ATE355282T1 - Biologisch aktive derivate des methylenblaus - Google Patents

Biologisch aktive derivate des methylenblaus

Info

Publication number
ATE355282T1
ATE355282T1 AT02726300T AT02726300T ATE355282T1 AT E355282 T1 ATE355282 T1 AT E355282T1 AT 02726300 T AT02726300 T AT 02726300T AT 02726300 T AT02726300 T AT 02726300T AT E355282 T1 ATE355282 T1 AT E355282T1
Authority
AT
Austria
Prior art keywords
biologically active
methylene blue
active derivatives
derivatives
photodisinfection
Prior art date
Application number
AT02726300T
Other languages
English (en)
Inventor
Stanley Beames Brown
Cassandra Claire O'grady
John Griffiths
Kirste Joanne Mellish
Richard George Tunstall
David John Howard Roberts
David Ian Vernon
Original Assignee
Photopharmica Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Photopharmica Ltd filed Critical Photopharmica Ltd
Application granted granted Critical
Publication of ATE355282T1 publication Critical patent/ATE355282T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
    • C07D279/18—[b, e]-condensed with two six-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/003—Thiazine dyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4986—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with sulfur as the only hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02—Local antiseptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Disinfection or sterilisation of materials or objects, in general; Accessories therefor
    • A61L2/02—Disinfection or sterilisation of materials or objects, in general; Accessories therefor using physical processes
    • A61L2/08—Radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Disinfection or sterilisation of materials or objects, in general; Accessories therefor
    • A61L2/16—Disinfection or sterilisation of materials or objects, in general; Accessories therefor using chemical substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Disinfection or sterilisation of materials or objects, in general; Accessories therefor
    • A61L2/16—Disinfection or sterilisation of materials or objects, in general; Accessories therefor using chemical substances
    • A61L2/23—Solid materials, e.g. granules, powders, blocks or tablets
    • A61L2/232—Solid materials, e.g. granules, powders, blocks or tablets layered or coated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2103/00—Materials or objects being the target of disinfection or sterilisation
    • A61L2103/05—Living organisms or biological materials

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Birds (AREA)
  • Biomedical Technology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Cardiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Ophthalmology & Optometry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT02726300T 2001-05-30 2002-05-30 Biologisch aktive derivate des methylenblaus ATE355282T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0113121.8A GB0113121D0 (en) 2001-05-30 2001-05-30 Biologically active photosensitisers
GBGB0123945.8A GB0123945D0 (en) 2001-05-30 2001-10-05 Biologically active photosensitisers

Publications (1)

Publication Number Publication Date
ATE355282T1 true ATE355282T1 (de) 2006-03-15

Family

ID=26246135

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02726300T ATE355282T1 (de) 2001-05-30 2002-05-30 Biologisch aktive derivate des methylenblaus

Country Status (20)

Country Link
US (6) US7371744B2 (de)
EP (3) EP1790642A1 (de)
JP (2) JP4554198B2 (de)
KR (3) KR20040015723A (de)
CN (2) CN100491362C (de)
AT (1) ATE355282T1 (de)
AU (1) AU2002256784B2 (de)
BR (1) BR0209783A (de)
CA (1) CA2448303C (de)
CY (1) CY1108091T1 (de)
DE (1) DE60218454T2 (de)
DK (1) DK1392666T3 (de)
ES (1) ES2280533T3 (de)
GB (2) GB0113121D0 (de)
MX (1) MXPA03010916A (de)
NO (1) NO324321B1 (de)
NZ (1) NZ529682A (de)
PT (1) PT1392666E (de)
WO (1) WO2002096896A1 (de)
ZA (1) ZA200309215B (de)

Families Citing this family (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6283956B1 (en) 1998-11-30 2001-09-04 David H. McDaniels Reduction, elimination, or stimulation of hair growth
US9192780B2 (en) 1998-11-30 2015-11-24 L'oreal Low intensity light therapy for treatment of retinal, macular, and visual pathway disorders
US6887260B1 (en) 1998-11-30 2005-05-03 Light Bioscience, Llc Method and apparatus for acne treatment
US20060212025A1 (en) * 1998-11-30 2006-09-21 Light Bioscience, Llc Method and apparatus for acne treatment
GB0113121D0 (en) 2001-05-30 2001-07-18 Univ Leeds Biologically active photosensitisers
US7368221B2 (en) * 2002-06-17 2008-05-06 Verification Technologies, Inc. Changing light absorption by disruption of conjugation
JP2006522660A (ja) 2003-04-10 2006-10-05 ライト バイオサイエンス，エルエルシー 細胞増殖及び遺伝子発現を調節するためのフォトモジュレーション方法及び装置
ES2572976T3 (es) 2003-07-31 2016-06-03 Gentlewaves Llc Sistema y método para el tratamiento fotodinámico de la piel
US20050053895A1 (en) 2003-09-09 2005-03-10 The Procter & Gamble Company Attention: Chief Patent Counsel Illuminated electric toothbrushes emitting high luminous intensity toothbrush
GB0322756D0 (en) * 2003-09-29 2003-10-29 Univ Aberdeen Methods of chemical synthesis
EP1687286A1 (de) * 2003-11-28 2006-08-09 Photopharmica Limited Entwicklungen bei biologisch wirksamen methylen-blau-derivaten (2)
BRPI0503921A (pt) * 2004-06-18 2006-07-18 Oreal composição cosmética, processos para tintura das fibras queratìnicas, processo para clareamento das fibras queratìnicas, dispositivo com múltiplos compartimentos, uso de composto hidroxialquilado e uso de uma composição de tintura
US7326258B2 (en) 2004-06-18 2008-02-05 L'oreal S.A. Compositions comprising hydroxyalkyl direct dyes, implementation processes and uses thereof
US8240312B2 (en) 2004-09-09 2012-08-14 Osnat Feuerstein Method and means for exerting a phototoxic effect of visible light on microorganisms
US20080166304A1 (en) * 2004-09-17 2008-07-10 The General Hospital Corpoartion Inactivation of Microorganisms With Multidrug Resistance Inhibitors and Phenothiaziniums
GB0420888D0 (en) * 2004-09-20 2004-10-20 Photopharmica Ltd Compounds and uses
GB0420893D0 (en) * 2004-09-20 2004-10-20 Photopharmica Ltd Photosensitisers and their uses
CN101084204B (zh) * 2004-09-23 2012-12-05 卫思道制药有限公司 包括亚甲蓝(mtc)在内的二氨基吩噻嗪鎓化合物的化学合成和纯化方法
SI2322517T1 (sl) 2004-09-23 2019-06-28 Wista Laboratories Ltd. Postopki za kemijsko sintezo in čiščenje diaminofenotiazinijevih spojin, vključno metiltioninijevega klorida (MTC)
WO2006036885A2 (en) * 2004-09-24 2006-04-06 Verification Technologies, Inc. Changing light absorption by disruption of conjugation
US7101997B2 (en) * 2004-10-07 2006-09-05 Honeywell International Inc. Method for producing phenothiazinium compounds
US20060222592A1 (en) * 2005-04-05 2006-10-05 Clemens Burda Nanoparticles and methods of manufacturing nanoparticles for electronic and non-electronic applications
GB0602125D0 (en) * 2006-02-03 2006-03-15 Univ Belfast Sensitizer-incorporated biomaterials
US20070255356A1 (en) 2006-04-28 2007-11-01 Ondine International, Ltd. Photodisinfection delivery devices and methods
MY148145A (en) 2006-07-11 2013-03-15 Wista Lab Ltd Methods of synthesis and/or purification of diaminophenothiazinium compounds
