ATE350373T1 - Radiomarkierte alkylamino-benzothiazole und - benzothiazole sowie ihre verwendung als d4- liganden - Google Patents

Radiomarkierte alkylamino-benzothiazole und - benzothiazole sowie ihre verwendung als d4- liganden

Info

Publication number
ATE350373T1
ATE350373T1 AT03075959T AT03075959T ATE350373T1 AT E350373 T1 ATE350373 T1 AT E350373T1 AT 03075959 T AT03075959 T AT 03075959T AT 03075959 T AT03075959 T AT 03075959T AT E350373 T1 ATE350373 T1 AT E350373T1
Authority
AT
Austria
Prior art keywords
benzothiazoles
radiom
alkylamino
ligands
labeled
Prior art date
Application number
AT03075959T
Other languages
English (en)
Inventor
Ludo E J Kennis
Josephus C Mertens
Serge M A Pieters
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Application granted granted Critical
Publication of ATE350373T1 publication Critical patent/ATE350373T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
AT03075959T 1996-05-10 1997-05-02 Radiomarkierte alkylamino-benzothiazole und - benzothiazole sowie ihre verwendung als d4- liganden ATE350373T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP96201282 1996-05-10

Publications (1)

Publication Number Publication Date
ATE350373T1 true ATE350373T1 (de) 2007-01-15

Family

ID=8223970

Family Applications (2)

Application Number Title Priority Date Filing Date
AT97923913T ATE277917T1 (de) 1996-05-10 1997-05-02 Alkylaminobenzothiazole und -benzoxazole derivate
AT03075959T ATE350373T1 (de) 1996-05-10 1997-05-02 Radiomarkierte alkylamino-benzothiazole und - benzothiazole sowie ihre verwendung als d4- liganden

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT97923913T ATE277917T1 (de) 1996-05-10 1997-05-02 Alkylaminobenzothiazole und -benzoxazole derivate

Country Status (28)

Country Link
US (2) US6103725A (de)
EP (2) EP1325917B1 (de)
JP (1) JP3237759B2 (de)
KR (1) KR100330699B1 (de)
CN (1) CN1074766C (de)
AR (1) AR007079A1 (de)
AT (2) ATE277917T1 (de)
AU (1) AU710175B2 (de)
BG (1) BG64097B1 (de)
BR (1) BR9709065A (de)
CA (1) CA2253453C (de)
CZ (1) CZ295639B6 (de)
DE (2) DE69730962T2 (de)
EA (1) EA001360B1 (de)
EE (1) EE03563B1 (de)
ES (2) ES2230605T3 (de)
HU (1) HUP9902993A3 (de)
ID (1) ID16889A (de)
IL (1) IL126968A0 (de)
MY (1) MY117852A (de)
NO (1) NO311027B1 (de)
NZ (1) NZ332309A (de)
PL (1) PL190721B1 (de)
SK (1) SK282919B6 (de)
TR (1) TR199802253T2 (de)
TW (1) TW593290B (de)
WO (1) WO1997043271A1 (de)
ZA (1) ZA974053B (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1293804B1 (it) 1997-08-01 1999-03-10 Recordati Chem Pharm Diarilalchilpiperazine attive sulle basse vie urinarie
US6281216B1 (en) * 1998-02-09 2001-08-28 Duphar International Research B.V. 2-aminoquinoline derivatives having d4-agonistic activity
EP0982030A3 (de) 1998-08-17 2000-05-10 Pfizer Products Inc. 2,7-substituierte Octahydropyrrolo(1,2-a)pyrazinderivate als 5ht 1a Liganden
CN1325397A (zh) * 1998-09-30 2001-12-05 纽罗根公司 2－哌嗪烷基氨基苯并吡咯衍生物∶多巴胺受体亚型特异配体
US6284759B1 (en) * 1998-09-30 2001-09-04 Neurogen Corporation 2-piperazinoalkylaminobenzo-azole derivatives: dopamine receptor subtype specific ligands
US6107313A (en) * 1998-10-02 2000-08-22 Combichem, Inc. Dopamine receptor antagonists
WO2001000604A1 (fr) * 1999-06-30 2001-01-04 Santen Pharmaceutical Co., Ltd. Ligand de liaison avec le recepteur sigma-1 du cerveau
AU2001249679A1 (en) 2000-03-31 2001-10-15 Ortho-Mcneil Pharmaceutical, Inc. Phenyl-substituted imidazopyridines
US6436939B2 (en) 2000-03-31 2002-08-20 Ortho-Mcneil Pharmaceutical, Inc. Method for using 2-aryloxyalkylaminobenzoxazoles and 2-aryloxyalkylaminobenzothiazoles as H3 antagonists
GB0203299D0 (en) * 2002-02-12 2002-03-27 Glaxo Group Ltd Novel compounds
MXPA05002575A (es) 2002-09-06 2005-09-08 Johnson & Johnson Compuestos heterociclicos.
US9017724B2 (en) 2004-02-24 2015-04-28 The General Hospital Corporation Catalytic radiofluorination
CA2552356C (en) * 2004-02-24 2013-11-19 The General Hospital Corporation Catalytic radiofluorination
US8257680B1 (en) 2004-02-24 2012-09-04 The General Hospital Corporation Catalytic radiofluorination
FR2877005A1 (fr) * 2004-10-22 2006-04-28 Bioprojet Soc Civ Ile Nouveaux derives d'arylpiperazine
US7731940B2 (en) 2006-01-25 2010-06-08 The Regents Of The University Of California Compositions and methods related to serotonin 5-HT1A receptors
EP3231804B1 (de) 2008-03-21 2021-03-03 The General Hospital Corporation Verbindungen und zusammensetzungen für den nachweis und die behandlung von morbus alzheimer und verwandten erkrankungen
JP2019528301A (ja) * 2016-08-26 2019-10-10 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ インドールアミン２，３−ジオキシゲナーゼの阻害剤およびその使用方法
PT109740B (pt) * 2016-11-14 2020-07-30 Hovione Farmaciencia Sa Processo para a preparação de brometo de umeclidínio
KR102823891B1 (ko) * 2020-01-14 2025-06-20 서울대학교산학협력단 혈관생성 저해 효과를 가지는 n-페닐벤조티아졸-2-아민 화합물 및 그를 포함하는 약제학적 조성물
CN116730948B (zh) * 2022-03-02 2026-05-05 圣奥化学科技有限公司 一种合成n-环己基-2-苯并噻唑的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU564702B2 (en) * 1984-05-22 1987-08-20 Sumitomo Chemical Company, Limited Novel radioactive iodospiroperidol and process for its preparation
DE3874187T2 (de) * 1987-04-08 1993-04-08 Salutar Inc Nachweis fuer amyloidose und alzheimer'sche krankheit sowie reagens hierfuer.
US4929618A (en) * 1988-03-25 1990-05-29 Ube Industries, Ltd. Piperdine and piperazine derivatives, and antihistaminic pharmaceutical compositions containing the same
FR2656609B1 (fr) * 1989-12-28 1992-03-27 Synthelabo Derives de 2-aminopyrimidine-4-carboxamide, leur preparation et leur application en therapeutique.
US5731438A (en) * 1996-08-01 1998-03-24 Isis Pharmaceuticals, Inc. N-(aminoalkyl)-and/or N-(amidoalkyl)-dinitrogen heterocycles

Also Published As

Publication number Publication date
EE9800378A (et) 1999-04-15
SK282919B6 (sk) 2003-01-09
EP0912533B1 (de) 2004-09-29
BR9709065A (pt) 1999-08-03
JP3237759B2 (ja) 2001-12-10
AR007079A1 (es) 1999-10-13
EP0912533A1 (de) 1999-05-06
NO985227L (no) 1999-01-11
EE03563B1 (et) 2001-12-17
CZ355398A3 (cs) 1999-02-17
NO311027B1 (no) 2001-10-01
AU710175B2 (en) 1999-09-16
EA199801000A1 (ru) 1999-04-29
BG102819A (en) 1999-08-31
TR199802253T2 (xx) 1999-02-22
IL126968A0 (en) 1999-09-22
DE69730962D1 (de) 2004-11-04
DE69737217D1 (de) 2007-02-15
KR20000005227A (ko) 2000-01-25
HUP9902993A3 (en) 2002-01-28
NO985227D0 (no) 1998-11-09
CA2253453C (en) 2007-01-16
EP1325917A1 (de) 2003-07-09
BG64097B1 (bg) 2003-12-31
CZ295639B6 (cs) 2005-09-14
ID16889A (id) 1997-11-20
EA001360B1 (ru) 2001-02-26
ES2279923T3 (es) 2007-09-01
AU2956097A (en) 1997-12-05
MY117852A (en) 2004-08-30
ATE277917T1 (de) 2004-10-15
CN1074766C (zh) 2001-11-14
TW593290B (en) 2004-06-21
HK1018457A1 (en) 1999-12-24
ES2230605T3 (es) 2005-05-01
HK1057044A1 (en) 2004-03-12
WO1997043271A1 (en) 1997-11-20
CN1218461A (zh) 1999-06-02
NZ332309A (en) 1999-08-30
PL329849A1 (en) 1999-04-12
DE69730962T2 (de) 2006-03-30
EP1325917B1 (de) 2007-01-03
ZA974053B (en) 1998-11-09
SK153298A3 (en) 1999-03-12
US6224849B1 (en) 2001-05-01
PL190721B1 (pl) 2005-12-30
HUP9902993A2 (hu) 2000-05-28
CA2253453A1 (en) 1997-11-20
JP2000503667A (ja) 2000-03-28
US6103725A (en) 2000-08-15
DE69737217T2 (de) 2007-11-08
KR100330699B1 (ko) 2002-08-27

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties