ATE333462T1 - 17 beta-amino und hydroxylamino-11 beta- arylsteroide und deren derivate mit hormonalen agonist- oder antagonisteigenschaften - Google Patents

17 beta-amino und hydroxylamino-11 beta- arylsteroide und deren derivate mit hormonalen agonist- oder antagonisteigenschaften

Info

Publication number
ATE333462T1
ATE333462T1 AT99924207T AT99924207T ATE333462T1 AT E333462 T1 ATE333462 T1 AT E333462T1 AT 99924207 T AT99924207 T AT 99924207T AT 99924207 T AT99924207 T AT 99924207T AT E333462 T1 ATE333462 T1 AT E333462T1
Authority
AT
Austria
Prior art keywords
beta
hydroxylamino
derivatives
amino
antagonist properties
Prior art date
Application number
AT99924207T
Other languages
English (en)
Inventor
C Edgar Cook
John A Kepler
Gary S Bartley
Rupa S Shetty
Original Assignee
Res Triangle Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Res Triangle Inst filed Critical Res Triangle Inst
Application granted granted Critical
Publication of ATE333462T1 publication Critical patent/ATE333462T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/16—Masculine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/36—Antigestagens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT99924207T 1998-05-29 1999-05-28 17 beta-amino und hydroxylamino-11 beta- arylsteroide und deren derivate mit hormonalen agonist- oder antagonisteigenschaften ATE333462T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/086,560 US6262042B1 (en) 1998-05-29 1998-05-29 17β-amino and hydroxylamino-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties

Publications (1)

Publication Number Publication Date
ATE333462T1 true ATE333462T1 (de) 2006-08-15

Family

ID=22199388

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99924207T ATE333462T1 (de) 1998-05-29 1999-05-28 17 beta-amino und hydroxylamino-11 beta- arylsteroide und deren derivate mit hormonalen agonist- oder antagonisteigenschaften

Country Status (24)

Country Link
US (3) US6262042B1 (de)
EP (1) EP1082337B1 (de)
JP (1) JP4545929B2 (de)
KR (1) KR100611289B1 (de)
CN (1) CN100357311C (de)
AT (1) ATE333462T1 (de)
AU (1) AU753382B2 (de)
BR (1) BR9910794A (de)
CA (1) CA2333669C (de)
CY (1) CY1106443T1 (de)
CZ (1) CZ300313B6 (de)
DE (1) DE69932432T8 (de)
DK (1) DK1082337T3 (de)
ES (1) ES2270596T3 (de)
HU (1) HU228770B1 (de)
ID (1) ID26885A (de)
IL (1) IL139861A (de)
NO (1) NO317988B1 (de)
NZ (1) NZ507985A (de)
PL (1) PL198055B1 (de)
PT (1) PT1082337E (de)
RU (1) RU2238943C2 (de)
SK (1) SK285748B6 (de)
WO (1) WO1999062928A1 (de)

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US6982251B2 (en) * 2000-12-20 2006-01-03 Schering Corporation Substituted 2-azetidinones useful as hypocholesterolemic agents
HU230253B1 (hu) 2001-01-26 2015-11-30 Merck Sharp & Dohme Corp Peroxiszóma proliferátor-aktivált receptor (PPAR) aktivátor(ok) és szterin-abszorpció inhibitor(ok) kombinációi és alkalmazásuk vaszkuláris indikációk kezelésére
DK1355644T3 (da) 2001-01-26 2006-10-23 Schering Corp Anvendelse af substituerede azetidinonforbindelser til behandling af sitosterolæmi
US7071181B2 (en) 2001-01-26 2006-07-04 Schering Corporation Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors
JP2005504091A (ja) 2001-09-21 2005-02-10 シェーリング　コーポレイション ステロール吸収阻害剤としてアゼチジノンを用いる黄色腫の処置
US7053080B2 (en) 2001-09-21 2006-05-30 Schering Corporation Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors
ES2190373B1 (es) * 2001-12-07 2004-10-16 J. URIACH & CIA, S.A. Uso del acido 2-hidroxi- o 2-acetiloxi-4-trifluorometilbenzoico como agente para el tratamiento y prevencion del deterioro cognitivo ligero.
WO2004043457A1 (en) 2002-11-06 2004-05-27 Schering Corporation Cholesterol absorptions inhibitors for the treatment of autoimmune disorders
US7459442B2 (en) 2003-03-07 2008-12-02 Schering Corporation Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
CA2517571C (en) 2003-03-07 2011-07-05 Schering Corporation Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
JP2006519869A (ja) 2003-03-07 2006-08-31 シェーリング　コーポレイション 置換アゼチジノン化合物、置換アゼチジノン化合物を調製するためのプロセス、それらの処方物および使用
JP4589919B2 (ja) 2003-03-07 2010-12-01 シェーリング コーポレイション 高コレステロール血症の処置のための、置換アゼチジノン化合物、これらの処方物および使用
US8097606B2 (en) * 2003-07-23 2012-01-17 Corcept Therapeutics, Inc. Antiglucocorticoids for the treatment of catatonia
US20070249573A1 (en) * 2006-04-13 2007-10-25 Gerd Schubert 17alpha-substituted 4-(3-oxoestra-4,9-dien-11beta-yl)-benzoic acid, its derivatives and process for its production
US9517240B2 (en) 2006-09-26 2016-12-13 The Regents Of The University Of California Methods and compositions for cancer prevention and treatment
WO2008039482A2 (en) * 2006-09-26 2008-04-03 The Regents Of The University Of California Methods and compositions for cancer prevention and treatment
US8299050B2 (en) * 2008-01-29 2012-10-30 Laboratoire Hra-Pharma Method for treating uterine fibroids
US8778969B2 (en) * 2009-11-07 2014-07-15 Peter H Proctor Nitrone, nitroso, and nitroxide spintraps and spin labels and their hydroxylamines
US9096641B2 (en) * 2013-06-05 2015-08-04 Evestra, Inc. Imidazolyl progesterone antagonists

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US4686085A (en) * 1980-04-14 1987-08-11 Thomas Jefferson University Stroke treatment utilizing extravascular circulation of oxygenated synthetic nutrients to treat tissue hypoxic and ischemic disorders
ZA8231B (en) 1981-01-09 1982-11-24 Roussel Uclaf New 11 -substituted steroid derivatives, their preparation, their use as medicaments, the compositions containing them and the new intermediates thus obtained
FR2522328B1 (fr) 1982-03-01 1986-02-14 Roussel Uclaf Nouveaux produits derives de la structure 3-ceto 4,9 19-nor steroides, leur procede de preparation et leur application comme medicaments
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US5962444A (en) 1998-05-29 1999-10-05 Research Triangle Institute 17β-nitro-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties
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Also Published As

Publication number Publication date
SK18092000A3 (sk) 2001-04-09
US6620801B2 (en) 2003-09-16
ID26885A (id) 2001-02-15
US6262042B1 (en) 2001-07-17
PT1082337E (pt) 2006-11-30
EP1082337B1 (de) 2006-07-19
CA2333669A1 (en) 1999-12-09
PL344413A1 (en) 2001-11-05
HK1035196A1 (en) 2001-11-16
US7018991B2 (en) 2006-03-28
CN100357311C (zh) 2007-12-26
US20020065257A1 (en) 2002-05-30
CN1303391A (zh) 2001-07-11
IL139861A (en) 2005-09-25
CZ300313B6 (cs) 2009-04-15
CZ20004446A3 (cs) 2001-04-11
WO1999062928A1 (en) 1999-12-09
DE69932432D1 (de) 2006-08-31
JP2002531381A (ja) 2002-09-24
DK1082337T3 (da) 2006-12-04
KR20010052427A (ko) 2001-06-25
NZ507985A (en) 2003-11-28
DE69932432T2 (de) 2007-03-15
CA2333669C (en) 2008-08-26
BR9910794A (pt) 2001-02-13
AU4076199A (en) 1999-12-20
HUP0103109A2 (hu) 2002-01-28
KR100611289B1 (ko) 2006-08-10
JP4545929B2 (ja) 2010-09-15
PL198055B1 (pl) 2008-05-30
IL139861A0 (en) 2002-02-10
SK285748B6 (sk) 2007-07-06
NO20005989D0 (no) 2000-11-27
HUP0103109A3 (en) 2002-09-30
AU753382B2 (en) 2002-10-17
DE69932432T8 (de) 2007-08-23
EP1082337A1 (de) 2001-03-14
RU2238943C2 (ru) 2004-10-27
ES2270596T3 (es) 2007-04-01
EP1082337A4 (de) 2004-12-29
US20040023936A1 (en) 2004-02-05
NO20005989L (no) 2000-11-27
HU228770B1 (en) 2013-05-28
NO317988B1 (no) 2005-01-17
CY1106443T1 (el) 2011-10-12

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