ATE339419T1 - Pyrazolenthaltende zusammensetzungen und ihre verwendung als gsk-3 inhibitoren - Google Patents

Pyrazolenthaltende zusammensetzungen und ihre verwendung als gsk-3 inhibitoren

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Publication number
ATE339419T1
ATE339419T1 AT03767010T AT03767010T ATE339419T1 AT E339419 T1 ATE339419 T1 AT E339419T1 AT 03767010 T AT03767010 T AT 03767010T AT 03767010 T AT03767010 T AT 03767010T AT E339419 T1 ATE339419 T1 AT E339419T1
Authority
AT
Austria
Prior art keywords
gsk
pyrazole
inhibitors
containing compositions
compositions
Prior art date
Application number
AT03767010T
Other languages
English (en)
Inventor
Cornelia J Forster
Larry C Park
Marion W Wannamaker
Yung-Mae Yao
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Application granted granted Critical
Publication of ATE339419T1 publication Critical patent/ATE339419T1/de

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    • C07—ORGANIC CHEMISTRY
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
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    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

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  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Psychiatry (AREA)
  • Pulmonology (AREA)
  • Hospice & Palliative Care (AREA)
  • Virology (AREA)
  • Vascular Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Psychology (AREA)
  • Obesity (AREA)
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  • Communicable Diseases (AREA)
  • Urology & Nephrology (AREA)
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  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
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AT03767010T 2002-08-02 2003-07-31 Pyrazolenthaltende zusammensetzungen und ihre verwendung als gsk-3 inhibitoren ATE339419T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US40096702P 2002-08-02 2002-08-02

Publications (1)

Publication Number Publication Date
ATE339419T1 true ATE339419T1 (de) 2006-10-15

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AT03767010T ATE339419T1 (de) 2002-08-02 2003-07-31 Pyrazolenthaltende zusammensetzungen und ihre verwendung als gsk-3 inhibitoren

Country Status (25)

Country Link
US (2) US7491730B2 (de)
EP (1) EP1532145B1 (de)
JP (3) JP4733388B2 (de)
KR (1) KR20050032105A (de)
CN (2) CN1319968C (de)
AR (1) AR040773A1 (de)
AT (1) ATE339419T1 (de)
AU (2) AU2003257078B2 (de)
BR (1) BR0313176A (de)
CA (1) CA2494100C (de)
CO (1) CO5700772A2 (de)
DE (1) DE60308387T2 (de)
DK (1) DK1532145T3 (de)
EA (1) EA200500299A1 (de)
EC (1) ECSP055640A (de)
ES (1) ES2273043T3 (de)
IL (1) IL166620A (de)
MX (1) MXPA05001367A (de)
NO (1) NO20051100L (de)
NZ (2) NZ550883A (de)
PL (1) PL374967A1 (de)
PT (1) PT1532145E (de)
TW (1) TWI324157B (de)
WO (1) WO2004013140A1 (de)
ZA (1) ZA200501124B (de)

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WO2009145814A2 (en) * 2008-03-10 2009-12-03 Vertex Pharmaceuticals Incorporated Pyrimidines and pyridines useful as inhibitors of protein kinases
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