ATE347356T1 - Hydroxamsäurederivate als antibakterielle arzneimittel - Google Patents

Hydroxamsäurederivate als antibakterielle arzneimittel

Info

Publication number: ATE347356T1
Authority: AT; Austria
Prior art keywords: group; alkyl; acid derivatives; hydroxamic acid; antibacterial drugs
Prior art date: 1998-05-16

Application number

AT99922317T

Other languages

English (en)

Inventor

Michael George Hunter

Raymond Paul Beckett

John Martin Clements

Mark Whittaker

Zoe Marie Spavold

Original Assignee

Vernalis Oxford Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-05-16

Filing date

1999-05-14

Publication date

2006-12-15

1999-05-14 Application filed by Vernalis Oxford Ltd filed Critical Vernalis Oxford Ltd

2006-12-15 Application granted granted Critical

2006-12-15 Publication of ATE347356T1 publication Critical patent/ATE347356T1/de

Links

NEAQRZUHTPSBBM-UHFFFAOYSA-N 2-hydroxy-3,3-dimethyl-7-nitro-4h-isoquinolin-1-one Chemical compound C1=C([N+]([O-])=O)C=C2C(=O)N(O)C(C)(C)CC2=C1 NEAQRZUHTPSBBM-UHFFFAOYSA-N 0.000 title 1
239000002253 acid Substances 0.000 title 1
229940124350 antibacterial drug Drugs 0.000 title 1
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 3
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
125000003161 (C1-C6) alkylene group Chemical group 0.000 abstract 1
125000006700 (C1-C6) alkylthio group Chemical group 0.000 abstract 1
125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
125000004450 alkenylene group Chemical group 0.000 abstract 1
230000000844 anti-bacterial effect Effects 0.000 abstract 1
229940088710 antibiotic agent Drugs 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
125000001246 bromo group Chemical group Br* 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
125000001309 chloro group Chemical group Cl* 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
125000001153 fluoro group Chemical group F* 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
150000002431 hydrogen Chemical class 0.000 abstract 1
-1 hydroxy, mercapto Chemical group 0.000 abstract 1
125000002346 iodo group Chemical group I* 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4453—Non condensed piperidines, e.g. piperocaine only substituted in position 1, e.g. propipocaine, diperodon
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents

Landscapes

Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Pain & Pain Management (AREA)
Emergency Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Thiazole And Isothizaole Compounds (AREA)
Pyridine Compounds (AREA)

AT99922317T 1998-05-16 1999-05-14 Hydroxamsäurederivate als antibakterielle arzneimittel ATE347356T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GBGB9810464.9A GB9810464D0 (en)	1998-05-16	1998-05-16	Hydroxamic acid derivatives

Publications (1)

Publication Number	Publication Date
ATE347356T1 true ATE347356T1 (de)	2006-12-15

Family

ID=10832125

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99922317T ATE347356T1 (de)	1998-05-16	1999-05-14	Hydroxamsäurederivate als antibakterielle arzneimittel

Country Status (23)

