ATE335083T1 - Methode und system zur erhöhten produktion von kommerziell wichtigen exoproteinen in gram- positiven bakterien - Google Patents

Methode und system zur erhöhten produktion von kommerziell wichtigen exoproteinen in gram- positiven bakterien

Info

Publication number
ATE335083T1
ATE335083T1 AT94908357T AT94908357T ATE335083T1 AT E335083 T1 ATE335083 T1 AT E335083T1 AT 94908357 T AT94908357 T AT 94908357T AT 94908357 T AT94908357 T AT 94908357T AT E335083 T1 ATE335083 T1 AT E335083T1
Authority
AT
Austria
Prior art keywords
exoproteins
gram
pct
positive bacteria
increased production
Prior art date
Application number
AT94908357T
Other languages
English (en)
Inventor
Vesa Kontinen
Matti Sarvas
Original Assignee
Novozymes As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novozymes As filed Critical Novozymes As
Application granted granted Critical
Publication of ATE335083T1 publication Critical patent/ATE335083T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/75—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Bacillus

Landscapes

  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AT94908357T 1993-02-26 1994-02-25 Methode und system zur erhöhten produktion von kommerziell wichtigen exoproteinen in gram- positiven bakterien ATE335083T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US2415493A 1993-02-26 1993-02-26

Publications (1)

Publication Number Publication Date
ATE335083T1 true ATE335083T1 (de) 2006-08-15

Family

ID=21819138

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94908357T ATE335083T1 (de) 1993-02-26 1994-02-25 Methode und system zur erhöhten produktion von kommerziell wichtigen exoproteinen in gram- positiven bakterien

Country Status (9)

Country Link
US (1) US5780261A (de)
EP (1) EP0686195B1 (de)
JP (2) JPH08507207A (de)
CN (1) CN1080307C (de)
AT (1) ATE335083T1 (de)
AU (1) AU6142694A (de)
DE (1) DE69434807T2 (de)
DK (1) DK0686195T3 (de)
WO (1) WO1994019471A1 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6630328B2 (en) 1909-07-15 2003-10-07 Genencor International, Inc. Increasing production of proteins in gram-positive microorganisms
US7118757B1 (en) * 1988-12-19 2006-10-10 Wyeth Holdings Corporation Meningococcal class 1 outer-membrane protein vaccine
KR0169913B1 (ko) * 1996-03-14 1999-01-15 김은영 신균주 바실러스속 ds11과 이로부터 생산되는 신규 파이타아제
US5945278A (en) * 1996-07-08 1999-08-31 The Finnish National Public Health Institute Method and system for enhanced production of commercially important exoproteins in gram-positive bacteria
US5919999A (en) 1996-11-14 1999-07-06 Queen's University At Kingston Enhanced transport with a plastid membrane transport protein
US20030157642A1 (en) 1997-07-15 2003-08-21 Caldwell Robert M. Increasing production of proteins in gram-positive microorganisms
WO1999004006A1 (en) * 1997-07-15 1999-01-28 Genencor International, Inc. Increasing production of proteins in gram-positive microorganisms
US6506579B1 (en) 1997-07-15 2003-01-14 Genencor International, Inc. Increasing production of proteins in gram-positive microorganisms using SecG
DE69829670T2 (de) * 1997-07-16 2006-01-12 Genencor International, Inc., Palo Alto Erhöhung der proteinproduktion in gram-positiven mikroorganismen
ATE320264T1 (de) * 1997-12-05 2006-04-15 Virginia Tech Intell Prop Ein impfstoff mit einem überexprimierenden homologen antigen sowie verfahren zu dessen herstellung
EP1038959A1 (de) 1999-03-17 2000-09-27 Aventis Behring Gesellschaft mit beschränkter Haftung Faktor VIII ohne B-Domän, der ein oder mehrere Insertionsstücke von verkürztem Intron I des Faktors IX enthält
US20050000666A1 (en) * 2003-05-06 2005-01-06 Novozymes A/S Use of hemicellulase composition in mechanical pulp production
WO2005056799A1 (en) 2003-12-10 2005-06-23 Novozymes A/S A cell with improved secretion mediated by mrga protein or homologue
CA2585717A1 (en) 2004-10-27 2006-05-04 Medimmune Inc. Modulation of antibody specificity by tailoring the affinity to cognate antigens
JP5226958B2 (ja) * 2007-02-22 2013-07-03 花王株式会社 組換え微生物
CN103443278B (zh) 2011-03-23 2017-07-04 诺维信公司 生产分泌型多肽的方法
WO2012127002A1 (en) 2011-03-23 2012-09-27 Novozymes A/S Sweet-tasting polypeptide from gram-positive bacteria
EP2546272A1 (de) 2011-07-15 2013-01-16 Ticona GmbH Verfahren zur Herstellung von Oxymethylenpolymeren
CN104845923B (zh) * 2014-02-14 2018-03-23 中国科学院微生物研究所 生产l‑组氨酸的方法及其专用重组菌
DK3775222T5 (da) 2018-03-26 2024-08-19 Novozymes As Chaperoneproteiner fra svampe
US12492391B2 (en) 2019-01-30 2025-12-09 Novozymes A/S Cognate foldase co-expression
EP3935160A1 (de) 2019-03-08 2022-01-12 Novozymes A/S Mittel und verfahren zur verbesserung der proteaseexpression
CN114945665A (zh) * 2020-01-15 2022-08-26 丹尼斯科美国公司 用于增强地衣芽孢杆菌中蛋白产生的组合物和方法
KR20240099301A (ko) 2021-11-16 2024-06-28 다니스코 유에스 인크. 바실러스 세포에서 단백질 생산을 향상시키기 위한 조성물 및 방법
WO2024146919A1 (en) 2023-01-05 2024-07-11 Basf Se Use of foldases to improve heterologous expression of secreted molecules
EP4737583A1 (de) 2023-06-28 2026-05-06 Kao Corporation Verfahren zur herstellung eines proteins von interesse

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4952508A (en) * 1980-03-10 1990-08-28 Cetus Corporation Method and vector organism for controlled accumulation of cloned heterologous gene products in Bacillus subtilis
US4711843A (en) * 1980-12-31 1987-12-08 Cetus Corporation Method and vector organism for controlled accumulation of cloned heterologous gene products in Bacillus subtilis
US4994379A (en) * 1983-03-09 1991-02-19 Cetus Corporation Modified signal peptides
US5017477A (en) * 1985-10-25 1991-05-21 Biotechnica International, Inc. Enhancing DNA sequencies derived from the sacQ gene
US4879213A (en) * 1986-12-05 1989-11-07 Scripps Clinic And Research Foundation Synthetic polypeptides and antibodies related to Epstein-Barr virus early antigen-diffuse
US4965197A (en) * 1987-06-12 1990-10-23 Massachusetts Institute Of Technology Coryneform expression and secretion system

Also Published As

Publication number Publication date
WO1994019471A1 (en) 1994-09-01
DK0686195T3 (da) 2006-11-27
DE69434807T2 (de) 2007-03-29
JP2004350691A (ja) 2004-12-16
EP0686195A1 (de) 1995-12-13
JP4202985B2 (ja) 2008-12-24
JPH08507207A (ja) 1996-08-06
CN1120853A (zh) 1996-04-17
EP0686195B1 (de) 2006-08-02
AU6142694A (en) 1994-09-14
US5780261A (en) 1998-07-14
DE69434807D1 (de) 2006-09-14
CN1080307C (zh) 2002-03-06

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