ATE352618T1 - Rezeptor 5, der eine für den zelltod verantwortliche domäne enthält - Google Patents
Rezeptor 5, der eine für den zelltod verantwortliche domäne enthältInfo
- Publication number
- ATE352618T1 ATE352618T1 AT98912966T AT98912966T ATE352618T1 AT E352618 T1 ATE352618 T1 AT E352618T1 AT 98912966 T AT98912966 T AT 98912966T AT 98912966 T AT98912966 T AT 98912966T AT E352618 T1 ATE352618 T1 AT E352618T1
- Authority
- AT
- Austria
- Prior art keywords
- receptor
- cell death
- proteins
- domain responsible
- antagonists
- Prior art date
Links
- 230000030833 cell death Effects 0.000 title 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 abstract 2
- 239000005557 antagonist Substances 0.000 abstract 2
- 102000003390 tumor necrosis factor Human genes 0.000 abstract 2
- 108050001718 Death domains Proteins 0.000 abstract 1
- 102000010170 Death domains Human genes 0.000 abstract 1
- 101000610604 Homo sapiens Tumor necrosis factor receptor superfamily member 10B Proteins 0.000 abstract 1
- 102000053594 human TNFRSF10B Human genes 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000005962 receptors Human genes 0.000 abstract 1
- 108020003175 receptors Proteins 0.000 abstract 1
- 238000010188 recombinant method Methods 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7151—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for tumor necrosis factor [TNF], for lymphotoxin [LT]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Neurology (AREA)
- Gastroenterology & Hepatology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Neurosurgery (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Urology & Nephrology (AREA)
- Psychiatry (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Microbiology (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4084697P | 1997-03-17 | 1997-03-17 | |
| US5402197P | 1997-07-29 | 1997-07-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE352618T1 true ATE352618T1 (de) | 2007-02-15 |
Family
ID=26717514
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98912966T ATE352618T1 (de) | 1997-03-17 | 1998-03-17 | Rezeptor 5, der eine für den zelltod verantwortliche domäne enthält |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US7803615B1 (de) |
| EP (1) | EP0970213B1 (de) |
| JP (2) | JP4330180B2 (de) |
| KR (1) | KR100527638B1 (de) |
| CN (2) | CN1624128A (de) |
| AT (1) | ATE352618T1 (de) |
| AU (1) | AU747635B2 (de) |
| CA (2) | CA2644454A1 (de) |
| DE (1) | DE69836956T2 (de) |
| DK (1) | DK0970213T3 (de) |
| ES (1) | ES2281126T3 (de) |
| NZ (2) | NZ337795A (de) |
| PT (1) | PT970213E (de) |
| WO (1) | WO1998041629A2 (de) |
Families Citing this family (83)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7429646B1 (en) | 1995-06-05 | 2008-09-30 | Human Genome Sciences, Inc. | Antibodies to human tumor necrosis factor receptor-like 2 |
| US7888466B2 (en) | 1996-01-11 | 2011-02-15 | Human Genome Sciences, Inc. | Human G-protein chemokine receptor HSATU68 |
| WO1997033904A1 (en) | 1996-03-12 | 1997-09-18 | Human Genome Sciences, Inc. | Death domain containing receptors |
| US7357927B2 (en) | 1996-03-12 | 2008-04-15 | Human Genome Sciences, Inc. | Death domain containing receptors |
| US6713061B1 (en) | 1996-03-12 | 2004-03-30 | Human Genome Sciences, Inc. | Death domain containing receptors |
