DK1082337T3 - 17-beta-amino- og hydroxylamino-11-beta-arylsteroider og deres derivater, som har agonistiske eller antagonistiske, hormonale egenskaber - Google Patents

17-beta-amino- og hydroxylamino-11-beta-arylsteroider og deres derivater, som har agonistiske eller antagonistiske, hormonale egenskaber

Info

Publication number
DK1082337T3
DK1082337T3 DK99924207T DK99924207T DK1082337T3 DK 1082337 T3 DK1082337 T3 DK 1082337T3 DK 99924207 T DK99924207 T DK 99924207T DK 99924207 T DK99924207 T DK 99924207T DK 1082337 T3 DK1082337 T3 DK 1082337T3
Authority
DK
Denmark
Prior art keywords
beta
hydroxylamino
agonistic
antagonistic
derivatives
Prior art date
Application number
DK99924207T
Other languages
Danish (da)
English (en)
Inventor
John A Kepler
C Edgar Cook
Gary S Bartley
Rupa S Shetty
Original Assignee
Res Triangle Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Res Triangle Inst filed Critical Res Triangle Inst
Application granted granted Critical
Publication of DK1082337T3 publication Critical patent/DK1082337T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/16—Masculine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/36—Antigestagens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK99924207T 1998-05-29 1999-05-28 17-beta-amino- og hydroxylamino-11-beta-arylsteroider og deres derivater, som har agonistiske eller antagonistiske, hormonale egenskaber DK1082337T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/086,560 US6262042B1 (en) 1998-05-29 1998-05-29 17β-amino and hydroxylamino-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties

Publications (1)

Publication Number Publication Date
DK1082337T3 true DK1082337T3 (da) 2006-12-04

Family

ID=22199388

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99924207T DK1082337T3 (da) 1998-05-29 1999-05-28 17-beta-amino- og hydroxylamino-11-beta-arylsteroider og deres derivater, som har agonistiske eller antagonistiske, hormonale egenskaber

Country Status (24)

Country Link
US (3) US6262042B1 (de)
EP (1) EP1082337B1 (de)
JP (1) JP4545929B2 (de)
KR (1) KR100611289B1 (de)
CN (1) CN100357311C (de)
AT (1) ATE333462T1 (de)
AU (1) AU753382B2 (de)
BR (1) BR9910794A (de)
CA (1) CA2333669C (de)
CY (1) CY1106443T1 (de)
CZ (1) CZ300313B6 (de)
DE (1) DE69932432T8 (de)
DK (1) DK1082337T3 (de)
ES (1) ES2270596T3 (de)
HU (1) HU228770B1 (de)
ID (1) ID26885A (de)
IL (1) IL139861A (de)
NO (1) NO317988B1 (de)
NZ (1) NZ507985A (de)
PL (1) PL198055B1 (de)
PT (1) PT1082337E (de)
RU (1) RU2238943C2 (de)
SK (1) SK285748B6 (de)
WO (1) WO1999062928A1 (de)

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US6982251B2 (en) * 2000-12-20 2006-01-03 Schering Corporation Substituted 2-azetidinones useful as hypocholesterolemic agents
RS20100015A (sr) 2001-01-26 2010-12-31 Schering Corporation Kombinacija aktivatora receptora aktiviranog peroksizom- proliferatorom (ppar) fenofibrata sa inhibitorom apsorpcije sterola ezetimibom za vaskularne indikacije
US7071181B2 (en) 2001-01-26 2006-07-04 Schering Corporation Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors
PT1355644E (pt) 2001-01-26 2006-11-30 Schering Corp Utilização de compostos azetidinona substituídos para o tratamento de sitosterolemia
EP1429756B1 (de) 2001-09-21 2006-11-22 Schering Corporation Behandlung von xanthom mittels azetidinon-derivate als hemmer der sterol absorption
US7053080B2 (en) 2001-09-21 2006-05-30 Schering Corporation Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors
ES2190373B1 (es) * 2001-12-07 2004-10-16 J. URIACH & CIA, S.A. Uso del acido 2-hidroxi- o 2-acetiloxi-4-trifluorometilbenzoico como agente para el tratamiento y prevencion del deterioro cognitivo ligero.
JP2006508188A (ja) 2002-11-06 2006-03-09 シェーリング　コーポレイション 脱髄の処置のためのコレステロール吸収インヒビター
CN1756755A (zh) 2003-03-07 2006-04-05 先灵公司 取代的2－吖丁啶酮化合物、其制剂及其治疗高胆甾醇血症的用途
US7459442B2 (en) 2003-03-07 2008-12-02 Schering Corporation Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
CN1756756A (zh) 2003-03-07 2006-04-05 先灵公司 取代的2－吖丁啶酮化合物、其制剂及其治疗高胆甾醇血症的用途
DE602004016123D1 (de) 2003-03-07 2008-10-09 Schering Corp Substituierte azetidinon-derivate, deren pharmazeutische formulierungen und deren verwendung zur behandlung von hypercholesterolemia
US8097606B2 (en) * 2003-07-23 2012-01-17 Corcept Therapeutics, Inc. Antiglucocorticoids for the treatment of catatonia
US20070249573A1 (en) * 2006-04-13 2007-10-25 Gerd Schubert 17alpha-substituted 4-(3-oxoestra-4,9-dien-11beta-yl)-benzoic acid, its derivatives and process for its production
US9517240B2 (en) 2006-09-26 2016-12-13 The Regents Of The University Of California Methods and compositions for cancer prevention and treatment
WO2008039482A2 (en) * 2006-09-26 2008-04-03 The Regents Of The University Of California Methods and compositions for cancer prevention and treatment
US8299050B2 (en) * 2008-01-29 2012-10-30 Laboratoire Hra-Pharma Method for treating uterine fibroids
US8778969B2 (en) * 2009-11-07 2014-07-15 Peter H Proctor Nitrone, nitroso, and nitroxide spintraps and spin labels and their hydroxylamines
US9096641B2 (en) * 2013-06-05 2015-08-04 Evestra, Inc. Imidazolyl progesterone antagonists

