ATE426602T1 - 1,4-diazabicycloalkanderivate, deren herstellung und verwendung - Google Patents

1,4-diazabicycloalkanderivate, deren herstellung und verwendung

Info

Publication number
ATE426602T1
ATE426602T1 AT07101576T AT07101576T ATE426602T1 AT E426602 T1 ATE426602 T1 AT E426602T1 AT 07101576 T AT07101576 T AT 07101576T AT 07101576 T AT07101576 T AT 07101576T AT E426602 T1 ATE426602 T1 AT E426602T1
Authority
AT
Austria
Prior art keywords
diseases
disorders
compounds
nervous system
disorders related
Prior art date
Application number
AT07101576T
Other languages
English (en)
Inventor
Dan Peters
Gunnar Olsen
Elsebet Nielsen
Tino Joergensen
Philip Ahring
Original Assignee
Neurosearch As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurosearch As filed Critical Neurosearch As
Application granted granted Critical
Publication of ATE426602T1 publication Critical patent/ATE426602T1/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT07101576T 2002-09-30 2003-09-29 1,4-diazabicycloalkanderivate, deren herstellung und verwendung ATE426602T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA200201456 2002-09-30
DKPA200201738 2002-11-11
US42636802P 2002-11-15 2002-11-15

Publications (1)

Publication Number Publication Date
ATE426602T1 true ATE426602T1 (de) 2009-04-15

Family

ID=32045613

Family Applications (2)

Application Number Title Priority Date Filing Date
AT03798094T ATE353899T1 (de) 2002-09-30 2003-09-29 Neue 1,4-diazabicycloalkanderivate, deren herstellung und verwendung
AT07101576T ATE426602T1 (de) 2002-09-30 2003-09-29 1,4-diazabicycloalkanderivate, deren herstellung und verwendung

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT03798094T ATE353899T1 (de) 2002-09-30 2003-09-29 Neue 1,4-diazabicycloalkanderivate, deren herstellung und verwendung

Country Status (11)

Country Link
US (1) US7220741B2 (de)
EP (2) EP1785425B1 (de)
AT (2) ATE353899T1 (de)
AU (1) AU2003266222B2 (de)
CA (1) CA2496585C (de)
DE (2) DE60326894D1 (de)
DK (1) DK1551835T3 (de)
ES (1) ES2280836T3 (de)
NZ (1) NZ538512A (de)
PL (1) PL375025A1 (de)
WO (1) WO2004029053A1 (de)

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WO2006087305A1 (en) 2005-02-16 2006-08-24 Neurosearch A/S Novel diazabicyclic aryl derivatives and their medical use
ATE495178T1 (de) 2005-02-16 2011-01-15 Neurosearch As Diazabicyclische arylderivate und ihre verwendung als chinolinergische liganden an nikotin- acetylcholin-rezeptoren
WO2007138039A1 (en) 2006-05-30 2007-12-06 Neurosearch A/S Novel 1,4-diaza-bicyclo[3.2.2]nonyl pyrimidinyl derivatives and their medical use
TW200811155A (en) * 2006-05-30 2008-03-01 Glaxo Group Ltd Compounds
WO2007138038A1 (en) * 2006-05-30 2007-12-06 Neurosearch A/S Novel 1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl derivatives and their medical use
US7683084B2 (en) 2006-06-27 2010-03-23 Abbott Laboratories Thiazoline and oxazoline derivatives and their methods of use
MX2008016338A (es) 2006-06-27 2009-01-16 Abbott Lab Derivados de pirrol y sus metodos de uso.
US8492378B2 (en) 2006-08-03 2013-07-23 Takeda Pharmaceutical Company Limited GSK-3β inhibitor
JP2010519193A (ja) * 2007-02-15 2010-06-03 アージェンタ ディスカバリー リミテッド Ｍ３ムスカリン受容体としての複素環式誘導体
WO2009024516A1 (en) * 2007-08-17 2009-02-26 Neurosearch A/S Novel 1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl derivatives useful as nicotinic acetylcholine receptor ligands
CN101796054A (zh) * 2007-08-17 2010-08-04 神经研究公司 用作烟碱型乙酰胆碱受体配体的新颖的1,4-二氮杂-二环[3.2.2]壬基嘧啶基衍生物
WO2009024517A1 (en) 2007-08-17 2009-02-26 Neurosearch A/S Novel 1,4-diaza-bicyclo[3.2.2]nonyl heteroaryl derivatives useful as nicotinic acetylcholine receptor ligands
DE102007053771A1 (de) * 2007-11-12 2009-05-14 Merck Patent Gmbh Organische Elektrolumineszenzvorrichtungen
US20100305108A1 (en) * 2007-11-14 2010-12-02 Neurosearch A/S Novel 1,4-diaza-bicyclo[3.2.2]nonyl pyrimidine derivatives and their medical use
RU2010114662A (ru) * 2007-11-14 2011-12-20 Ньюросёрч А/С (Dk) Новые производные 1,4-диазабицикло(3.2.2)нонилпиримидина и их медицинское применение
GB0723719D0 (en) * 2007-12-04 2008-01-16 Glaxo Group Ltd Compounds
GB0723815D0 (en) * 2007-12-05 2008-01-16 Glaxo Group Ltd Compounds
GB0723814D0 (en) * 2007-12-05 2008-01-16 Glaxo Group Ltd Compounds
US8383657B2 (en) 2007-12-21 2013-02-26 Abbott Laboratories Thiazolylidine urea and amide derivatives and methods of use thereof
MX2010008714A (es) 2008-02-07 2010-09-24 Abbott Lab Derivados de amida como moduladores alostericos positivos y metodos de uso de los mismos.
JP2011513459A (ja) 2008-03-11 2011-04-28 ノイロサーチ アクティーゼルスカブ ニコチン性アセチルコリン受容体のモジュレーターとして有用な、新規な１，４−ジアザ−ビシクロ［３．２．２］ノニルオキサジアゾリル誘導体
US7786171B2 (en) 2008-04-04 2010-08-31 Abbott Laboratories Amide derivatives as positive allosteric modulators and methods of use thereof
WO2009150138A1 (en) * 2008-06-10 2009-12-17 Neurosearch A/S Novel oxadiazolyl-diazabicyclononane derivatives and their medical use
WO2010018352A1 (en) * 2008-08-12 2010-02-18 Argenta Discovery Limited Heterocyclic compounds used in the treatment of diseases where enhanced m3 receptor activation is implicated
WO2010043539A1 (en) * 2008-10-13 2010-04-22 Neurosearch A/S Novel oxadiazolyl-diazabicyclononane derivatives and their medical use
US20110257161A1 (en) * 2008-12-04 2011-10-20 Neurosearch A/S Novel diaza-bicyclononyl-phenyl derivatives and their medical use
US20120028967A1 (en) 2009-01-21 2012-02-02 Neurosearch A/S Novel diaza-bicyclononyl-pyrimidinyl derivatives and their medical use
WO2010084120A1 (en) 2009-01-21 2010-07-29 Neurosearch A/S N-oxides of 1,4-diaza-bicyclo[3.2.2]nonyl pyrimidinyl derivatives useful as nicotinic acetylcholine receptor ligands
EP2389380A1 (de) * 2009-01-26 2011-11-30 NeuroSearch A/S N-oxide von diazabicyclononylpyrimidinderivaten und deren medizinische verwendung
CN102300574A (zh) 2009-01-26 2011-12-28 神经研究公司 新的吲哚基-*二唑基-二氮杂二环壬烷衍生物及它们的医药和诊断用途
WO2010086278A1 (en) 2009-01-27 2010-08-05 Neurosearch A/S Novel benzodioxolyl-oxadiazolyl-diazabicyclononane derivatives and their medical use
US20110319397A1 (en) 2009-01-27 2011-12-29 Neurosearch A/S Novel n-oxides of furanyl-oxadiazolyl-diazabicyclononane derivatives and their medical use
US20120028968A1 (en) 2009-01-27 2012-02-02 Neurosearch A/S Novel dibenzofuranyl-oxadiazolyl-diazabicyclononane derivatives and their medical use
WO2010130768A1 (en) * 2009-05-14 2010-11-18 Neurosearch A/S Novel 1,4-diaza-bicyclo[3.2.1]octane derivatives useful as nicotinic acetylcholine receptor modulators
EP2498826A1 (de) 2009-11-11 2012-09-19 NeuroSearch AS Markierte pyrrolyl-oxadiazolyl-diazabicyclononanderivative und ihre verwendung für diagnoseverfahren
EP2513097A1 (de) * 2009-12-18 2012-10-24 NeuroSearch AS Diazabicyclononyl-oxadiazol-verbindungen und ihre verwendung als nikotinische acetylcholinrezeptormodulatoren
US8986654B2 (en) 2011-04-15 2015-03-24 Danpet Ab Labelled and un-labelled methyl-pyrrolyl-oxadiazolyl-diazabicyclononane derivatives and their medical use
WO2014060381A1 (de) 2012-10-18 2014-04-24 Bayer Cropscience Ag Heterocyclische verbindungen als schädlingsbekämpfungsmittel
CN105037343B (zh) * 2015-05-27 2018-02-02 山东师范大学 有机配体和Cu(I)双金属硫杂冠醚大环的合成方法
CN110946865B (zh) 2015-12-10 2024-01-26 Ptc医疗公司 用于治疗亨廷顿病的方法
EP3634953B1 (de) 2017-06-05 2024-01-03 PTC Therapeutics, Inc. Verbindungen zur behandlung von morbus huntington
CN111163838B (zh) 2017-06-28 2023-03-28 Ptc医疗公司 用于治疗亨廷顿氏病的方法
MX2019015578A (es) 2017-06-28 2020-07-28 Ptc Therapeutics Inc Metodos para tratar la enfermedad de huntington.
RU2020105929A (ru) 2017-08-04 2021-09-06 Скайхоук Терапьютикс, Инк. Способы и композиции для модулирования сплайсинга
JP7399870B2 (ja) 2018-03-27 2023-12-18 ピーティーシー セラピューティクス， インコーポレイテッド ハンチントン病を処置するための化合物
KR20210038845A (ko) 2018-06-27 2021-04-08 피티씨 테라퓨틱스, 인크. 헌팅턴병 치료를 위한 헤테로아릴 화합물
PL3814357T3 (pl) 2018-06-27 2024-09-16 Ptc Therapeutics, Inc. Związki heterocykliczne i heteroarylowe do leczenia choroby huntingtona
EP3814360B8 (de) 2018-06-27 2024-11-06 PTC Therapeutics, Inc. Heteroaryl verbindungen zur behandlung von morbus huntington
EP3920926A4 (de) 2019-02-05 2022-10-19 Skyhawk Therapeutics, Inc. Verfahren und zusammensetzungen zur modulierung der spleissung
JP7603592B2 (ja) 2019-02-05 2024-12-20 スカイホーク・セラピューティクス・インコーポレーテッド スプライシングを調節するための方法および組成物
CN119638696A (zh) 2019-02-06 2025-03-18 斯基霍克疗法公司 用于调节剪接的方法和组合物
WO2020163544A1 (en) 2019-02-06 2020-08-13 Skyhawk Therapeutics, Inc. Methods and compositions for modulating splicing
CN114245794B (zh) 2019-05-13 2024-09-13 Ptc医疗公司 用于治疗亨廷顿氏病的化合物

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FR2786770B1 (fr) 1998-12-04 2001-01-19 Synthelabo Derives de 1,4-diazabicyclo[3.2.2.]nonane, leur preparation et leur application en therapeutique
FR2804430B1 (fr) * 2000-01-28 2002-03-22 Sanofi Synthelabo Derives de 4-heteroaryl-1,4-diazabicyclo[3.2.2] nonane, leur preparation et leur application en therapeutique
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Also Published As

Publication number Publication date
DE60326894D1 (de) 2009-05-07
EP1551835A1 (de) 2005-07-13
ES2280836T3 (es) 2007-09-16
US20060122172A1 (en) 2006-06-08
US7220741B2 (en) 2007-05-22
ATE353899T1 (de) 2007-03-15
CA2496585C (en) 2012-05-29
WO2004029053A1 (en) 2004-04-08
AU2003266222A1 (en) 2004-04-19
DK1551835T3 (da) 2007-06-04
EP1785425A3 (de) 2007-06-06
DE60311853T2 (de) 2007-06-21
NZ538512A (en) 2006-12-22
CA2496585A1 (en) 2004-04-08
AU2003266222B2 (en) 2009-10-01
EP1785425A2 (de) 2007-05-16
DE60311853D1 (de) 2007-03-29
EP1551835B1 (de) 2007-02-14
EP1785425B1 (de) 2009-03-25
PL375025A1 (en) 2005-11-14

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