| US6635743B1 (en) | 1996-03-22 | 2003-10-21 | Human Genome Sciences, Inc. | Apoptosis inducing molecule II and methods of use |
| US7964190B2 (en) | 1996-03-22 | 2011-06-21 | Human Genome Sciences, Inc. | Methods and compositions for decreasing T-cell activity |
| US6433147B1 (en) | 1997-01-28 | 2002-08-13 | Human Genome Sciences, Inc. | Death domain containing receptor-4 |
| US7452538B2 (en) | 1997-01-28 | 2008-11-18 | Human Genome Sciences, Inc. | Death domain containing receptor 4 antibodies and methods |
| US8329179B2 (en) | 1997-01-28 | 2012-12-11 | Human Genome Sciences, Inc. | Death domain containing receptor 4 antibodies and methods |
| EP1012274B2 (de) | 1997-01-28 | 2011-06-15 | Human Genome Sciences, Inc. | "death-domain"-enthaltender rezeptor 4 (dr4), ein mitglied der tnf-rezeptor superfamilie, welcher an trail (apo-2l) bindet |
| US6072047A (en) | 1997-02-13 | 2000-06-06 | Immunex Corporation | Receptor that binds trail |
| US7528239B1 (en) * | 1997-02-13 | 2009-05-05 | Immunex Corporation | Receptor that binds trail |
| US6872568B1 (en) * | 1997-03-17 | 2005-03-29 | Human Genome Sciences, Inc. | Death domain containing receptor 5 antibodies |
| US20080248046A1 (en) * | 1997-03-17 | 2008-10-09 | Human Genome Sciences, Inc. | Death domain containing receptor 5 |
| US20050233958A1 (en) * | 1997-03-17 | 2005-10-20 | Human Genome Sciences, Inc. | Death domain containing receptor 5 |
| DE69836956T2 (de) | 1997-03-17 | 2007-10-31 | Human Genome Sciences, Inc. | Rezeptor 5, der eine für den zelltod verantwortliche domäne enthält |
| US6342369B1 (en) | 1997-05-15 | 2002-01-29 | Genentech, Inc. | Apo-2-receptor |
| US20100152426A1 (en) * | 1997-05-15 | 2010-06-17 | Ashkenazi Avi J | Apo-2 receptor fusion proteins |
| EP1860187B1 (de) * | 1997-05-15 | 2011-07-13 | Genentech, Inc. | Apo-2-Rezeptor |
| WO1999011791A2 (en) * | 1997-09-05 | 1999-03-11 | University Of Washington | Tumor necrosis factor family receptors and ligands, encoding nucleic acids and related binding agents |
| WO1999012963A2 (en) * | 1997-09-12 | 1999-03-18 | Biogen, Inc. | Cysteine rich receptors: trail |
| ATE443723T1 (de) * | 1998-06-12 | 2009-10-15 | Genentech Inc | Monoklonale antikörper, kreuz-reaktive antikörper und deren produktionsverfahren |
| EP2357192A1 (de) | 1999-02-26 | 2011-08-17 | Human Genome Sciences, Inc. | Menschliches alpha-Endokin und Verfahren zu seiner Verwendung |
| AU4817200A (en) * | 1999-05-04 | 2000-11-17 | Human Genome Sciences, Inc. | Death domain containing receptor 5 |
| JP2003507064A (ja) * | 1999-08-25 | 2003-02-25 | ゲノム セラピューティックス コーポレーション | 膜結合タンパク質単離用膜貫通トラップ |
| BR0108187A (pt) * | 2000-02-11 | 2005-04-05 | Inst Genetics Llc | Moléculas trade e usos relacionados com as mesmas |
| AU2048501A (en) | 2000-02-16 | 2001-08-27 | Genentech Inc. | Uses of agonists and antagonists to modulate activity of tnf-related molecules |
| AU2001247616B2 (en) | 2000-04-11 | 2007-06-14 | Genentech, Inc. | Multivalent antibodies and uses therefor |
| TWI318983B (en) | 2000-05-02 | 2010-01-01 | Uab Research Foundation | An antibody selective for a tumor necrosis factor-related apoptosis-inducing ligand receptor and uses thereof |
| US7279160B2 (en) | 2000-05-02 | 2007-10-09 | The Uab Research Foundation | Combinations of DR5 antibodies and other therapeutic agents |
