ATE349890T1 - Adjuvant für transkutane immunisation - Google Patents
Adjuvant für transkutane immunisationInfo
- Publication number
- ATE349890T1 ATE349890T1 AT03017154T AT03017154T ATE349890T1 AT E349890 T1 ATE349890 T1 AT E349890T1 AT 03017154 T AT03017154 T AT 03017154T AT 03017154 T AT03017154 T AT 03017154T AT E349890 T1 ATE349890 T1 AT E349890T1
- Authority
- AT
- Austria
- Prior art keywords
- transcutane
- immunization
- adjuvant
- transcutane immunization
- Prior art date
Links
- 239000002671 adjuvant Substances 0.000 title 1
- 230000003053 immunization Effects 0.000 title 1
- 238000002649 immunization Methods 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55522—Cytokines; Lymphokines; Interferons
- A61K2039/55527—Interleukins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55544—Bacterial toxins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Nanotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dispersion Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Organic Chemistry (AREA)
- Dermatology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/749,164 US5910306A (en) | 1996-11-14 | 1996-11-14 | Transdermal delivery system for antigen |
| US08/896,085 US5980898A (en) | 1996-11-14 | 1997-07-17 | Adjuvant for transcutaneous immunization |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE349890T1 true ATE349890T1 (de) | 2007-01-15 |
Family
ID=27669393
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03017154T ATE349890T1 (de) | 1996-11-14 | 1997-11-14 | Adjuvant für transkutane immunisation |
| AT97947608T ATE274805T1 (de) | 1996-11-14 | 1997-11-14 | Zusatzstoff für transkutane immunisierung |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97947608T ATE274805T1 (de) | 1996-11-14 | 1997-11-14 | Zusatzstoff für transkutane immunisierung |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US5980898A (de) |
| EP (4) | EP1014787B1 (de) |
| JP (1) | JP4584361B2 (de) |
| KR (1) | KR100517028B1 (de) |
| CN (1) | CN1279976C (de) |
| AP (1) | AP9901540A0 (de) |
| AT (2) | ATE349890T1 (de) |
| AU (1) | AU744537B2 (de) |
| BR (1) | BR9712952A (de) |
| CA (1) | CA2272417C (de) |
| DE (2) | DE69737218T2 (de) |
| IL (1) | IL129919A (de) |
| NZ (1) | NZ335749A (de) |
| WO (1) | WO1998020734A1 (de) |
Families Citing this family (295)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020032316A1 (en) * | 1995-03-31 | 2002-03-14 | Cantab Pharmaceuticals Research Limited | Hapten-carrier conjugates for use in drug-abuse therapy and methods for preparation of same |
| US6365165B1 (en) | 1995-09-22 | 2002-04-02 | Corixa Corporation | Leishmania antigens for use in the therapy and diagnosis of Leishmaniasis |
| US6638517B2 (en) | 1995-09-22 | 2003-10-28 | Corixa Corporation | Leishmania antigens for use in the therapy and diagnosis of leishmaniasis |
| US6500437B1 (en) | 1995-09-22 | 2002-12-31 | Corixa Corporation | Leishmania antigens for use in the therapy and diagnosis of leishmaniasis |
| US6375955B1 (en) * | 1995-09-22 | 2002-04-23 | Corixa Corporation | Leishmania antigens for use in the therapy and diagnosis of leishmaniasis |
| US6613337B1 (en) | 1997-02-12 | 2003-09-02 | Corixa Corporation | Leishmania antigens for use in the therapy and diagnosis of leishmaniasis |
| US6607731B1 (en) | 1995-09-22 | 2003-08-19 | Corixa Corporation | Leishmania antigens for use in the therapy and diagnosis of leishmaniasis |
| EP0909323B1 (de) | 1996-01-04 | 2007-02-28 | Novartis Vaccines and Diagnostics, Inc. | Bakterioferritin aus helicobacter pylori |
| US6797276B1 (en) | 1996-11-14 | 2004-09-28 | The United States Of America As Represented By The Secretary Of The Army | Use of penetration enhancers and barrier disruption agents to enhance the transcutaneous immune response |
