ATE353899T1 - Neue 1,4-diazabicycloalkanderivate, deren herstellung und verwendung - Google Patents

Neue 1,4-diazabicycloalkanderivate, deren herstellung und verwendung

Info

Publication number
ATE353899T1
ATE353899T1 AT03798094T AT03798094T ATE353899T1 AT E353899 T1 ATE353899 T1 AT E353899T1 AT 03798094 T AT03798094 T AT 03798094T AT 03798094 T AT03798094 T AT 03798094T AT E353899 T1 ATE353899 T1 AT E353899T1
Authority
AT
Austria
Prior art keywords
diseases
disorders
compounds
nervous system
disorders related
Prior art date
Application number
AT03798094T
Other languages
English (en)
Inventor
Dan Peters
Gunnar M Olsen
Elsebet Nielsen
Tino Joergensen
Philip K Ahring
Original Assignee
Neurosearch As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurosearch As filed Critical Neurosearch As
Application granted granted Critical
Publication of ATE353899T1 publication Critical patent/ATE353899T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT03798094T 2002-09-30 2003-09-29 Neue 1,4-diazabicycloalkanderivate, deren herstellung und verwendung ATE353899T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA200201456 2002-09-30
DKPA200201738 2002-11-11
US42636802P 2002-11-15 2002-11-15

Publications (1)

Publication Number Publication Date
ATE353899T1 true ATE353899T1 (de) 2007-03-15

Family

ID=32045613

Family Applications (2)

Application Number Title Priority Date Filing Date
AT07101576T ATE426602T1 (de) 2002-09-30 2003-09-29 1,4-diazabicycloalkanderivate, deren herstellung und verwendung
AT03798094T ATE353899T1 (de) 2002-09-30 2003-09-29 Neue 1,4-diazabicycloalkanderivate, deren herstellung und verwendung

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT07101576T ATE426602T1 (de) 2002-09-30 2003-09-29 1,4-diazabicycloalkanderivate, deren herstellung und verwendung

Country Status (11)

Country Link
US (1) US7220741B2 (de)
EP (2) EP1785425B1 (de)
AT (2) ATE426602T1 (de)
AU (1) AU2003266222B2 (de)
CA (1) CA2496585C (de)
DE (2) DE60326894D1 (de)
DK (1) DK1551835T3 (de)
ES (1) ES2280836T3 (de)
NZ (1) NZ538512A (de)
PL (1) PL375025A1 (de)
WO (1) WO2004029053A1 (de)

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DE602004023586D1 (de) 2003-02-27 2009-11-26 Neurosearch As Neue diazabicyclische arylderivate
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WO2006071184A1 (en) * 2004-12-28 2006-07-06 Astrazeneca Ab Aryl sulphonamide modulators
US7662812B2 (en) 2005-02-16 2010-02-16 Neurosearch A/S Diazabicyclic aryl derivatives and their use as chinolinergic ligands at nicotinic acetylcholine receptors
EP1866314B1 (de) 2005-02-16 2010-09-15 NeuroSearch A/S Neue diazabicyclische arylderivate und medizinische verwendung dafür
TW200811155A (en) * 2006-05-30 2008-03-01 Glaxo Group Ltd Compounds
WO2007138038A1 (en) 2006-05-30 2007-12-06 Neurosearch A/S Novel 1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl derivatives and their medical use
AU2007267177A1 (en) 2006-05-30 2007-12-06 Neurosearch A/S Novel 1,4-diaza-bicyclo[3.2.2]nonyl pyrimidinyl derivative and its medical use
CA2659762A1 (en) 2006-06-27 2008-01-03 Abbott Laboratories Thiazoline and oxazoline derivatives and their methods of use
EP2041085A1 (de) 2006-06-27 2009-04-01 Abbott Laboratories Pyrrolderivate und ihre anwendungsverfahren
US8492378B2 (en) 2006-08-03 2013-07-23 Takeda Pharmaceutical Company Limited GSK-3β inhibitor
EP2121688A1 (de) * 2007-02-15 2009-11-25 Argenta Discovery Ltd Heterocyclische derivate als m3-muskarine rezeptoren
EP2190846A1 (de) * 2007-08-17 2010-06-02 Neurosearch A/S Als nikotin-actelcholin-rezeptorliganden geeignete 1,4-diaza-bicycl0(3.2.2)n0nyl-pyrimidinylderivate
US7935695B2 (en) 2007-08-17 2011-05-03 Neurosearch A/S 1,4-diaza-bicyclo[3.2.2]nonyl heteroaryl derivatives useful as nicotinic acetylcholine receptor ligands
JP2010536725A (ja) * 2007-08-17 2010-12-02 ノイロサーチ アクティーゼルスカブ ニコチン性アセチルコリン受容体リガンドとして有用な新規１，４−ジアザ−ビシクロ〔３．２．２〕ノニルオキサジアゾリル誘導体
DE102007053771A1 (de) * 2007-11-12 2009-05-14 Merck Patent Gmbh Organische Elektrolumineszenzvorrichtungen
US20100305108A1 (en) * 2007-11-14 2010-12-02 Neurosearch A/S Novel 1,4-diaza-bicyclo[3.2.2]nonyl pyrimidine derivatives and their medical use
EP2209783B8 (de) 2007-11-14 2016-06-01 Saniona A/S Neuartige 1,4-diaza-bicyclo-[3,2,2]-nonyl-pyrimidin-derivate und ihre medizinische verwendung
GB0723719D0 (en) * 2007-12-04 2008-01-16 Glaxo Group Ltd Compounds
GB0723815D0 (en) * 2007-12-05 2008-01-16 Glaxo Group Ltd Compounds
GB0723814D0 (en) * 2007-12-05 2008-01-16 Glaxo Group Ltd Compounds
US8383657B2 (en) 2007-12-21 2013-02-26 Abbott Laboratories Thiazolylidine urea and amide derivatives and methods of use thereof
JP2011511800A (ja) 2008-02-07 2011-04-14 アボット・ラボラトリーズ 正のアロステリックな修飾物質としてのアミド誘導体およびこれらの使用方法
CA2718194A1 (en) 2008-03-11 2009-09-17 Neurosearch A/S Novel 1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl derivatives useful as modulator of nicotinic acetylcholine receptors
US7786171B2 (en) 2008-04-04 2010-08-31 Abbott Laboratories Amide derivatives as positive allosteric modulators and methods of use thereof
WO2009150138A1 (en) * 2008-06-10 2009-12-17 Neurosearch A/S Novel oxadiazolyl-diazabicyclononane derivatives and their medical use
WO2010018352A1 (en) * 2008-08-12 2010-02-18 Argenta Discovery Limited Heterocyclic compounds used in the treatment of diseases where enhanced m3 receptor activation is implicated
US20110263577A1 (en) * 2008-10-13 2011-10-27 Neurosearch A/S Novel oxadiazolyl-diazabicyclononane derivatives and their medical use
US20110257161A1 (en) * 2008-12-04 2011-10-20 Neurosearch A/S Novel diaza-bicyclononyl-phenyl derivatives and their medical use
US20120004214A1 (en) 2009-01-21 2012-01-05 Neurosearch A/S N-oxides of 1,4-diaza-bicyclo[3.2.2]nonyl pyrimidinyl derivatives useful as nicotinic acetylcholine receptor ligands
US20120028967A1 (en) 2009-01-21 2012-02-02 Neurosearch A/S Novel diaza-bicyclononyl-pyrimidinyl derivatives and their medical use
US8778928B2 (en) 2009-01-26 2014-07-15 Danpet Ab Indolyl-oxadiazolyl-diazabicyclononane derivatives and their medical and diagnostical use
US20120004215A1 (en) * 2009-01-26 2012-01-05 Neurosearch A/S N-oxides of diazabicyclononyl pyrimidine derivatives and their medical use
US20120238553A1 (en) 2009-01-27 2012-09-20 Neurosearch A/S Novel benzodioxolyl-oxadiazolyl-diazabicyclononane derivatives and their medical use
WO2010086280A1 (en) 2009-01-27 2010-08-05 Neurosearch A/S Novel n-oxides of furanyl-oxadiazolyl-diazabicyclononane derivatives and their medical use
WO2010086279A1 (en) 2009-01-27 2010-08-05 Neurosearch A/S Novel dibenzofuranyl-oxadiazolyl-diazabicyclononane derivatives and their medical use
US20120071469A1 (en) * 2009-05-14 2012-03-22 Neurosearch A/S Novel 1,4-diaza-bicyclo[3.2.1]octane derivatives useful as nicotinic acetylcholine receptor modulators
WO2011058002A1 (en) 2009-11-11 2011-05-19 Neurosearch A/S Labelled pyrrolyl-oxadiazolyl-diazabicyclononane derivatives and their use in diagnostic methods
WO2011073296A1 (en) 2009-12-18 2011-06-23 Neurosearch A/S Diazabicyclononyl oxadiazole compounds and their use as nicotinic acetylcholine receptor modulators
US8986654B2 (en) 2011-04-15 2015-03-24 Danpet Ab Labelled and un-labelled methyl-pyrrolyl-oxadiazolyl-diazabicyclononane derivatives and their medical use
WO2014060381A1 (de) 2012-10-18 2014-04-24 Bayer Cropscience Ag Heterocyclische verbindungen als schädlingsbekämpfungsmittel
CN105037343B (zh) * 2015-05-27 2018-02-02 山东师范大学 有机配体和Cu(I)双金属硫杂冠醚大环的合成方法
IL294124B2 (en) 2015-12-10 2024-02-01 Ptc Therapeutics Inc Methods for treating huntington's disease
US11407753B2 (en) 2017-06-05 2022-08-09 Ptc Therapeutics, Inc. Compounds for treating Huntington's disease
WO2019005993A1 (en) 2017-06-28 2019-01-03 Ptc Therapeutics, Inc. METHODS OF TREATING HUNTINGTON'S DISEASE
US11382918B2 (en) 2017-06-28 2022-07-12 Ptc Therapeutics, Inc. Methods for treating Huntington's Disease
WO2019028440A1 (en) 2017-08-04 2019-02-07 Skyhawk Therapeutics, Inc. METHODS AND COMPOSITIONS FOR MODULATING SPLICING
MX2020009957A (es) 2018-03-27 2021-01-15 Ptc Therapeutics Inc Compuestos para el tratamiento de enfermedad de hungtinton.
EP3814360B8 (de) 2018-06-27 2024-11-06 PTC Therapeutics, Inc. Heteroaryl verbindungen zur behandlung von morbus huntington
EP3814345B8 (de) 2018-06-27 2024-10-30 PTC Therapeutics, Inc. Heteroaryl verbindungen zur behandlung von morbus huntington
PL3814357T3 (pl) 2018-06-27 2024-09-16 Ptc Therapeutics, Inc. Związki heterocykliczne i heteroarylowe do leczenia choroby huntingtona
WO2020163248A1 (en) 2019-02-04 2020-08-13 Skyhawk Therapeutics, Inc. Methods and compositions for modulating splicing
EP3920915A4 (de) 2019-02-05 2022-10-05 Skyhawk Therapeutics, Inc. Verfahren und zusammensetzungen zur modulierung der spleissung
CN114126613A (zh) 2019-02-05 2022-03-01 斯基霍克疗法公司 用于调节剪接的方法和组合物
CN113661162A (zh) 2019-02-06 2021-11-16 斯基霍克疗法公司 用于调节剪接的方法和组合物
WO2020163544A1 (en) 2019-02-06 2020-08-13 Skyhawk Therapeutics, Inc. Methods and compositions for modulating splicing
WO2020231977A1 (en) 2019-05-13 2020-11-19 Ptc Therapeutics, Inc. Compounds for treating huntington's disease

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NZ226000A (en) 1987-09-10 1991-06-25 Merck Sharp & Dohme Oxadiazolyl-azabicycloheptanes and pharmaceutical compositions
US5478939A (en) * 1994-07-20 1995-12-26 American Cyanamid Company (R,R) and (S,S) 2,5-diazabicyclo [2,2,1]heptane derivatives
FR2786770B1 (fr) 1998-12-04 2001-01-19 Synthelabo Derives de 1,4-diazabicyclo[3.2.2.]nonane, leur preparation et leur application en therapeutique
FR2804430B1 (fr) * 2000-01-28 2002-03-22 Sanofi Synthelabo Derives de 4-heteroaryl-1,4-diazabicyclo[3.2.2] nonane, leur preparation et leur application en therapeutique
FR2809731B1 (fr) * 2000-05-31 2002-07-19 Sanofi Synthelabo Derives de 1,4-diazabicyclo-[3.2.2] nonane-pheylisoxazole, leur preparation et leur application en therapeutique
FR2809732B1 (fr) 2000-05-31 2002-07-19 Sanofi Synthelabo DERIVES DE 4(-2-PHENYLTHIAZOL-5-yl)-1,4-DIAZABICYCLO-[3.2.2] NONANE, LEUR PREPARATION ET LEUR APPLICATION ENTHERAPEUTIQUE
US20020086871A1 (en) * 2000-12-29 2002-07-04 O'neill Brian Thomas Pharmaceutical composition for the treatment of CNS and other disorders
FR2832714B1 (fr) 2001-11-23 2004-07-16 Sanofi Synthelabo Derives de 4-(oxazolopyridin-2-yl)-1,4-diazabicyclo[3.2.2] nonane, leur preparation et leur application en therapeutique
FR2832712B1 (fr) 2001-11-23 2004-02-13 Sanofi Synthelabo Derives de 4-(oxadiazol-3-yl)-1,4-diazabicyclo[3.2.2]nonane, leur preparation et leur application en therapeutique
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Also Published As

Publication number Publication date
CA2496585C (en) 2012-05-29
DE60311853T2 (de) 2007-06-21
AU2003266222A1 (en) 2004-04-19
US7220741B2 (en) 2007-05-22
WO2004029053A1 (en) 2004-04-08
DK1551835T3 (da) 2007-06-04
NZ538512A (en) 2006-12-22
DE60326894D1 (de) 2009-05-07
EP1551835A1 (de) 2005-07-13
ATE426602T1 (de) 2009-04-15
PL375025A1 (en) 2005-11-14
EP1785425A2 (de) 2007-05-16
EP1551835B1 (de) 2007-02-14
EP1785425A3 (de) 2007-06-06
AU2003266222B2 (en) 2009-10-01
US20060122172A1 (en) 2006-06-08
EP1785425B1 (de) 2009-03-25
DE60311853D1 (de) 2007-03-29
CA2496585A1 (en) 2004-04-08
ES2280836T3 (es) 2007-09-16

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