ATE356385T1 - Verfahren zur vorhersage der bindungsaffinität der mhc-peptid-komplexe - Google Patents

Verfahren zur vorhersage der bindungsaffinität der mhc-peptid-komplexe

Info

Publication number
ATE356385T1
ATE356385T1 AT03735590T AT03735590T ATE356385T1 AT E356385 T1 ATE356385 T1 AT E356385T1 AT 03735590 T AT03735590 T AT 03735590T AT 03735590 T AT03735590 T AT 03735590T AT E356385 T1 ATE356385 T1 AT E356385T1
Authority
AT
Austria
Prior art keywords
mhc
peptide
binding affinity
further relates
invention further
Prior art date
Application number
AT03735590T
Other languages
English (en)
Inventor
Ignace Lasters
Johan Desmet
Original Assignee
Algonomics N V
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Algonomics N V filed Critical Algonomics N V
Application granted granted Critical
Publication of ATE356385T1 publication Critical patent/ATE356385T1/de

Links

Classifications

    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B15/00—ICT specially adapted for analysing two-dimensional [2D] or three-dimensional [3D] molecular structures, e.g. structural or functional relations or structure alignment
    • G16B15/20—Protein or domain folding
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B15/00—ICT specially adapted for analysing two-dimensional [2D] or three-dimensional [3D] molecular structures, e.g. structural or functional relations or structure alignment
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Evolutionary Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Theoretical Computer Science (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT03735590T 2002-06-10 2003-06-10 Verfahren zur vorhersage der bindungsaffinität der mhc-peptid-komplexe ATE356385T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP02447115 2002-06-10

Publications (1)

Publication Number Publication Date
ATE356385T1 true ATE356385T1 (de) 2007-03-15

Family

ID=29724618

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03735590T ATE356385T1 (de) 2002-06-10 2003-06-10 Verfahren zur vorhersage der bindungsaffinität der mhc-peptid-komplexe

Country Status (6)

Country Link
US (3) US7702465B2 (de)
EP (1) EP1516275B1 (de)
AT (1) ATE356385T1 (de)
AU (1) AU2003236728A1 (de)
DE (1) DE60312330T2 (de)
WO (1) WO2003105058A2 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1759323A2 (de) 2004-04-21 2007-03-07 AlgoNomics N.V. Verfahren zur affinitätsbewertung von peptid-/proteinkomplexen
US20070192033A1 (en) * 2006-02-16 2007-08-16 Microsoft Corporation Molecular interaction predictors
US8396671B2 (en) * 2006-02-16 2013-03-12 Microsoft Corporation Cluster modeling, and learning cluster specific parameters of an adaptive double threading model
US8706421B2 (en) * 2006-02-16 2014-04-22 Microsoft Corporation Shift-invariant predictions
US20100068217A1 (en) * 2006-08-25 2010-03-18 Kwong Peter D Epitope-transplant scaffolds and their use
US8121797B2 (en) 2007-01-12 2012-02-21 Microsoft Corporation T-cell epitope prediction
WO2011119484A1 (en) * 2010-03-23 2011-09-29 Iogenetics, Llc Bioinformatic processes for determination of peptide binding
JP6069212B2 (ja) 2010-12-02 2017-02-01 ビオノール イミュノ エーエスＢｉｏｎｏｒ Ｉｍｍｕｎｏ Ａｓ ペプチド骨格設計
JP6294076B2 (ja) 2011-01-06 2018-03-14 ビオノール イミュノ エーエスＢｉｏｎｏｒ Ｉｍｍｕｎｏ Ａｓ 多量体ペプチド
WO2013182661A1 (en) 2012-06-06 2013-12-12 Bionor Immuno As Peptides derived from viral proteins for use as immunogens and dosage reactants
US11566052B2 (en) 2015-11-11 2023-01-31 Lonza Ltd. CRISPR-associated (Cas) proteins with reduced immunogenicity
US20190237158A1 (en) * 2016-08-31 2019-08-01 Medgenome, Inc. Methods to analyze genetic alterations in cancer to identify therapeutic peptide vaccines and kits therefore
JP2020505931A (ja) 2017-02-03 2020-02-27 ロンザ リミテッドＬｏｎｚａ Ｌｉｍｉｔｅｄ 生物学的製品の製造において複数の細胞を分析しタンパク質配列変異体を検出する方法
EP3894188A4 (de) * 2018-12-10 2022-11-16 University of Notre Dame du Lac Vorhersage der affinität unter verwendung struktureller und physikalischer modellierung
US10515715B1 (en) 2019-06-25 2019-12-24 Colgate-Palmolive Company Systems and methods for evaluating compositions
FR3103621A1 (fr) 2019-11-22 2021-05-28 Commissariat A L'energie Atomique Et Aux Energies Alternatives Procédé et système pour sélectionner des variants d’une protéine thérapeutique moins immunogènes que cette protéine thérapeutique
JP2025513714A (ja) 2022-03-22 2025-04-30 モルフォシス・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング Ｃｄ３に特異的な脱免疫抗体
WO2025087681A1 (en) 2023-10-26 2025-05-01 Morphosys Ag Bispecific antibodies against cd3 and cd20
US20250239325A1 (en) * 2024-01-18 2025-07-24 Nec Laboratories America, Inc. Binding affinity prediction using 3d gnns