| US5980898A (en) | 1996-11-14 | 1999-11-09 | The United States Of America As Represented By The U.S. Army Medical Research & Material Command | Adjuvant for transcutaneous immunization |
| US20060002949A1 (en) | 1996-11-14 | 2006-01-05 | Army Govt. Of The Usa, As Rep. By Secretary Of The Office Of The Command Judge Advocate, Hq Usamrmc. | Transcutaneous immunization without heterologous adjuvant |
| EP0979080B9 (de) * | 1997-01-02 | 2012-02-22 | Thomas Jefferson University | Verfahren zur modulation der immunreaktion in einem infektierten säugetier mittels transmukosales eingeben eines modulationsmittel |
| EP1486215A3 (de) * | 1997-03-21 | 2006-04-12 | Chiron Corporation | Detoxifizierte Mutanten bakterieller ADP-ribosylierender Toxine als parenterale Adjuvantien |
| US6818222B1 (en) * | 1997-03-21 | 2004-11-16 | Chiron Corporation | Detoxified mutants of bacterial ADP-ribosylating toxins as parenteral adjuvants |
| FR2766193B1 (fr) * | 1997-07-18 | 2001-09-14 | Inst Curie | Polypeptide chimerique comprenant le fragment b de la toxine shiga et des peptides d'interet therapeutique |
| US20030125278A1 (en) * | 1997-08-13 | 2003-07-03 | Tang De-Chu C. | Immunization of animals by topical applications of a salmonella-based vector |
| US5993852A (en) * | 1997-08-29 | 1999-11-30 | Pharmaderm Laboratories Ltd. | Biphasic lipid vesicle composition for transdermal administration of an immunogen |
| BR9813930A (pt) | 1997-11-06 | 2006-12-19 | Chiron Spa | antìgeno neisserial |
| US6914131B1 (en) | 1998-10-09 | 2005-07-05 | Chiron S.R.L. | Neisserial antigens |
| GB9800487D0 (en) * | 1998-01-09 | 1998-03-04 | Oratol Limited | Therapies |
| ATE446368T1 (de) | 1998-01-14 | 2009-11-15 | Novartis Vaccines & Diagnostic | Antigene aus neisseria meningitidis |
| EP1356823B1 (de) * | 1998-02-25 | 2013-01-02 | THE GOVERNMENT OF THE UNITED STATES, as represented by THE SECRETARY OF THE ARMY | Verwendung von Hautpenetrationsförderern und für die Zerstörung der oberen Hautschichten geeigneten Mitteln zur Erhöhung der durch ein Adjuvant induzierten Immunantwort |
| EP1849477A1 (de) * | 1998-02-25 | 2007-10-31 | THE GOVERNMENT OF THE UNITED STATES, as represented by THE SECRETARY OF THE ARMY | Verwendung von Mitteln zur Verbesserung der Hautpenetration und schrankenbrechenden Mitteln zur Verbesserung der transkutanen Immunantwort |
| EP1061951B1 (de) * | 1998-02-25 | 2003-08-27 | THE GOVERNMENT OF THE UNITED STATES, as represented by THE SECRETARY OF THE ARMY | Verwendung von hautpenetrationsförderern und für die zerstörung der oberen hautschichten geeigneten mitteln zur erhöhung der durch adp-ribosylating-exotoxin induzierten immunantwort |
| JP4820000B2 (ja) * | 1998-05-15 | 2011-11-24 | アラン エム グリーン | 免疫処置のためのベロ毒素bサブユニット |
| AU770498B2 (en) * | 1998-06-19 | 2004-02-26 | Merieux Oravax | LT and CT in parenteral immunization methods against helicobacter infection |
| US6210672B1 (en) | 1998-10-20 | 2001-04-03 | Torrey Pines Institute For Molecular Studies | Topical immunostimulation to induce Langerhans cell migration |
| US7229621B2 (en) * | 1998-10-20 | 2007-06-12 | Torrey Pines Institute For Molecular Studies | Method to enhance the immunogenicity of an antigen |
| CA2359586A1 (en) * | 1998-12-22 | 2000-06-29 | Boyce Thompson Institute For Plant Research | Orally immunogenic bacterial enterotoxins expressed in transgenic plants |
| AU765429B2 (en) * | 1999-01-22 | 2003-09-18 | Powderject Research Limited | Method of enhancing needleless transdermal powdered drug delivery |
| EP1031346B1 (de) * | 1999-01-27 | 2002-05-02 | Idea Ag | Nichtinvasive Impfung durch die Haut |
| WO2000061184A2 (en) * | 1999-04-08 | 2000-10-19 | Glenn Gregory M | Dry formulation for transcutaneous immunization |
| US6558670B1 (en) | 1999-04-19 | 2003-05-06 | Smithkline Beechman Biologicals S.A. | Vaccine adjuvants |
| DK1187629T3 (da) | 1999-04-19 | 2005-01-17 | Glaxosmithkline Biolog Sa | Adjuvanssammensætning omfattende saponin og et immunostimulerende oligonucleotid |
| NZ571167A (en) | 1999-04-30 | 2010-05-28 | Novartis Vaccines & Diagnostic | Fragments from Neisseria protein ORF 953 and their use in medicaments and diagnostic reagents |
| US20040009936A1 (en) | 1999-05-03 | 2004-01-15 | Tang De-Chu C. | Vaccine and drug delivery by topical application of vectors and vector extracts |
| ID30407A (id) | 1999-05-13 | 2001-11-29 | American Cyanamid Co | Formulasi-formulasi kombinasi bahan penambah |
| GB9911683D0 (en) | 1999-05-19 | 1999-07-21 | Chiron Spa | Antigenic peptides |
| AU5315000A (en) * | 1999-06-03 | 2000-12-28 | Gregory M. Glenn | Indicators for monitoring the technique of transcutaneous immunization |
| US20020151515A1 (en) * | 1999-06-18 | 2002-10-17 | Roberts Bruce L. | Preparation and use of superior vaccines |
| GB9916529D0 (en) | 1999-07-14 | 1999-09-15 | Chiron Spa | Antigenic peptides |
| US6835184B1 (en) | 1999-09-24 | 2004-12-28 | Becton, Dickinson And Company | Method and device for abrading skin |
| GB9923060D0 (en) * | 1999-09-29 | 1999-12-01 | Chiron Spa | Vaccine |
| GB9924351D0 (en) | 1999-10-14 | 1999-12-15 | Brennan Frank | Immunomodulation methods and compositions |
| PT2275551E (pt) | 1999-10-29 | 2015-06-29 | Novartis Vaccines & Diagnostic | Péptidos antigénicos de neisseria |
| US7041296B1 (en) * | 1999-11-12 | 2006-05-09 | The United States Of America As Represented By The Department Of Health And Human Services | Methods of treating inflammatory bowel disease using cholera toxin B subunit |
| GB9928196D0 (en) | 1999-11-29 | 2000-01-26 | Chiron Spa | Combinations of B, C and other antigens |
| ES2588917T3 (es) | 2000-01-17 | 2016-11-07 | Glaxosmithkline Biologicals Sa | Vacuna de VME suplementada contra meningococo |
| PT2270030E (pt) | 2000-02-28 | 2012-07-24 | Novartis Vaccines & Diagnostic | Expressão heteróloga de proteínas de neisseria |
| AU2001245552A1 (en) * | 2000-03-09 | 2001-09-17 | Emory University | Transcutaneous immunization for large particulate antigens |
| US6595947B1 (en) | 2000-05-22 | 2003-07-22 | Becton, Dickinson And Company | Topical delivery of vaccines |
| GB0013810D0 (en) | 2000-06-06 | 2000-07-26 | Celltech Chiroscience Ltd | Biological products |
| GB0017999D0 (en) | 2000-07-21 | 2000-09-13 | Smithkline Beecham Biolog | Novel device |
| GB0022742D0 (en) | 2000-09-15 | 2000-11-01 | Smithkline Beecham Biolog | Vaccine |
| ATE534401T1 (de) | 2000-10-18 | 2011-12-15 | Glaxosmithkline Biolog Sa | Mage antigen gekoppelt an einem protein d fragment enthaltende impfstoffe |
| US7939087B2 (en) | 2000-10-27 | 2011-05-10 | Novartis Vaccines And Diagnostics, Inc. | Nucleic acids and proteins from Streptococcus groups A & B |
| DE60117164T2 (de) * | 2000-11-07 | 2006-08-03 | Immuno Vaccine Technologies Inc., Halifax | Impfstoffe mit erhöhter immunantwort und verfahren zur deren herstellung |
| WO2002038177A2 (en) | 2000-11-10 | 2002-05-16 | Wyeth Holdings Corporation | Adjuvant combination formulations |
| ATE442858T1 (de) * | 2000-11-27 | 2009-10-15 | Powderject Vaccines Inc | Nukleinsäureadjuvantien |
| US20030162733A1 (en) * | 2000-11-27 | 2003-08-28 | Haynes Joel R. | Nucleic acid adjuvants |
| EP1372708B1 (de) * | 2001-02-13 | 2008-06-18 | GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY OF THE ARMY | Impstoffe zur transkutanen immunisierung gegen reisediarrhö |
| EP1372706B1 (de) * | 2001-03-09 | 2010-12-01 | ID Biomedical Corporation of Quebec | Proteosom-liposaccharid-vakzine-adjuvans |
| EP1377299A4 (de) * | 2001-03-19 | 2009-11-11 | Intercell Usa Inc | Transkutane immunstimulation |
| JP2004525921A (ja) * | 2001-03-19 | 2004-08-26 | イオマイ コーポレイシヨン | 経皮免疫用パッチ |
| US20040109869A1 (en) * | 2001-03-19 | 2004-06-10 | Iomai Corporation | Transcutaneous immunostimulation |
| GB0107661D0 (en) | 2001-03-27 | 2001-05-16 | Chiron Spa | Staphylococcus aureus |
| GB0107658D0 (en) | 2001-03-27 | 2001-05-16 | Chiron Spa | Streptococcus pneumoniae |
| CA2447795A1 (en) * | 2001-05-23 | 2002-11-28 | Duotol Ab | Suppression of allergic reactions by transdermal administration of allergens in conjunction with or conjugated to toxin subunits or fragments thereof |
| ES2268050T3 (es) * | 2001-06-08 | 2007-03-16 | Becton, Dickinson And Company | Dispositivo para manipular un conjunto de agujas o abrasion. |
| GB0115176D0 (en) | 2001-06-20 | 2001-08-15 | Chiron Spa | Capular polysaccharide solubilisation and combination vaccines |
| GB0118249D0 (en) | 2001-07-26 | 2001-09-19 | Chiron Spa | Histidine vaccines |
| AU2002367977B2 (en) | 2001-08-13 | 2008-06-19 | University Of Rochester | Transcutaneous immunization against papillomavirus with papillomavirus virus-like particles |
| EP3254687A1 (de) | 2001-10-04 | 2017-12-13 | Genetics Institute LLC | Verfahren und zusammensetzungen zur modulation der interleukin-21-rezeptoraktivität |
| GB0124317D0 (en) | 2001-10-10 | 2001-11-28 | Celltech R&D Ltd | Biological products |
| US20040120964A1 (en) * | 2001-10-29 | 2004-06-24 | Mikszta John A. | Needleless vaccination using chimeric yellow fever vaccine-vectored vaccines against heterologous flaviviruses |
| EP1439870B1 (de) * | 2001-10-29 | 2009-01-14 | Becton, Dickinson and Company | Vorrichtung für die abgabe einer substanz |
| ES2386386T3 (es) | 2001-12-12 | 2012-08-20 | Novartis Vaccines And Diagnostics S.R.L. | Inmunización contra Chlamydia trachomatis |
| US20040137004A1 (en) * | 2002-03-19 | 2004-07-15 | Glenn Gregory M | Patch for transcutaneous immunization |
| MY139721A (en) * | 2002-04-19 | 2009-10-30 | Cpex Pharmaceuticals Inc | Pharmaceutical composition |
| GB0210121D0 (en) | 2002-05-02 | 2002-06-12 | Celltech R&D Ltd | Biological products |
| BR122019027966B8 (pt) | 2002-05-02 | 2021-07-27 | Wyeth Corp | conjugado monomérico de derivado de caliqueamicina/anti-corpo anti-cd22 e uso dos mesmos |
| JP4418745B2 (ja) | 2002-05-28 | 2010-02-24 | ユセベ ファルマ ソシエテ アノニム | 抗体peg位置異性体、それを含む組成物及びその使用 |
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| CA2506318C (en) | 2002-11-15 | 2011-07-12 | Chiron Srl | Unexpected surface proteins in neisseria meningitidis |
| GB0303337D0 (en) | 2003-02-13 | 2003-03-19 | Celltech R&D Ltd | Biological products |
| EP1447080A1 (de) * | 2003-02-13 | 2004-08-18 | Bestewil Holding B.V. | Methode zur Herstellung von Virosomen-artigen Partikeln |
| EP2241330A1 (de) | 2003-02-14 | 2010-10-20 | The Curators Of The University Of Missouri | Empfängnisverhütende Verfahren und Zusammensetzungen betreffend proteasomale Störung |
| GB2398783A (en) | 2003-02-26 | 2004-09-01 | Antonio Lanzavecchia | A method for producing immortalised human B memory lymphocytes |
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| GB0308198D0 (en) | 2003-04-09 | 2003-05-14 | Chiron Srl | ADP-ribosylating bacterial toxin |
| BR0318307A (pt) | 2003-05-21 | 2006-07-11 | Ares Trading Sa | polipeptìdeo, molécula de ácido nucleico purificado, vetor, célula hospedeira, ligante, composto, método para diagnosticar uma doença em um paciente, uso de um polipeptìdeo, composição farmacêutica, composição de vacina, métodos para tratar uma doença para monitorar o tratamento terapêutico de doença em um paciente, método para a identificação de um composto que é efetivo no tratamento e/ou diagnóstico de doença, kit, e, animal não-humano transgênico ou knockout |
| US20060035242A1 (en) | 2004-08-13 | 2006-02-16 | Michelitsch Melissa D | Prion-specific peptide reagents |
| CA2536249A1 (en) | 2003-08-25 | 2005-03-10 | 3M Innovative Properties Company | Delivery of immune response modifier compounds |
| US20050048090A1 (en) * | 2003-09-03 | 2005-03-03 | Rau Allen H. | Temperature changing skin care product |
| GB0323103D0 (en) | 2003-10-02 | 2003-11-05 | Chiron Srl | De-acetylated saccharides |
| EP1708744A4 (de) * | 2003-12-09 | 2009-07-15 | Intercell Usa Inc | Gm1-bindungsdefiziente exotoxine zur verwendung als immunadjuvantien |
| IL159273A0 (en) * | 2003-12-09 | 2004-06-01 | Transpharma Medical Ltd | Transdermal delivery system for sustained release of polypeptides |
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1997
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- 1997-11-14 AT AT03017154T patent/ATE349890T1/de active
- 1997-11-14 NZ NZ335749A patent/NZ335749A/xx not_active IP Right Cessation
- 1997-11-14 KR KR10-1999-7004299A patent/KR100517028B1/ko not_active Expired - Fee Related
- 1997-11-14 CN CNB97180947XA patent/CN1279976C/zh not_active Expired - Fee Related
- 1997-11-14 AU AU52652/98A patent/AU744537B2/en not_active Ceased
- 1997-11-14 AT AT97947608T patent/ATE274805T1/de not_active IP Right Cessation
- 1997-11-14 EP EP97947608A patent/EP1014787B1/de not_active Expired - Lifetime
- 1997-11-14 WO PCT/US1997/021324 patent/WO1998020734A1/en not_active Ceased
- 1997-11-14 EP EP10183575A patent/EP2272526A3/de not_active Withdrawn
- 1997-11-14 JP JP52294298A patent/JP4584361B2/ja not_active Expired - Fee Related
- 1997-11-14 AP APAP/P/1999/001540A patent/AP9901540A0/en unknown
- 1997-11-14 DE DE69737218T patent/DE69737218T2/de not_active Expired - Lifetime
- 1997-11-14 BR BR9712952-6A patent/BR9712952A/pt active Search and Examination
- 1997-11-14 CA CA002272417A patent/CA2272417C/en not_active Expired - Fee Related
- 1997-11-14 DE DE69730534T patent/DE69730534T2/de not_active Expired - Lifetime
- 1997-11-14 EP EP05002995A patent/EP1557177A1/de not_active Withdrawn
- 1997-11-14 EP EP03017154A patent/EP1384403B1/de not_active Revoked
- 1997-11-14 IL IL129919A patent/IL129919A/en not_active IP Right Cessation
-
1999
- 1999-03-12 US US09/266,803 patent/US7037499B1/en not_active Expired - Fee Related
-
2006
- 2006-01-19 US US11/334,349 patent/US20060269593A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US7037499B1 (en) | 2006-05-02 |
| EP1384403A1 (de) | 2004-01-28 |
| WO1998020734A1 (en) | 1998-05-22 |
| CA2272417A1 (en) | 1998-05-22 |
| EP1014787A4 (de) | 2002-08-07 |
| DE69737218D1 (de) | 2007-02-15 |
| EP1014787B1 (de) | 2004-09-01 |
| KR100517028B1 (ko) | 2005-09-26 |
| KR20000053306A (ko) | 2000-08-25 |
| CA2272417C (en) | 2003-07-29 |
| IL129919A0 (en) | 2000-02-29 |
| ATE274805T1 (de) | 2004-09-15 |
| EP2272526A3 (de) | 2012-02-08 |
| JP4584361B2 (ja) | 2010-11-17 |
| DE69730534T2 (de) | 2005-09-15 |
| DE69730534D1 (de) | 2004-10-07 |
| US5980898A (en) | 1999-11-09 |
| BR9712952A (pt) | 1999-12-07 |
| DE69737218T2 (de) | 2007-11-08 |
| EP2272526A2 (de) | 2011-01-12 |
| JP2001511115A (ja) | 2001-08-07 |
| EP1557177A1 (de) | 2005-07-27 |
| CN1241906A (zh) | 2000-01-19 |
| AU744537B2 (en) | 2002-02-28 |
| NZ335749A (en) | 2001-01-26 |
| EP1384403B1 (de) | 2007-01-03 |
| CN1279976C (zh) | 2006-10-18 |
| US20060269593A1 (en) | 2006-11-30 |
| EP1014787A1 (de) | 2000-07-05 |
| IL129919A (en) | 2008-04-13 |
| AU5265298A (en) | 1998-06-03 |
| AP9901540A0 (en) | 1999-06-30 |
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