ATE36163T1 - Reines praeparat des antibiotikums l 17054 und verfahren zu seiner herstellung. - Google Patents

Reines praeparat des antibiotikums l 17054 und verfahren zu seiner herstellung.

Info

Publication number: ATE36163T1
Authority: AT; Austria
Prior art keywords: antibiotic; production; pure preparation; antibiotic substance; new
Prior art date: 1983-03-22

Application number

AT84102666T

Other languages

English (en)

Inventor

Adriano Malabarba

Angelo Borghi

Paolo Strazzolini

Bruno Cavalleri

Carolina Coronelli

Original Assignee

Lepetit Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-03-22

Filing date

1984-03-12

Publication date

1988-08-15

1984-03-12 Application filed by Lepetit Spa filed Critical Lepetit Spa

1988-08-15 Application granted granted Critical

1988-08-15 Publication of ATE36163T1 publication Critical patent/ATE36163T1/de

Links

230000003115 biocidal effect Effects 0.000 title abstract 5
238000004519 manufacturing process Methods 0.000 title 1
238000000034 method Methods 0.000 title 1
239000000126 substance Substances 0.000 abstract 4
108010053950 Teicoplanin Proteins 0.000 abstract 2
241000192125 Firmicutes Species 0.000 abstract 1
230000000845 anti-microbial effect Effects 0.000 abstract 1
DDTDNCYHLGRFBM-YZEKDTGTSA-N chembl2367892 Chemical compound CC(=O)N[C@H]1[C@@H](O)[C@H](O)[C@H](CO)O[C@H]1O[C@@H]([C@H]1C(N[C@@H](C2=CC(O)=CC(O[C@@H]3[C@H]([C@H](O)[C@H](O)[C@@H](CO)O3)O)=C2C=2C(O)=CC=C(C=2)[C@@H](NC(=O)[C@@H]2NC(=O)[C@@H]3C=4C=C(O)C=C(C=4)OC=4C(O)=CC=C(C=4)[C@@H](N)C(=O)N[C@H](CC=4C=C(Cl)C(O5)=CC=4)C(=O)N3)C(=O)N1)C(O)=O)=O)C(C=C1Cl)=CC=C1OC1=C(O[C@H]3[C@H]([C@@H](O)[C@H](O)[C@H](CO)O3)NC(C)=O)C5=CC2=C1 DDTDNCYHLGRFBM-YZEKDTGTSA-N 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
BJNLLBUOHPVGFT-QRZIFLFXSA-N teichomycin Chemical compound CCCCCCCCCC(=O)N[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC(C(=C1)OC=2C(=CC(=CC=2)[C@@H](O[C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@H]2C(N[C@H](C3=CC(O)=CC(O[C@@H]4[C@H]([C@@H](O)[C@H](O)[C@@H](CO)O4)O)=C3C=3C(O)=CC=C(C=3)[C@@H](NC3=O)C(=O)N2)C(O)=O)=O)Cl)=C(OC=2C(=CC(C[C@H](C(N4)=O)NC(=O)[C@H](N)C=5C=C(O6)C(O)=CC=5)=CC=2)Cl)C=C1[C@H]3NC(=O)[C@@H]4C1=CC6=CC(O)=C1 BJNLLBUOHPVGFT-QRZIFLFXSA-N 0.000 abstract 1
229960001608 teicoplanin Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
- C12P1/04—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using bacteria
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
- C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/19—Antibiotic
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/27—Cyclic peptide or cyclic protein

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
Pharmacology & Pharmacy (AREA)
Communicable Diseases (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Mycology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biotechnology (AREA)
Microbiology (AREA)
Oncology (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Compounds Of Unknown Constitution (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Saccharide Compounds (AREA)
Peptides Or Proteins (AREA)
Fodder In General (AREA)

AT84102666T 1983-03-22 1984-03-12 Reines praeparat des antibiotikums l 17054 und verfahren zu seiner herstellung. ATE36163T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB838307847A GB8307847D0 (en)	1983-03-22	1983-03-22	Antibiotics l 17054 and l 17046
EP84102666A EP0119575B1 (de)	1983-03-22	1984-03-12	Reines Präparat des Antibiotikums L 17054 und Verfahren zu seiner Herstellung

Publications (1)

Publication Number	Publication Date
ATE36163T1 true ATE36163T1 (de)	1988-08-15

Family

ID=10539998

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT84102666T ATE36163T1 (de)	1983-03-22	1984-03-12	Reines praeparat des antibiotikums l 17054 und verfahren zu seiner herstellung.
AT84102665T ATE38676T1 (de)	1983-03-22	1984-03-12	Antibiotikum l 17046 und verfahren zu seiner herstellung.

