EE03563B1 - Alküülaminobensotiasooli ja -bensoksasooli derivaadid - Google Patents

Alküülaminobensotiasooli ja -bensoksasooli derivaadid

Info

Publication number
EE03563B1
EE03563B1 EE9800378A EE9800378A EE03563B1 EE 03563 B1 EE03563 B1 EE 03563B1 EE 9800378 A EE9800378 A EE 9800378A EE 9800378 A EE9800378 A EE 9800378A EE 03563 B1 EE03563 B1 EE 03563B1
Authority
EE
Estonia
Prior art keywords
alkylaminobenzothiazole
benzoxazole derivatives
benzoxazole
derivatives
Prior art date
Application number
EE9800378A
Other languages
English (en)
Estonian (et)
Other versions
EE9800378A (et
Inventor
Edmond Josephine Kennis Ludo
Carolus Mertens Josephus
Maria Aloysius Pieters Serge
Original Assignee
Janssen Pharmaceutica N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.
Publication of EE9800378A publication Critical patent/EE9800378A/xx
Publication of EE03563B1 publication Critical patent/EE03563B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
EE9800378A 1996-05-10 1997-05-02 Alküülaminobensotiasooli ja -bensoksasooli derivaadid EE03563B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP96201282 1996-05-10
PCT/EP1997/002505 WO1997043271A1 (en) 1996-05-10 1997-05-02 Alkylaminobenzothiazole and -benzoxazole derivatives

Publications (2)

Publication Number Publication Date
EE9800378A EE9800378A (et) 1999-04-15
EE03563B1 true EE03563B1 (et) 2001-12-17

Family

ID=8223970

Family Applications (1)

Application Number Title Priority Date Filing Date
EE9800378A EE03563B1 (et) 1996-05-10 1997-05-02 Alküülaminobensotiasooli ja -bensoksasooli derivaadid

Country Status (28)

Country Link
US (2) US6103725A (de)
EP (2) EP1325917B1 (de)
JP (1) JP3237759B2 (de)
KR (1) KR100330699B1 (de)
CN (1) CN1074766C (de)
AR (1) AR007079A1 (de)
AT (2) ATE350373T1 (de)
AU (1) AU710175B2 (de)
BG (1) BG64097B1 (de)
BR (1) BR9709065A (de)
CA (1) CA2253453C (de)
CZ (1) CZ295639B6 (de)
DE (2) DE69730962T2 (de)
EA (1) EA001360B1 (de)
EE (1) EE03563B1 (de)
ES (2) ES2279923T3 (de)
HU (1) HUP9902993A3 (de)
ID (1) ID16889A (de)
IL (1) IL126968A0 (de)
MY (1) MY117852A (de)
NO (1) NO311027B1 (de)
NZ (1) NZ332309A (de)
PL (1) PL190721B1 (de)
SK (1) SK282919B6 (de)
TR (1) TR199802253T2 (de)
TW (1) TW593290B (de)
WO (1) WO1997043271A1 (de)
ZA (1) ZA974053B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1293804B1 (it) 1997-08-01 1999-03-10 Recordati Chem Pharm Diarilalchilpiperazine attive sulle basse vie urinarie
US6281216B1 (en) * 1998-02-09 2001-08-28 Duphar International Research B.V. 2-aminoquinoline derivatives having d4-agonistic activity
EP0982030A3 (de) 1998-08-17 2000-05-10 Pfizer Products Inc. 2,7-substituierte Octahydropyrrolo(1,2-a)pyrazinderivate als 5ht 1a Liganden
AU6280199A (en) * 1998-09-30 2000-04-17 Neurogen Corporation 2-piperazino alkylamino benzoazole derivatives: dopamine receptor subtype specific ligands
US6284759B1 (en) 1998-09-30 2001-09-04 Neurogen Corporation 2-piperazinoalkylaminobenzo-azole derivatives: dopamine receptor subtype specific ligands
US6107313A (en) * 1998-10-02 2000-08-22 Combichem, Inc. Dopamine receptor antagonists
WO2001000604A1 (fr) * 1999-06-30 2001-01-04 Santen Pharmaceutical Co., Ltd. Ligand de liaison avec le recepteur sigma-1 du cerveau
AU2001249679A1 (en) 2000-03-31 2001-10-15 Ortho-Mcneil Pharmaceutical, Inc. Phenyl-substituted imidazopyridines
AU2001251083A1 (en) 2000-03-31 2001-10-15 Ortho-Mcneil Pharmaceutical, Inc. Method for using 2-aryloxyalkylaminobenzoxazoles and 2-aryloxyalkylaminobenzothiazoles as h3 antagonists
GB0203299D0 (en) * 2002-02-12 2002-03-27 Glaxo Group Ltd Novel compounds
WO2004022060A2 (en) 2002-09-06 2004-03-18 Janssen Pharmaceutica, N.V. (1h-benzoimidazol-2-yl)-(piperazinyl)-methanone derivatives and related compounds as histamine h4-receptor antagonists for the treatment of inflammatory and allergic disorders
US9017724B2 (en) 2004-02-24 2015-04-28 The General Hospital Corporation Catalytic radiofluorination
US8257680B1 (en) 2004-02-24 2012-09-04 The General Hospital Corporation Catalytic radiofluorination
EP2388017B1 (de) * 2004-02-24 2014-12-24 The General Hospital Corporation Katalytische Radiofluorierung
FR2877005A1 (fr) * 2004-10-22 2006-04-28 Bioprojet Soc Civ Ile Nouveaux derives d'arylpiperazine
US7731940B2 (en) 2006-01-25 2010-06-08 The Regents Of The University Of California Compositions and methods related to serotonin 5-HT1A receptors
EP3231804B1 (de) 2008-03-21 2021-03-03 The General Hospital Corporation Verbindungen und zusammensetzungen für den nachweis und die behandlung von morbus alzheimer und verwandten erkrankungen
KR20190040502A (ko) * 2016-08-26 2019-04-18 브리스톨-마이어스 스큅 컴퍼니 인돌아민 2,3-디옥시게나제의 억제제 및 그의 사용 방법
PT109740B (pt) 2016-11-14 2020-07-30 Hovione Farmaciencia Sa Processo para a preparação de brometo de umeclidínio
KR102823891B1 (ko) * 2020-01-14 2025-06-20 서울대학교산학협력단 혈관생성 저해 효과를 가지는 n-페닐벤조티아졸-2-아민 화합물 및 그를 포함하는 약제학적 조성물