| US7476383B2 (en) | 2000-05-02 | 2009-01-13 | The Uab Research Foundation | Antibody selective for DR4 and uses thereof |
| WO2001096528A2 (en) | 2000-06-15 | 2001-12-20 | Human Genome Sciences, Inc. | Human tumor necrosis factor delta and epsilon |
| AU2001268427B2 (en) | 2000-06-16 | 2007-03-29 | Glaxosmithkline Intellectual Property Limited | Antibodies that immunospecifically bind to blys |
| ATE415978T1 (de) | 2000-07-27 | 2008-12-15 | Genentech Inc | Sequentielle verabreichung von cpt-11 und apo-2l polypeptid |
| US20030228309A1 (en) * | 2000-11-08 | 2003-12-11 | Theodora Salcedo | Antibodies that immunospecifically bind to TRAIL receptors |
| US20060062786A1 (en) * | 2000-11-08 | 2006-03-23 | Human Genome Sciences, Inc. | Antibodies that immunospecifically bind to TRAIL receptors |
| AU2002256895B2 (en) | 2001-05-18 | 2008-09-18 | Kirin Beer Kabushiki Kaisha | Anti-TRAIL-R antibodies |
| US7361341B2 (en) | 2001-05-25 | 2008-04-22 | Human Genome Sciences, Inc. | Methods of treating cancer using antibodies that immunospecifically bind to trail receptors |
| US20050214209A1 (en) * | 2001-05-25 | 2005-09-29 | Human Genome Sciences, Inc. | Antibodies that immunospecifically bind to TRAIL receptors |
| CN100594935C (zh) | 2001-05-25 | 2010-03-24 | 人体基因组科学有限公司 | 免疫特异性结合trail受体的抗体 |
| US7348003B2 (en) | 2001-05-25 | 2008-03-25 | Human Genome Sciences, Inc. | Methods of treating cancer using antibodies that immunospecifically bind to TRAIL receptors |
| US20090226429A1 (en) * | 2001-05-25 | 2009-09-10 | Human Genome Sciences, Inc. | Antibodies That Immunospecifically Bind to TRAIL Receptors |
| US20050129616A1 (en) * | 2001-05-25 | 2005-06-16 | Human Genome Sciences, Inc. | Antibodies that immunospecifically bind to TRAIL receptors |
| PT1409544E (pt) | 2001-07-03 | 2009-09-16 | Genentech Inc | Anticorpos de dr4 humanos e suas utilizações |
| WO2003011318A1 (en) * | 2001-08-01 | 2003-02-13 | Genset S.A. | Agonists and antagonists of famoset for use in the treatment of metabolic disorders |
| WO2003029420A2 (en) | 2001-10-02 | 2003-04-10 | Genentech, Inc. | Apo-2 ligand variants and uses thereof |
| EP1439225A4 (de) | 2001-10-04 | 2005-10-26 | Kansai Tech Licensing Org Co | Dr5-gen-promotor und siah-1-gen-promotor |
| US7842668B1 (en) | 2001-11-13 | 2010-11-30 | Genentech, Inc. | Apo-2 ligand/trail formulations |
| EP1450847B1 (de) | 2001-11-13 | 2010-09-29 | Genentech, Inc. | Zusammensetzungen basierend auf APO2-Ligand/ TRAIL und ihre Verwendung |
| US7741285B2 (en) | 2001-11-13 | 2010-06-22 | Genentech, Inc. | APO-2 ligand/trail formulations |
| EP1465925A4 (de) * | 2001-12-20 | 2006-02-08 | Human Genome Sciences Inc | "antikörper, die sich immunspezifisch an trail?rezeptoren binden" |
| WO2003106974A2 (en) * | 2002-06-18 | 2003-12-24 | Irm Llc | Diagnosis and treatment of chemoresistant tumors |
| EP2500032A1 (de) | 2002-06-24 | 2012-09-19 | Genentech, Inc. | APO-2-Liganden-/Trailvarianten und Verwendungen dafür |
| BRPI0509201A (pt) | 2004-03-23 | 2007-08-28 | Biogen Idec Inc | agentes de acoplamento de receptor e usos terapêuticos destes |
| RU2410438C2 (ru) * | 2004-08-06 | 2011-01-27 | Дженентек, Инк. | Анализы и способы, использующие биомаркеры |
| DE602005027848D1 (de) | 2004-08-06 | 2011-06-16 | Genentech Inc | Tests und verfahren unter verwendung von biomarkern |
| US20090175854A1 (en) * | 2004-09-08 | 2009-07-09 | Genentech, Inc. | Methods of using death receptor ligands and CD20 antibodies |
| JP2008513367A (ja) * | 2004-09-08 | 2008-05-01 | ジェネンテック・インコーポレーテッド | デスレセプターリガンド及びcd20抗体の使用方法 |
| JO3000B1 (ar) | 2004-10-20 | 2016-09-05 | Genentech Inc | مركبات أجسام مضادة . |
| US8029783B2 (en) | 2005-02-02 | 2011-10-04 | Genentech, Inc. | DR5 antibodies and articles of manufacture containing same |
| WO2006083937A2 (en) | 2005-02-02 | 2006-08-10 | The Uab Research Foundation | Agents and methods related to reducing resistance to apoptosis-inducing death receptor agonists |
| AU2006279618A1 (en) * | 2005-08-16 | 2007-02-22 | Genentech, Inc. | Apoptosis sensitivity to Apo2L/TRAIL by testing for 'GalNac-T14 expression in cells/tissues |
| PE20071101A1 (es) * | 2005-08-31 | 2007-12-21 | Amgen Inc | Polipeptidos y anticuerpos |
| CA2626082C (en) | 2005-10-13 | 2017-04-11 | Human Genome Sciences, Inc. | Methods and compositions for use in treatment of patients with autoantibody positive disease |
| US9726673B2 (en) | 2005-11-23 | 2017-08-08 | Genentech, Inc. | Methods and compositions related to B cell assays |
| WO2010042890A2 (en) | 2008-10-10 | 2010-04-15 | Anaphore, Inc. | Polypeptides that bind trail-ri and trail-r2 |
| CA2749512A1 (en) * | 2009-04-03 | 2010-10-07 | Institute Of Basic Medical Sciences, Chinese Academy Of Medical Sciences | Antigenic determinants recognized by anti-human death receptor dr5 monoclonal antibody ad5-10, derivatives and use thereof |
| CA2773428A1 (en) * | 2009-09-10 | 2011-03-17 | Lonza Biologics Plc | Method and system for polypeptide purification |
| WO2011057099A2 (en) | 2009-11-05 | 2011-05-12 | The Uab Research Foundation | Treating basal-like genotype cancers |
| US8703712B2 (en) | 2010-03-18 | 2014-04-22 | The Uab Research Foundation | Targeting cancer stem cells with DR5 agonists |
| NZ610153A (en) | 2010-10-29 | 2014-07-25 | Daiichi Sankyo Co Ltd | Novel anti-dr5 antibody |
| AR084141A1 (es) | 2010-11-19 | 2013-04-24 | Imai Toshio | Anticuerpos neutralizadores anti-ccl20 |
| WO2012117336A2 (en) | 2011-02-28 | 2012-09-07 | Istituto Di Ricovero E Cura A Carattere Scientifico Materno-Infantile Burlo Garofolo - Ospedale Di Alta Specializzazione E Di Rilievo Nazionale Per La Salute Della Donna E Del Bambino | Apoptosis-inducing molecules and uses therefor |
| WO2012151317A1 (en) | 2011-05-03 | 2012-11-08 | Genentech, Inc. | Vascular disruption agents and uses thereof |
| PT2970473T (pt) | 2013-03-14 | 2017-10-26 | Bristol Myers Squibb Co | Combinação de agonista de dr5 e antagonista anti-pd-1 e métodos de utilização |
| ES2623260T3 (es) | 2013-03-22 | 2017-07-10 | Koninklijke Philips N.V. | Dispositivo para el tratamiento no invasivo de la piel usando luz laser |
| CN104693308B (zh) * | 2013-12-05 | 2020-08-04 | 同济大学 | 感受胞内pH变化的Smad5蛋白及其应用 |
| EP3323428A1 (de) | 2016-11-17 | 2018-05-23 | CNRS Centre National de la Recherche Scientifique | Selektive c-flip-hemmer als antikrebsmittel |
| CN108997503B (zh) * | 2017-06-06 | 2021-07-23 | 深圳市中科艾深医药有限公司 | 人sDR5-Fc重组融合蛋白及其作为制备治疗生殖系统炎症的药物中的应用 |
