ATE293981T1 - System zur oralen wirkstoffabgabe zur steigerung der bioverfügbarkeit von aktiviertem glycyrrhetin - Google Patents

System zur oralen wirkstoffabgabe zur steigerung der bioverfügbarkeit von aktiviertem glycyrrhetin

Info

Publication number: ATE293981T1
Authority: AT; Austria
Prior art keywords: bioavailability; glycyrrhetin; activated; increase; active delivery
Prior art date: 1998-09-21

Application number

AT99943450T

Other languages

English (en)

Inventor

Kanji Takada

Original Assignee

Amato Pharm Prod Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-09-21

Filing date

1999-09-20

Publication date

2005-05-15

1999-09-20 Application filed by Amato Pharm Prod Ltd filed Critical Amato Pharm Prod Ltd

2005-05-15 Application granted granted Critical

2005-05-15 Publication of ATE293981T1 publication Critical patent/ATE293981T1/de

Links

MPDGHEJMBKOTSU-YKLVYJNSSA-N 18beta-glycyrrhetic acid Chemical class C([C@H]1C2=CC(=O)[C@H]34)[C@@](C)(C(O)=O)CC[C@]1(C)CC[C@@]2(C)[C@]4(C)CC[C@@H]1[C@]3(C)CC[C@H](O)C1(C)C MPDGHEJMBKOTSU-YKLVYJNSSA-N 0.000 title 1
239000004378 Glycyrrhizin Substances 0.000 abstract 2
238000012377 drug delivery Methods 0.000 abstract 2
LPLVUJXQOOQHMX-UHFFFAOYSA-N glycyrrhetinic acid glycoside Natural products C1CC(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2=O)C(O)=O)C)(C)CC2)(C)C2C(C)(C)C1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O LPLVUJXQOOQHMX-UHFFFAOYSA-N 0.000 abstract 2
229960004949 glycyrrhizic acid Drugs 0.000 abstract 2
UYRUBYNTXSDKQT-UHFFFAOYSA-N glycyrrhizic acid Natural products CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(=O)O)OC6OC(C(O)C(O)C6OC7OC(O)C(O)C(O)C7C(=O)O)C(=O)O UYRUBYNTXSDKQT-UHFFFAOYSA-N 0.000 abstract 2
235000019410 glycyrrhizin Nutrition 0.000 abstract 2
LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 abstract 2
239000002738 chelating agent Substances 0.000 abstract 1
239000003937 drug carrier Substances 0.000 abstract 1
230000002708 enhancing effect Effects 0.000 abstract 1
230000007062 hydrolysis Effects 0.000 abstract 1
238000006460 hydrolysis reaction Methods 0.000 abstract 1
230000000968 intestinal effect Effects 0.000 abstract 1
229940126701 oral medication Drugs 0.000 abstract 1
150000007524 organic acids Chemical class 0.000 abstract 1
238000001179 sorption measurement Methods 0.000 abstract 1
239000004094 surface-active agent Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4891—Coated capsules; Multilayered drug free capsule shells
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
- A61K9/025—Suppositories; Bougies; Bases therefor; Ovules characterised by shape or structure, e.g. hollow layered, coated
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/2853—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers, poly(lactide-co-glycolide)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Molecular Biology (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Gastroenterology & Hepatology (AREA)
Chemical Kinetics & Catalysis (AREA)
Biophysics (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT99943450T 1998-09-21 1999-09-20 System zur oralen wirkstoffabgabe zur steigerung der bioverfügbarkeit von aktiviertem glycyrrhetin ATE293981T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP28604098		1998-09-21
PCT/JP1999/005153 WO2000016784A1 (en)	1998-09-21	1999-09-20	Oral drug delivery system for enhancing the bioavailability of activated glycyrrhetin

Publications (1)

Publication Number	Publication Date
ATE293981T1 true ATE293981T1 (de)	2005-05-15

Family

ID=17699200

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99943450T ATE293981T1 (de)	1998-09-21	1999-09-20	System zur oralen wirkstoffabgabe zur steigerung der bioverfügbarkeit von aktiviertem glycyrrhetin

Country Status (8)

Country	Link
EP (1)	EP1116489B1 (de)
KR (1)	KR20010075144A (de)
CN (1)	CN1181827C (de)
AT (1)	ATE293981T1 (de)
AU (1)	AU5654699A (de)
CA (1)	CA2344306A1 (de)
DE (1)	DE69925007T2 (de)
WO (1)	WO2000016784A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2001289653A1 (en) *	2000-07-14	2002-01-30	Universiteit Gent	Composite solid shaped articles for the controlled delivery of biologically active ingredients
EP2260845A3 (de)	2002-06-21	2012-08-22	L'Oréal	Verwendung von Polyphenolen zur Behandlung der Alopezie
KR200454122Y1 (ko) *	2008-09-25	2011-06-16	대우조선해양 주식회사	선박의 배기가스 배출촉진장치
US20210046011A1 (en)	2019-08-12	2021-02-18	Massachusetts Institute Of Technology	Articles and methods for administration of therapeutic agents

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ZA825384B (en) *	1981-07-31	1983-05-25	Tillott J B Ltd	Orally administrable pharmaceutical compositions
JPS58140012A (ja) *	1982-02-15	1983-08-19	Kodama Kk	徐放性インドメタシン坐剤
US4894234A (en) *	1984-10-05	1990-01-16	Sharma Shri C	Novel drug delivery system for antiarrhythmics
JPH0623093B2 (ja) *	1984-11-05	1994-03-30	大正製薬株式会社	痔疾用坐剤
JPH0816051B2 (ja) *	1988-12-07	1996-02-21	エスエス製薬株式会社	徐放性坐剤
JPH03255037A (ja) *	1990-03-02	1991-11-13	Santen Pharmaceut Co Ltd	グリチルリチン製剤
JPH04261117A (ja) *	1991-02-14	1992-09-17	Santen Pharmaceut Co Ltd	グリチルリチン坐剤
JPH0597680A (ja) *	1991-10-04	1993-04-20	Sanwa Kagaku Kenkyusho Co Ltd	グリチルリチン坐剤
IT1255895B (it) *	1992-10-20	1995-11-17	Laura Chiodini	Composizioni farmaceutiche contenenti una calcitonina
KR0157280B1 (ko) *	1992-11-06	1998-11-16	나까토미 히로타카	하부소화관 방출성의 경구의약제제
JPH06192107A (ja) *	1992-12-25	1994-07-12	Sanwa Kagaku Kenkyusho Co Ltd	グリチルリチン経口剤
US5637319A (en) *	1995-03-01	1997-06-10	Takada; Kanji	Controlled-release preparations
JP3185206B2 (ja) *	1995-07-20	2001-07-09	田辺製薬株式会社	消化管下部放出型被覆カプセル製剤
JPH10226650A (ja) *	1997-02-18	1998-08-25	Ono Pharmaceut Co Ltd	グリチルリチン経口投与製剤
ATE500815T1 (de) *	1997-12-08	2011-03-15	Dietrich Rango	Neue suppositoriumsform mit säureempfindlichem wirkstoff

1999
- 1999-09-20 AT AT99943450T patent/ATE293981T1/de not_active IP Right Cessation
- 1999-09-20 KR KR1020017003396A patent/KR20010075144A/ko not_active Ceased
- 1999-09-20 EP EP99943450A patent/EP1116489B1/de not_active Expired - Lifetime
- 1999-09-20 CA CA002344306A patent/CA2344306A1/en not_active Abandoned
- 1999-09-20 CN CNB998111724A patent/CN1181827C/zh not_active Expired - Fee Related
- 1999-09-20 WO PCT/JP1999/005153 patent/WO2000016784A1/ja not_active Ceased
- 1999-09-20 DE DE69925007T patent/DE69925007T2/de not_active Expired - Fee Related
- 1999-09-20 AU AU56546/99A patent/AU5654699A/en not_active Abandoned

Also Published As

Publication number	Publication date
DE69925007T2 (de)	2006-02-02
CN1181827C (zh)	2004-12-29
CA2344306A1 (en)	2000-03-30
AU5654699A (en)	2000-04-10
CN1319018A (zh)	2001-10-24
WO2000016784A1 (en)	2000-03-30
KR20010075144A (ko)	2001-08-09
EP1116489A4 (de)	2002-06-05
EP1116489B1 (de)	2005-04-27
EP1116489A1 (de)	2001-07-18
DE69925007D1 (de)	2005-06-02

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Legal Events

Date	Code	Title	Description
2005-10-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties