ATE321871T1 - Ein autoreguliertes tetracyclin-reguliertes system fur die induzierte genexpression in eukaryoten - Google Patents
Ein autoreguliertes tetracyclin-reguliertes system fur die induzierte genexpression in eukaryotenInfo
- Publication number
- ATE321871T1 ATE321871T1 AT96921541T AT96921541T ATE321871T1 AT E321871 T1 ATE321871 T1 AT E321871T1 AT 96921541 T AT96921541 T AT 96921541T AT 96921541 T AT96921541 T AT 96921541T AT E321871 T1 ATE321871 T1 AT E321871T1
- Authority
- AT
- Austria
- Prior art keywords
- tta
- tetracycline
- expression
- ttak
- autoregulatory
- Prior art date
Links
- 230000014509 gene expression Effects 0.000 title abstract 6
- 241000206602 Eukaryota Species 0.000 title 1
- 239000004098 Tetracycline Substances 0.000 abstract 4
- 108090000623 proteins and genes Proteins 0.000 abstract 4
- 229960002180 tetracycline Drugs 0.000 abstract 4
- 229930101283 tetracycline Natural products 0.000 abstract 4
- 235000019364 tetracycline Nutrition 0.000 abstract 4
- 150000003522 tetracyclines Chemical class 0.000 abstract 4
- 230000001042 autoregulative effect Effects 0.000 abstract 3
- 108060001084 Luciferase Proteins 0.000 abstract 2
- 239000005089 Luciferase Substances 0.000 abstract 2
- 241001465754 Metazoa Species 0.000 abstract 1
- 210000004748 cultured cell Anatomy 0.000 abstract 1
- 230000003247 decreasing effect Effects 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 239000013612 plasmid Substances 0.000 abstract 1
- 102000040430 polynucleotide Human genes 0.000 abstract 1
- 108091033319 polynucleotide Proteins 0.000 abstract 1
- 239000002157 polynucleotide Substances 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 230000001105 regulatory effect Effects 0.000 abstract 1
- 231100000331 toxic Toxicity 0.000 abstract 1
- 230000002588 toxic effect Effects 0.000 abstract 1
- 230000009261 transgenic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/635—Externally inducible repressor mediated regulation of gene expression, e.g. tetR inducible by tetracyline
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
- C12N2830/005—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination repressible enhancer/promoter combination, e.g. KRAB
- C12N2830/006—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination repressible enhancer/promoter combination, e.g. KRAB tet repressible
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/44—Vectors comprising a special translation-regulating system being a specific part of the splice mechanism, e.g. donor, acceptor
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Saccharide Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/474,169 US5851796A (en) | 1995-06-07 | 1995-06-07 | Autoregulatory tetracycline-regulated system for inducible gene expression in eucaryotes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE321871T1 true ATE321871T1 (de) | 2006-04-15 |
Family
ID=23882456
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT96921541T ATE321871T1 (de) | 1995-06-07 | 1996-06-07 | Ein autoreguliertes tetracyclin-reguliertes system fur die induzierte genexpression in eukaryoten |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US5851796A (de) |
| EP (1) | EP0832254B1 (de) |
| JP (1) | JPH11507539A (de) |
| AT (1) | ATE321871T1 (de) |
| AU (1) | AU6274596A (de) |
| DE (1) | DE69635992T2 (de) |
| WO (1) | WO1996040946A1 (de) |
Families Citing this family (64)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997020943A1 (en) * | 1995-12-01 | 1997-06-12 | Introgene B.V. | Regulated protein expression in stably transfected mammalian cells |
| US5891718A (en) * | 1996-03-27 | 1999-04-06 | Vical Incorporated | Tetracycline inducible/repressible systems |
| DE19635568C1 (de) * | 1996-09-02 | 1998-03-26 | Gsf Forschungszentrum Umwelt | Vektorsysteme zur konditionalen Genexpression |
| WO1998037185A2 (en) * | 1997-02-20 | 1998-08-27 | The Board Of Regents Of The University Of Texas System | Vectors for controlled gene expression |
| US6087166A (en) | 1997-07-03 | 2000-07-11 | Basf Aktiengesellschaft | Transcriptional activators with graded transactivation potential |
| WO1999036554A1 (en) * | 1998-01-16 | 1999-07-22 | Pharmacia & Upjohn Company | An autoregulatory system for validating microbial genes as possible antimicrobial targets using a tetracycline-controllable element |
| US6878516B1 (en) | 1998-01-16 | 2005-04-12 | Pharmacia & Upjohn Company | Autoregulatory system for validating microbial genes as possible antimicrobial targets using a tetracycline-controllable element |
| US7037663B2 (en) * | 1998-02-19 | 2006-05-02 | Eastern Virginia Medical School | Human zona pellucida protein 3 and uses thereof |
| US7019114B2 (en) * | 1998-02-19 | 2006-03-28 | Eastern Virginia Medical School | Recombinant, biologically active human zona pellucida protein 3 (HZP3) to test male fertility |
| DE19831420A1 (de) * | 1998-07-14 | 2000-01-20 | Hoechst Marion Roussel De Gmbh | Expressionssysteme enthaltend chimäre Promotoren mit Bindungsstellen für rekombinante Transkriptionsfaktoren |
| US20050037335A1 (en) * | 1998-11-07 | 2005-02-17 | Wolfgang Hillen | Method for identifying novel transcriptional regulatory proteins |
| US6706491B1 (en) | 1999-04-09 | 2004-03-16 | The Board Of Trustees Of The University Of Illinois | Reagents and methods for identifying and modulating expression of genes regulated by p21 |
| JP4836375B2 (ja) * | 1999-06-07 | 2011-12-14 | ティーイーティー システムズ ホールディング ゲーエムベーハー ウント ツェーオー． カーゲー | 新規の、ｔｅｔリプレッサーに基づく転写調節タンパク質 |
| GB2355459B (en) | 1999-11-29 | 2001-09-26 | Isis Innovation | A dominant conditional lethal genetic system |
| JP2005516586A (ja) * | 2001-07-20 | 2005-06-09 | ボード オブ トラスティーズ オブ ザ ユニヴァースティ オブ イリノイ | 癌の処置に対する遺伝子標的を同定するための試薬および方法 |
| EP1421104A4 (de) * | 2001-08-02 | 2005-08-24 | Trinity Biomedical Technology | Humane zona-pellucida-proteine und verfahren zu deren verwendung bei der diagnose männlicher unfruchtbarkeit |
| GB2402675B (en) * | 2003-05-12 | 2008-02-20 | Oxitec Ltd | Resistance dilution |
| GB2403475B (en) * | 2003-07-01 | 2008-02-06 | Oxitec Ltd | Stable integrands |
| GB2404382B (en) * | 2003-07-28 | 2008-01-30 | Oxitec Ltd | Pest control |
| US20090123468A1 (en) | 2003-10-24 | 2009-05-14 | Gencia Corporation | Transducible polypeptides for modifying metabolism |
| US8507277B2 (en) | 2003-10-24 | 2013-08-13 | Gencia Corporation | Nonviral vectors for delivering polynucleotides |
| US8062891B2 (en) | 2003-10-24 | 2011-11-22 | Gencia Corporation | Nonviral vectors for delivering polynucleotides to plants |
| US8133733B2 (en) | 2003-10-24 | 2012-03-13 | Gencia Corporation | Nonviral vectors for delivering polynucleotides to target tissues |
| CA2543257C (en) | 2003-10-24 | 2013-12-31 | Gencia Corporation | Methods and compositions for delivering polynucleotides |
| US20080307549A1 (en) | 2005-08-03 | 2008-12-11 | Adelaide Research & Innovation Pty Ltd. | Polysaccharide Synthases |
| US20090183269A1 (en) * | 2006-02-10 | 2009-07-16 | Oxitec Limited | Gene expression system using alternative splicing in insects |
| GB2443186A (en) | 2006-10-25 | 2008-04-30 | Oxitec Ltd | Expression system for mediating alternative splicing |
| US8080647B2 (en) * | 2006-11-22 | 2011-12-20 | Pioneer Hi Bred International Inc | Tetracycline repressor and uses thereof |
| UA100692C2 (ru) | 2007-05-02 | 2013-01-25 | Мериал Лимитед | Днк-плазмиды, имеющие повышенную экспрессию и стабильность |
| US8257956B2 (en) * | 2008-10-28 | 2012-09-04 | E. I. Du Pont De Nemours And Company | Sulfonylurea-responsive repressor proteins |
