents for arresting infection
US5017372A (en) *	1986-04-14	1991-05-21	Medicis Corporation	Method of producing antibody-fortified dry whey
SE459715B (sv) *	1986-09-08	1989-07-31	Karl J Allsing	Foerfarande vid s.k.roterande filter samt filter
SE459140B (sv) *	1986-11-25	1989-06-12	Albuglobe Ab	Hydrolys av vassleprotein foer att underlaetta avskiljning av fett daerifraan
US5221734A (en) *	1987-10-01	1993-06-22	Ciba-Geigy Corporation	Process for preparing a polypeptide growth factor for milk
GB8723094D0 (en)	1987-10-01	1987-11-04	Ciba Geigy Ag	Polypeptide growth factor from milk
US5047249A (en) *	1988-07-22	1991-09-10	John Morris Co., Inc.	Compositions and methods for treating skin conditions and promoting wound healing
US5043431A (en) *	1989-09-11	1991-08-27	Codon	Method and apparatus for the production of TGF-β
US5037532A (en) *	1989-09-28	1991-08-06	Exxon Research & Engineering Company	Slurry hydrotreating process
US5122536A (en) *	1989-10-12	1992-06-16	Perricone Nicholas V	Method for the topical treatment of psoriasis
AUPN271295A0 (en) *	1995-05-02	1995-05-25	Gropep Pty Ltd	Method of treatment
US5981606A (en) *	1991-03-01	1999-11-09	Warner-Lambert Company	Therapeutic TGF-beta-wound healing compositions and methods for preparing and using same
EP0527283B1 (de)	1991-08-12	1997-11-26	Societe Des Produits Nestle S.A.	Nahrungsmittelzusammensetzung
CA2095057C (en)	1992-06-19	1998-06-16	Peter John Degen	Production of sterile milk through dynamic microfiltration
US5256437A (en) *	1992-06-19	1993-10-26	Pall Corporation	Product and process of making sterile milk through dynamic microfiltration
US5527350A (en) *	1993-02-24	1996-06-18	Star Medical Technologies, Inc.	Pulsed infrared laser treatment of psoriasis
US6036979A (en) *	1993-11-29	2000-03-14	Van Den Bergh Foods Co., Division Of Conopco, Inc.	Manufacture of spreadable low-fat cheese
JP3759984B2 (ja) *	1995-10-13	2006-03-29	よつ葉乳業株式会社	牛乳プロテオースペプトンのコンポーネント３の精製法
EP0894094B1 (de) *	1996-03-15	2005-05-11	BioEqual AG	Verfahren zur gewinnung eines komplexes aus wachstumsfaktoren
EP1052013A1 (de)	1997-04-09	2000-11-15	Societe Des Ceramiques Techniques	Makroporöser Träger mit einem Permeabilitätsgradient und Methode zu dessen Herstellung
US6139901A (en) *	1997-09-16	2000-10-31	New Zealand Milk Products (North Amerca) Inc.	Membrane filtered milk proteins varying in composition and functional attributes
US6312755B1 (en) *	1999-07-16	2001-11-06	Ampc	Whey treatment process for achieving high concentration of α-lactalbumin
WO2001025276A1 (en) *	1999-10-06	2001-04-12	Campina B.V.	Process for obtaining growth factor preparations (tgf-beta and igf-1) from milk products having low mutual cross-contamination
AU6232899A (en) *	1999-10-06	2001-05-10	Campina Melkunie B.V.	Use of transforming growth factor beta and growth factors in the treatment and prevention of diseases of the intestinal mucosa
FR2827290B1 (fr) *	2001-07-13	2004-07-09	Pierre Jouan Biotechnologies Sa	Procede d'obtention d'une fraction proteique enrichie en tgf-beta sous forme activee, fraction proteique et applications therapeutiques
ATE420108T1 (de) *	2001-07-20	2009-01-15	Campina Bv	Verfahren zur herstellung von preparationen aus milchprodukten, welche wachstumsfaktoren (tgf- beta und igf-1), lactoperoxidase und immunglobuline mit niedriger gegenseitiger verunreinigung enthalten
US7763257B2 (en) *	2004-12-09	2010-07-27	Christina Juneau	Compositions comprising transforming growth factor (TGF)-β1 and TGF-β2 in admixture of proteins obtained from dairy products
FR2889068B1 (fr)	2005-07-29	2012-03-02	Cie Laitiere Europeenne	Nouvelles fractions proteiques laitieres et leur utilisation pour la prevention ou le traitement des maladies inflammatoires chroniques
NZ567126A (en)	2005-10-04	2010-09-30	Advitech Inc	A dairy derived composition comprising beta-lactoglobulin, IGF and TGF-beta for use in treating chronic intestinal inflammatory disease

2001
- 2001-07-13 FR FR0109390A patent/FR2827290B1/fr not_active Expired - Fee Related
2002
- 2002-07-12 EP EP02764984A patent/EP1409539B1/de not_active Expired - Lifetime
- 2002-07-12 DE DE60210304T patent/DE60210304T2/de not_active Expired - Lifetime
- 2002-07-12 JP JP2003512270A patent/JP4688092B2/ja not_active Expired - Lifetime
- 2002-07-12 ES ES02764984T patent/ES2258154T3/es not_active Expired - Lifetime
- 2002-07-12 DK DK02764984T patent/DK1409539T3/da active
- 2002-07-12 WO PCT/FR2002/002489 patent/WO2003006500A1/fr not_active Ceased
- 2002-07-12 US US10/469,530 patent/US7141262B2/en not_active Expired - Lifetime
- 2002-07-12 AT AT02764984T patent/ATE321781T1/de active
- 2002-07-12 NZ NZ529180A patent/NZ529180A/en not_active IP Right Cessation
- 2002-07-12 AU AU2002329364A patent/AU2002329364B8/en not_active Expired
- 2002-07-12 CA CA2434303A patent/CA2434303C/fr not_active Expired - Lifetime
2003
- 2003-10-24 GB GBGB0324873.9A patent/GB0324873D0/en not_active Ceased
2005
- 2005-07-13 US US11/181,186 patent/US20050250698A1/en not_active Abandoned
- 2005-07-13 US US11/181,139 patent/US8937043B2/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
DK1409539T3 (da)	2006-07-31
US7141262B2 (en)	2006-11-28
ES2258154T3 (es)	2006-08-16
FR2827290A1 (fr)	2003-01-17
US20050250697A1 (en)	2005-11-10
EP1409539B1 (de)	2006-03-29
FR2827290B1 (fr)	2004-07-09
US20040097714A1 (en)	2004-05-20
JP2005506316A (ja)	2005-03-03
US20050250698A1 (en)	2005-11-10
JP4688092B2 (ja)	2011-05-25
DE60210304T2 (de)	2006-12-07
CA2434303C (fr)	2013-05-14
NZ529180A (en)	2005-05-27
US8937043B2 (en)	2015-01-20
AU2002329364B8 (en)	2008-12-04
WO2003006500A1 (fr)	2003-01-23
DE60210304D1 (de)	2006-05-18
GB0324873D0 (en)	2003-11-26
CA2434303A1 (fr)	2003-01-23
EP1409539A1 (de)	2004-04-21
AU2002329364B2 (en)	2008-07-24

Legal Events

Date

Code

Title

Description

2007-01-15

UEP

Publication of translation of european patent specification

Ref document number: 1409539

Country of ref document: EP

Publication	Publication Date	Title
DE60210304D1 (de)	2006-05-18	Verfahren zur herstellung einer proteinhaltigen fraktion, mit beta-tgf in aktivierter form bereichert, sowie die so erhaltene fraktion und deren therapeutische verwendungen
ATE376362T1 (de)	2007-11-15	Verfahren zur herstellung eines lactosefreien milchprodukts
NZ585594A (en)	2012-09-28	Methods for casein production
Butylina et al.	2006	Fractionation of whey-derived peptides using a combination of ultrafiltration and nanofiltration
KR101645957B1 (ko)	2016-08-05	분비 면역글로블린이 풍부한 우유 분획 제조방법
BR9915573A (pt)	2001-08-14	Processo de preparação de uma composição protéica e uma fórmula infantil contendo a mesma
DE602005021485D1 (de)	2010-07-08	Verfahren und zusammensetzungen mit molkeproteinisolaten
MX381074B (es)	2025-03-12	Composiciones funcionales derivadas de frijol mungo.
CA2259761A1 (en)	1999-07-21	A continuous process of dynamic high-pressure homogenization for the denaturation of proteins
RU2013142354A (ru)	2015-03-27	Сыр и его получение
EA200000049A1 (ru)	2000-08-28	Способ производства стерильного обезжиренного молока
BRPI0603380A (pt)	2007-04-27	método para preparar material de proteìna do soro de leite desflavorizado, e, produto alimentìcio contendo soro de leite
ATE364322T1 (de)	2007-07-15	Verfahren zur herstellung eines beta- laktoglobulin-angereichertes molkenproteinkonzentrates und darauf basierender texturverstärker zur verwendung in milchprodukten
CY1107082T1 (el)	2012-10-24	Μεθοδος καθαρισμου αλβουμινης η οποια περιλαμβανει ενα σταδιο νανοδιηθησης, διαλυμα και συνθεση για θεραπευτικη χρηση που περιεχουν την ιδια
DE502004004681D1 (de)	2007-09-27	Verfahren zur herstellung von salzen schwach koordinierender aniomen, derartige salze sowie deren verwendung
DE602004025248D1 (de)	2010-03-11	Verfahren zur herstellung eines konzentrierten milchproteinbestandteils
AU2017311557B2 (en)	2022-02-10	Process for producing infant formula products and dairy products
MX2009006717A (es)	2009-09-23	Procedimiento para el tratamiento de un flujo de materiales.
ATE465998T1 (de)	2010-05-15	Verfahren zur herstellung und reinigung von 1,7'- dimethyl-2'-propyl-2,5'-bi-1h-benzimidazol
ATE247628T1 (de)	2003-09-15	Verfahren zur herstellung von gabapentin
MX2007003149A (es)	2007-05-16	Metodo para desaborizar materiales derivados de soja usando electrodialisis.
DE50214894D1 (de)	2011-03-17	Verfahren zur herstellung von oxirancarbonsäuren und derivaten davon
JP2000281639A (ja)	2000-10-10	乳由来の尿素含有組成物及びその製造法
JP5546718B2 (ja)	2014-07-09	ラクトシルセラミド組成物及びその製造方法
DE69425353D1 (de)	2000-08-31	Verfahren zur Rückgewinnung von Rohstoffen bei der Herstellung von Aspartam