Country	Link
US (3)	US6441042B1 (de)
EP (2)	EP1079819B1 (de)
JP (1)	JP2002515427A (de)
KR (1)	KR100634089B1 (de)
CN (1)	CN1300210A (de)
AT (1)	ATE347356T1 (de)
AU (1)	AU754063B2 (de)
BR (1)	BR9910488A (de)
CA (1)	CA2332713C (de)
CY (1)	CY1106452T1 (de)
DE (1)	DE69934309T2 (de)
DK (1)	DK1079819T3 (de)
ES (1)	ES2278444T3 (de)
GB (2)	GB9810464D0 (de)
HU (1)	HUP0102290A3 (de)
IL (2)	IL139059A0 (de)
NO (1)	NO20005782L (de)
NZ (1)	NZ507560A (de)
PL (1)	PL344438A1 (de)
PT (1)	PT1079819E (de)
TR (1)	TR200003376T2 (de)
WO (1)	WO1999059568A1 (de)
ZA (1)	ZA200006131B (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PL194240B1 (pl) *	1998-02-07	2007-05-31	British Biotech Pharm	Zastosowanie pochodnych N-formylohydroksyloaminy i amidowa pochodna N-formylohydroksyloaminy
GB9810464D0 (en) *	1998-05-16	1998-07-15	British Biotech Pharm	Hydroxamic acid derivatives
ES2242411T3 (es) *	1999-08-10	2005-11-01	Vernalis (Oxford) Ltd	Agentes antibacterianos.
FR2801591B1 (fr) *	1999-11-30	2002-03-01	Aventis Pharma Sa	Derives macrocycliques de l'acide hydroxamique, leur preparation et les compositions qui les contiennent
AU2180201A (en) *	1999-11-30	2001-06-12	Aventis Pharma S.A.	Hydroxamic acid macrocyclic derivatives, preparation method and compositions containing same
EP1237862A1 (de) *	1999-12-17	2002-09-11	Versicor, Inc.	Succinat-verbindungen, zusammensetzungen sowie verfahren zur anwendung und herstellung
GB9929979D0 (en) *	1999-12-17	2000-02-09	Darwin Discovery Ltd	Hydroxamic acid derivatives
WO2002028829A2 (en) *	2000-09-25	2002-04-11	Questcor Pharmaceuticals, Inc.	Peptide deformylase inhibitors
AU2002212541A1 (en) *	2000-11-23	2002-06-03	British Biotech Pharmaceuticals Ltd	Ydroxamic acid or n-formyl hydroxylamine derivatives as inhibitors of bakterial polypeptide deformylase for treating microbial infections
JP2004532826A (ja) *	2001-03-19	2004-10-28	スローン−ケッタリングインスティトゥートフォーカンサーリサーチ	（ｓ，ｒ，ｒ）−（−）−アクチノニンおよびそのアナログの不斉合成、ならびにそれらの使用
US20040267015A1 (en) *	2001-04-05	2004-12-30	Ajita Bhat	Peptide deformylase inhibitors
GB0128943D0 (en)	2001-12-04	2002-01-23	Novo Pharmaceuticals De Ltd	Bacterial enzyme inhibitors
JP4190862B2 (ja) *	2001-12-18	2008-12-03	シャープ株式会社	表示装置およびその駆動方法
GB0208579D0 (en) *	2002-04-13	2002-05-22	British Biotech Pharm	Antibacterial agents
DE10320453A1 (de) *	2003-05-08	2004-11-25	Morphochem AG Aktiengesellschaft für kombinatorische Chemie	Neue Bioisostere von Actinonin
ES2582555T3 (es) *	2007-11-29	2016-09-13	Inolex Investment Corporation	Conservantes para composiciones cosméticas, de tocador y farmacéuticas
DE102011088962A1 (de) *	2011-12-19	2013-06-20	Beiersdorf Ag	Wirkstoffkombinationen aus einer oder mehreren Carbonsäuren, insbesondereHydroxycarbonsäuren, und einer oder mehreren physiologisch unbedenklichen Hydroxamsäure sowie kosmetische oder dermatologische Zubereitungen, solcheWirkstoffkombinationen enthaltend
US10829440B2 (en)	2015-06-12	2020-11-10	Brown University	Antibacterial compounds and methods of making and using same
CN111787800B (zh) *	2017-06-29	2022-11-25	金伯利-克拉克环球有限公司	包含二异羟肟酸的抗微生物组合物及用其抑制微生物生长的方法
CN108672095A (zh) *	2018-05-04	2018-10-19	广东省资源综合利用研究所	γ-羟基烷基羟肟酸及其制备方法与应用
US11555010B2 (en)	2019-07-25	2023-01-17	Brown University	Diamide antimicrobial agents

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1028921A (en)	1962-01-23	1966-05-11	Ranjeet Bhagwan Singh	New antibiotic
US4303662A (en) *	1980-11-24	1981-12-01	E. R. Squibb & Sons, Inc.	Carboxyacyl, mercapto and acylmercapto derivatives of heterobicyclo compounds
JPH0670019B2 (ja)	1989-07-21	1994-09-07	明治製菓株式会社	新抗生物質ｓｆ２１９７ｃ物質およびその製造法
GB8919251D0 (en) *	1989-08-24	1989-10-04	British Bio Technology	Compounds
JPH03157372A (ja)	1989-11-13	1991-07-05	Yamanouchi Pharmaceut Co Ltd	Ｙｌ―０１８６９ｐ物質及びその製造法
WO1992022523A2 (en)	1991-06-14	1992-12-23	Research Corporation Technologies, Inc.	Peptide derivatives of collagenase inhibitor
GB9223904D0 (en) *	1992-11-13	1993-01-06	British Bio Technology	Inhibition of cytokine production
FI960803L (fi) *	1993-08-23	1996-04-22	Immunex Corp	TNF-alfa-sekreetion inhibiittoreita
JP3157372B2 (ja)	1993-11-29	2001-04-16	三洋電機株式会社	フィルタ
AU690703B2 (en) *	1994-06-22	1998-04-30	British Biotech Pharmaceuticals Limited	Metalloproteinase inhibitors
US5532265A (en)	1994-11-30	1996-07-02	The Board Of Trustees Of The Leland Stanford Junior University	Treatment of central nervous system inflammatory disease with matrix metalloprotease inhibitors
GB9507799D0 (en) *	1995-04-18	1995-05-31	British Biotech Pharm	Metalloproteinase inhibitors
US6281245B1 (en) *	1996-10-28	2001-08-28	Versicor, Inc.	Methods for solid-phase synthesis of hydroxylamine compounds and derivatives, and combinatorial libraries thereof
AU5187698A (en)	1996-12-06	1998-06-29	Cancerforskningsfondet Af 1989	Inhibition of invasive remodelling
ZA9711121B (en) *	1996-12-13	1998-06-23	Handelman Joseph H	Reduction of hair growth.
PL194240B1 (pl) *	1998-02-07	2007-05-31	British Biotech Pharm	Zastosowanie pochodnych N-formylohydroksyloaminy i amidowa pochodna N-formylohydroksyloaminy
GB9810464D0 (en) *	1998-05-16	1998-07-15	British Biotech Pharm	Hydroxamic acid derivatives

1998
- 1998-05-16 GB GBGB9810464.9A patent/GB9810464D0/en not_active Ceased
1999
- 1999-05-14 AT AT99922317T patent/ATE347356T1/de not_active IP Right Cessation
- 1999-05-14 EP EP99922317A patent/EP1079819B1/de not_active Expired - Lifetime
- 1999-05-14 DE DE69934309T patent/DE69934309T2/de not_active Expired - Fee Related
- 1999-05-14 JP JP2000549233A patent/JP2002515427A/ja not_active Withdrawn
- 1999-05-14 IL IL13905999A patent/IL139059A0/xx not_active IP Right Cessation
- 1999-05-14 BR BR9910488-1A patent/BR9910488A/pt not_active Application Discontinuation
- 1999-05-14 DK DK99922317T patent/DK1079819T3/da active
- 1999-05-14 PT PT99922317T patent/PT1079819E/pt unknown
- 1999-05-14 EP EP06009622A patent/EP1754477A3/de not_active Withdrawn
- 1999-05-14 AU AU39421/99A patent/AU754063B2/en not_active Ceased
- 1999-05-14 NZ NZ507560A patent/NZ507560A/xx unknown
- 1999-05-14 GB GB0024789A patent/GB2353708A/en not_active Withdrawn
- 1999-05-14 KR KR1020007012819A patent/KR100634089B1/ko not_active Expired - Fee Related
- 1999-05-14 CN CN99806057A patent/CN1300210A/zh active Pending
- 1999-05-14 ES ES99922317T patent/ES2278444T3/es not_active Expired - Lifetime
- 1999-05-14 CA CA002332713A patent/CA2332713C/en not_active Expired - Fee Related
- 1999-05-14 HU HU0102290A patent/HUP0102290A3/hu unknown
- 1999-05-14 US US09/700,424 patent/US6441042B1/en not_active Expired - Fee Related
- 1999-05-14 TR TR2000/03376T patent/TR200003376T2/xx unknown
- 1999-05-14 PL PL99344438A patent/PL344438A1/xx unknown
- 1999-05-14 WO PCT/GB1999/001541 patent/WO1999059568A1/en not_active Ceased
2000
- 2000-10-16 IL IL139059A patent/IL139059A/en unknown
- 2000-10-30 ZA ZA200006131A patent/ZA200006131B/en unknown
- 2000-11-15 NO NO20005782A patent/NO20005782L/no not_active Application Discontinuation
2002
- 2002-06-26 US US10/179,227 patent/US6992190B2/en not_active Expired - Fee Related
2005
- 2005-08-22 US US11/207,813 patent/US7323563B2/en not_active Expired - Fee Related
2007
- 2007-03-01 CY CY20071100285T patent/CY1106452T1/el unknown