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DE289539C (de)
DE290198C (de)
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US4686085A (en) * 1980-04-14 1987-08-11 Thomas Jefferson University Stroke treatment utilizing extravascular circulation of oxygenated synthetic nutrients to treat tissue hypoxic and ischemic disorders
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FR2522328B1 (fr) 1982-03-01 1986-02-14 Roussel Uclaf Nouveaux produits derives de la structure 3-ceto 4,9 19-nor steroides, leur procede de preparation et leur application comme medicaments
DE3306121A1 (de) * 1983-02-18 1984-09-06 Schering AG, 1000 Berlin und 4709 Bergkamen 11ss-aryl-spirolaktone in der steroidreihe, verfahren zu deren herstellung und diese verbindungen enthaltende pharmazeutische praeparate
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US5962444A (en) 1998-05-29 1999-10-05 Research Triangle Institute 17β-nitro-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties
US6172052B1 (en) 1998-12-04 2001-01-09 Research Triangle Institute 17β-acyl-17α-propynyl-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties
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Also Published As

Publication number Publication date
CY1106443T1 (el) 2011-10-12
SK285748B6 (sk) 2007-07-06
HK1035196A1 (en) 2001-11-16
ES2270596T3 (es) 2007-04-01
CZ300313B6 (cs) 2009-04-15
JP4545929B2 (ja) 2010-09-15
KR20010052427A (ko) 2001-06-25
EP1082337B1 (de) 2006-07-19
KR100611289B1 (ko) 2006-08-10
HUP0103109A2 (hu) 2002-01-28
ID26885A (id) 2001-02-15
US7018991B2 (en) 2006-03-28
RU2238943C2 (ru) 2004-10-27
US6262042B1 (en) 2001-07-17
PL344413A1 (en) 2001-11-05
US20020065257A1 (en) 2002-05-30
CN1303391A (zh) 2001-07-11
CZ20004446A3 (cs) 2001-04-11
ATE333462T1 (de) 2006-08-15
HU228770B1 (en) 2013-05-28
AU753382B2 (en) 2002-10-17
CA2333669C (en) 2008-08-26
US6620801B2 (en) 2003-09-16
SK18092000A3 (sk) 2001-04-09
EP1082337A4 (de) 2004-12-29
NO20005989L (no) 2000-11-27
BR9910794A (pt) 2001-02-13
DE69932432D1 (de) 2006-08-31
DE69932432T2 (de) 2007-03-15
CA2333669A1 (en) 1999-12-09
IL139861A (en) 2005-09-25
US20040023936A1 (en) 2004-02-05
CN100357311C (zh) 2007-12-26
NZ507985A (en) 2003-11-28
PT1082337E (pt) 2006-11-30
NO20005989D0 (no) 2000-11-27
AU4076199A (en) 1999-12-20
HUP0103109A3 (en) 2002-09-30
EP1082337A1 (de) 2001-03-14
IL139861A0 (en) 2002-02-10
NO317988B1 (no) 2005-01-17
JP2002531381A (ja) 2002-09-24
PL198055B1 (pl) 2008-05-30
DE69932432T8 (de) 2007-08-23
WO1999062928A1 (en) 1999-12-09

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