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
AT84102665T ATE38676T1 (de)	1983-03-22	1984-03-12	Antibiotikum l 17046 und verfahren zu seiner herstellung.

Country Status (15)

Country	Link
US (4)	US4645827A (de)
EP (2)	EP0119574B1 (de)
JP (2)	JPS59213395A (de)
KR (2)	KR910008626B1 (de)
AT (2)	ATE36163T1 (de)
AU (2)	AU567549B2 (de)
CA (2)	CA1238040A (de)
DE (2)	DE3475196D1 (de)
DK (2)	DK161284A (de)
ES (2)	ES530815A0 (de)
GB (1)	GB8307847D0 (de)
IE (2)	IE57118B1 (de)
IL (2)	IL71230A (de)
NZ (2)	NZ207579A (de)
ZA (2)	ZA842006B (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8307847D0 (en) *	1983-03-22	1983-04-27	Lepetit Spa	Antibiotics l 17054 and l 17046
US4696817A (en) *	1983-10-11	1987-09-29	The Dow Chemical Company	Extraction of teichomycin A2 from whole culture fermentation broth
AU579120B2 (en) *	1983-12-16	1988-11-17	Gruppo Lepetit S.P.A.	Chemical process for preparing antibiotic L 17392 (deglucoteicoplanin) and its salts
GB8333624D0 (en) *	1983-12-16	1984-01-25	Lepetit Spa	Antibiotics l 17054 and l 17392
IT1173329B (it) *	1984-02-21	1987-06-24	Lepetit Spa	Procedimento per la trasformazione quantitativa di teicoplanina a2 fattore 1 in teicoplanina a2 fattore 3
GB8420405D0 (en) *	1984-08-10	1984-09-12	Lepetit Spa	Preparing antibiotic l 17046
GB8428619D0 (en) *	1984-11-13	1984-12-19	Lepetit Spa	Derivatives of antibiotic l 17046
IT1187705B (it) *	1985-07-24	1987-12-23	Montefluos Spa	Polimeri fluorurati e resine da essi derivate
GB8522574D0 (en) *	1985-09-12	1985-10-16	Lepetit Spa	Amides of teicoplanin compounds
GB8608809D0 (en) *	1986-04-11	1986-05-14	Lepetit Spa	Antibiotic
US4845194A (en) *	1987-02-27	1989-07-04	Eli Lilly And Company	Glycopeptide recovery process
GB8704847D0 (en) *	1987-03-02	1987-04-08	Lepetit Spa	Substituted alkylamides of teicoplanin compounds
GB8715735D0 (en) *	1987-07-03	1987-08-12	Lepetit Spa	De-mannosyl teicoplanin derivatives
ES2084595T3 (es) *	1988-12-27	1996-05-16	Lepetit Spa	Procedimiento quimico mejorado para preparar el antibiotico l/17392 (desglucoteicoplanina) y sus sales.
US5500410A (en) *	1989-03-29	1996-03-19	Gruppo Lepetit S.P.A.	Substituted alkylamide derivatives of teicoplanin
US5185320A (en) *	1989-04-03	1993-02-09	Gruppo Lepetit S.P.A.	O56 -alkyl derivatives of aglycone and pseudo aglycones of teicoplanin
DE69127645T2 (de)	1990-03-28	1998-02-12	Lepetit Spa	Verfahren zur Herstellung von Mannosylteicoplaninderivaten und Mannosylteicoplaninaglykon
DE69117304T2 (de) *	1990-12-05	1996-08-29	Lepetit Spa	38-decarboxy-38-hydroxymethylderivate von teicoplaninantibiotika, und verfahren zu deren herstellung
US5455240A (en) *	1994-06-20	1995-10-03	The Rockefeller University	Modulators of pneumococcal adhesion to cellular targets involving the platelet activating factor receptor, and uses thereof
EP0912604B1 (de)	1996-04-23	2001-11-14	Biosearch Italia S.p.A.	Chemisches Verfahren zur Herstellung von Amidderivaten von A 40926 Antibiotikum
ES2278101T3 (es) *	2003-09-17	2007-08-01	Alpharma Aps	Composicion de teicoplanina con actividad antibiotica mejorada.