| WO2010068821A1 (en) | 2008-12-10 | 2010-06-17 | Synthetic Genomics, Inc. | Production of branched-chain alcohols by photosynthetic microoraganisms |
| US8956834B2 (en) | 2009-06-29 | 2015-02-17 | Synthetic Genomics, Inc. | Acyl-ACP thioesterase genes and uses therefor |
| WO2011019858A1 (en) | 2009-08-11 | 2011-02-17 | Synthetic Genomics, Inc. | Microbial production of fatty alcohols |
| EP2473597A4 (de) | 2009-09-04 | 2013-05-15 | Harvard College | Herstellung sekretierter bioprodukte aus photosynthese-mikroben |
| US8530207B2 (en) | 2010-12-23 | 2013-09-10 | Exxonmobil Research And Engineering Company | Photosynthetic microorganisms comprising exogenous prokaryotic acyl-ACP thioesterases and methods for producing fatty acids |
| WO2012087670A2 (en) | 2010-12-23 | 2012-06-28 | Exxonmobil Research And Engineering Company | Genetically engineered microorganisms comprising 4-hydroxybenzoly-coa thioesterases and methods of using the same for producing free fatty acids and fatty acid derivatives |
| WO2012087676A2 (en) | 2010-12-23 | 2012-06-28 | Exxonmobil Research And Enginnering Company | Production of fatty acids and fatty acid derivatives by recombinant microorganisms expressing polypeptides having lipolytic activity |
| US8940508B2 (en) | 2010-12-31 | 2015-01-27 | Exxonmobil Research And Engineering Company | Enhancement of biomass production by disruption of light energy dissipation pathways |
| EP2691510A4 (de) | 2011-03-31 | 2014-11-12 | Exxonmobil Res & Eng Co | Stoffwechselweg-anzielung durch transkriptionsfaktor-überexpression |
| US20130005590A1 (en) * | 2011-06-06 | 2013-01-03 | The Regents Of The University Of California | Synthetic biology tools |
| WO2013003597A1 (en) | 2011-06-30 | 2013-01-03 | Exxonmobil Research And Engineering Company | Regulation of toxin and antitoxin genes for biological containment |
| BR112014007115A2 (pt) | 2011-09-27 | 2017-04-25 | Exxonmobil Res & Eng Co | éster sintases de cera acil-acp |
| US9096834B2 (en) | 2012-02-24 | 2015-08-04 | Exxonmobil Research And Engineering Company | Recombinant microorganisms comprising thioesterase and lysophosphatidic acid acyltransferase genes for fatty acid production |
| ES2795842T3 (es) | 2012-02-24 | 2020-11-24 | Exxonmobil Res & Eng Co | Producción mejorada de ácidos grasos y derivados de ácidos grasos por microorganismos recombinantes |
| US8962299B2 (en) | 2012-02-29 | 2015-02-24 | Exxonmobil Research And Engineering Company | Four-gene pathway for wax ester synthesis |
| GB2500113A (en) | 2012-03-05 | 2013-09-11 | Oxitec Ltd | Arthropod male germline gene expression system |
| US9181568B2 (en) | 2012-04-23 | 2015-11-10 | Exxonmobil Research And Engineering Company | Cell systems and methods for improving fatty acid synthesis by expression of dehydrogenases |
| GB201303932D0 (en) | 2013-03-05 | 2013-04-17 | Oxitec Ltd | Muscle actin promoter |
| GB2526867A (en) | 2014-06-05 | 2015-12-09 | Oxitec Ltd | Gene expression system |
| US12121539B2 (en) | 2015-09-11 | 2024-10-22 | Biosceptre (Aust) Pty Ltd | Chimeric antigen receptors and uses thereof |
| US20170267984A1 (en) | 2016-03-18 | 2017-09-21 | Exxonmobil Research And Engineering Company | Chlorophyllase overproduction to enhance photosynthetic efficiency |
| US20190185865A1 (en) * | 2016-07-06 | 2019-06-20 | Danmarks Tekniske Universitet | Use of prokaryotic transcriptional activators as metabolite biosensors in eukaryotic cells |
| EP3491134B1 (de) | 2016-08-01 | 2023-10-11 | University of Pittsburgh - of The Commonwealth System of Higher Education | Menschliche induzierte pluripotente stammzellen zur hocheffizienten genmanipulation |
