ATE323774T1 - Antitumor-gentherapie bei immuno-und/oder entzündungsmodulation - Google Patents

Antitumor-gentherapie bei immuno-und/oder entzündungsmodulation

Info

Publication number: ATE323774T1
Authority: AT; Austria
Prior art keywords: agent; contg; genome; dna fragment; viral vector
Prior art date: 1993-09-29

Application number

AT01110326T

Other languages

English (en)

Inventor

Bruce Acres

Original Assignee

Transgene Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-09-29

Filing date

1994-09-28

Publication date

2006-05-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9451366&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE323774(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1994-09-28 Application filed by Transgene Sa filed Critical Transgene Sa

2006-05-15 Application granted granted Critical

2006-05-15 Publication of ATE323774T1 publication Critical patent/ATE323774T1/de

Links

206010061218 Inflammation Diseases 0.000 title 1
230000000259 anti-tumor effect Effects 0.000 title 1
238000001415 gene therapy Methods 0.000 title 1
230000004054 inflammatory process Effects 0.000 title 1
206010028980 Neoplasm Diseases 0.000 abstract 4
201000011510 cancer Diseases 0.000 abstract 3
210000004027 cell Anatomy 0.000 abstract 3
239000003795 chemical substances by application Substances 0.000 abstract 3
101150084750 1 gene Proteins 0.000 abstract 2
239000012634 fragment Substances 0.000 abstract 2
239000013603 viral vector Substances 0.000 abstract 2
241000894006 Bacteria Species 0.000 abstract 1
102000019034 Chemokines Human genes 0.000 abstract 1
108010012236 Chemokines Proteins 0.000 abstract 1
108090000695 Cytokines Proteins 0.000 abstract 1
102000004127 Cytokines Human genes 0.000 abstract 1
241000124008 Mammalia Species 0.000 abstract 1
101000686985 Mouse mammary tumor virus (strain C3H) Protein PR73 Proteins 0.000 abstract 1
241000700605 Viruses Species 0.000 abstract 1
239000002671 adjuvant Substances 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
230000028993 immune response Effects 0.000 abstract 1
208000015181 infectious disease Diseases 0.000 abstract 1
230000002458 infectious effect Effects 0.000 abstract 1
230000028709 inflammatory response Effects 0.000 abstract 1
210000004698 lymphocyte Anatomy 0.000 abstract 1
244000045947 parasite Species 0.000 abstract 1
229920001184 polypeptide Polymers 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1
102000004196 processed proteins & peptides Human genes 0.000 abstract 1
231100000617 superantigen Toxicity 0.000 abstract 1
230000010415 tropism Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2013—IL-2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2026—IL-4
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2033—IL-5
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/204—IL-6
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2046—IL-7
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/53—Colony-stimulating factor [CSF]
- C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/56—IFN-alpha
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
- C12N2710/24141—Use of virus, viral particle or viral elements as a vector
- C12N2710/24143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Zoology (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Gastroenterology & Hepatology (AREA)
Genetics & Genomics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Immunology (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Toxicology (AREA)
Biotechnology (AREA)
Biomedical Technology (AREA)
General Engineering & Computer Science (AREA)
Wood Science & Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Plant Pathology (AREA)
Microbiology (AREA)
Physics & Mathematics (AREA)
General Chemical & Material Sciences (AREA)
Virology (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

AT01110326T 1993-09-29 1994-09-28 Antitumor-gentherapie bei immuno-und/oder entzündungsmodulation ATE323774T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9311601A FR2710536B1 (fr)	1993-09-29	1993-09-29	Usage anti-cancéreux d'un vecteur viral comportant un gène modulateur de la réponse immunitaire et/ou inflammatoire.

Publications (1)

Publication Number	Publication Date
ATE323774T1 true ATE323774T1 (de)	2006-05-15

Family

ID=9451366

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT01110326T ATE323774T1 (de)	1993-09-29	1994-09-28	Antitumor-gentherapie bei immuno-und/oder entzündungsmodulation
AT94928924T ATE247714T1 (de)	1993-09-29	1994-09-28	Antitumor-gentherapie bei immuno-und/oder entzuendungmodulation

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
AT94928924T ATE247714T1 (de)	1993-09-29	1994-09-28	Antitumor-gentherapie bei immuno-und/oder entzuendungmodulation

Country Status (12)

Country	Link
EP (2)	EP0721510B1 (de)
JP (1)	JP4094053B2 (de)
AT (2)	ATE323774T1 (de)
AU (1)	AU709336C (de)
DE (2)	DE69433060T2 (de)
DK (2)	DK1156119T3 (de)
ES (2)	ES2204922T3 (de)
FR (1)	FR2710536B1 (de)
HK (1)	HK1042728B (de)
PT (2)	PT721510E (de)
SG (1)	SG96534A1 (de)
WO (1)	WO1995009241A2 (de)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5833975A (en) *	1989-03-08	1998-11-10	Virogenetics Corporation	Canarypox virus expressing cytokine and/or tumor-associated antigen DNA sequence
US5662896A (en)	1988-03-21	1997-09-02	Chiron Viagene, Inc.	Compositions and methods for cancer immunotherapy
US6093700A (en)	1995-05-11	2000-07-25	Thomas Jefferson University	Method of inducing an immune response using vaccinia virus recombinants encoding GM-CSF
DE69535288T2 (de) *	1994-05-13	2007-04-05	Thomas Jefferson University	Verfahren zur induzierung einer immunantwort mittels rekombinanten vaccinia-viren, die das gm-csf-gen exprimieren
US6045802A (en) *	1994-10-03	2000-04-04	The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services	Enhanced immune response to an antigen by a composition of a recombinant virus expressing the antigen with a recombinant virus expressing an immunostimulatory molecule
US6165460A (en) *	1995-07-10	2000-12-26	Therion Biologics Corporation	Generation of immune responses to prostate-specific antigen (PSA)
US6544523B1 (en)	1996-11-13	2003-04-08	Chiron Corporation	Mutant forms of Fas ligand and uses thereof
GB2324960A (en) *	1997-05-09	1998-11-11	Univ Manchester	Delivery of naked DNA for wound healing
EP1900818A3 (de)	1997-11-06	2008-06-11	Novartis Vaccines and Diagnostics S.r.l.	Neissersche Antigene
WO1999036544A2 (en)	1998-01-14	1999-07-22	Chiron S.P.A.	Neisseria meningitidis antigens
EP2261347A3 (de)	1998-05-01	2012-01-11	Novartis Vaccines and Diagnostics, Inc.	Antigene und Zusammensetzungen gegen Neisseria meningitidis
CA2372235A1 (en)	1999-04-30	2000-11-09	Rino Rappuoli	Conserved neisserial antigens
GB9911683D0 (en)	1999-05-19	1999-07-21	Chiron Spa	Antigenic peptides
GB9916529D0 (en)	1999-07-14	1999-09-15	Chiron Spa	Antigenic peptides
EP1226253A2 (de)	1999-10-29	2002-07-31	Chiron S.P.A.	Antigene peptide aus neisseria
CA2871789C (en)	2000-01-17	2017-04-04	Novartis Vaccines And Diagnostics S.R.L.	Outer membrane vesicle (omv) vaccine comprising n. meningitidis serogroup b outer membrane proteins
ATE439372T1 (de)	2000-10-27	2009-08-15	Novartis Vaccines & Diagnostic	Nukleinsäuren und proteine von gruppen a und b- streptokokken
EP1366167A2 (de) *	2001-01-26	2003-12-03	Transgene S.A.	Biologisches material zur herstellung pharmazeutischer zusammensetzungen zur behandlung von säugetieren
GB0107658D0 (en)	2001-03-27	2001-05-16	Chiron Spa	Streptococcus pneumoniae
GB0107661D0 (en)	2001-03-27	2001-05-16	Chiron Spa	Staphylococcus aureus
EP1281767A3 (de)	2001-07-31	2003-05-28	Aladar A. Szalay	Lichtausstrahlende Mikroorganismen und Zellen für die Diagnose und Therapie von Tumoren
EP2168596B1 (de)	2001-12-12	2012-05-23	Novartis Vaccines and Diagnostics S.r.l.	Immunisierung gegen Chlamydia trachomatis
EP1369491A1 (de)	2002-06-05	2003-12-10	Aladar A. Szalay	Lichtemittierende Mikroorganismen und Zellen für die Diagnose und Therapie von Krankheiten assoziiert mit Wunden oder entzündetem Gewebe
ES2544527T3 (es)	2002-07-31	2015-09-01	Seattle Genetics, Inc.	Conjugados de fármacos y su uso para tratar el cáncer, una enfermedad autoinmune o una enfermedad infecciosa
JP4634710B2 (ja) *	2002-07-31	2011-02-16	ゲネルクスコーポレーション	腫瘍の診断および治療のための微生物および細胞
GB0308198D0 (en)	2003-04-09	2003-05-14	Chiron Srl	ADP-ribosylating bacterial toxin
WO2005047458A2 (en)	2003-06-18	2005-05-26	Genelux Corporation	Modified recombinant vaccina viruses and other microorganisms, uses thereof
US8268324B2 (en)	2004-03-29	2012-09-18	Galpharma Co., Ltd.	Modified galectin 9 proteins and use thereof
CN101351213B (zh) *	2005-09-07	2013-10-02	詹纳里克斯公司	使用表达gm-csf的痘病毒系统性治疗转移性癌和/或全身散布性癌
RU2313349C2 (ru) *	2006-01-16	2007-12-27	Михаил Аркадьевич Шурдов	Способ лечения онкологических заболеваний
ATE522541T1 (de)	2006-06-09	2011-09-15	Novartis Ag	Bakterielle adhäsine konformere
WO2008100292A2 (en)	2006-10-16	2008-08-21	Genelux Corporation	Modified vaccinia virus strains for use in diagnostic and therapeutic methods
NZ596595A (en)	2009-05-12	2013-05-31	Transgene Sa	Method for orthopoxvirus production and purification
IN2012DN01577A (de)	2009-07-21	2015-06-05	Transgene Sa
TWI690322B (zh)	2012-10-02	2020-04-11	法商傳斯堅公司	含病毒的調配物及其使用
AU2015357225B2 (en)	2014-12-01	2020-04-09	Transgene Sa	Stable liquid vaccinia virus formulations
CA3061678A1 (en)	2017-05-15	2018-11-22	Janssen Vaccines & Prevention B.V.	Stable virus-containing composition
US11052147B2 (en)	2017-05-15	2021-07-06	Janssen Vaccines & Prevention B.V.	Stable virus-containing composition

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2583429B1 (fr) *	1985-06-18	1989-11-03	Transgene Sa	Vecteur d'expression de l'interferon u dans les cellules de mammifere, procede pour sa mise en oeuvre et produit obtenu et composition pharmaceutique contenant l'interferon u
FR2583770B1 (fr) *	1985-06-21	1988-08-19	Transgene Sa	Expression de l'il-2 humaine dans les cellules de mammiferes par un poxvirus recombine
US5342774A (en) *	1991-05-23	1994-08-30	Ludwig Institute For Cancer Research	Nucleotide sequence encoding the tumor rejection antigen precursor, MAGE-1
EP0607309B1 (de) *	1991-10-04	2003-01-08	Whitehead Institute For Biomedical Research	Regulierung der systemischen immunantworten mittels zytokinen und antigenen
CA2121127A1 (en) *	1991-10-25	1993-04-29	Robert E. Sobol	Lymphokine gene therapy of cancer
US5314813A (en) *	1992-02-19	1994-05-24	Scripps Research Institute	Drosophila cell lines expressing genes encoding MHC class I antigens and B2-microglobulin and capable of assembling empty complexes and methods of making said cell lines
FR2688514A1 (fr) *	1992-03-16	1993-09-17	Centre Nat Rech Scient	Adenovirus recombinants defectifs exprimant des cytokines et medicaments antitumoraux les contenant.
WO1994004196A1 (en) *	1992-08-14	1994-03-03	Imperial Cancer Research Technology Limited	Tumour therapy

1993
- 1993-09-29 FR FR9311601A patent/FR2710536B1/fr not_active Expired - Fee Related
1994
- 1994-09-28 PT PT94928924T patent/PT721510E/pt unknown
- 1994-09-28 ES ES94928924T patent/ES2204922T3/es not_active Expired - Lifetime
- 1994-09-28 DK DK01110326T patent/DK1156119T3/da active
- 1994-09-28 SG SG9608019A patent/SG96534A1/en unknown
- 1994-09-28 PT PT01110326T patent/PT1156119E/pt unknown
- 1994-09-28 AU AU78159/94A patent/AU709336C/en not_active Expired
- 1994-09-28 WO PCT/FR1994/001133 patent/WO1995009241A2/fr not_active Ceased
- 1994-09-28 EP EP94928924A patent/EP0721510B1/de not_active Expired - Lifetime
- 1994-09-28 AT AT01110326T patent/ATE323774T1/de active
- 1994-09-28 JP JP51015095A patent/JP4094053B2/ja not_active Expired - Lifetime
- 1994-09-28 EP EP01110326A patent/EP1156119B9/de not_active Expired - Lifetime
- 1994-09-28 ES ES01110326T patent/ES2260117T3/es not_active Expired - Lifetime
- 1994-09-28 AT AT94928924T patent/ATE247714T1/de active
- 1994-09-28 DE DE69433060T patent/DE69433060T2/de not_active Expired - Lifetime
- 1994-09-28 DK DK94928924T patent/DK0721510T3/da active
- 1994-09-28 DE DE69434708T patent/DE69434708T2/de not_active Expired - Lifetime
2002
- 2002-05-21 HK HK02103801.1A patent/HK1042728B/zh not_active IP Right Cessation

Also Published As

Publication number	Publication date
EP1156119B9 (de)	2006-08-30
AU7815994A (en)	1995-04-18
ES2260117T3 (es)	2006-11-01
PT1156119E (pt)	2006-08-31
FR2710536B1 (fr)	1995-12-22
DK0721510T3 (da)	2003-11-17
DE69434708D1 (de)	2006-05-24
AU709336C (en)	2002-06-13
DE69434708T2 (de)	2007-04-05
EP0721510B1 (de)	2003-08-20
ES2204922T3 (es)	2004-05-01
EP0721510A1 (de)	1996-07-17
AU709336B2 (en)	1999-08-26
HK1042728B (zh)	2006-11-24
JP4094053B2 (ja)	2008-06-04
EP1156119B1 (de)	2006-04-19
DE69433060T2 (de)	2004-06-03
DK1156119T3 (da)	2006-06-06
FR2710536A1 (fr)	1995-04-07
SG96534A1 (en)	2003-06-16
EP1156119A3 (de)	2002-10-23
WO1995009241A2 (fr)	1995-04-06
PT721510E (pt)	2003-11-28
JPH09502993A (ja)	1997-03-25
ATE247714T1 (de)	2003-09-15
EP1156119A2 (de)	2001-11-21
WO1995009241A3 (fr)	1995-06-22
DE69433060D1 (de)	2003-09-25
HK1042728A1 (en)	2002-08-23

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2007-03-15

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Publication	Publication Date	Title
ATE247714T1 (de)	2003-09-15	Antitumor-gentherapie bei immuno-und/oder entzuendungmodulation
GR3032660T3 (en)	2000-06-30	Lymphokine gene therapy of cancer.
Thompson et al.	1986	Eradication of disseminated murine leukemia by treatment with high-dose interleukin 2.
Saito et al.	1982	Induction of interferon-γ in mouse spleen cells by OK-432, a preparation of Streptococcus pyogenes
DE69233186D1 (de)	2003-10-09	Karcinoembryonale antigen expremierende rekombinante viren und methoden ihrer anwendung
ZA886471B (en)	1989-04-26	Conjugates of cytokines with imunologulins
Saito et al.	1984	Activated macrophages are responsible for the tumor‐inhibitory effect in mice receiving intravenous injection of OK‐432
DE3684732D1 (de)	1992-05-14	Adoptivimmuntherapie als behandlungsmodalitaet bei menschen.
CA2282300A1 (en)	1998-08-27	Recombinant pox virus for immunization against muc1 tumor-associated antigen
ZA875681B (en)	1988-04-27	Recombinant vaccine
AU7679787A (en)	1988-02-18	Expression of a tumor-specific antigen by a recombinant vector virus and use thereof in preventive or curative treatment of the corresponding tumor
Ratliff et al.	1981	Interferon induction and augmentation of natural-killer activity by Staphylococcus protein A
Ju et al.	1998	Adenovirus-mediated combined suicide gene and interleukin-2 gene therapy for the treatment of established tumor and induction of antitumor immunity
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