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1496386A (en) *	1975-03-05	1977-12-30	Lepetit Spa	Antibiotics
JPS5592387A (en) *	1978-12-29	1980-07-12	Taisho Pharmaceut Co Ltd	Antibiotic substance tm-531
US4357325A (en) *	1981-04-20	1982-11-02	Eli Lilly And Company	Methods of controlling Pasteurella infections
RO86375B1 (ro) *	1982-03-24	1985-04-01	Eli Lilly And Company	Procedeu pentru prepararea antibioticului a 41030
FI73697C (fi) *	1982-06-08	1987-11-09	Lepetit Spa	Foerfarande foer framstaellning av individuella faktorer 1, 2, 3, 4 och 5 av teikomysin a2.
US4485102A (en) *	1982-08-16	1984-11-27	American Cyanamid Company	High potency, mycelial-free avoparcin alkyl sulfate complex, and method for the preparation thereof
GB8307847D0 (en) *	1983-03-22	1983-04-27	Lepetit Spa	Antibiotics l 17054 and l 17046
US4489102A (en) *	1983-04-04	1984-12-18	At&T Technologies, Inc.	Radiation-stimulated deposition of aluminum
US4479897A (en) *	1983-04-27	1984-10-30	Eli Lilly And Company	Actaplanin antibiotics
US4521335A (en) *	1983-07-13	1985-06-04	Smithkline Beckman Corporation	Aglycone and pseudo-aglycones of the AAD 216 antibiotics
GB8333624D0 (en) *	1983-12-16	1984-01-25	Lepetit Spa	Antibiotics l 17054 and l 17392
IT1173329B (it) *	1984-02-21	1987-06-24	Lepetit Spa	Procedimento per la trasformazione quantitativa di teicoplanina a2 fattore 1 in teicoplanina a2 fattore 3

1983
- 1983-03-22 GB GB838307847A patent/GB8307847D0/en active Pending
1984
- 1984-03-12 EP EP84102665A patent/EP0119574B1/de not_active Expired
- 1984-03-12 AT AT84102666T patent/ATE36163T1/de not_active IP Right Cessation
- 1984-03-12 EP EP84102666A patent/EP0119575B1/de not_active Expired
- 1984-03-12 DE DE8484102665T patent/DE3475196D1/de not_active Expired
- 1984-03-12 DE DE8484102666T patent/DE3473148D1/de not_active Expired
- 1984-03-12 AT AT84102665T patent/ATE38676T1/de not_active IP Right Cessation
- 1984-03-13 IL IL71230A patent/IL71230A/xx unknown
- 1984-03-13 IL IL71231A patent/IL71231A/xx unknown
- 1984-03-19 ZA ZA842006A patent/ZA842006B/xx unknown
- 1984-03-19 US US06/591,096 patent/US4645827A/en not_active Expired - Fee Related
- 1984-03-19 ZA ZA842005A patent/ZA842005B/xx unknown
- 1984-03-19 US US06/590,950 patent/US4650855A/en not_active Expired - Fee Related
- 1984-03-20 AU AU25897/84A patent/AU567549B2/en not_active Ceased
- 1984-03-20 AU AU25898/84A patent/AU567550B2/en not_active Ceased
- 1984-03-21 CA CA000450155A patent/CA1238040A/en not_active Expired
- 1984-03-21 KR KR1019840001457A patent/KR910008626B1/ko not_active Expired
- 1984-03-21 CA CA000450156A patent/CA1238041A/en not_active Expired
- 1984-03-21 NZ NZ207579A patent/NZ207579A/en unknown
- 1984-03-21 IE IE692/84A patent/IE57118B1/en not_active IP Right Cessation
- 1984-03-21 DK DK161284A patent/DK161284A/da not_active IP Right Cessation
- 1984-03-21 ES ES530815A patent/ES530815A0/es active Granted
- 1984-03-21 IE IE691/84A patent/IE57117B1/en not_active IP Right Cessation
- 1984-03-21 KR KR1019840001456A patent/KR910008645B1/ko not_active Expired
- 1984-03-21 ES ES530816A patent/ES530816A0/es active Granted
- 1984-03-21 DK DK161184A patent/DK161184A/da not_active IP Right Cessation
- 1984-03-21 NZ NZ207580A patent/NZ207580A/en unknown
- 1984-03-22 JP JP59053680A patent/JPS59213395A/ja active Pending
- 1984-03-22 JP JP59053679A patent/JPS59213394A/ja active Pending
1986
- 1986-11-10 US US06/928,958 patent/US4699977A/en not_active Expired - Fee Related
1991
- 1991-05-17 US US07/702,797 patent/US5132286A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
ATE38676T1 (de)	1988-12-15
EP0119574A2 (de)	1984-09-26
IE57118B1 (en)	1992-05-06
ZA842006B (en)	1985-01-30
DK161284D0 (da)	1984-03-21
KR910008645B1 (ko)	1991-10-19
KR840008163A (ko)	1984-12-13
EP0119574B1 (de)	1988-11-17
JPS59213394A (ja)	1984-12-03
US4650855A (en)	1987-03-17
NZ207580A (en)	1987-03-31
US5132286A (en)	1992-07-21
IE840692L (en)	1984-09-22
EP0119574A3 (en)	1985-06-12
NZ207579A (en)	1987-03-31
IE57117B1 (en)	1992-05-06
IE840691L (en)	1984-09-22
US4699977A (en)	1987-10-13
EP0119575B1 (de)	1988-08-03
EP0119575A3 (en)	1985-06-19
ES8504838A1 (es)	1985-05-01
IL71231A0 (en)	1984-06-29
ES8504839A1 (es)	1985-05-01
KR910008626B1 (ko)	1991-10-19
DE3475196D1 (en)	1988-12-22
DK161284A (da)	1984-09-23
CA1238040A (en)	1988-06-14
CA1238041A (en)	1988-06-14
DK161184A (da)	1984-09-23
AU2589784A (en)	1984-09-27
IL71230A (en)	1987-09-16
IL71231A (en)	1987-09-16
AU2589884A (en)	1984-09-27
IL71230A0 (en)	1984-06-29
AU567549B2 (en)	1987-11-26
ZA842005B (en)	1985-01-30
AU567550B2 (en)	1987-11-26
KR840008162A (ko)	1984-12-13
JPS59213395A (ja)	1984-12-03
DE3473148D1 (en)	1988-09-08
ES530815A0 (es)	1985-05-01
EP0119575A2 (de)	1984-09-26
DK161184D0 (da)	1984-03-21
ES530816A0 (es)	1985-05-01
GB8307847D0 (en)	1983-04-27
US4645827A (en)	1987-02-24

