ATE341328T1 - Buprenorphin hydrochlorid enthaltende pflaster - Google Patents
Buprenorphin hydrochlorid enthaltende pflasterInfo
- Publication number
- ATE341328T1 ATE341328T1 AT01906203T AT01906203T ATE341328T1 AT E341328 T1 ATE341328 T1 AT E341328T1 AT 01906203 T AT01906203 T AT 01906203T AT 01906203 T AT01906203 T AT 01906203T AT E341328 T1 ATE341328 T1 AT E341328T1
- Authority
- AT
- Austria
- Prior art keywords
- adhesive
- fatty acid
- acid ester
- buprenorphine hydrochloride
- drug
- Prior art date
Links
- 229960001889 buprenorphine hydrochloride Drugs 0.000 title abstract 2
- UAIXRPCCYXNJMQ-RZIPZOSSSA-N buprenorphine hydrochlorie Chemical compound [Cl-].C([C@]12[C@H]3OC=4C(O)=CC=C(C2=4)C[C@@H]2[C@]11CC[C@]3([C@H](C1)[C@](C)(O)C(C)(C)C)OC)C[NH+]2CC1CC1 UAIXRPCCYXNJMQ-RZIPZOSSSA-N 0.000 title abstract 2
- 239000000853 adhesive Substances 0.000 abstract 3
- 230000001070 adhesive effect Effects 0.000 abstract 3
- 235000014113 dietary fatty acids Nutrition 0.000 abstract 3
- 229930195729 fatty acid Natural products 0.000 abstract 3
- 239000000194 fatty acid Substances 0.000 abstract 3
- -1 fatty acid ester Chemical class 0.000 abstract 3
- 238000010521 absorption reaction Methods 0.000 abstract 2
- 239000012790 adhesive layer Substances 0.000 abstract 2
- 229940079593 drug Drugs 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 239000003623 enhancer Substances 0.000 abstract 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 abstract 2
- 239000007788 liquid Substances 0.000 abstract 2
- URAYPUMNDPQOKB-UHFFFAOYSA-N triacetin Chemical compound CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 229920001214 Polysorbate 60 Polymers 0.000 abstract 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 abstract 1
- RMRJXGBAOAMLHD-IHFGGWKQSA-N buprenorphine Chemical compound C([C@]12[C@H]3OC=4C(O)=CC=C(C2=4)C[C@@H]2[C@]11CC[C@]3([C@H](C1)[C@](C)(O)C(C)(C)C)OC)CN2CC1CC1 RMRJXGBAOAMLHD-IHFGGWKQSA-N 0.000 abstract 1
- 229960001736 buprenorphine Drugs 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 235000013773 glyceryl triacetate Nutrition 0.000 abstract 1
- 239000001087 glyceryl triacetate Substances 0.000 abstract 1
- 235000014655 lactic acid Nutrition 0.000 abstract 1
- 239000004310 lactic acid Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000006353 oxyethylene group Chemical group 0.000 abstract 1
- 150000005846 sugar alcohols Polymers 0.000 abstract 1
- 229960002622 triacetin Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Pain & Pain Management (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2000049298A JP4659943B2 (ja) | 2000-02-25 | 2000-02-25 | 塩酸ブプレノルフィン含有貼付剤 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE341328T1 true ATE341328T1 (de) | 2006-10-15 |
Family
ID=18571263
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01906203T ATE341328T1 (de) | 2000-02-25 | 2001-02-22 | Buprenorphin hydrochlorid enthaltende pflaster |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US7056527B2 (de) |
| EP (1) | EP1174137B1 (de) |
| JP (1) | JP4659943B2 (de) |
| KR (1) | KR100709930B1 (de) |
| CN (1) | CN1187049C (de) |
| AT (1) | ATE341328T1 (de) |
| AU (1) | AU782249B2 (de) |
| CA (1) | CA2368356C (de) |
| DE (1) | DE60123529T2 (de) |
| ES (1) | ES2272443T3 (de) |
| HK (1) | HK1040616B (de) |
| PT (1) | PT1174137E (de) |
| WO (1) | WO2001062254A1 (de) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5968547A (en) | 1997-02-24 | 1999-10-19 | Euro-Celtique, S.A. | Method of providing sustained analgesia with buprenorphine |
| DK1611884T3 (da) * | 2003-03-18 | 2012-12-10 | Hisamitsu Pharmaceutical Co | Plaster, indeholdende diclofenac |
| DE602004011055T2 (de) * | 2003-07-25 | 2008-12-18 | Euro-Celtique S.A. | Präoperative behandlung von postoperativen schmerzen |
| US8236292B2 (en) * | 2004-06-04 | 2012-08-07 | Camurus Ab | Liquid depot formulations |
| DE102005011517A1 (de) * | 2005-03-10 | 2006-09-21 | Grünenthal GmbH | Transdermales therapeutisches System zur Verabreichung von Analgetika |
| US20060223786A1 (en) * | 2005-04-01 | 2006-10-05 | Smith David J | Transdermal pain control method and device |
| US20070248657A1 (en) * | 2006-04-25 | 2007-10-25 | Smith David J | Multi-compartment transdermal pain control device |
| CA2674915C (en) | 2006-10-17 | 2015-06-30 | Penick Corporation | Process for preparing oxymorphone |
| US20080125592A1 (en) * | 2006-10-17 | 2008-05-29 | Penick Corporation | Process for preparing oxymorphone, naltrexone, and buprenorphine |
| US20100221313A1 (en) * | 2008-12-01 | 2010-09-02 | Innovative Pharmaceuticals, Llc | Transdermal reservoir patch |
| TWI541246B (zh) | 2008-12-08 | 2016-07-11 | 歐陸斯迪公司 | 二氫羥戊甲嗎啡 |
| CN101612141B (zh) * | 2009-07-29 | 2012-10-03 | 考司美德制药株式会社 | 丁丙诺啡贴剂 |
| JP2012158572A (ja) * | 2011-02-02 | 2012-08-23 | Nitto Denko Corp | 貼付製剤の製造方法 |
| DE102011076653A1 (de) * | 2011-05-27 | 2012-11-29 | Acino Ag | Transdermales therapeutisches System enthaltend Buprenorphin und eine alpha-Hydroxysäure |
| EA201491164A1 (ru) * | 2011-12-12 | 2014-10-30 | ЭлТиЭс ЛОМАНН ТЕРАПИ-ЗЮСТЕМ АГ | Трансдермальная система доставки |
| HRP20210068T1 (hr) | 2012-07-26 | 2021-03-05 | Camurus Ab | Opioidne formulacije |
| WO2014016428A1 (en) | 2012-07-26 | 2014-01-30 | Camurus Ab | Opioid formulations |
| CN103893154A (zh) * | 2012-12-26 | 2014-07-02 | 江苏康倍得药业有限公司 | 包含丁丙诺啡的透皮给药系统 |
| WO2014105480A1 (en) * | 2012-12-28 | 2014-07-03 | Teikoku Pharma Usa, Inc. | Extended buprenorphine transdermal delivery compositions and methods for using the same |
| JP6151935B2 (ja) * | 2013-03-11 | 2017-06-21 | 日東電工株式会社 | 経皮吸収促進用組成物および貼付製剤 |
| GB201309654D0 (en) | 2013-05-30 | 2013-07-17 | Euro Celtique Sa | Method |
| KR102358377B1 (ko) | 2016-12-28 | 2022-02-03 | 히사미쓰 세이야꾸 가부시키가이샤 | 첩부제 |
| CN110013602B (zh) * | 2019-04-17 | 2021-10-26 | 杨高云 | 用于治疗肢端型白癜风的手套及其制备方法 |
| US11872320B2 (en) | 2021-02-25 | 2024-01-16 | Hisamitsu Pharmaceutical Co., Inc. | Method for treating osteoarthritis |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4879297A (en) | 1987-06-01 | 1989-11-07 | Warner-Lambert Company | Fatty acids and their small chain esters as penetration enhancers in aqueous systems |