Also Published As

Publication number	Publication date
CA2332713C (en)	2008-04-01
TR200003376T2 (tr)	2001-03-21
GB9810464D0 (en)	1998-07-15
HUP0102290A2 (hu)	2001-11-28
DK1079819T3 (da)	2007-04-10
KR100634089B1 (ko)	2006-10-17
US20060211732A1 (en)	2006-09-21
EP1079819A1 (de)	2001-03-07
CN1300210A (zh)	2001-06-20
US6992190B2 (en)	2006-01-31
US7323563B2 (en)	2008-01-29
EP1079819B1 (de)	2006-12-06
CA2332713A1 (en)	1999-11-25
ES2278444T3 (es)	2007-08-01
US20020198241A1 (en)	2002-12-26
EP1754477A2 (de)	2007-02-21
NO20005782D0 (no)	2000-11-15
IL139059A (en)	2006-12-31
KR20010034861A (ko)	2001-04-25
PT1079819E (pt)	2007-03-30
CY1106452T1 (el)	2011-10-12
NZ507560A (en)	2003-06-30
EP1754477A3 (de)	2007-03-14
AU3942199A (en)	1999-12-06
IL139059A0 (en)	2001-11-25
GB0024789D0 (en)	2000-11-22
JP2002515427A (ja)	2002-05-28
GB2353708A (en)	2001-03-07
ZA200006131B (en)	2002-01-30
PL344438A1 (en)	2001-11-05
US6441042B1 (en)	2002-08-27
AU754063B2 (en)	2002-10-31
DE69934309T2 (de)	2007-07-05
WO1999059568A1 (en)	1999-11-25
BR9910488A (pt)	2001-01-09
DE69934309D1 (de)	2007-01-18
NO20005782L (no)	2001-01-15
HUP0102290A3 (en)	2001-12-28

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2007-07-15

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Publication	Publication Date	Title
DE69934309D1 (de)	2007-01-18	Hydroxamsäurederivate als antibakterielle arzneimittel
GB2349884A (en)	2000-11-15	Antibacterial agents
DK0487411T3 (da)	1996-04-15	Erythromycinderivater, fremgangsmåde til deres fremstilling, mellemprodukter dertil samt deres anvendelse som lægemidler
BR0012615A (pt)	2004-03-30	Amidas aromáticas heterocìclicas fungicidas e suas composições, métodos de uso e preparação
BR9809531A (pt)	2000-06-20	Composições herbicidas.
BR0210028A (pt)	2004-06-22	Agentes antibacterianos
PT768086E (pt)	2003-01-31	Tratamento de tinido utilizando agentes neuroprotectores
ATE399545T1 (de)	2008-07-15	Mittel zur verringerung der eigeweidefette
BR9807330A (pt)	2000-04-18	Agentes inibidores do progresso de pterìgio e recorrência pós-operatória do mesmo
ATE255554T1 (de)	2003-12-15	Cyclopentenonderivate
BR0209430A (pt)	2004-08-03	Compostos heterocìclicos
AP9701140A0 (en)	1998-01-31	New hydroximic acid derivatives.
ES2059918T3 (es)	1994-11-16	Metazacloro monoclinico y procedimiento para su fabricacion.
ATE194912T1 (de)	2000-08-15	Mittel zur vorsorge und heilung von typ i allergischen krankheiten
DE69904519D1 (de)	2003-01-30	Sulfonamid-Derivate
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