ATE343569T1 - Aromatische hydroxamsäurederivate, die sich als hdac inhibitoren eignen - Google Patents

Aromatische hydroxamsäurederivate, die sich als hdac inhibitoren eignen

Info

Publication number: ATE343569T1
Authority: AT; Austria
Prior art keywords: acid derivatives; hydroxamic acid; hdac inhibitors; derivatives suitable; aromatic hydroxamic
Prior art date: 2001-06-15

Application number

AT02791436T

Other languages

English (en)

Inventor

Ulrike Leser-Reiff

Tim Dr Sattelkau

Gerd Zimmermann

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-06-15

Filing date

2002-06-13

Publication date

2006-11-15

2002-06-13 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2006-11-15 Application granted granted Critical

2006-11-15 Publication of ATE343569T1 publication Critical patent/ATE343569T1/de

Links

NEAQRZUHTPSBBM-UHFFFAOYSA-N 2-hydroxy-3,3-dimethyl-7-nitro-4h-isoquinolin-1-one Chemical compound C1=C([N+]([O-])=O)C=C2C(=O)N(O)C(C)(C)CC2=C1 NEAQRZUHTPSBBM-UHFFFAOYSA-N 0.000 title 1
239000002253 acid Substances 0.000 title 1
239000003276 histone deacetylase inhibitor Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/40—Acylated substituent nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/10—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to carbon atoms of six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
- C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
- C07D211/16—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with acylated ring nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/10—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/14—Radicals substituted by nitrogen atoms not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
- C07D317/58—Radicals substituted by nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pyridine Compounds (AREA)

AT02791436T 2001-06-15 2002-06-13 Aromatische hydroxamsäurederivate, die sich als hdac inhibitoren eignen ATE343569T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP01114496		2001-06-15

Publications (1)

Publication Number	Publication Date
ATE343569T1 true ATE343569T1 (de)	2006-11-15

Family

ID=8177731

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02791436T ATE343569T1 (de)	2001-06-15	2002-06-13	Aromatische hydroxamsäurederivate, die sich als hdac inhibitoren eignen

Country Status (32)

Country	Link
US (2)	US6784173B2 (de)
EP (1)	EP1401824B1 (de)
JP (1)	JP4195377B2 (de)
KR (2)	KR100910958B1 (de)
CN (1)	CN1271066C (de)
AR (1)	AR036055A1 (de)
AT (1)	ATE343569T1 (de)
AU (1)	AU2002355626B2 (de)
BG (1)	BG108450A (de)
BR (1)	BR0210424A (de)
CA (1)	CA2449804A1 (de)
CO (1)	CO5540280A2 (de)
CZ (1)	CZ200425A3 (de)
DE (1)	DE60215652T2 (de)
EC (1)	ECSP034896A (de)
ES (1)	ES2272800T3 (de)
GT (1)	GT200200121A (de)
HR (1)	HRP20031019A2 (de)
HU (1)	HUP0401233A3 (de)
IL (1)	IL159097A0 (de)
MA (1)	MA27041A1 (de)
MX (1)	MXPA03011501A (de)
NO (1)	NO20035555D0 (de)
NZ (1)	NZ529874A (de)
PA (1)	PA8548001A1 (de)
PE (1)	PE20030086A1 (de)
PL (1)	PL366729A1 (de)
RS (1)	RS98203A (de)
RU (1)	RU2289580C2 (de)
SK (1)	SK172004A3 (de)
WO (1)	WO2003011851A2 (de)
ZA (1)	ZA200309260B (de)

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US20100087328A1 (en) *	2005-03-01	2010-04-08	The Regents Of The University Of Michigan	Brm expression and related diagnostics
WO2006094068A2 (en) *	2005-03-01	2006-09-08	The Regents Of The University Of Michigan	Hdac inhibitors that promote brm expression and brm related diagnostics
JP2008536925A (ja)	2005-04-20	2008-09-11	メルクエンドカムパニーインコーポレーテッド	ベンゾチオフェンヒドロキサム酸誘導体
GB0509223D0 (en)	2005-05-05	2005-06-15	Chroma Therapeutics Ltd	Enzyme inhibitors
GB0509225D0 (en)	2005-05-05	2005-06-15	Chroma Therapeutics Ltd	Inhibitors of enzymatic activity
JP2008540574A (ja)	2005-05-11	2008-11-20	タケダサンディエゴインコーポレイテッド	ヒストンデアセチラーゼ阻害剤
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JP2009520695A (ja) *	2005-12-15	2009-05-28	ヴィキュロンファーマシューティカルズインコーポレイテッド	抗菌活性を有するｎ−ヒドロキシアミド誘導体
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EP1979326B1 (de)	2006-01-19	2012-10-03	Janssen Pharmaceutica N.V.	Pyridin- und pyrimidinderivate als inhibitoren von histondeacetylase
GB0603041D0 (en) *	2006-02-15	2006-03-29	Angeletti P Ist Richerche Bio	Therapeutic compounds
GB0619753D0 (en)	2006-10-06	2006-11-15	Chroma Therapeutics Ltd	Enzyme inhibitors
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US10059723B2 (en)	2011-02-28	2018-08-28	Biomarin Pharmaceutical Inc.	Histone deacetylase inhibitors
WO2012118782A1 (en)	2011-02-28	2012-09-07	Repligen Corporation	Histone deacetylase inhibitors
RU2665554C2 (ru)	2013-03-15	2018-08-31	Байомарин Фармасьютикал Инк.	Ингибиторы hdac
EP2826769A1 (de)	2013-07-18	2015-01-21	Institut de Recherche pour le Développement ( IRD)	Verbindungen zur Behandlung und/oder Vorbeugung parasitärer Erkrankungen und Verfahren zu deren Herstellung
KR101536050B1 (ko) *	2013-07-30	2015-07-13	충북대학교 산학협력단	신규 이사틴 기반 히드록삼산 및 이를 유효성분으로 포함하는 항암용 조성물
EP3062783B1 (de)	2013-10-18	2020-08-12	The General Hospital Corporation	Bildgebung von histondeacetylasen mit einem radiotracer mittels positronenemissionstomografie
TR201816176T4 (tr)	2014-03-12	2018-11-21	Chong Kun Dang Pharmaceutical Corp	Histon deasetilaz 6 inhibitörleri olarak yeni bileşikler ve bunu içeren farmasötik bileşimler.
WO2019185413A1 (en)	2018-03-27	2019-10-03	Basf Se	Pesticidal substituted cyclopropyl derivatives
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2002
- 2002-06-11 US US10/167,677 patent/US6784173B2/en not_active Expired - Fee Related
- 2002-06-12 PA PA20028548001A patent/PA8548001A1/es unknown
- 2002-06-13 RU RU2003137578/04A patent/RU2289580C2/ru not_active IP Right Cessation
- 2002-06-13 SK SK17-2004A patent/SK172004A3/sk unknown
- 2002-06-13 ES ES02791436T patent/ES2272800T3/es not_active Expired - Lifetime
- 2002-06-13 BR BR0210424-5A patent/BR0210424A/pt not_active IP Right Cessation
- 2002-06-13 PE PE2002000510A patent/PE20030086A1/es not_active Application Discontinuation
- 2002-06-13 AT AT02791436T patent/ATE343569T1/de not_active IP Right Cessation
- 2002-06-13 KR KR1020037016358A patent/KR100910958B1/ko not_active Expired - Fee Related
- 2002-06-13 NZ NZ529874A patent/NZ529874A/xx unknown
- 2002-06-13 KR KR1020097010546A patent/KR20090059172A/ko not_active Withdrawn
- 2002-06-13 HU HU0401233A patent/HUP0401233A3/hu unknown
- 2002-06-13 PL PL02366729A patent/PL366729A1/xx not_active Application Discontinuation
- 2002-06-13 EP EP02791436A patent/EP1401824B1/de not_active Expired - Lifetime
- 2002-06-13 CZ CZ200425A patent/CZ200425A3/cs unknown
- 2002-06-13 RS YUP-982/03A patent/RS98203A/sr unknown
- 2002-06-13 HR HR20031019A patent/HRP20031019A2/xx not_active Application Discontinuation
- 2002-06-13 MX MXPA03011501A patent/MXPA03011501A/es active IP Right Grant
- 2002-06-13 AR ARP020102231A patent/AR036055A1/es unknown
- 2002-06-13 IL IL15909702A patent/IL159097A0/xx unknown
- 2002-06-13 CA CA002449804A patent/CA2449804A1/en not_active Abandoned
- 2002-06-13 AU AU2002355626A patent/AU2002355626B2/en not_active Ceased
- 2002-06-13 JP JP2003517043A patent/JP4195377B2/ja not_active Expired - Fee Related
- 2002-06-13 CN CNB028120108A patent/CN1271066C/zh not_active Expired - Fee Related
- 2002-06-13 DE DE60215652T patent/DE60215652T2/de not_active Expired - Fee Related
- 2002-06-13 WO PCT/EP2002/006488 patent/WO2003011851A2/en not_active Ceased
- 2002-06-14 GT GT200200121A patent/GT200200121A/es unknown
2003
- 2003-11-27 ZA ZA200309260A patent/ZA200309260B/en unknown
- 2003-12-10 CO CO03108279A patent/CO5540280A2/es not_active Application Discontinuation
- 2003-12-11 EC EC2003004896A patent/ECSP034896A/es unknown
- 2003-12-12 MA MA27440A patent/MA27041A1/fr unknown
- 2003-12-12 NO NO20035555A patent/NO20035555D0/no not_active Application Discontinuation
- 2003-12-15 BG BG108450A patent/BG108450A/xx unknown
2004
- 2004-05-17 US US10/847,166 patent/US20040214862A1/en not_active Abandoned

Also Published As

Publication number	Publication date
HRP20031019A2 (en)	2005-08-31
HUP0401233A2 (hu)	2004-10-28
SK172004A3 (en)	2004-07-07
IL159097A0 (en)	2004-05-12
CA2449804A1 (en)	2003-02-13
HUP0401233A3 (en)	2007-05-29
US20040214862A1 (en)	2004-10-28
KR20090059172A (ko)	2009-06-10
US6784173B2 (en)	2004-08-31
RS98203A (sr)	2007-02-05
CO5540280A2 (es)	2005-07-29
AR036055A1 (es)	2004-08-04
MA27041A1 (fr)	2004-12-20
GT200200121A (es)	2003-06-19
NO20035555D0 (no)	2003-12-12
RU2003137578A (ru)	2005-05-20
CN1516697A (zh)	2004-07-28
RU2289580C2 (ru)	2006-12-20
HK1065787A1 (en)	2005-03-04
JP2005502641A (ja)	2005-01-27
DE60215652T2 (de)	2007-08-23
ECSP034896A (es)	2004-01-28
PL366729A1 (en)	2005-02-07
WO2003011851A2 (en)	2003-02-13
NZ529874A (en)	2004-12-24
PE20030086A1 (es)	2003-02-08
ZA200309260B (en)	2005-02-28
WO2003011851A3 (en)	2003-09-18
MXPA03011501A (es)	2004-03-09
CN1271066C (zh)	2006-08-23
PA8548001A1 (es)	2003-01-24
BG108450A (en)	2005-01-31
AU2002355626B2 (en)	2008-09-25
BR0210424A (pt)	2004-08-17
US20030013757A1 (en)	2003-01-16
EP1401824B1 (de)	2006-10-25
DE60215652D1 (de)	2006-12-07
KR100910958B1 (ko)	2009-08-05
JP4195377B2 (ja)	2008-12-10
KR20040018270A (ko)	2004-03-02
EP1401824A2 (de)	2004-03-31
ES2272800T3 (es)	2007-05-01
CZ200425A3 (cs)	2004-04-14

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