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL86832A (en) * 1987-06-22 2002-09-12 Medeva Holdings Bv A recombinant DNA molecule containing a nucleotide sequence of part of the region encoding HBV pre-1s, an immunogenic particle containing multiple peptide monomers containing a pre-s1 epitope and pharmaceutical preparations containing it
US5780036A (en) * 1991-08-26 1998-07-14 The Scripps Research Institute Peptides for inducing cytotoxic T lymphocyte responses to hepattis B virus
ATE359561T1 (de) 1997-06-02 2007-05-15 Univ Johns Hopkins Rechnerverfahren freie energieberechnung für ligandenentwurf verwendend und die voraussage von bindenden zielen
GB9712892D0 (en) * 1997-06-20 1997-08-20 Eclagen Ltd Identification of mhc binding peptides

Also Published As

Publication number Publication date
US20100168398A1 (en) 2010-07-01
EP1516275A2 (de) 2005-03-23
WO2003105058A2 (en) 2003-12-18
US20060111554A1 (en) 2006-05-25
AU2003236728A1 (en) 2003-12-22
EP1516275B1 (de) 2007-03-07
WO2003105058A3 (en) 2004-09-16
AU2003236728A8 (en) 2003-12-22
US20120202247A1 (en) 2012-08-09
DE60312330T2 (de) 2007-11-22
US7702465B2 (en) 2010-04-20
DE60312330D1 (de) 2007-04-19

Similar Documents

Publication Publication Date Title
DE60312330D1 (de) Verfahren zur vorhersage der bindungsaffinität der mhc-peptid-komplexe
Tilley et al. Identification of a small molecule inhibitor of the IL-2/IL-2Rα receptor interaction which binds to IL-2
Olsson et al. Epitope‐specificity of recombinant antibodies reveals promiscuous peptide‐binding properties
CY1124802T1 (el) Δεσμευτικοι παραγοντες σκληροστινης
TW200732350A (en) Methods for generating monovalent IgG
BRPI0415230A (pt) anticorpo biespecìfico de substituição de proteìnas funcionais
BR122018016031B8 (pt) processo para produzir um anticorpo monoclonal variante com resposta de adcc realçada
DK1819830T3 (da) Fremgangsmåder til antistofgenerering
CR10462A (es) Anticuerpos de alta afinidad hacia receptor de il-6 humano
WO2022091094A3 (en) Agents binding modified antigen presented peptides and use of same
IN2009DN05758A (de)
ZA200604026B (en) IL-23 and its receptor ; related reagents and methods
Bui et al. Structural prediction of peptides binding to MHC class I molecules
UA92154C2 (ru) Rage-слитые белки и способы их применения
Kurimoto et al. Structural and functional mosaic nature of MHC class I molecules in their peptide-free form
ATE454404T1 (de) Intrazelluläre antikörper
ATE495252T1 (de) Neuartige phagenanzeigetechnologien
Morgan et al. Circular dichroism determination of class I MHC‐peptide equilibrium dissociation constants
ATE468351T1 (de) Peptidaptamer zum neutralisieren der bindung von platelet-antigen-spezifischen antikörpern und diagnostische und therapeutische anwendungen, die dieses enthalten
NO20053304L (no) NOGO A bindingsmolekyler og farmasoytisk anvendelse av disse
Wan et al. Large‐scale molecular dynamics simulations of HLA‐A* 0201 complexed with a tumor‐specific antigenic peptide: Can the α3 and β2m domains be neglected?
Musiket et al. Numeral modeling of fracture failure of recycled aggregate concrete beams under high loading rates
WO2007008647A3 (en) Diagnosing and grading gliomas using a proteomics approach
MX2023007583A (es) Metodos para obtener anticuerpos que se unen a proteinas transmembranarias y celulas que los producen.
PT1512004E (pt) Metodo para mapear e eliminar epitopos para celulas t

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1516275

Country of ref document: EP