| EP3910331A1 (de) | 2020-05-15 | 2021-11-17 | iOmx Therapeutics AG | Intrazelluläre kinase in verbindung mit resistenz gegen t-zell-vermittelte zytotoxizität und verwendungen davon |
| EP4257132A1 (de) | 2022-04-08 | 2023-10-11 | iOmx Therapeutics AG | Sik3-inhibitoren zum behandeln von krankheiten, die gegen death-rezeptor -signaltransduktion resistent sind |
| WO2024175554A1 (en) | 2023-02-21 | 2024-08-29 | Institut Curie | Trail agonists for use in the treatment of cancer in patients having an activating alteration of fgfr3 |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4002531A (en) * | 1976-01-22 | 1977-01-11 | Pierce Chemical Company | Modifying enzymes with polyethylene glycol and product produced thereby |
| US5807715A (en) * | 1984-08-27 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin |
| US4946778A (en) * | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US5530101A (en) * | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| GB8928874D0 (en) * | 1989-12-21 | 1990-02-28 | Celltech Ltd | Humanised antibodies |
| US5349053A (en) * | 1990-06-01 | 1994-09-20 | Protein Design Labs, Inc. | Chimeric ligand/immunoglobulin molecules and their uses |
| EP0510691B1 (de) * | 1991-04-26 | 2004-11-03 | Osaka Bioscience Institute | Für ein menschliches Zelloberflächen-Antigen kodierende DNS |
| IL99120A0 (en) * | 1991-08-07 | 1992-07-15 | Yeda Res & Dev | Multimers of the soluble forms of tnf receptors,their preparation and pharmaceutical compositions containing them |
| US5565332A (en) * | 1991-09-23 | 1996-10-15 | Medical Research Council | Production of chimeric antibodies - a combinatorial approach |
| US5447851B1 (en) * | 1992-04-02 | 1999-07-06 | Univ Texas System Board Of | Dna encoding a chimeric polypeptide comprising the extracellular domain of tnf receptor fused to igg vectors and host cells |
| GB9214857D0 (en) * | 1992-07-13 | 1992-08-26 | Medical Res Council | Human nucleic acid fragments and their use |
| US5643575A (en) * | 1993-10-27 | 1997-07-01 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
| KR100510234B1 (ko) * | 1995-06-29 | 2005-11-25 | 임뮤넥스 코포레이션 | 세포소멸을 유도하는 시토킨 |
| EP1012274B2 (de) | 1997-01-28 | 2011-06-15 | Human Genome Sciences, Inc. | "death-domain"-enthaltender rezeptor 4 (dr4), ein mitglied der tnf-rezeptor superfamilie, welcher an trail (apo-2l) bindet |
| US6433147B1 (en) | 1997-01-28 | 2002-08-13 | Human Genome Sciences, Inc. | Death domain containing receptor-4 |
| US6072047A (en) | 1997-02-13 | 2000-06-06 | Immunex Corporation | Receptor that binds trail |
| US20020160446A1 (en) | 2000-11-14 | 2002-10-31 | Holtzman Douglas A. | Novel genes encoding proteins having prognostic diagnostic preventive therapeutic and other uses |
| US6313269B1 (en) | 1997-03-14 | 2001-11-06 | Smithkline Beecham Corporation | Tumor necrosis factor related receptor, TR6 |
| US20010010924A1 (en) * | 1997-03-14 | 2001-08-02 | Keith Charles Deen | Tumor necrosis factor related receptor, tr6 polynecleotides |
| US6872568B1 (en) | 1997-03-17 | 2005-03-29 | Human Genome Sciences, Inc. | Death domain containing receptor 5 antibodies |
| DE69836956T2 (de) | 1997-03-17 | 2007-10-31 | Human Genome Sciences, Inc. | Rezeptor 5, der eine für den zelltod verantwortliche domäne enthält |
| EP1007562A4 (de) | 1997-04-16 | 2000-09-27 | Millennium Pharm Inc | Tomornekrosefaktorrezeptor verwandte proteine tango-63d und tango-63e |
| US6342369B1 (en) | 1997-05-15 | 2002-01-29 | Genentech, Inc. | Apo-2-receptor |
| EP1860187B1 (de) * | 1997-05-15 | 2011-07-13 | Genentech, Inc. | Apo-2-Rezeptor |
| JP2002508663A (ja) | 1997-06-18 | 2002-03-19 | ジェネンテク,インコーポレイテッド | Apo−2DcR |
| AU756759B2 (en) | 1997-06-26 | 2003-01-23 | Immunex Corporation | Protein that binds trail |
| PT1181319E (pt) | 1999-05-28 | 2009-07-14 | Genentech Inc | Anticorpos quiméricos contra dr4 e suas utilizações |
| ZA200002867B (en) | 1999-06-09 | 2001-12-07 | Pfizer Prod Inc | Process for preparing sertraline from chiral tetralone. |
| TWI318983B (en) | 2000-05-02 | 2010-01-01 | Uab Research Foundation | An antibody selective for a tumor necrosis factor-related apoptosis-inducing ligand receptor and uses thereof |
-
1998
- 1998-03-17 DE DE69836956T patent/DE69836956T2/de not_active Revoked
- 1998-03-17 NZ NZ337795A patent/NZ337795A/en not_active IP Right Cessation
- 1998-03-17 JP JP54079098A patent/JP4330180B2/ja not_active Expired - Fee Related
- 1998-03-17 CA CA002644454A patent/CA2644454A1/en not_active Abandoned
- 1998-03-17 NZ NZ508381A patent/NZ508381A/xx not_active IP Right Cessation
- 1998-03-17 WO PCT/US1998/005377 patent/WO1998041629A2/en not_active Ceased
- 1998-03-17 US US09/042,583 patent/US7803615B1/en not_active Expired - Fee Related
- 1998-03-17 PT PT98912966T patent/PT970213E/pt unknown
- 1998-03-17 CN CNA2004100949179A patent/CN1624128A/zh active Pending
- 1998-03-17 DK DK98912966T patent/DK0970213T3/da active
- 1998-03-17 KR KR10-1999-7008466A patent/KR100527638B1/ko not_active Expired - Fee Related
- 1998-03-17 AT AT98912966T patent/ATE352618T1/de active
- 1998-03-17 CA CA002285040A patent/CA2285040C/en not_active Expired - Lifetime
- 1998-03-17 AU AU67635/98A patent/AU747635B2/en not_active Withdrawn - After Issue
- 1998-03-17 ES ES98912966T patent/ES2281126T3/es not_active Expired - Lifetime
- 1998-03-17 CN CNB988045370A patent/CN1184315C/zh not_active Expired - Lifetime
- 1998-03-17 EP EP98912966A patent/EP0970213B1/de not_active Revoked
-
2001
- 2001-12-07 US US10/005,842 patent/US20020098550A1/en not_active Abandoned
-
2007
- 2007-10-03 JP JP2007260427A patent/JP2008081503A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| CA2285040C (en) | 2009-01-27 |
| KR20000076364A (ko) | 2000-12-26 |
| JP4330180B2 (ja) | 2009-09-16 |
| JP2001520513A (ja) | 2001-10-30 |
| PT970213E (pt) | 2007-04-30 |
| US20020098550A1 (en) | 2002-07-25 |
| CA2285040A1 (en) | 1998-09-24 |
| CN1624128A (zh) | 2005-06-08 |
| JP2008081503A (ja) | 2008-04-10 |
| DE69836956D1 (de) | 2007-03-15 |
| DE69836956T2 (de) | 2007-10-31 |
| EP0970213B1 (de) | 2007-01-24 |
| KR100527638B1 (ko) | 2005-11-23 |
| US7803615B1 (en) | 2010-09-28 |
| CN1275162A (zh) | 2000-11-29 |
| NZ508381A (en) | 2002-09-27 |
| NZ337795A (en) | 2001-06-29 |
| EP0970213A2 (de) | 2000-01-12 |
| ES2281126T3 (es) | 2007-09-16 |
| CA2644454A1 (en) | 1998-09-24 |
| AU747635B2 (en) | 2002-05-16 |
| CN1184315C (zh) | 2005-01-12 |
| WO1998041629A2 (en) | 1998-09-24 |
| HK1025352A1 (en) | 2000-11-10 |
| DK0970213T3 (da) | 2007-05-21 |
| AU6763598A (en) | 1998-10-12 |
| WO1998041629A3 (en) | 1998-10-29 |
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