ATE337413T1 - Methoden zur verbesserung der sensitivität und spezifität von screeningverfahren für krebs und krebs-vorstufen - Google Patents

Methoden zur verbesserung der sensitivität und spezifität von screeningverfahren für krebs und krebs-vorstufen

Info

Publication number
ATE337413T1
ATE337413T1 AT00918364T AT00918364T ATE337413T1 AT E337413 T1 ATE337413 T1 AT E337413T1 AT 00918364 T AT00918364 T AT 00918364T AT 00918364 T AT00918364 T AT 00918364T AT E337413 T1 ATE337413 T1 AT E337413T1
Authority
AT
Austria
Prior art keywords
precancer
cancer
methods
specificity
sensitivity
Prior art date
Application number
AT00918364T
Other languages
English (en)
Inventor
Stanley N Lapidus
Anthony P Shuber
Original Assignee
Exact Sciences Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Exact Sciences Corp filed Critical Exact Sciences Corp
Application granted granted Critical
Publication of ATE337413T1 publication Critical patent/ATE337413T1/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333—Saccharide [e.g., DNA, etc.]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AT00918364T 1999-03-26 2000-03-24 Methoden zur verbesserung der sensitivität und spezifität von screeningverfahren für krebs und krebs-vorstufen ATE337413T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/277,016 US6143529A (en) 1996-08-14 1999-03-26 Methods for improving sensitivity and specificity of screening assays

Publications (1)

Publication Number Publication Date
ATE337413T1 true ATE337413T1 (de) 2006-09-15

Family

ID=23059077

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00918364T ATE337413T1 (de) 1999-03-26 2000-03-24 Methoden zur verbesserung der sensitivität und spezifität von screeningverfahren für krebs und krebs-vorstufen

Country Status (8)

Country Link
US (1) US6143529A (de)
EP (1) EP1185693B1 (de)
JP (3) JP2002539848A (de)
AT (1) ATE337413T1 (de)
AU (1) AU761722B2 (de)
CA (1) CA2369045C (de)
DE (1) DE60030281T2 (de)
WO (1) WO2000058514A2 (de)

