ATE321781T1 - Verfahren zur herstellung einer proteinhaltigen fraktion, mit beta-tgf in aktivierter form bereichert, sowie die so erhaltene fraktion und deren therapeutische verwendungen - Google Patents

Verfahren zur herstellung einer proteinhaltigen fraktion, mit beta-tgf in aktivierter form bereichert, sowie die so erhaltene fraktion und deren therapeutische verwendungen

Info

Publication number: ATE321781T1
Authority: AT; Austria
Prior art keywords: tgf; beta; fraction; solution; activated form
Prior art date: 2001-07-13

Application number

AT02764984T

Other languages

English (en)

Inventor

Jean-Louis Maubois

Jacques Fauquant

Pierre Jouan

Michel Bourtourault

Original Assignee

Pierre Jouan Biotechnologies Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-07-13

Filing date

2002-07-12

Publication date

2006-04-15

2002-07-12 Application filed by Pierre Jouan Biotechnologies Sa filed Critical Pierre Jouan Biotechnologies Sa

2006-04-15 Application granted granted Critical

2006-04-15 Publication of ATE321781T1 publication Critical patent/ATE321781T1/de

Links

108090000623 proteins and genes Proteins 0.000 title abstract 4
102000004169 proteins and genes Human genes 0.000 title abstract 4
238000004519 manufacturing process Methods 0.000 title 1
230000001225 therapeutic effect Effects 0.000 title 1
238000001471 micro-filtration Methods 0.000 abstract 4
102000004887 Transforming Growth Factor beta Human genes 0.000 abstract 3
108090001012 Transforming Growth Factor beta Proteins 0.000 abstract 3
235000018102 proteins Nutrition 0.000 abstract 3
239000012465 retentate Substances 0.000 abstract 3
108010046377 Whey Proteins Proteins 0.000 abstract 2
238000011026 diafiltration Methods 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 abstract 2
239000005862 Whey Substances 0.000 abstract 1
102000007544 Whey Proteins Human genes 0.000 abstract 1
230000002378 acidificating effect Effects 0.000 abstract 1
239000008346 aqueous phase Substances 0.000 abstract 1
238000001035 drying Methods 0.000 abstract 1
239000006193 liquid solution Substances 0.000 abstract 1
235000013336 milk Nutrition 0.000 abstract 1
239000008267 milk Substances 0.000 abstract 1
210000004080 milk Anatomy 0.000 abstract 1
239000000843 powder Substances 0.000 abstract 1
230000001376 precipitating effect Effects 0.000 abstract 1
235000021119 whey protein Nutrition 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/20—Milk; Whey; Colostrum
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
- A23J1/00—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites
- A23J1/20—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites from milk, e.g. casein; from whey
- A23J1/205—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites from milk, e.g. casein; from whey from whey, e.g. lactalbumine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1841—Transforming growth factor [TGF]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/495—Transforming growth factor [TGF]
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/12—Growth hormone, growth factor other than t-cell or b-cell growth factor, and growth hormone releasing factor; related peptides

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Zoology (AREA)
Physical Education & Sports Medicine (AREA)
Epidemiology (AREA)
Biochemistry (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Rheumatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Biomedical Technology (AREA)
Cell Biology (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Toxicology (AREA)
Biotechnology (AREA)
Polymers & Plastics (AREA)
Food Science & Technology (AREA)
Virology (AREA)
Biophysics (AREA)
Developmental Biology & Embryology (AREA)
Dermatology (AREA)
Neurology (AREA)
Pain & Pain Management (AREA)
Transplantation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AT02764984T 2001-07-13 2002-07-12 Verfahren zur herstellung einer proteinhaltigen fraktion, mit beta-tgf in aktivierter form bereichert, sowie die so erhaltene fraktion und deren therapeutische verwendungen ATE321781T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR0109390A FR2827290B1 (fr)	2001-07-13	2001-07-13	Procede d'obtention d'une fraction proteique enrichie en tgf-beta sous forme activee, fraction proteique et applications therapeutiques

Publications (1)

Publication Number	Publication Date
ATE321781T1 true ATE321781T1 (de)	2006-04-15

Family

ID=8865500

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02764984T ATE321781T1 (de)	2001-07-13	2002-07-12	Verfahren zur herstellung einer proteinhaltigen fraktion, mit beta-tgf in aktivierter form bereichert, sowie die so erhaltene fraktion und deren therapeutische verwendungen

Country Status (13)

Country	Link
US (3)	US7141262B2 (de)
EP (1)	EP1409539B1 (de)
JP (1)	JP4688092B2 (de)
AT (1)	ATE321781T1 (de)
AU (1)	AU2002329364B8 (de)
CA (1)	CA2434303C (de)
DE (1)	DE60210304T2 (de)
DK (1)	DK1409539T3 (de)
ES (1)	ES2258154T3 (de)
FR (1)	FR2827290B1 (de)
GB (1)	GB0324873D0 (de)
NZ (1)	NZ529180A (de)
WO (1)	WO2003006500A1 (de)

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DE69925870T2 (de) *	1999-10-06	2005-12-08	Campina B.V.	Verfahren zur bereitstellung von wachstumsfaktozubereitungen (tgf-beta und igf-1) mit niedriger gegenseitiger verunreinigung aus milchprodukten
FR2827290B1 (fr)	2001-07-13	2004-07-09	Pierre Jouan Biotechnologies Sa	Procede d'obtention d'une fraction proteique enrichie en tgf-beta sous forme activee, fraction proteique et applications therapeutiques
CN1555384B (zh)	2001-07-20	2010-05-26	坎皮纳公司	从乳制品获得具有低相互交叉污染的生长因子(TGF-β和IGF-1)、乳过氧化物酶和免疫球蛋白制剂的方法
US7763257B2 (en)	2004-12-09	2010-07-27	Christina Juneau	Compositions comprising transforming growth factor (TGF)-β1 and TGF-β2 in admixture of proteins obtained from dairy products
FR2889068B1 (fr)	2005-07-29	2012-03-02	Cie Laitiere Europeenne	Nouvelles fractions proteiques laitieres et leur utilisation pour la prevention ou le traitement des maladies inflammatoires chroniques
NZ567126A (en)	2005-10-04	2010-09-30	Advitech Inc	A dairy derived composition comprising beta-lactoglobulin, IGF and TGF-beta for use in treating chronic intestinal inflammatory disease

2001
- 2001-07-13 FR FR0109390A patent/FR2827290B1/fr not_active Expired - Fee Related
2002
- 2002-07-12 US US10/469,530 patent/US7141262B2/en not_active Expired - Lifetime
- 2002-07-12 WO PCT/FR2002/002489 patent/WO2003006500A1/fr not_active Ceased
- 2002-07-12 DE DE60210304T patent/DE60210304T2/de not_active Expired - Lifetime
- 2002-07-12 CA CA2434303A patent/CA2434303C/fr not_active Expired - Lifetime
- 2002-07-12 NZ NZ529180A patent/NZ529180A/en not_active IP Right Cessation
- 2002-07-12 EP EP02764984A patent/EP1409539B1/de not_active Expired - Lifetime
- 2002-07-12 ES ES02764984T patent/ES2258154T3/es not_active Expired - Lifetime
- 2002-07-12 DK DK02764984T patent/DK1409539T3/da active
- 2002-07-12 AT AT02764984T patent/ATE321781T1/de active
- 2002-07-12 JP JP2003512270A patent/JP4688092B2/ja not_active Expired - Lifetime
- 2002-07-12 AU AU2002329364A patent/AU2002329364B8/en not_active Expired
2003
- 2003-10-24 GB GBGB0324873.9A patent/GB0324873D0/en not_active Ceased
2005
- 2005-07-13 US US11/181,139 patent/US8937043B2/en not_active Expired - Lifetime
- 2005-07-13 US US11/181,186 patent/US20050250698A1/en not_active Abandoned

Also Published As

Publication number	Publication date
EP1409539B1 (de)	2006-03-29
AU2002329364B2 (en)	2008-07-24
AU2002329364B8 (en)	2008-12-04
DE60210304D1 (de)	2006-05-18
US20050250697A1 (en)	2005-11-10
US8937043B2 (en)	2015-01-20
US20040097714A1 (en)	2004-05-20
FR2827290B1 (fr)	2004-07-09
DK1409539T3 (da)	2006-07-31
US20050250698A1 (en)	2005-11-10
JP2005506316A (ja)	2005-03-03
GB0324873D0 (en)	2003-11-26
EP1409539A1 (de)	2004-04-21
NZ529180A (en)	2005-05-27
WO2003006500A1 (fr)	2003-01-23
DE60210304T2 (de)	2006-12-07
US7141262B2 (en)	2006-11-28
FR2827290A1 (fr)	2003-01-17
CA2434303C (fr)	2013-05-14
JP4688092B2 (ja)	2011-05-25
ES2258154T3 (es)	2006-08-16
CA2434303A1 (fr)	2003-01-23

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