| EP0375689B1 (de) * | 1987-06-01 | 1992-08-12 | Warner-Lambert Company | Eine pharmazeutische zusammensetzung angepasst an die transdermale applikation eines opioids. |
| EP0432945A1 (de) | 1989-12-12 | 1991-06-19 | Warner-Lambert Company | Transdermales Abgabesystem zur Behandlung der Kokain- und Heroinsucht |
| JP2849937B2 (ja) * | 1990-04-18 | 1999-01-27 | 日東電工株式会社 | 医療用貼付剤 |
| JP2507158B2 (ja) * | 1990-08-23 | 1996-06-12 | 積水化学工業株式会社 | 経皮吸収製剤 |
| JP2669951B2 (ja) | 1991-03-28 | 1997-10-29 | 雍憲 森本 | 麻薬性鎮痛剤を含有する経皮吸収組成物 |
| US5238933A (en) * | 1991-10-28 | 1993-08-24 | Sri International | Skin permeation enhancer compositions |
| JPH0710754A (ja) * | 1993-06-28 | 1995-01-13 | Sekisui Chem Co Ltd | 経皮吸収貼付剤 |
| JP2819236B2 (ja) | 1994-05-06 | 1998-10-30 | 日東電工株式会社 | 経皮吸収製剤 |
| DE4446600A1 (de) | 1994-12-24 | 1996-06-27 | Lohmann Therapie Syst Lts | Transdermale Resorption von Wirkstoffen aus unterkühlten Schmelzen |
| JPH1045571A (ja) * | 1996-07-29 | 1998-02-17 | Sekisui Chem Co Ltd | 貼付剤 |
-
2000
- 2000-02-25 JP JP2000049298A patent/JP4659943B2/ja not_active Expired - Fee Related
-
2001
- 2001-02-22 DE DE60123529T patent/DE60123529T2/de not_active Expired - Lifetime
- 2001-02-22 CN CNB018002838A patent/CN1187049C/zh not_active Expired - Fee Related
- 2001-02-22 WO PCT/JP2001/001293 patent/WO2001062254A1/ja not_active Ceased
- 2001-02-22 CA CA002368356A patent/CA2368356C/en not_active Expired - Fee Related
- 2001-02-22 PT PT01906203T patent/PT1174137E/pt unknown
- 2001-02-22 US US09/959,117 patent/US7056527B2/en not_active Expired - Fee Related
- 2001-02-22 KR KR1020017013683A patent/KR100709930B1/ko not_active Expired - Fee Related
- 2001-02-22 ES ES01906203T patent/ES2272443T3/es not_active Expired - Lifetime
- 2001-02-22 HK HK02101841.7A patent/HK1040616B/en not_active IP Right Cessation
- 2001-02-22 AU AU34122/01A patent/AU782249B2/en not_active Ceased
- 2001-02-22 EP EP01906203A patent/EP1174137B1/de not_active Expired - Lifetime
- 2001-02-22 AT AT01906203T patent/ATE341328T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| US20020182247A1 (en) | 2002-12-05 |
| KR20010111591A (ko) | 2001-12-19 |
| CN1362879A (zh) | 2002-08-07 |
| CA2368356C (en) | 2009-08-25 |
| CN1187049C (zh) | 2005-02-02 |
| AU3412201A (en) | 2001-09-03 |
| EP1174137B1 (de) | 2006-10-04 |
| ES2272443T3 (es) | 2007-05-01 |
| DE60123529D1 (de) | 2006-11-16 |
| JP4659943B2 (ja) | 2011-03-30 |
| EP1174137A1 (de) | 2002-01-23 |
| DE60123529T2 (de) | 2007-06-14 |
| US7056527B2 (en) | 2006-06-06 |
| KR100709930B1 (ko) | 2007-04-24 |
| HK1040616B (en) | 2006-12-29 |
| EP1174137A4 (de) | 2003-05-21 |
| WO2001062254A1 (fr) | 2001-08-30 |
| CA2368356A1 (en) | 2001-08-30 |
| PT1174137E (pt) | 2006-12-29 |
| AU782249B2 (en) | 2005-07-14 |
| JP2001233769A (ja) | 2001-08-28 |
| HK1040616A1 (en) | 2002-06-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |