ATE344039T1 - Nicht-calcemische, transkriptionell-aktive, schwefelhaltige analoga von 1-alpha, 25- dihydroxyvitamin d3 mit antiproliferativer wirkung - Google Patents

Nicht-calcemische, transkriptionell-aktive, schwefelhaltige analoga von 1-alpha, 25- dihydroxyvitamin d3 mit antiproliferativer wirkung

Info

Publication number: ATE344039T1
Authority: AT; Austria
Prior art keywords: dihydroxyvitamin; calcemic; alpha; sulfur containing; transcriptionally active
Prior art date: 1999-04-01

Application number

AT00921523T

Other languages

English (en)

Inventor

Gary H Posner

Jae Kyoo Lee

Qiang Wang

Kenneth R Crawford

Gyoonhee Han

Original Assignee

Univ Johns Hopkins

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-04-01

Filing date

2000-03-31

Publication date

2006-11-15

2000-03-31 Application filed by Univ Johns Hopkins filed Critical Univ Johns Hopkins

2006-11-15 Application granted granted Critical

2006-11-15 Publication of ATE344039T1 publication Critical patent/ATE344039T1/de

Links

NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 title abstract 2
230000001028 anti-proliverative effect Effects 0.000 title abstract 2
229910052717 sulfur Inorganic materials 0.000 title abstract 2
239000011593 sulfur Substances 0.000 title abstract 2
GMRQFYUYWCNGIN-NKMMMXOESA-N calcitriol Chemical class C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CCCC(C)(C)O)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C GMRQFYUYWCNGIN-NKMMMXOESA-N 0.000 title 1
230000000125 calcaemic effect Effects 0.000 abstract 1
229960005084 calcitriol Drugs 0.000 abstract 1
239000012634 fragment Substances 0.000 abstract 1
238000000338 in vitro Methods 0.000 abstract 1
238000001727 in vivo Methods 0.000 abstract 1
230000002103 transcriptional effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/08—Antiseborrheics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Dermatology (AREA)
Nutrition Science (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

AT00921523T 1999-04-01 2000-03-31 Nicht-calcemische, transkriptionell-aktive, schwefelhaltige analoga von 1-alpha, 25- dihydroxyvitamin d3 mit antiproliferativer wirkung ATE344039T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US12732899P	1999-04-01	1999-04-01
US12847899P	1999-04-09	1999-04-09

Publications (1)

Publication Number	Publication Date
ATE344039T1 true ATE344039T1 (de)	2006-11-15

Family

ID=26825543

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT00921523T ATE344039T1 (de)	1999-04-01	2000-03-31	Nicht-calcemische, transkriptionell-aktive, schwefelhaltige analoga von 1-alpha, 25- dihydroxyvitamin d3 mit antiproliferativer wirkung

Country Status (13)

Country	Link
US (1)	US6380408B1 (de)
EP (2)	EP1180035B1 (de)
JP (2)	JP3630101B2 (de)
AT (1)	ATE344039T1 (de)
CA (1)	CA2366586C (de)
CY (1)	CY1107548T1 (de)
DE (1)	DE60031666T2 (de)
DK (1)	DK1180035T3 (de)
ES (2)	ES2274785T3 (de)
HK (1)	HK1044293B (de)
MX (1)	MXPA01009693A (de)
PT (1)	PT1180035E (de)
WO (1)	WO2000059513A1 (de)

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ATE428692T1 (de) *	2001-08-22	2009-05-15	Univ Johns Hopkins	24-schwefel-substituierte 1-alpha-25-dihydroxy- vitamin-d3-analogen
US6559138B1 (en) *	2001-09-21	2003-05-06	Syntex (U.S.A.) Llc	3-Desoxy-vitamin D3 analog esters
US7101865B2 (en)	2002-06-13	2006-09-05	Cytochroma Inc.	24-sulfoximine vitamin D3 compounds
CA2510228C (en) *	2002-12-18	2012-10-30	Johns Hopkins University	25-so2-substituted analogs of 1.alpha.,25-dihydroxyvitamin d3
CA2544502A1 (en) *	2003-11-25	2005-06-09	Wisconsin Alumni Research Foundation	Vitamin d analogs for obesity prevention and treatment
WO2006074227A2 (en) *	2005-01-04	2006-07-13	Johns Hopkins University	HIGHLY ANTIPROLIFERATIVE, LOW-CALCEMIC, ANALOGS OF THE HORMONE 1α, 25-DIHYDROXYVITAMIN D3 WITH CARBONYL SIDE CHAINS
US20090137828A1 (en) *	2005-08-18	2009-05-28	Bioxell S.P.A.	Synthesis of 1A-Fluoro-25-Hydroxy-16-23E-Diene-26,27-Bishomo-20-Epi-Cholecalciferol
US20070122477A1 (en) *	2005-10-12	2007-05-31	Cytochroma, Inc.	Methods and articles for treating 25-hydroxyvitamin D insufficiency and deficiency
PT3095447T (pt)	2006-02-03	2022-01-24	Opko Renal Llc	Tratamento da insuficiência e deficiência de vitamina d com 25-hidroxivitamina d2 e 25-hidroxivitamina d3
DK2037936T3 (da)	2006-06-21	2014-09-22	Opko Renal Llc	Fremgangsmåde til behandling og forebyggelse af sekundær hyperparathyroidisme
WO2008131267A2 (en) *	2007-04-18	2008-10-30	Johns Hopkins University	Low calcemic, highly antiproliferative, analogs of calcitriol
ES3047207T3 (en)	2007-04-25	2025-12-03	Opko Renal Llc	Method of safely and effectively treating and preventing secondary hyperparathyroidism in chronic kidney disease
CA2683628C (en) *	2007-04-25	2018-03-06	Cytochroma Inc.	Method of treating vitamin d insufficiency and deficiency
EP2148685A4 (de) *	2007-04-25	2010-07-28	Cytochroma Inc	Verfahren und verbindungen für die vitamin-d-therapie
KR101691876B1 (ko)	2007-04-25	2017-01-02	사이토크로마 인코포레이티드	비타민 ｄ 화합물과 밀랍성 담체를 포함하는 경구 조절성 방출 조성물
ES2593356T3 (es)	2008-04-02	2016-12-07	Opko Ireland Global Holdings, Ltd.	Métodos, composiciones, usos y kits útiles para la deficiencia de la vitamina D y trastornos relacionados
WO2011088209A2 (en) *	2010-01-13	2011-07-21	Cytochroma Inc.	1-deoxy analogs of vitamin d-related compounds
WO2011119610A2 (en)	2010-03-23	2011-09-29	Wisconsin Alumni Research Foundation	(20S)-2-METHYLENE-19-NOR-22-DIMETHYL-1α,25- DIHYDROXYVITAMIN D3 AND (20R)-2-METHYLENE-19-NOR-22- DIMETHYL-1α,25-HYDROXYVITAMIN D3
US8664206B2 (en)	2010-03-23	2014-03-04	Wisconsin Alumni Research Foundation	Diastereomers of 2-methylene-19-nor-22-methyl-1α,25-dihydroxyvitamin D3
US11672809B2 (en)	2010-03-29	2023-06-13	Eirgen Pharma Ltd.	Methods and compositions for reducing parathyroid levels
US8788551B2 (en)	2011-11-15	2014-07-22	Seagate Technology Llc	Random number generation using switching regulators
US9201630B2 (en)	2012-02-10	2015-12-01	Seagate Technology Llc	Random number generation using startup variances
KR101847947B1 (ko)	2013-03-15	2018-05-28	옵코 아이피 홀딩스 Ⅱ 인코포레이티드	안정화되고 변형된 비타민 ｄ 방출 제형
US10220047B2 (en)	2014-08-07	2019-03-05	Opko Ireland Global Holdings, Ltd.	Adjunctive therapy with 25-hydroxyvitamin D and articles therefor
KR20180123100A (ko)	2016-03-28	2018-11-14	옵코 아일랜드 글로벌 홀딩스 리미티드	비타민 d 치료 방법
WO2025094144A1 (en)	2023-11-02	2025-05-08	Eirgen Pharma Ltd.	Controlling loss of kidney function

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JPS5119752A (en)	1974-08-07	1976-02-17	Masayuki Ishikawa	1 arufua* 2 arufuaa jihidorokishikorekarushifuerooruno seiho
US4224231A (en)	1979-09-04	1980-09-23	Wisconsin Alumni Research Foundation	Derivatives of 25-hydroxycholecalciferol
US4927815A (en) *	1988-04-29	1990-05-22	Wisconsin Alumni Research Foundation	Compounds effective in inducing cell differentiation and process for preparing same
JPH0667898B2 (ja) *	1989-02-15	1994-08-31	大同ほくさん株式会社	２２，２３―セコビタミンｄ若しくはその活性型またはそれらの誘導体の製造方法
US5401732A (en)	1989-02-23	1995-03-28	Leo Pharmaceutical Products Ltd. A/S Kemiske Fabrik Produkionsaktiese Skab	Vitamin D analogues
US4973584A (en) *	1989-03-09	1990-11-27	Deluca Hector F	Novel 1α-hydroxyvitamin D2 epimer and derivatives
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US6043386A (en)	1998-06-03	2000-03-28	John Hopkins University	Non-calcemic, antiproliferative, transcriptionally active 24-fluorinated hybrid analogs of 1α,-25-dihydroxy vitamin D3

2000
- 2000-03-31 ES ES00921523T patent/ES2274785T3/es not_active Expired - Lifetime
- 2000-03-31 MX MXPA01009693A patent/MXPA01009693A/es active IP Right Grant
- 2000-03-31 HK HK02106019.2A patent/HK1044293B/en not_active IP Right Cessation
- 2000-03-31 WO PCT/US2000/008462 patent/WO2000059513A1/en not_active Ceased
- 2000-03-31 AT AT00921523T patent/ATE344039T1/de active
- 2000-03-31 US US09/541,060 patent/US6380408B1/en not_active Expired - Lifetime
- 2000-03-31 DE DE60031666T patent/DE60031666T2/de not_active Expired - Lifetime
- 2000-03-31 EP EP00921523A patent/EP1180035B1/de not_active Expired - Lifetime
- 2000-03-31 CA CA002366586A patent/CA2366586C/en not_active Expired - Lifetime
- 2000-03-31 JP JP2000609076A patent/JP3630101B2/ja not_active Expired - Fee Related
- 2000-03-31 PT PT00921523T patent/PT1180035E/pt unknown
- 2000-03-31 ES ES06020197.7T patent/ES2614632T3/es not_active Expired - Lifetime
- 2000-03-31 EP EP06020197.7A patent/EP1745787B1/de not_active Expired - Lifetime
- 2000-03-31 DK DK00921523T patent/DK1180035T3/da active
2004
- 2004-10-01 JP JP2004289968A patent/JP3796508B2/ja not_active Expired - Fee Related
2007
- 2007-01-29 CY CY20071100119T patent/CY1107548T1/el unknown

Also Published As

Publication number	Publication date
EP1180035A4 (de)	2003-07-30
MXPA01009693A (es)	2002-03-14
CA2366586A1 (en)	2000-10-12
CA2366586C (en)	2004-06-22
JP3630101B2 (ja)	2005-03-16
JP2002541112A (ja)	2002-12-03
JP3796508B2 (ja)	2006-07-12
DE60031666T2 (de)	2007-08-30
US6380408B1 (en)	2002-04-30
ES2274785T3 (es)	2007-06-01
DE60031666D1 (de)	2006-12-14
EP1745787A3 (de)	2007-02-07
CY1107548T1 (el)	2013-03-13
EP1180035A1 (de)	2002-02-20
EP1745787B1 (de)	2016-11-09
JP2005023087A (ja)	2005-01-27
DK1180035T3 (da)	2007-03-05
WO2000059513A1 (en)	2000-10-12
EP1180035B1 (de)	2006-11-02
PT1180035E (pt)	2007-02-28
EP1745787A2 (de)	2007-01-24
HK1044293B (en)	2007-06-08
HK1044293A1 (en)	2002-10-18
ES2614632T3 (es)	2017-06-01
WO2000059513A8 (en)	2001-02-15

Legal Events

Date

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Title

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2007-07-15

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