ATE326536T1 - Herstellung von biologisch aktiven molekülen - Google Patents

Herstellung von biologisch aktiven molekülen

Info

Publication number
ATE326536T1
ATE326536T1 AT00919108T AT00919108T ATE326536T1 AT E326536 T1 ATE326536 T1 AT E326536T1 AT 00919108 T AT00919108 T AT 00919108T AT 00919108 T AT00919108 T AT 00919108T AT E326536 T1 ATE326536 T1 AT E326536T1
Authority
AT
Austria
Prior art keywords
production
biologically active
active molecules
molecules
biologically
Prior art date
Application number
AT00919108T
Other languages
English (en)
Inventor
Menachem Rubinstein
Bianling Liu
Daniela Novick
Pierre Graber
Original Assignee
Yeda Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yeda Res & Dev filed Critical Yeda Res & Dev
Application granted granted Critical
Publication of ATE326536T1 publication Critical patent/ATE326536T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6472—Cysteine endopeptidases (3.4.22)
    • C12N9/6475—Interleukin 1-beta convertase-like enzymes (3.4.22.10; 3.4.22.36; 3.4.22.63)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/545—IL-1

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Steroid Compounds (AREA)
AT00919108T 1999-04-13 2000-04-13 Herstellung von biologisch aktiven molekülen ATE326536T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IL12942799A IL129427A0 (en) 1999-04-13 1999-04-13 Preparation of biologically active molecules

Publications (1)

Publication Number Publication Date
ATE326536T1 true ATE326536T1 (de) 2006-06-15

Family

ID=11072700

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00919108T ATE326536T1 (de) 1999-04-13 2000-04-13 Herstellung von biologisch aktiven molekülen

Country Status (23)

Country Link
US (1) US7098002B1 (de)
EP (1) EP1169460B1 (de)
JP (1) JP4822587B2 (de)
KR (1) KR100682185B1 (de)
CN (1) CN1324140C (de)
AR (1) AR023468A1 (de)
AT (1) ATE326536T1 (de)
AU (1) AU781342B2 (de)
BR (1) BR0009782A (de)
CA (1) CA2368994C (de)
DE (1) DE60028022T2 (de)
DK (1) DK1169460T3 (de)
EA (1) EA006825B1 (de)
EE (1) EE05591B1 (de)
ES (1) ES2259287T3 (de)
IL (3) IL129427A0 (de)
MX (1) MXPA01010487A (de)
NO (1) NO329525B1 (de)
PT (1) PT1169460E (de)
SI (1) SI1169460T1 (de)
UA (1) UA73940C2 (de)
WO (1) WO2000061768A2 (de)
ZA (1) ZA200108364B (de)

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AU1336701A (en) * 1999-10-20 2001-04-30 Scios Inc. Functional cloning of genes encoding proteins/enzymes involved in proteolytic cleavage
US7273722B2 (en) 2000-11-29 2007-09-25 Allergan, Inc. Neurotoxins with enhanced target specificity
JP2004530432A (ja) 2001-03-08 2004-10-07 アレス・トレーディング・ソシエテ・アノニム インターロイキン−１８変異体、その産生および使用
IL142246A0 (en) * 2001-03-26 2002-03-10 Applied Research Systems Method and kit for quantitation of polypeptides
EP1483298A4 (de) 2002-02-11 2007-03-14 Zymogenetics Inc Materialien und verfahren zur herstellung dimerer wachstumsfaktoren
PT1597369E (pt) * 2003-02-21 2008-01-10 Univ Gent Processo de produção de polipéptidos fundidos, recombinantes, utilizando as enzimas caspases para amaturação
EP1651751B1 (de) * 2003-08-06 2015-11-18 University Of Maryland Biotechnology Institute Gentechnisch hergestellte proteasen zur affinitätsreinigung und prozessierung von fusionsproteinen
CA2545024A1 (en) * 2003-11-24 2005-06-02 Novo Nordisk A/S Fusion proteins and methods of cleavage of such proteins
CA2558811A1 (en) 2004-03-08 2005-09-22 Zymogenetics, Inc. Dimeric fusion proteins and materials and methods for producing them
DK2154151T3 (da) * 2005-09-19 2011-09-05 Allergan Inc Clostridiumtoksinaktiverbare clostridiumtoksiner
JP5093783B2 (ja) * 2006-04-20 2012-12-12 クリングルファーマ株式会社 Ｈｇｆ前駆体蛋白質改変体及びその活性型蛋白質
DE102007008596B4 (de) * 2007-02-15 2010-09-02 Friedrich-Schiller-Universität Jena Biologisch wirksame Moleküle auf Grundlage von PNA und siRNA, Verfahren zu deren zellspezifischen Aktivierung sowie Applikationskit zur Verabreichung
EP2190861A4 (de) * 2007-08-22 2011-03-30 Univ California Aktivierbare bindende polypeptide und verfahren zu deren identifikation und anwendung
KR100980315B1 (ko) * 2007-10-01 2010-09-07 한국생명공학연구원 대장균시스템을 이용한 인위적 활성화가 가능한 카스파제전구체 대량생산 및 활성화 방법
DE102009043743B4 (de) 2009-03-13 2016-10-13 Friedrich-Schiller-Universität Jena Zellspezifisch wirksame Moleküle auf Grundlage von siRNA sowie Applikationskits zu deren Herstellung und Verwendung
EP3543256A1 (de) 2009-01-12 2019-09-25 Cytomx Therapeutics Inc. Modifizierte antikörperzusammensetzungen, verfahren zur herstellung und verwendung davon
US8399219B2 (en) * 2009-02-23 2013-03-19 Cytomx Therapeutics, Inc. Protease activatable interferon alpha proprotein
CN103923897B (zh) * 2013-01-11 2016-06-01 中国人民解放军军事医学科学院生物工程研究所 caspase重组酶原及其编码基因与应用
CN103388001B (zh) * 2013-07-16 2016-01-20 中国人民解放军第四军医大学 一种含凝血酶切割位点gst膜型表达载体及转染阳性细胞的方法
EP3083977B1 (de) 2013-12-20 2018-02-28 F. Hoffmann-La Roche AG Verbesserte rekombinante polypeptidherstellungsverfahren
RU2017137788A (ru) 2015-03-30 2019-04-30 Гринлайт Байосайенсис, Инк. Бесклеточное получение рибонуклеиновой кислоты
AU2016282334B2 (en) 2015-06-24 2022-07-21 F. Hoffmann-La Roche Ag Anti-transferrin receptor antibodies with tailored affinity
MX2018003822A (es) 2015-10-02 2018-06-22 Hoffmann La Roche Anticuerpos biespecificos contra el cd20 humano y el receptor de transferrina humano y metodos de uso.
AR106189A1 (es) 2015-10-02 2017-12-20 Hoffmann La Roche ANTICUERPOS BIESPECÍFICOS CONTRA EL A-b HUMANO Y EL RECEPTOR DE TRANSFERRINA HUMANO Y MÉTODOS DE USO
SG11201808721YA (en) 2016-04-06 2018-11-29 Greenlight Biosciences Inc Cell-free production of ribonucleic acid
WO2019075167A1 (en) 2017-10-11 2019-04-18 Greenlight Biosciences, Inc. METHODS AND COMPOSITIONS FOR THE PRODUCTION OF NUCLEOSIDE TRIPHOSPHATE AND RIBONUCLEIC ACID
KR20200080749A (ko) * 2018-12-27 2020-07-07 주식회사 폴루스 N-말단의 메티오닌이 절단된 목적 단백질 발현용 유전자 발현 카세트 및 이를 이용하여 n-말단의 메티오닌이 절단된 목적 단백질을 생산하는 방법
CN114555791B (zh) * 2019-08-13 2026-07-14 伦敦国王学院 Il-1超家族时空限制性活性细胞因子铠装的免疫应答细胞

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US5824297A (en) * 1990-06-25 1998-10-20 Oncogene Science, Inc. Tissue-derived tumor growth inhibitors, methods of preparation and uses thereof
EP0538398A4 (en) * 1990-06-25 1993-12-29 Oncogene Science, Inc. Tissue-derived tumor growth inhibitors, methods for preparation and uses thereof
DE69229252T2 (de) * 1991-08-16 1999-12-16 Merck & Co., Inc. DNS, welche das Interleukin-1B-Vorläufer-Converting-Enzym kodiert
JP3404038B2 (ja) 1991-12-31 2003-05-06 ザイモジェネティクス，インコーポレイティド トロンビンの製造方法
JPH06125784A (ja) * 1992-01-17 1994-05-10 Takeda Chem Ind Ltd モノクローナル抗体，ハイブリドーマ，その製造法および用途
US6303369B1 (en) * 1993-09-30 2001-10-16 Carl Spana Protein expression system
CA2238885A1 (en) 1995-12-29 1997-07-10 Incyte Pharmaceuticals, Inc. Nucleic acids encoding interferon gamma inducing factor-2
JP4059941B2 (ja) * 1996-08-26 2008-03-12 社団法人芝蘭会 Ｒｈｏ標的タンパク質ｐ１４０ｍＤｉａ
AT405516B (de) * 1997-02-27 1999-09-27 Immuno Ag Faktor x-analoge mit modifizierter proteasespaltstelle
JPH10327872A (ja) * 1997-05-30 1998-12-15 Otsuka Pharmaceut Co Ltd Ｂｃｌ−２相互作用蛋白遺伝子ｂｉｓ
EP1013763B1 (de) 1997-08-07 2011-02-02 Toray Industries, Inc. Methode zur herstellung von canine interleukin 18

Also Published As

Publication number Publication date
WO2000061768A2 (en) 2000-10-19
DE60028022D1 (de) 2006-06-22
KR20020007365A (ko) 2002-01-26
EP1169460B1 (de) 2006-05-17
JP4822587B2 (ja) 2011-11-24
IL145842A0 (en) 2002-07-25
UA73940C2 (uk) 2005-10-17
BR0009782A (pt) 2002-01-08
EA006825B1 (ru) 2006-04-28
CN1353761A (zh) 2002-06-12
HK1044351A1 (en) 2002-10-18
AR023468A1 (es) 2002-09-04
EA200101078A1 (ru) 2002-04-25
EE05591B1 (et) 2012-10-15
US7098002B1 (en) 2006-08-29
CA2368994C (en) 2010-03-09
NO329525B1 (no) 2010-11-01
AU3985100A (en) 2000-11-14
IL129427A0 (en) 2000-02-17
EP1169460A2 (de) 2002-01-09
CN1324140C (zh) 2007-07-04
MXPA01010487A (es) 2002-05-06
EE200100530A (et) 2002-12-16
DK1169460T3 (da) 2006-09-18
IL145842A (en) 2008-06-05
WO2000061768A3 (en) 2001-02-08
SI1169460T1 (sl) 2006-08-31
ZA200108364B (en) 2002-10-11
KR100682185B1 (ko) 2007-02-12
DE60028022T2 (de) 2006-09-28
CA2368994A1 (en) 2000-10-19
JP2002541813A (ja) 2002-12-10
PT1169460E (pt) 2006-07-31
AU781342B2 (en) 2005-05-19
ES2259287T3 (es) 2006-10-01
NO20014966L (no) 2001-12-11
NO20014966D0 (no) 2001-10-12

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