Legal Events

Date	Code	Title	Description
1989-01-15	UEP	Publication of translation of european patent specification
1994-12-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE36163T1 (de)	1988-08-15	Reines praeparat des antibiotikums l 17054 und verfahren zu seiner herstellung.
FI863687A0 (fi)	1986-09-12	Amider av teikoplaninfoereningar.
IE863381L (en)	1987-06-30	Antibiotics
ES8500931A1 (es)	1984-11-01	Procedimiento para la obtencion de acidos quinoloncarboxilicos
PT78315A (en)	1984-04-01	Process for preparing penems and pharmaceutical preparations containing them
DK347788D0 (da)	1988-06-24	Teicoplaninlignende forbindelser, fremgangsmaade og mikroorganisme til fremstilling deraf og farmaceutisk praeparat indeholdende saadanne forbindelser
ATE200492T1 (de)	2001-04-15	7-acyl-3-(substituierte carbamoyloxy) cephem verbindungen, verfahren zu ihrer herstellung und anwendung
HUT41053A (en)	1987-03-30	Process for preparing ester derivatives of l 17046 antibiotic
FR2409999A1 (fr)	1979-06-22	Produits de degradation de l'antibiotique appele rubradirine et de sa forme b, leur procede de preparation et leur application comme agents antibacteriens
DK362089D0 (da)	1989-07-21	Amider af n15-alkyl- og n15,n15-dialkyl-teicoplaninderivater
DK144284D0 (da)	1984-02-29	2'-desoxyoxanosin,den fremstilling og anvendelse
FI873270L (fi)	1987-07-27	De-(acetylglukosaminyl)-di(dehydro) -deoxi-teikoplaninderivat.
YU48092A (sh)	1994-06-24	Postupak za dobijanje dvostruko blokiranih 1 karba(1-delta)-3-cefem-4-karboksilnih kiselina
EP0721985A4 (de)	1998-08-26	Die substanz it-62-b und sie enthaltende medizinische zubereitungen
SU1455633A1 (ru)	1999-05-27	О,о-диизопропил-о-[1, 1-диметил-2-пропилтио-2-(о-о-диизопропилфосфорил)- имино]-этилфосфат, обладающий бактерицидной активностью