| BR112019002771A2 (pt) | 2016-08-12 | 2019-05-14 | Oxitec Ltd | polinucleotídeo de módulo de controle de união de doublesex, sistema de expressão de gene, plasmídeo vetor de expressão, inseto geneticamente engenheirado, métodos para produzir insetos geneticamente engenheirados, para cultivar seletivamente insetos macho geneticamente engenheirados, para reduzir uma população de inseto selvagem, para criar um mosquito aedes aegypti transgênico e para detectar a presença de uma molécula de dna, local alvo cromossômico de aedes aegypti, mosquito aedes aegypti geneticamente engenheirado, molécula de dna, e, kit de detecção de dna. |
| EP3634449A4 (de) | 2017-05-08 | 2021-03-17 | Gritstone Oncology, Inc. | Alphavirus-neoantigen-vektoren |
| EP3758736B1 (de) | 2018-03-02 | 2024-05-01 | The United States of America, as represented by The Secretary, Department of Health and Human Services | Il-34 zur anwendung in einem verfahren zur behandlung von retinaler entzündung und neurodegeneration |
| AR117409A1 (es) | 2018-03-29 | 2021-08-04 | Oxitec Ltd | Noctuidas autolimitantes |
| CN112166193A (zh) | 2018-05-21 | 2021-01-01 | 生物权威（英国）有限公司 | 具有经修饰的接头结构域的嵌合抗原受体及其用途 |
| MX2021014525A (es) | 2019-05-30 | 2022-03-17 | Gritstone Bio Inc | Adenovirus modificados. |
| KR102880907B1 (ko) | 2019-11-11 | 2025-11-04 | 벤더르빌트 유니버시티 | 한타바이러스에 대한 인간 모노클로날 항체 및 이의 사용 방법 |
| CN116438308A (zh) | 2020-08-06 | 2023-07-14 | 磨石生物公司 | 多表位疫苗盒 |
| CN116113643A (zh) * | 2020-09-05 | 2023-05-12 | 银杏生物制品公司 | 合成表达系统 |
| WO2022241455A1 (en) * | 2021-05-12 | 2022-11-17 | Baylor College Of Medicine | A synthetic circuit for buffering gene dosage variation between individual mammalian cells |
| EP4355882A2 (de) * | 2021-06-15 | 2024-04-24 | Modernatx, Inc. | Manipulierte polynukleotide zur zelltyp- oder mikroumgebungsspezifischen expression |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3934454A1 (de) * | 1989-10-14 | 1991-04-18 | Merck Patent Gmbh | Regulierbare expressionsvektoren fuer bacillus |
| AU8059891A (en) * | 1990-06-13 | 1992-01-07 | Trustees Of Princeton University, The | A (lac) repressor-hsv vp16 chimeric transcriptional activator protein system functioning in transfected mammalian cells |
| GB9028062D0 (en) * | 1990-12-24 | 1991-02-13 | Agricultural & Food Res | Production of transgenic animals |
| DE4100594A1 (de) * | 1991-01-08 | 1992-07-09 | Inst Genbiologische Forschung | Neue plasmide zur zeitlichen und oertlichen kontrollierten expression eines heterologen produktes in pflanzen |
| AU664847B2 (en) * | 1991-05-15 | 1995-12-07 | Cell Genesys, Inc. | Genomic modifications with homologous DNA targeting |
| GB9113097D0 (en) * | 1991-06-18 | 1991-08-07 | Boehringer Ingelheim Int | Chimeric gene |
| US5464758A (en) * | 1993-06-14 | 1995-11-07 | Gossen; Manfred | Tight control of gene expression in eucaryotic cells by tetracycline-responsive promoters |
| US5866755A (en) * | 1993-06-14 | 1999-02-02 | Basf Aktiengellschaft | Animals transgenic for a tetracycline-regulated transcriptional inhibitor |
-
1995
- 1995-06-07 US US08/474,169 patent/US5851796A/en not_active Expired - Lifetime
-
1996
- 1996-06-07 AT AT96921541T patent/ATE321871T1/de active
- 1996-06-07 JP JP9502206A patent/JPH11507539A/ja not_active Ceased
- 1996-06-07 DE DE69635992T patent/DE69635992T2/de not_active Expired - Lifetime
- 1996-06-07 AU AU62745/96A patent/AU6274596A/en not_active Abandoned
- 1996-06-07 WO PCT/US1996/010109 patent/WO1996040946A1/en not_active Ceased
- 1996-06-07 EP EP96921541A patent/EP0832254B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| WO1996040946A1 (en) | 1996-12-19 |
| EP0832254A1 (de) | 1998-04-01 |
| US5851796A (en) | 1998-12-22 |
| JPH11507539A (ja) | 1999-07-06 |
| DE69635992D1 (de) | 2006-05-18 |
| EP0832254B1 (de) | 2006-03-29 |
| AU6274596A (en) | 1996-12-30 |
| DE69635992T2 (de) | 2007-02-01 |
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| UEP | Publication of translation of european patent specification |
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