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US6818404B2 (en) * 1997-10-23 2004-11-16 Exact Sciences Corporation Methods for detecting hypermethylated nucleic acid in heterogeneous biological samples
CA2362251C (en) 1999-02-25 2008-06-17 Exact Sciences Corporation Methods for preserving dna integrity
DE60029092T2 (de) * 1999-04-09 2007-02-01 Exact Sciences Corp., Marlborough Verfahren zur detektion von nukleinsäuren, welche auf krebs hinweisen
US6586177B1 (en) * 1999-09-08 2003-07-01 Exact Sciences Corporation Methods for disease detection
US6849403B1 (en) * 1999-09-08 2005-02-01 Exact Sciences Corporation Apparatus and method for drug screening
DE60043896D1 (de) 1999-12-07 2010-04-08 Exact Sciences Corp Verfahren zum nachweis von lungenneoplasmen in fäkalen proben
US6919174B1 (en) * 1999-12-07 2005-07-19 Exact Sciences Corporation Methods for disease detection
US7250252B2 (en) * 1999-12-30 2007-07-31 David Aaron Katz Amplification based polymorphism detection
US6585646B2 (en) * 2000-11-29 2003-07-01 Hermetic Diagnostics, Inc. Screening test and procedure using skin patches
US6911308B2 (en) * 2001-01-05 2005-06-28 Exact Sciences Corporation Methods for detecting, grading or monitoring an H. pylori infection
US6428964B1 (en) 2001-03-15 2002-08-06 Exact Sciences Corporation Method for alteration detection
US6727354B2 (en) * 2001-12-12 2004-04-27 Quest Diagnostics Investments, Inc. Compositions and methods for TIGR genotyping assays
US20030180765A1 (en) * 2002-02-01 2003-09-25 The Johns Hopkins University Digital amplification for detection of mismatch repair deficient tumor cells
WO2003071252A2 (en) 2002-02-15 2003-08-28 Exact Sciences Corporation Methods for analysis of molecular events
WO2004046386A1 (en) * 2002-11-15 2004-06-03 Genomic Health, Inc. Gene expression profiling of egfr positive cancer
US20040231909A1 (en) 2003-01-15 2004-11-25 Tai-Yang Luh Motorized vehicle having forward and backward differential structure
WO2004071572A2 (en) * 2003-02-06 2004-08-26 Genomic Health, Inc. Gene expression markers for response to egfr inhibitor drugs
CA2516553C (en) * 2003-02-20 2013-04-16 Genomic Health, Inc. Use of intronic rna to measure gene expression
ITMI20030434A1 (it) 2003-03-07 2004-09-08 Istituto Oncologico Romagnolo Coope Rativa Sociale Metodo per l'individuazione di tumori del colon-retto.
CA2527321A1 (en) * 2003-05-30 2004-12-23 Genomic Health, Inc. Gene expression markers for response to egfr inhibitor drugs
EP3170906B1 (de) 2003-06-24 2018-08-22 Genomic Health, Inc. Vorhersage der wahrscheinlichkeit eines wiederauftretens von krebs
EP3330875B1 (de) * 2003-07-10 2021-12-01 Genomic Health, Inc. Expressionsprofilalgorithmus und -test zur prognose des wiederauftretens von brustkrebs
CA2542656A1 (en) * 2003-10-16 2005-05-06 Genomic Health, Inc. Qrt-pcr assay system for gene expression profiling
CA2551267C (en) * 2003-12-23 2012-05-01 Genomic Health, Inc. Universal amplification of fragmented rna
US7871769B2 (en) * 2004-04-09 2011-01-18 Genomic Health, Inc. Gene expression markers for predicting response to chemotherapy
WO2005108621A1 (en) * 2004-04-30 2005-11-17 Yale University Methods and compositions for cancer diagnosis
US7981607B2 (en) 2004-08-27 2011-07-19 Esoterix Genetic Laboratories LLC Method for detecting recombinant event
CA2585025A1 (en) * 2004-10-22 2006-05-04 Redpath Integrated Pathology, Inc. Dynamic genomic deletion expansion and formulation of molecular marker panels for integrated molecular pathology diagnosis and characterization of tissue, cellular fluid, and purefluid specimens
US9109256B2 (en) 2004-10-27 2015-08-18 Esoterix Genetic Laboratories, Llc Method for monitoring disease progression or recurrence
CA2585561C (en) * 2004-11-05 2018-07-17 Genomic Health, Inc. Esr1, pgr, bcl2 and scube2 group score as indicators of breast cancer prognosis and prediction of treatment response
CA2585571C (en) * 2004-11-05 2020-01-21 Genomic Health, Inc. Predicting response to chemotherapy using gene expression markers
WO2006094149A2 (en) * 2005-03-01 2006-09-08 Exact Sciences Corporation Methods and compositions for detecting adenoma
WO2007044071A2 (en) 2005-04-21 2007-04-19 Exact Sciences Corporation Analysis of heterogeneous nucleic acid samples
US20070248546A1 (en) * 2005-11-09 2007-10-25 Exact Sciences Corporation Clinical algorithm for excluding patients identified in virtual imaging
JPWO2008090930A1 (ja) * 2007-01-23 2010-05-20 オリンパス株式会社 癌の診断方法
WO2009066695A1 (ja) * 2007-11-20 2009-05-28 Olympus Corporation 糞便試料の調製方法、糞便試料調製用溶液、及び採便用キット
EP2816122A1 (de) 2008-02-15 2014-12-24 Mayo Foundation For Medical Education And Research Neoplasmanachweis von einer Stuhlprobe
GB201107466D0 (en) 2011-05-05 2011-06-15 Loktionov Alexandre Device and method for non-invasive collection of colorectal mucocellular layer and disease detection
US9341628B2 (en) 2012-11-30 2016-05-17 Interpace Diagnostics Corporation Methods for measuring carcinoembryonic antigen
ES2859645T3 (es) 2013-03-14 2021-10-04 Mayo Found Medical Education & Res Detección de neoplasia
JP6294614B2 (ja) 2013-05-08 2018-03-14 有限会社マイテック 癌関連物質の定量方法
WO2015066695A1 (en) 2013-11-04 2015-05-07 Exact Sciences Corporation Multiple-control calibrators for dna quantitation
EP4209600A1 (de) 2013-12-19 2023-07-12 Exact Sciences Corporation Synthetische nukleinsäurekontrollmoleküle
US10184154B2 (en) 2014-09-26 2019-01-22 Mayo Foundation For Medical Education And Research Detecting cholangiocarcinoma
WO2016160454A1 (en) 2015-03-27 2016-10-06 Exact Sciences Corporation Detecting esophageal disorders
KR20250172724A (ko) 2015-08-31 2025-12-09 메이오 파운데이션 포 메디칼 에쥬케이션 앤드 리써치 위 신생물 검출 방법
AU2017300534B2 (en) 2016-07-19 2023-11-23 Exact Sciences Corporation Nucleic acid control molecules from non-human organisms
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ATE270712T1 (de) * 1995-03-17 2004-07-15 Wayne John Cancer Inst Nachweis von melanomenmetastasen unter verwendung eines mehrfachmarker-tests
DE19736691A1 (de) * 1997-08-22 1999-02-25 Michael Prof Dr Med Giesing Verfahren zur Charakterisierung und Identifizierung disseminierter und metastasierter Krebszellen

Also Published As

Publication number Publication date
EP1185693B1 (de) 2006-08-23
US6143529A (en) 2000-11-07
CA2369045A1 (en) 2000-10-05
CA2369045C (en) 2010-06-01
AU3918900A (en) 2000-10-16
WO2000058514A3 (en) 2001-12-13
AU761722B2 (en) 2003-06-05
WO2000058514A2 (en) 2000-10-05
JP2002539848A (ja) 2002-11-26
JP2010172347A (ja) 2010-08-12
JP2013116131A (ja) 2013-06-13
EP1185693A2 (de) 2002-03-13
DE60030281D1 (de) 2006-10-05
DE60030281T2 (de) 2007-08-30

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