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3480340D1 (en) * 1984-05-22 1989-12-07 Sumitomo Chemical Co Novel radioactive iodospiroperidol and process for its preparation
AU620327B2 (en) * 1987-04-08 1992-02-20 Salutar, Inc. Amyloidosis and alzheimer's disease diagnostic assay and reagents therefor
US4929618A (en) * 1988-03-25 1990-05-29 Ube Industries, Ltd. Piperdine and piperazine derivatives, and antihistaminic pharmaceutical compositions containing the same
FR2656609B1 (fr) * 1989-12-28 1992-03-27 Synthelabo Derives de 2-aminopyrimidine-4-carboxamide, leur preparation et leur application en therapeutique.
US5731438A (en) * 1996-08-01 1998-03-24 Isis Pharmaceuticals, Inc. N-(aminoalkyl)-and/or N-(amidoalkyl)-dinitrogen heterocycles

Also Published As

Publication number Publication date
CN1218461A (zh) 1999-06-02
NZ332309A (en) 1999-08-30
TR199802253T2 (xx) 1999-02-22
ES2230605T3 (es) 2005-05-01
NO311027B1 (no) 2001-10-01
US6103725A (en) 2000-08-15
EA001360B1 (ru) 2001-02-26
ATE277917T1 (de) 2004-10-15
BG102819A (en) 1999-08-31
AR007079A1 (es) 1999-10-13
HK1018457A1 (en) 1999-12-24
SK282919B6 (sk) 2003-01-09
EA199801000A1 (ru) 1999-04-29
SK153298A3 (en) 1999-03-12
DE69737217D1 (de) 2007-02-15
NO985227L (no) 1999-01-11
BG64097B1 (bg) 2003-12-31
ES2279923T3 (es) 2007-09-01
BR9709065A (pt) 1999-08-03
JP3237759B2 (ja) 2001-12-10
CZ295639B6 (cs) 2005-09-14
HUP9902993A2 (hu) 2000-05-28
IL126968A0 (en) 1999-09-22
EP1325917B1 (de) 2007-01-03
NO985227D0 (no) 1998-11-09
ZA974053B (en) 1998-11-09
DE69730962D1 (de) 2004-11-04
US6224849B1 (en) 2001-05-01
CN1074766C (zh) 2001-11-14
ATE350373T1 (de) 2007-01-15
KR100330699B1 (ko) 2002-08-27
ID16889A (id) 1997-11-20
EP1325917A1 (de) 2003-07-09
AU710175B2 (en) 1999-09-16
EP0912533A1 (de) 1999-05-06
DE69730962T2 (de) 2006-03-30
EP0912533B1 (de) 2004-09-29
WO1997043271A1 (en) 1997-11-20
PL329849A1 (en) 1999-04-12
HUP9902993A3 (en) 2002-01-28
TW593290B (en) 2004-06-21
CA2253453C (en) 2007-01-16
AU2956097A (en) 1997-12-05
CZ355398A3 (cs) 1999-02-17
HK1057044A1 (en) 2004-03-12
MY117852A (en) 2004-08-30
KR20000005227A (ko) 2000-01-25
PL190721B1 (pl) 2005-12-30
EE9800378A (et) 1999-04-15
CA2253453A1 (en) 1997-11-20
DE69737217T2 (de) 2007-11-08
JP2000503667A (ja) 2000-03-28

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Legal Events

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KB4A Valid patent at the end of a year

Effective date: 20021231

KB4A Valid patent at the end of a year

Effective date: 20031231

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Effective date: 20041231

KB4A Valid patent at the end of a year

Effective date: 20051231

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Effective date: 20061231

KB4A Valid patent at the end of a year

Effective date: 20071231

KB4A Valid patent at the end of a year

Effective date: 20081231

MM4A Lapsed by not paying the annual fees

Effective date: 20090502