US20080139991A1 (en) * 2006-12-08 2008-06-12 Ondine International, Ltd. Method of wound disinfecting and tissue welding
US8227459B2 (en) * 2007-04-03 2012-07-24 Prosetta Antiviral Inc. Diamino-phenothiazinyl derivatives as antiviral treatments
EP2749552B1 (de) * 2007-04-17 2015-11-18 Codman & Shurtleff, Inc. Curcumin-Resveratrol-Hybride
US8383865B2 (en) * 2007-04-17 2013-02-26 Codman & Shurtleff, Inc. Curcumin derivatives
US20080269205A1 (en) * 2007-04-27 2008-10-30 Ondine International, Ltd. Methods to prevent vertical transmission of infectious diseases
RU2339382C1 (ru) * 2007-07-23 2008-11-27 Государственное учреждение научный центр здоровья детей РАМН (ГУ НЦЗД РАМН) Средство для лечения атопического дерматита
US20090035725A1 (en) * 2007-08-02 2009-02-05 Ondine International, Ltd. Photodisinfection of oral cavity
RU2349311C1 (ru) * 2007-08-02 2009-03-20 Михаил Владимирович Кутушов Применение дериватов нафталина в качестве средств для лечения онкологических заболеваний
US20090093470A1 (en) * 2007-10-08 2009-04-09 Ondine International, Ltd. Photodynamic therapy process and photosensitizer compositions therefor
ES2689302T3 (es) * 2008-02-13 2018-11-13 Andreas Rose Dispositivo de suministro de luz que proporciona un patrón radial de emisión de luz
US7985776B2 (en) 2008-06-27 2011-07-26 Codman & Shurtleff, Inc. Iontophoretic delivery of curcumin and curcumin analogs for the treatment of Alzheimer's Disease
GB2475005A (en) * 2008-08-01 2011-05-04 Ondine Int Ltd Composition and method for treatment of mrsa
WO2010036617A1 (en) * 2008-09-23 2010-04-01 Ondine International Holdings Ltd. Portable photodynamic disinfection light delivery device for catheter disinfection
MX2011003277A (es) * 2008-10-14 2012-09-21 Salubrious Pharmaceuticals LLC Proceso para el tratamiento de la artritis reumatoide, temblores/enfermedad de parkinson, esclerosis multiple y cancer de tipo no viral.
US20100286585A1 (en) * 2009-01-26 2010-11-11 Codman & Shurtleff, Inc. Shunt Delivery of Curcumin
US7723515B1 (en) * 2009-01-26 2010-05-25 Codman & Shurtleff, Inc. Methylene blue—curcumin analog for the treatment of alzheimer's disease
US20100256125A1 (en) * 2009-04-06 2010-10-07 Zila Pharmaceuticals, Inc. Use of improved toluidine blue in photodynamic therapy
US20110217202A1 (en) * 2010-03-08 2011-09-08 Lynn Cook Winterton Active oxygen disinfection system and use thereof
JP5868955B2 (ja) * 2010-04-30 2016-02-24 プロセッタ アンチバイラル インコーポレイテッド 抗ウイルス化合物
US8579964B2 (en) 2010-05-05 2013-11-12 Neovasc Inc. Transcatheter mitral valve prosthesis
WO2012125983A1 (en) 2011-03-17 2012-09-20 Prosetta Antiviral Inc. Antiviral treatments
EP2699241B1 (de) 2011-04-20 2016-07-27 Prosetta Antiviral Inc. Antivirale verbindungen
US20120301904A1 (en) 2011-04-26 2012-11-29 Prosetta Antiviral, Inc Multiprotein assemblies
US9308087B2 (en) 2011-04-28 2016-04-12 Neovasc Tiara Inc. Sequentially deployed transcatheter mitral valve prosthesis
US9554897B2 (en) 2011-04-28 2017-01-31 Neovasc Tiara Inc. Methods and apparatus for engaging a valve prosthesis with tissue
AU2012305327B2 (en) * 2011-09-05 2016-07-14 Hiroshi Maeda Polymer-type fluorescent molecule probe
US9345573B2 (en) 2012-05-30 2016-05-24 Neovasc Tiara Inc. Methods and apparatus for loading a prosthesis onto a delivery system
AU2013341383B2 (en) 2012-11-12 2017-08-24 The Roger B. And Ann K. Mcnamee Trust U/T/A/D Systems and methods for communicating a live event to users using the internet
US9572665B2 (en) 2013-04-04 2017-02-21 Neovasc Tiara Inc. Methods and apparatus for delivering a prosthetic valve to a beating heart
EP3212194A4 (de) 2014-10-29 2018-06-20 University Of Maryland Verfahren zur behandlung altersbedingter symptome bei säugetieren und zusammensetzungen dafür
ES2856841T3 (es) * 2014-10-31 2021-09-28 Klox Tech Inc Fibras y medios de tela fotoactivables
US10010400B2 (en) * 2015-03-30 2018-07-03 Taris Biomedical Llc Devices and methods for local delivery of drug to upper urinary tract
WO2017100927A1 (en) 2015-12-15 2017-06-22 Neovasc Tiara Inc. Transseptal delivery system
CN106901871B (zh) * 2015-12-23 2021-08-24 爱博诺德(北京)医疗科技股份有限公司 具有一个或多个附加部分的人工晶状体
JP7006940B2 (ja) 2016-01-29 2022-01-24 ニオバスク ティアラ インコーポレイテッド 流出の閉塞を回避するための人工弁
US10189862B2 (en) 2016-06-14 2019-01-29 The Chinese University Of Hong Kong Phenothiazine-pyridine compounds and uses thereof
WO2018090148A1 (en) 2016-11-21 2018-05-24 Neovasc Tiara Inc. Methods and systems for rapid retraction of a transcatheter heart valve delivery system
US11413240B2 (en) 2016-12-29 2022-08-16 Board Of Regents, The University Of Texas System Methylene blue solution for the treatment of oral lesions
KR101988240B1 (ko) * 2017-02-27 2019-06-12 주식회사 디알나노 피부질환에 사용되는 메틸렌 블루 복합체 및 이의 용도
CA3072418A1 (en) 2017-08-08 2019-02-14 Board Of Trustees Of Michigan State University Tunable luminescent organic salts for enhanced imaging and photodynamic therapy
CN111263622A (zh) 2017-08-25 2020-06-09 内奥瓦斯克迪亚拉公司 顺序展开的经导管二尖瓣假体
AU2019374743B2 (en) 2018-11-08 2022-03-03 Neovasc Tiara Inc. Ventricular deployment of a transcatheter mitral valve prosthesis
JP7430732B2 (ja) 2019-03-08 2024-02-13 ニオバスク ティアラ インコーポレイテッド 回収可能補綴物送達システム
US11510876B2 (en) 2019-03-29 2022-11-29 Mayo Foundation For Medical Education And Research In vivo targeting of extracellular vesicles
EP3946163B1 (de) 2019-04-01 2025-08-20 Neovasc Tiara Inc. Steuerbar einsetzbare klappenprothese
US11491006B2 (en) 2019-04-10 2022-11-08 Neovasc Tiara Inc. Prosthetic valve with natural blood flow
US12195755B2 (en) 2019-05-20 2025-01-14 Brown University Placental lipid bilayer for cell-free molecular interaction studies
EP4729110A2 (de) 2019-05-20 2026-04-22 Neovasc Tiara Inc. Einführvorrichtung mit hämostasemechanismus
WO2020257643A1 (en) 2019-06-20 2020-12-24 Neovasc Tiara Inc. Low profile prosthetic mitral valve
BR102019014681A2 (pt) * 2019-07-16 2021-01-26 Universidade De São Paulo - Usp processo de obtenção de superfícies poliméricas funcionalizadas com fotossensibilizadores, material polimérico funcionalizado e seu uso
WO2021087008A1 (en) 2019-10-28 2021-05-06 Brown University Bacterial beta-lactamase responsive hydrogels
EP4475796A1 (de) 2022-04-01 2024-12-18 Biolux Group SA Photodynamische lichttherapievorrichtung und verfahren zur behandlung von munderkrankungen
US20240245774A1 (en) 2023-01-25 2024-07-25 Ondine International Ag Composition and a photodynamic therapeutic method to shorten infectivity period and to induce sustained humoral and cellular t-cell responses against a targeted antigen in infected individuals

Family Cites Families (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3579339A (en) * 1967-05-23 1971-05-18 Du Pont Photopolymerizable dispersions and elements containing nonmigratory photoreducible dyes
US3641016A (en) * 1968-02-16 1972-02-08 Egyt Gyogyszervegyeszeti Gyar Thionine derivatives
US4001587A (en) * 1975-10-24 1977-01-04 Panchenkov Georgy Mitrofanovic Color indicator-dosimeter of ionizing radiation
JPS6020740B2 (ja) * 1976-07-14 1985-05-23 株式会社リコー カラ−像形成用感光材料
EP0128414A3 (de) 1983-06-06 1986-09-10 The Hilton - Davis Chemical Company Verfahren zur Desinfizierung von Toiletten
US4622395A (en) 1984-10-01 1986-11-11 Minnesota Mining And Manufacturing Company Phenoxazine and phenothiazine dyes and leuco forms thereof
DE3644369A1 (de) 1986-12-24 1988-07-07 Basf Ag Verfahren zur uebertragung von kationischen farbstoffen in ihrer deprotonierten, elektrisch neutralen form
JPS63187154A (ja) 1987-01-29 1988-08-02 Kishida Kagaku Kk 酸素検知剤
DE3710282A1 (de) 1987-03-28 1988-10-13 Hoechst Ag Photopolymerisierbares gemisch und daraus hergestelltes aufzeichnungsmaterial
US4844896A (en) * 1987-11-02 1989-07-04 Lim Technology Laboratories, Inc. Microencapsulated insecticidal pathogens
JP2879080B2 (ja) 1989-03-23 1999-04-05 株式会社リコー 電界発光素子
US5270144A (en) * 1989-07-10 1993-12-14 Tomoegawa Paper Co., Ltd. Toner for developing static charge images
WO1991016911A1 (en) * 1990-05-01 1991-11-14 The American National Red Cross Decontamination of whole blood and cellular components by phenthiazin-5-ium-dyes plus light
US5545516A (en) 1990-05-01 1996-08-13 The American National Red Cross Inactivation of extracellular enveloped viruses in blood and blood components by phenthiazin-5-ium dyes plus light
US5220009A (en) * 1990-05-03 1993-06-15 Yeda Research And Development Company Limited Phenothiazinium salts and their use for disinfecting aqueous effluents
JPH05170752A (ja) * 1991-04-26 1993-07-09 Takeda Chem Ind Ltd ３，７−ビス（ジ置換アミノ）フェノチアジン誘導体およびその製造法
US5344928A (en) 1991-04-26 1994-09-06 Takeda Chemical Industries, Ltd. Phenothiazine derivatives, their production and use
US5358876A (en) 1991-07-17 1994-10-25 Mitsubishi Gas Chemical Company, Inc. Oxygen indicator
US5239405A (en) 1991-09-06 1993-08-24 Donnelly Corporation Electrochemichromic solutions, processes for preparing and using the same, and devices manufactured with the same
ATE159661T1 (de) * 1992-04-30 1997-11-15 Eastman Dental Inst Medikament zur desinfektion der mundhöhle
JP3690825B2 (ja) * 1993-07-26 2005-08-31 エーザイ株式会社 三環式ヘテロ環含有スルホンアミドおよびスルホン酸エステル誘導体
US5635059A (en) 1994-10-20 1997-06-03 Aqua-Ion Systems, Inc. Method and apparatus for water treatment and purification using gas ion plasma source and disinfectant metal ion complexes
GB9506197D0 (en) 1995-03-27 1995-05-17 Hoffmann La Roche Inhibition of tau-tau association.
JPH08305026A (ja) * 1995-05-12 1996-11-22 Fuji Photo Film Co Ltd 画像記録方法
ATE253380T1 (de) 1996-01-16 2003-11-15 Zila Inc Verfahren und mittel zur in-vivo erkennung von mundhöhlenkrebs und von präkanzerösen zuständen
DE19640758C2 (de) 1996-10-02 1999-11-04 Rafael Lachky Mittel zur Behandlung von Diskusfischen
WO1998031219A1 (en) * 1997-01-21 1998-07-23 The American National Red Cross Intracellular and extracellular decontamination of whole blood and blood components by amphiphilic phenothiazin-5-ium dyes plus light
US20040055965A1 (en) 1997-06-13 2004-03-25 Hubig Stephan M. Recreational water treatment employing singlet oxygen
US6251127B1 (en) 1997-08-25 2001-06-26 Advanced Photodynamic Technologies, Inc. Dye treatment solution and photodynamic therapy and method of using same
US5811471A (en) * 1997-09-15 1998-09-22 Shanbrom Technologies Llc Disinfectant plastic sponge material
DE19750303A1 (de) 1997-11-13 1999-05-20 Henkel Kgaa Verwendung von alkylierten Phenothiazinen zum Färben von keratinhaltigen Fasern
US7229447B1 (en) 1998-08-25 2007-06-12 Advanced Photodynamics Technologies, Inc. Photodynamic therapy utilizing a solution of photosensitizing compound and surfactant
US6562295B1 (en) 1999-06-30 2003-05-13 Ceramoptec Industries, Inc. Bacteria resistant medical devices
JP2001124699A (ja) 1999-10-28 2001-05-11 Miura Co Ltd 溶存酸素濃度測定用指示薬
CA2401624C (en) * 2000-02-26 2011-08-16 Merrill A. Biel Photodynamic cellular and acellular organism eradication utilizing a photosensitive material and surfactant
AU2001244549A1 (en) 2000-03-22 2001-10-03 Bf Research Institute, Inc. Azure a analogues useful as probes in the diagnostic imaging for diseases due toaccumulation of amyloid and compositions for diagnostic imaging containing the analogues
AU2001258117A1 (en) * 2000-05-08 2001-11-20 The University Of British Columbia Supports for photosensitizer formulations
US6551346B2 (en) 2000-05-17 2003-04-22 Kent Crossley Method and apparatus to prevent infections
FR2810318B1 (fr) 2000-06-15 2005-09-23 Laurent Galey Derives de diamano-phenothiazine
US6623513B2 (en) 2001-01-19 2003-09-23 Advanced Photodynamic Technologies, Inc. Apparatus and method of photodynamic eradication of organisms utilizing pyrrolnitrin
GB2373787A (en) 2001-03-08 2002-10-02 Univ Central Lancashire Phenothiazinium derivatives and their use to reduce pathogenic contaminants
GB0106953D0 (en) 2001-03-20 2001-05-09 Univ Aberdeen Neufofibrillary labels
GB0113121D0 (en) 2001-05-30 2001-07-18 Univ Leeds Biologically active photosensitisers
WO2003007889A2 (en) 2001-07-17 2003-01-30 Research Development Foundation Therapeutic agents comprising pro-apoptotic proteins
US6551171B1 (en) * 2002-01-24 2003-04-22 Brian Hass Brassiere with detachable uniform pressure assembly
US7176308B2 (en) 2002-06-17 2007-02-13 Verification Technologies, Inc. Processes for preparing novel methylene blue derivative
US6952392B2 (en) 2002-06-17 2005-10-04 Verification Technologies, Inc. Laser reactive dyes for DVD copy protection system
GB0420888D0 (en) 2004-09-20 2004-10-20 Photopharmica Ltd Compounds and uses
US7220879B2 (en) 2004-10-01 2007-05-22 Rohm And Haas Company Method for inhibiting polymerization of (meth)acrylic acid and its esters using an inhibitor and a process for making a compound useful as such an inhibitor

Also Published As

Publication number Publication date
JP4554198B2 (ja) 2010-09-29
US20080268033A1 (en) 2008-10-30
CY1108091T1 (el) 2014-02-12
US7371744B2 (en) 2008-05-13
US7915254B2 (en) 2011-03-29
PT1392666E (pt) 2007-04-30
EP1790642A1 (de) 2007-05-30
ZA200309215B (en) 2005-05-25
CN100491362C (zh) 2009-05-27
KR20090010141A (ko) 2009-01-28
NO20035327D0 (no) 2003-11-28
JP2009280588A (ja) 2009-12-03
US20080275033A1 (en) 2008-11-06
KR100957260B1 (ko) 2010-05-12
NZ529682A (en) 2006-03-31
NO324321B1 (no) 2007-09-24
US7732439B2 (en) 2010-06-08
BR0209783A (pt) 2004-04-20
US8188074B2 (en) 2012-05-29
CA2448303A1 (en) 2002-12-05
US20080261960A1 (en) 2008-10-23
KR20090061684A (ko) 2009-06-16
EP2275416A1 (de) 2011-01-19
MXPA03010916A (es) 2004-10-28
EP1392666B1 (de) 2007-02-28
US20040147508A1 (en) 2004-07-29
GB0123945D0 (en) 2001-11-28
KR20040015723A (ko) 2004-02-19
ES2280533T3 (es) 2007-09-16
US20120302557A1 (en) 2012-11-29
CN1551872A (zh) 2004-12-01
US7855197B2 (en) 2010-12-21
DE60218454T2 (de) 2007-12-27
DE60218454D1 (de) 2007-04-12
CA2448303C (en) 2010-07-13
GB0113121D0 (en) 2001-07-18
CN101928262A (zh) 2010-12-29
JP2005500271A (ja) 2005-01-06
AU2002256784B2 (en) 2007-07-12
DK1392666T3 (da) 2007-05-07
HK1063788A1 (en) 2005-01-14
US20080312219A1 (en) 2008-12-18
WO2002096896A1 (en) 2002-12-05
EP1392666A1 (de) 2004-03-03

Similar Documents

Publication Publication Date Title
DE60218454D1 (de) Biologisch aktive derivate des methylenblaus
TR200101744T2 (tr) Fenilglisin türevleri.
ZA200309887B (en) Novel compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents.
TR200200579T2 (tr) Amino-tirazolpiridin türevleri.
NL300877I2 (nl) obeticholzuur
DE69915004D1 (de) 5-Oxo-pyrrolidine-2-Carbonsäure-Hydroxamidderivate
NO20020725D0 (no) Celleadhesjonsinhibitorer
DK1385514T5 (da) Spiroinden- og spiroindanforbindelser
ATE413388T1 (de) Muskarin antagonisten
SE0004245D0 (sv) Novel compounds and their use
ATE416157T1 (de) Inhibitoren von integrin alpha-v-beta-6
DK1036074T3 (da) S-Oxid-tetrahydrothiopyran-phenyloxazolidinoner
SI1578741T1 (sl) Aromatske spojine kot protivnetna imunomodulatorna in antiproliferativna sredstva
PT882726E (pt) Carbazol-carboxamidas como agonistas 5-ht1f
MXPA04006041A (es) Antivirales de piridoquinoxalina.
TR200201128T2 (tr) PDE4 inhibitörleri olarak tetrahidrotiyopiranfitalazinon türevleri.
TR200302288T2 (tr) Terapi için yeni bileşikler ve metotlar.
MY136297A (en) Piperazine derivatives having sst1 antagonistic activity
DE60112960D1 (de) Kondensierte pyridoindolderivate
PT1204659E (pt) Benzofuranos serotoninergicos
DE60121048D1 (de) PYRAZINOi1'2':1,6öPYRIDOi3,4-BöINDOLDERIVATE
MXPA02011234A (es) Nuevas bases de oxidacion 2,5-diaminopiridina utiles para el tinte de las fibras queratinicas.
BR0207966A (pt) Composição farmacêutica contendo derivados 1,3-tiazina
ATE218138T1 (de) N-substituierte azabicycloheptan-derivate, ihre herstellung und verwendung
ATE334977T1 (de) Discodermolid-analoga und ihre pharmazeutische verwendung

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1392666

Country of ref document: EP