ATE359370T1 - Heterologe antigene in stämmen zur impfung mit lebendzellen - Google Patents
Heterologe antigene in stämmen zur impfung mit lebendzellenInfo
- Publication number
- ATE359370T1 ATE359370T1 AT94909706T AT94909706T ATE359370T1 AT E359370 T1 ATE359370 T1 AT E359370T1 AT 94909706 T AT94909706 T AT 94909706T AT 94909706 T AT94909706 T AT 94909706T AT E359370 T1 ATE359370 T1 AT E359370T1
- Authority
- AT
- Austria
- Prior art keywords
- heterologue
- antigens
- strains
- live cell
- cell vaccination
- Prior art date
Links
- 239000000427 antigen Substances 0.000 title abstract 2
- 102000036639 antigens Human genes 0.000 title abstract 2
- 108091007433 antigens Proteins 0.000 title abstract 2
- 238000002255 vaccination Methods 0.000 title 1
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 abstract 2
- 241000607626 Vibrio cholerae Species 0.000 abstract 2
- 241000894006 Bacteria Species 0.000 abstract 1
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 230000001580 bacterial effect Effects 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 210000000349 chromosome Anatomy 0.000 abstract 1
- 101150027374 irgA gene Proteins 0.000 abstract 1
- 229910052742 iron Inorganic materials 0.000 abstract 1
- 230000001105 regulatory effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/107—Vibrio
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K14/245—Escherichia (G)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K14/25—Shigella (G)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/28—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Vibrionaceae (F)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/523—Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2050193A | 1993-02-22 | 1993-02-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE359370T1 true ATE359370T1 (de) | 2007-05-15 |
Family
ID=21798955
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94909706T ATE359370T1 (de) | 1993-02-22 | 1994-02-22 | Heterologe antigene in stämmen zur impfung mit lebendzellen |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US5747028A (de) |
| EP (1) | EP0692031B1 (de) |
| JP (1) | JPH08506963A (de) |
| AT (1) | ATE359370T1 (de) |
| AU (1) | AU683454B2 (de) |
| CA (1) | CA2156191A1 (de) |
| DE (1) | DE69434951D1 (de) |
| WO (1) | WO1994019482A1 (de) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9326174D0 (en) * | 1993-12-22 | 1994-02-23 | Biocine Sclavo | Mucosal adjuvant |
| WO1996000233A1 (en) * | 1994-06-24 | 1996-01-04 | Children's Hospital And Medical Center | Escherichia coli o157:h7 epithelial adhesin |
| JPH11507532A (ja) * | 1995-06-07 | 1999-07-06 | ワシントン ユニバーシティ | 環境に制限される生存能を有する組換え細菌システム |
| BR9711692A (pt) * | 1996-09-06 | 2000-10-24 | Commw Scient Ind Res Org | Promotor regulado de aço |
| WO1998023763A1 (en) * | 1996-11-29 | 1998-06-04 | The General Hospital Corporation | Heterologous antigens in live cell v. cholerae strains |
| US6818222B1 (en) | 1997-03-21 | 2004-11-16 | Chiron Corporation | Detoxified mutants of bacterial ADP-ribosylating toxins as parenteral adjuvants |
| EP0887403A3 (de) * | 1997-06-27 | 2000-12-06 | Chiron S.P.A. | Abgeschwächte Stämme von Vibrio cholerae |
| FR2766193B1 (fr) * | 1997-07-18 | 2001-09-14 | Inst Curie | Polypeptide chimerique comprenant le fragment b de la toxine shiga et des peptides d'interet therapeutique |
| ATE320264T1 (de) | 1997-12-05 | 2006-04-15 | Virginia Tech Intell Prop | Ein impfstoff mit einem überexprimierenden homologen antigen sowie verfahren zu dessen herstellung |
| CU22661A1 (es) * | 1997-12-30 | 2001-04-27 | Cnic Ct Nac Investigaciones | Nuevos candidatos vacunales de vibrio cholerae y método de obtención |
| EP1078007B1 (de) * | 1998-05-15 | 2005-11-23 | Institut Curie | Verotoxin b untereinheit zur immunisierunug |
| SE9801852D0 (sv) | 1998-05-26 | 1998-05-26 | Sbl Vaccin Ab | Method of producing thy A-strains of Vibro cholerae, suck strains and their use |
| WO2000011181A1 (en) | 1998-08-20 | 2000-03-02 | Connaught Laboratories Limited | NUCLEIC ACID MOLECULES ENCODING INCLUSION MEMBRANE PROTEIN C OF $i(CHLAMYDIA) |
| US6686339B1 (en) | 1998-08-20 | 2004-02-03 | Aventis Pasteur Limited | Nucleic acid molecules encoding inclusion membrane protein C of Chlamydia |
| US6693087B1 (en) | 1998-08-20 | 2004-02-17 | Aventis Pasteur Limited | Nucleic acid molecules encoding POMP91A protein of Chlamydia |
| CA2388337C (en) | 1999-10-22 | 2013-01-08 | Aventis Pasteur Limited | Method of inducing and/or enhancing an immune response to tumor antigens |
| AU1951001A (en) | 2000-04-06 | 2001-09-17 | Panacea Pharm Llc | Microbial delivery system |
| EP1792995A3 (de) | 2000-05-08 | 2007-06-13 | Sanofi Pasteur Limited | Chlamydia Antigene, entsprechende DNS Fragmente und ihre Verwendungen |
| DK1282702T3 (da) * | 2000-05-10 | 2007-04-02 | Sanofi Pasteur Ltd | Immunogene polypeptider, som er kodet af KAGE-minigener, og anvendelser deraf |
| US7135173B2 (en) * | 2000-07-13 | 2006-11-14 | Idaho Research Foundation, Inc. | Antiviral activity of Shiga toxin |
| US6541013B1 (en) | 2000-07-13 | 2003-04-01 | Idaho Research Foundation, Inc. | Methods and compositions for suppressing bovine leukemia virus with a Shiga toxin polypeptide |
| CN1484700A (zh) | 2000-11-02 | 2004-03-24 | �¼��¹�����ѧ | aopB基因,蛋白,同系物,片段和它们的变体,以及它们在细胞表面展示方面的应用 |
| ES2290449T3 (es) | 2002-04-09 | 2008-02-16 | Sanofi Pasteur Limited | Acido nucleico de cea modificado y vectores de expresion. |
| WO2004024067A2 (en) * | 2002-09-10 | 2004-03-25 | Vical Incorporated | Codon-optimized polynucleotide-based vaccines against bacillus anthracis infection |
| CA2550583C (en) * | 2003-10-08 | 2013-01-15 | Sanofi Pasteur, Inc. | Modified cea /b7 vector |
| AU2011230619C1 (en) | 2010-03-25 | 2016-06-23 | Oregon Health & Science University | CMV glycoproteins and recombinant vectors |
| HUE037408T2 (hu) | 2011-06-10 | 2018-08-28 | Univ Oregon Health & Science | CMV glikoproteinek és rekombináns vektorok |
| CA2789539A1 (en) | 2011-09-12 | 2013-03-12 | International Aids Vaccine Initiative | Immunoselection of recombinant vesicular stomatitis virus expressing hiv-1 proteins by broadly neutralizing antibodies |
| US9402894B2 (en) | 2011-10-27 | 2016-08-02 | International Aids Vaccine Initiative | Viral particles derived from an enveloped virus |
| ES2631608T3 (es) | 2012-06-27 | 2017-09-01 | International Aids Vaccine Initiative | Variante de la glicoproteína Env del VIH-1 |
| EP2848937A1 (de) | 2013-09-05 | 2015-03-18 | International Aids Vaccine Initiative | Verfahren zur Identifizierung neuartiger HIV-1-Immunogene |
| US10058604B2 (en) | 2013-10-07 | 2018-08-28 | International Aids Vaccine Initiative | Soluble HIV-1 envelope glycoprotein trimers |
| EP3069730A3 (de) | 2015-03-20 | 2017-03-15 | International Aids Vaccine Initiative | Lösliche hiv-1-hüllglykoproteintrimere |
| US9931394B2 (en) | 2015-03-23 | 2018-04-03 | International Aids Vaccine Initiative | Soluble HIV-1 envelope glycoprotein trimers |
| DK3503915T5 (da) * | 2016-08-26 | 2024-09-02 | Telesis Bio Inc | Genetisk modificerede Vibro natriegen |
| US10973908B1 (en) | 2020-05-14 | 2021-04-13 | David Gordon Bermudes | Expression of SARS-CoV-2 spike protein receptor binding domain in attenuated salmonella as a vaccine |
| US12537071B1 (en) | 2020-07-22 | 2026-01-27 | David Gordon Bermudes | Bacteria having boolean control pathways expressing therapeutic proteins including immunotherapeutic cytotoxins |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4882278A (en) * | 1983-04-29 | 1989-11-21 | President And Fellows Of Harvard College | Non-toxinogenic vibrio cholerae mutants |
| EP0251579A3 (de) * | 1986-06-24 | 1989-03-22 | Enterovax Research Pty. Ltd. | Markiersystem ohne Antibiotika |
| EP0257837A1 (de) * | 1986-08-19 | 1988-03-02 | Enterovax Research Pty. Ltd. | Hybrider Bakterienstamm |
| US5112749A (en) * | 1987-10-02 | 1992-05-12 | Praxis Biologics, Inc. | Vaccines for the malaria circumsporozoite protein |
| GB8730037D0 (en) * | 1987-12-23 | 1988-02-03 | Wellcome Found | Vaccines |
| FR2636842B1 (fr) * | 1988-09-27 | 1994-06-10 | Liege Universite Etat | Proteine de fusion d'une sequence derivee de la sous-unite b de la toxine cholerique et d'un antigene heterologue doue de proprietes immunogenes, compositions de vaccins les contenant et acides nucleiques recombinants contenant une sequence de nucleotides codant pour ladite proteine de fusion |
