ATE340785T1 - 2-phenylamino-4-trifluoromethyl-5-(benzyl- oder pyridin-4-ylmethyl)carbamoylpyrimidin-derivate als selektive cb2 cannabinoid-rezeptor modulatoren - Google Patents

2-phenylamino-4-trifluoromethyl-5-(benzyl- oder pyridin-4-ylmethyl)carbamoylpyrimidin-derivate als selektive cb2 cannabinoid-rezeptor modulatoren

Info

Publication number
ATE340785T1
ATE340785T1 AT03792390T AT03792390T ATE340785T1 AT E340785 T1 ATE340785 T1 AT E340785T1 AT 03792390 T AT03792390 T AT 03792390T AT 03792390 T AT03792390 T AT 03792390T AT E340785 T1 ATE340785 T1 AT E340785T1
Authority
AT
Austria
Prior art keywords
derivatives
carbamoylpyrimidine
phenylamino
ylmethyl
trifluoromethyl
Prior art date
Application number
AT03792390T
Other languages
English (en)
Inventor
Andrew John Eatherton
Gerard Martin Paul Giblin
Richard H Green
William Leonard Mitchell
Alan Naylor
Derek Anthony Rawlings
Brian Peter Slingsby
Andrew Richard Whittington
Jennifer Margaret Doughty
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0219500A external-priority patent/GB0219500D0/en
Priority claimed from GB0316332A external-priority patent/GB0316332D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Application granted granted Critical
Publication of ATE340785T1 publication Critical patent/ATE340785T1/de

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    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
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AT03792390T 2002-08-21 2003-08-19 2-phenylamino-4-trifluoromethyl-5-(benzyl- oder pyridin-4-ylmethyl)carbamoylpyrimidin-derivate als selektive cb2 cannabinoid-rezeptor modulatoren ATE340785T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0219500A GB0219500D0 (en) 2002-08-21 2002-08-21 Compounds
GB0316332A GB0316332D0 (en) 2003-07-11 2003-07-11 Novel compounds

Publications (1)

Publication Number Publication Date
ATE340785T1 true ATE340785T1 (de) 2006-10-15

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AT03792390T ATE340785T1 (de) 2002-08-21 2003-08-19 2-phenylamino-4-trifluoromethyl-5-(benzyl- oder pyridin-4-ylmethyl)carbamoylpyrimidin-derivate als selektive cb2 cannabinoid-rezeptor modulatoren

Country Status (8)

Country Link
US (1) US20060247261A1 (de)
EP (2) EP1534687B1 (de)
JP (1) JP2005539036A (de)
AT (1) ATE340785T1 (de)
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GB0402355D0 (en) * 2004-02-03 2004-03-10 Glaxo Group Ltd Novel compounds
GB0402356D0 (en) * 2004-02-03 2004-03-10 Glaxo Group Ltd Novel compounds
WO2005080350A1 (en) * 2004-02-23 2005-09-01 Glaxo Group Limited Pyrimidine derivatives as cannabinoid receptor modulators
GB0404105D0 (en) * 2004-02-24 2004-03-31 Glaxo Group Ltd Novel compounds
BRPI0511874A (pt) 2004-06-09 2008-01-15 Glaxo Group Ltd derivados da pirrolopiridina
MX2008001935A (es) * 2005-08-09 2008-03-26 Glaxo Group Ltd Derivados de imidazopiridina como ligandos del receptor de canabinoides.
GB0517188D0 (en) * 2005-08-22 2005-09-28 Glaxo Group Ltd Compounds
US8349876B2 (en) 2008-05-19 2013-01-08 The University Of Tennesee Research Foundation Pyridine non-classical cannabinoid compounds and related methods of use
CA2724733A1 (en) 2008-05-19 2009-11-26 The University Of Tennessee Research Foundation Pyrimidine classical cannabinoid compounds and related methods of use
JP2011520972A (ja) * 2008-05-19 2011-07-21 ユニヴァーシティ オブ テネシー リサーチ ファウンデーション，ザ ピリジンの古典的カンナビノイド化合物及び関連する使用方法
US8476439B2 (en) 2008-05-19 2013-07-02 The University Of Tennessee Research Foundation Pyridine classical cannabinoid compounds and related methods of use
EP2299819A4 (de) * 2008-05-19 2011-07-20 Univ Tennessee Res Foundation Nichtklassische pyridin-cannabinoidverbindungen und damit zusammenhängende verfahren zu ihrer verwendung
CA2724737A1 (en) * 2008-05-19 2009-11-26 The University Of Tennessee Research Foundation Pyrimidine non-classical cannabinoid compounds and related methods of use
EP2415765A4 (de) * 2009-03-30 2012-08-15 Astellas Pharma Inc Pyrimidinverbindung
KR101760158B1 (ko) * 2010-07-29 2017-07-20 아스텔라스세이야쿠 가부시키가이샤 축환 피리딘 화합물

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US5112820A (en) * 1990-03-05 1992-05-12 Sterling Drug Inc. Anti-glaucoma compositions containing 2- and 3-aminomethyl-6-arylcarbonyl- or 6-phenylthio-2,3-dihydropyrrolo-(1,2,3-de)-1,4-benzoxazines and method of use thereof
PL313973A1 (en) * 1993-10-12 1996-08-05 Du Pont Merck Pharma 1 n-alkyl-n-arylopyrimidin amines and their derivatives
WO1997009315A1 (en) * 1995-09-01 1997-03-13 Signal Pharmaceuticals, Inc. Pyrimidine carboxamides and related compounds and methods for treating inflammatory conditions
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JP2005539036A (ja) 2005-12-22
EP1534687A1 (de) 2005-06-01
EP1736470A3 (de) 2007-04-04
EP1736470A2 (de) 2006-12-27
WO2004018434A1 (en) 2004-03-04
DE60308699D1 (en) 2006-11-09
ES2273077T3 (es) 2007-05-01
DE60308699T2 (de) 2007-08-23
AU2003260436A1 (en) 2004-03-11
US20060247261A1 (en) 2006-11-02
EP1534687B1 (de) 2006-09-27

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