ATE347619T1 - VERFAHREN ZUR KREBSDETEKTION MITTELS VERSCHACHTELTER (ßNESTEDß) METHYLIERUNGSSPEZIFISCHER PCR - Google Patents

VERFAHREN ZUR KREBSDETEKTION MITTELS VERSCHACHTELTER (ßNESTEDß) METHYLIERUNGSSPEZIFISCHER PCR

Info

Publication number
ATE347619T1
ATE347619T1 AT01968105T AT01968105T ATE347619T1 AT E347619 T1 ATE347619 T1 AT E347619T1 AT 01968105 T AT01968105 T AT 01968105T AT 01968105 T AT01968105 T AT 01968105T AT E347619 T1 ATE347619 T1 AT E347619T1
Authority
AT
Austria
Prior art keywords
gene
nested
detecting
cancer
methylation
Prior art date
Application number
AT01968105T
Other languages
English (en)
Inventor
Steven A Belinsky
William A Palmisano
Original Assignee
Lovelace Respiratory Res Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22855593&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE347619(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lovelace Respiratory Res Inst filed Critical Lovelace Respiratory Res Inst
Application granted granted Critical
Publication of ATE347619T1 publication Critical patent/ATE347619T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AT01968105T 2000-08-25 2001-08-24 VERFAHREN ZUR KREBSDETEKTION MITTELS VERSCHACHTELTER (ßNESTEDß) METHYLIERUNGSSPEZIFISCHER PCR ATE347619T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US22805700P 2000-08-25 2000-08-25

Publications (1)

Publication Number Publication Date
ATE347619T1 true ATE347619T1 (de) 2006-12-15

Family

ID=22855593

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01968105T ATE347619T1 (de) 2000-08-25 2001-08-24 VERFAHREN ZUR KREBSDETEKTION MITTELS VERSCHACHTELTER (ßNESTEDß) METHYLIERUNGSSPEZIFISCHER PCR

Country Status (7)

Country Link
US (1) US7214485B2 (de)
EP (1) EP1352089B1 (de)
AT (1) ATE347619T1 (de)
AU (1) AU2001288379A1 (de)
CA (1) CA2421102A1 (de)
DE (1) DE60125065T2 (de)
WO (1) WO2002018649A1 (de)

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US6818404B2 (en) * 1997-10-23 2004-11-16 Exact Sciences Corporation Methods for detecting hypermethylated nucleic acid in heterogeneous biological samples
US7582420B2 (en) 2001-07-12 2009-09-01 Illumina, Inc. Multiplex nucleic acid reactions
US7611869B2 (en) 2000-02-07 2009-11-03 Illumina, Inc. Multiplexed methylation detection methods
US20110151438A9 (en) 2001-11-19 2011-06-23 Affymetrix, Inc. Methods of Analysis of Methylation
CA2488382A1 (en) * 2002-06-05 2003-12-18 Case Western Reserve University Methods and compositions for detecting cancers
DE60331852D1 (de) * 2002-12-02 2010-05-06 Illumina Cambridge Ltd Bestimmung der methylierung von nukleinsäuresequenzen
EP1602731B1 (de) * 2003-03-13 2010-08-04 Beijing Institute for Cancer Research VERFAHREN ZUR IN-VITRO-ERKENNUNG VON ANORMALER Magen-DYSPLASIE
EP1689887B1 (de) 2003-10-21 2012-03-21 Orion Genomics, LLC Verfahren zur quantitativen bestimmung der methylierungsdichte in einem dna-locus
WO2005042713A2 (en) * 2003-10-28 2005-05-12 The Johns Hopkins University Quantitative multiplex methylation-specific pcr
US20050196792A1 (en) * 2004-02-13 2005-09-08 Affymetrix, Inc. Analysis of methylation status using nucleic acid arrays
WO2006009870A2 (en) * 2004-06-17 2006-01-26 Epigenomics Ag Compositions and methods for preventing carry-over contamination in nucleic acid amplification reactions
EP3061833B1 (de) 2004-09-30 2018-03-14 Epigenomics AG Verfahren zur bereitstellung von dna-fragmenten aus einer archivierten probe
ATE547537T1 (de) 2005-04-15 2012-03-15 Epigenomics Ag Verfahren zur bestimmung der dna-methylierung in blut- oder urinproben
WO2007008693A2 (en) * 2005-07-09 2007-01-18 Lovelace Respiratory Research Institute Gene methylation as a biomarker in sputum
US7901882B2 (en) 2006-03-31 2011-03-08 Affymetrix, Inc. Analysis of methylation using nucleic acid arrays
US20080003609A1 (en) * 2006-05-10 2008-01-03 The Cleveland Clinic Foundation Method of detecting bladder urothelial carcinoma
CN101153336B (zh) 2006-09-27 2011-09-07 香港中文大学 检测dna甲基化程度的方法和试剂盒
US7599898B2 (en) * 2006-10-17 2009-10-06 International Business Machines Corporation Method and apparatus for improved regression modeling
EP2508623B1 (de) * 2006-11-20 2015-08-12 The Johns Hopkins University DNA-Methylierungsmarker und Verwendungsverfahren
WO2008096146A1 (en) 2007-02-07 2008-08-14 Solexa Limited Preparation of templates for methylation analysis
US20080213870A1 (en) * 2007-03-01 2008-09-04 Sean Wuxiong Cao Methods for obtaining modified DNA from a biological specimen
DK3101141T3 (da) 2007-06-08 2020-02-03 Epigenomics Ag Fremgangsmåde til methyleringsanalyse
US20100317002A1 (en) * 2007-10-11 2010-12-16 Bioview Ltd. Methods and kits for diagnosing lung cancer
WO2010048337A2 (en) 2008-10-22 2010-04-29 Illumina, Inc. Preservation of information related to genomic dna methylation
WO2010080617A2 (en) 2008-12-19 2010-07-15 The Board Of Trustees Of The University Of Illinois Detecting and sorting methylated dna using a synthetic nanopore
EP2218793A1 (de) * 2009-02-13 2010-08-18 Alphagenics International SA Erkennung von MGMT-Methylierung in Tumoren
US8748091B2 (en) * 2009-12-18 2014-06-10 The Board Of Trustees Of The University Of Illinois Characterizing stretched polynucleotides in a synthetic nanopassage
WO2011132798A1 (ja) * 2010-04-21 2011-10-27 国立大学法人鹿児島大学 新規なｄｎａメチル化解析方法
CN104250663B (zh) * 2013-06-27 2017-09-15 北京大学 甲基化CpG岛的高通量测序检测方法
CN116144755A (zh) * 2022-12-30 2023-05-23 中国辐射防护研究院 LncRNA作为氡暴露早期损伤诊断分子标志物的应用及筛选方法

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US4683202A (en) * 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US5965722A (en) * 1991-05-21 1999-10-12 Isis Pharmaceuticals, Inc. Antisense inhibition of ras gene with chimeric and alternating oligonucleotides
EP0519338B1 (de) 1991-06-20 1996-08-28 F. Hoffmann-La Roche Ag Verbesserte Methoden zur Nukleinsäure-Amplifizierung
JPH0690756A (ja) 1992-09-10 1994-04-05 Fuso Yakuhin Kogyo Kk ２段サーモサイクルｐｃｒ法
US5556773A (en) * 1993-08-06 1996-09-17 Yourno; Joseph Method and apparatus for nested polymerase chain reaction (PCR) with single closed reaction tubes
US5565331A (en) * 1993-11-12 1996-10-15 The Regents Of The University Of California Nucleic acids encoding neural axon outgrowth modulators
US5986076A (en) * 1994-05-11 1999-11-16 Trustees Of Boston University Photocleavable agents and conjugates for the detection and isolation of biomolecules
US5843649A (en) * 1995-03-01 1998-12-01 University Of Colorado Method of identifying clonal cell samples using heteroduplex generators
US5693467A (en) * 1995-05-19 1997-12-02 The American Type Culture Collection Mycoplasma polymerase chain reaction testing system using a set of mixed and single sequence primers
US5871917A (en) * 1996-05-31 1999-02-16 North Shore University Hospital Research Corp. Identification of differentially methylated and mutated nucleic acids
US6017704A (en) * 1996-06-03 2000-01-25 The Johns Hopkins University School Of Medicine Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids
US5786146A (en) * 1996-06-03 1998-07-28 The Johns Hopkins University School Of Medicine Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids
US6117635A (en) * 1996-07-16 2000-09-12 Intergen Company Nucleic acid amplification oligonucleotides with molecular energy transfer labels and methods based thereon
AU7829398A (en) * 1997-06-09 1998-12-30 University Of Southern California A cancer diagnostic method based upon dna methylation differences
US6818404B2 (en) * 1997-10-23 2004-11-16 Exact Sciences Corporation Methods for detecting hypermethylated nucleic acid in heterogeneous biological samples
US6033858A (en) * 1998-03-30 2000-03-07 Bastian; Frank O. Detection of transmissible spongiform encephalopathies
GB9811598D0 (en) 1998-05-30 1998-07-29 Imp College Innovations Ltd Diagnosis and treatment of cancer
US6255293B1 (en) * 1998-07-24 2001-07-03 Yeda Research And Development Co., Ltd. Prevention of metastasis with 5-aza-2′-deoxycytidine
US6143504A (en) * 1998-10-27 2000-11-07 Arch Development Corporation Methods and compositions for the diagnosis of fragile X syndrome
US6331393B1 (en) * 1999-05-14 2001-12-18 University Of Southern California Process for high-throughput DNA methylation analysis
WO2001006005A2 (en) 1999-07-15 2001-01-25 The University Of Bristol Diagnostic method comprising wt1 sequences
US6709818B1 (en) * 1999-10-13 2004-03-23 The Johns Hopkins University School Of Medicine Methods of diagnosing and treating hepatic cell proliferative disorders

Also Published As

Publication number Publication date
WO2002018649A1 (en) 2002-03-07
US20040038245A1 (en) 2004-02-26
EP1352089A1 (de) 2003-10-15
EP1352089B1 (de) 2006-12-06
AU2001288379A1 (en) 2002-03-13
CA2421102A1 (en) 2002-03-07
US7214485B2 (en) 2007-05-08
EP1352089A4 (de) 2004-10-20
DE60125065D1 (de) 2007-01-18
DE60125065T2 (de) 2007-06-28

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