| WO1991018092A1 (en) * | 1990-05-23 | 1991-11-28 | University Of Maryland At Baltimore | Acid-tolerant salmonella typhi, double aro mutants thereof and use as an oral vaccine for typhoid fever |
| SG46987A1 (en) * | 1992-04-10 | 1998-03-20 | Schweiz Serum & Impfinst | Recombinant live vaccines |
| US5330754A (en) * | 1992-06-29 | 1994-07-19 | Archana Kapoor | Membrane-associated immunogens of mycobacteria |
| CN1083524A (zh) * | 1992-07-06 | 1994-03-09 | 哈佛大学校长及研究员协会 | 作为霍乱疫苗缺失突变体 |
-
1994
- 1994-02-22 CA CA002156191A patent/CA2156191A1/en not_active Abandoned
- 1994-02-22 WO PCT/US1994/001780 patent/WO1994019482A1/en not_active Ceased
- 1994-02-22 EP EP94909706A patent/EP0692031B1/de not_active Expired - Lifetime
- 1994-02-22 DE DE69434951T patent/DE69434951D1/de not_active Expired - Lifetime
- 1994-02-22 AT AT94909706T patent/ATE359370T1/de not_active IP Right Cessation
- 1994-02-22 JP JP6519175A patent/JPH08506963A/ja active Pending
- 1994-02-22 AU AU62445/94A patent/AU683454B2/en not_active Ceased
-
1995
- 1995-06-07 US US08/480,510 patent/US5747028A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JPH08506963A (ja) | 1996-07-30 |
| US5747028A (en) | 1998-05-05 |
| AU6244594A (en) | 1994-09-14 |
| EP0692031A4 (de) | 1997-11-19 |
| CA2156191A1 (en) | 1994-09-01 |
| EP0692031A1 (de) | 1996-01-17 |
| WO1994019482A1 (en) | 1994-09-01 |
| DE69434951D1 (de) | 2007-05-24 |
| AU683454B2 (en) | 1997-11-13 |
| EP0692031B1 (de) | 2007-04-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE359370T1 (de) | Heterologe antigene in stämmen zur impfung mit lebendzellen | |
| ZA912397B (en) | Live vaccines | |
| Fairweather et al. | Immunization of mice against tetanus with fragments of tetanus toxin synthesized in Escherichia coli | |
| EP0584167B1 (de) | Für ein signalpeptid, ein selektiv wechselwirkendes polypeptid und eine membranankersequenz kodierende rekombinante dns | |
| ES2006925A6 (es) | Procedimiento para la preparacion de vectores de expresion. | |
| FI933757A0 (fi) | Expression av rekombinantproteiner i attenuerade bakterier | |
| NZ190524A (en) | Recombinant dna method for producing specific protein or polypeptide cleaving of bacterial gene for extracellular or periplasmic carrier protein | |
| ATE359084T1 (de) | Modifizierter hitzeschockprotein/peptidantigen komplex | |
| NO174630C (no) | Fremgangsmåte ved fremstilling av en vaksine mot streptokokkinfeksjoner | |
| AU8127494A (en) | Chimeric proteins comprising borrelia polypeptides: uses therefor | |
| ATE167061T1 (de) | Kreuzschützende salmonella impfstoffe | |
| ATE298798T1 (de) | Fusionsproteine zwischen antigene aminosäuresequenzen und beta - 2- mikroglobulin | |
| HU9401511D0 (en) | Vaccine against streptococcus suls infection | |
| GB9409985D0 (en) | Vaccine against mycobacterial infections | |
| MX9801089A (es) | Proteina hibrida que comprende epitopes estimulantes de celula auxiliar t y epitopes de celula b de la proteina de membrana externa mayor chlamydia trachomatis y su uso como vacuna. | |
| AU612683B2 (en) | Synthetic peptides, antibodies directed against them, and the use thereof | |
| DE69131624D1 (de) | Peptidzusammensetzung aus pseudomonas und methode diese herzustellen | |
| DK0646176T3 (da) | Levering og ekspression af et hybridoverfladeprotein på overfladen af grampositive bakterier | |
| GB9401795D0 (en) | Vaccines | |
| EP0949333A4 (de) | Mutierte antigene des masernvirus und die dafür kodierenden gene. | |
| Handl | Studies of STb (STII): A heat-stable enterotoxin of Escherichia coli. Prevalence, purification and development of immunoassay. | |
| DK230890A (da) | Dna-fragment, der koder for et pasteurella multocida-toxin eller for en subsekvens eller analog deraf, ekspressionsvektor, der omfatter dna-fragmentet, mikroorganisme, der udtrykker dette, fremgangsmaade til fremstilling af et pasteurella-multocida-toxin, diagnostisk middel samt anvendelse heraf, vaccine indeholdende et pasteurella-multocida-toxinderivat, anvendelse af pasteurella multocida-t m.m. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |