ATE362536T1 - Gdp-dissoziation stimulierendes protein, gehirnspezifisches nucleosomfügungsprotein, skelettmuskel-spezifisches ubiquitin- conjugationsenzym, zellproliferationsprotein, phosphatidylinositolkinase, nel verwandte proteine - Google Patents
Gdp-dissoziation stimulierendes protein, gehirnspezifisches nucleosomfügungsprotein, skelettmuskel-spezifisches ubiquitin- conjugationsenzym, zellproliferationsprotein, phosphatidylinositolkinase, nel verwandte proteineInfo
- Publication number
- ATE362536T1 ATE362536T1 AT02026841T AT02026841T ATE362536T1 AT E362536 T1 ATE362536 T1 AT E362536T1 AT 02026841 T AT02026841 T AT 02026841T AT 02026841 T AT02026841 T AT 02026841T AT E362536 T1 ATE362536 T1 AT E362536T1
- Authority
- AT
- Austria
- Prior art keywords
- protein
- specific
- phosphatidylinositolkinase
- nel
- brain
- Prior art date
Links
- 108090000623 proteins and genes Proteins 0.000 title abstract 8
- 102000004169 proteins and genes Human genes 0.000 title 3
- 102000004190 Enzymes Human genes 0.000 title 1
- 108090000790 Enzymes Proteins 0.000 title 1
- 101100133171 Gallus gallus NEL gene Proteins 0.000 title 1
- 101710107897 Nucleosome assembly protein Proteins 0.000 title 1
- 108050005377 Phosphatidylinositol kinases Proteins 0.000 title 1
- 102000017343 Phosphatidylinositol kinases Human genes 0.000 title 1
- 102000044159 Ubiquitin Human genes 0.000 title 1
- 108090000848 Ubiquitin Proteins 0.000 title 1
- 230000004663 cell proliferation Effects 0.000 title 1
- 230000021615 conjugation Effects 0.000 title 1
- 238000010494 dissociation reaction Methods 0.000 title 1
- 230000005593 dissociations Effects 0.000 title 1
- 230000004936 stimulating effect Effects 0.000 title 1
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 102000003839 Human Proteins Human genes 0.000 abstract 1
- 108090000144 Human Proteins Proteins 0.000 abstract 1
- 208000026350 Inborn Genetic disease Diseases 0.000 abstract 1
- 208000024556 Mendelian disease Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 238000010353 genetic engineering Methods 0.000 abstract 1
- 239000002773 nucleotide Substances 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
- 230000007170 pathology Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/93—Ligases (6)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP6341096 | 1996-03-19 | ||
| JP06916397A JP3646191B2 (ja) | 1996-03-19 | 1997-03-05 | ヒト遺伝子 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE362536T1 true ATE362536T1 (de) | 2007-06-15 |
Family
ID=26404531
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02026841T ATE362536T1 (de) | 1996-03-19 | 1997-03-19 | Gdp-dissoziation stimulierendes protein, gehirnspezifisches nucleosomfügungsprotein, skelettmuskel-spezifisches ubiquitin- conjugationsenzym, zellproliferationsprotein, phosphatidylinositolkinase, nel verwandte proteine |
Country Status (8)
| Country | Link |
|---|---|
| US (7) | US5831058A (de) |
| EP (6) | EP0796913A3 (de) |
| JP (1) | JP3646191B2 (de) |
| AT (1) | ATE362536T1 (de) |
| CA (2) | CA2641565C (de) |
| DE (1) | DE69737740T2 (de) |
| DK (1) | DK1295944T3 (de) |
| ES (1) | ES2284770T3 (de) |
Families Citing this family (94)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6410506B1 (en) * | 1995-05-19 | 2002-06-25 | Human Genome Sciences, Inc. | Transforming growth factor α HII |
| US20030170864A1 (en) * | 2000-05-30 | 2003-09-11 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| WO1998027205A2 (en) * | 1996-12-18 | 1998-06-25 | Genetics Institute, Inc. | Secreted proteins and polynucleotides encoding them |
| US5976837A (en) * | 1997-03-14 | 1999-11-02 | Genetics Institute, Inc. | Secreted proteins and polynucleotides encoding them |
| US5863779A (en) * | 1997-08-21 | 1999-01-26 | Incyte Pharmaceuticals, Inc. | UBC7-like ubiquitin-conjugating enzyme |
| WO1999050421A1 (en) * | 1998-03-27 | 1999-10-07 | University Of Leeds | Ubiquitin conjugating enzyme |
| US6171790B1 (en) * | 1998-05-01 | 2001-01-09 | Incyte Pharmaceuticals, Inc. | Human protease associated proteins |
| JP2000109433A (ja) * | 1998-08-05 | 2000-04-18 | Otsuka Pharmaceut Co Ltd | 神経変性疾患治療剤 |
| WO2000065052A1 (en) * | 1999-04-22 | 2000-11-02 | Habener Joel F | Bridge-1, a transcription factor |
| US7884066B2 (en) * | 1999-10-05 | 2011-02-08 | The Regents Of The University Of California | NELL-1 enhanced bone mineralization |
| WO2001069261A2 (en) * | 2000-03-15 | 2001-09-20 | Oxford Glycosciences (Uk) Ltd. | Proteins, genes and their use for diagnosis and treatment of vascular dementia |
| US6689877B2 (en) * | 2000-11-06 | 2004-02-10 | The Board Of Regents Of The University Of Nebraska | Methods and compositions for the treatment of human immunodeficiency virus infection |
| US20030039968A1 (en) * | 2001-07-10 | 2003-02-27 | Applera Corporation | Isolated human secreted proteins, nucleic acid molecules encoding human secreted proteins, and uses thereof |
| US20040049024A1 (en) * | 2001-12-07 | 2004-03-11 | Geoff Clark | Compositions and methods related to the minn1 tumor suppressor gene and protein |
| US20050276812A1 (en) | 2004-06-01 | 2005-12-15 | Genentech, Inc. | Antibody-drug conjugates and methods |
| ATE545428T1 (de) | 2002-12-16 | 2012-03-15 | Develogen Ag | Pik4cb involviert in der regulierung des energiestoffwechsels |
| EP1594889B1 (de) * | 2003-02-07 | 2011-04-06 | The Regents of The University of California | Nell-peptidexpressionssysteme und knochenbildende aktivität des nell-peptids |
| US7691607B2 (en) | 2004-02-09 | 2010-04-06 | The Regents Of The University Of California | Expression system of NELL peptide |
| US20100111856A1 (en) | 2004-09-23 | 2010-05-06 | Herman Gill | Zirconium-radiolabeled, cysteine engineered antibody conjugates |
| KR101270829B1 (ko) | 2004-09-23 | 2013-06-07 | 제넨테크, 인크. | 시스테인 유전자조작 항체 및 접합체 |
| EP1817059A2 (de) | 2004-12-01 | 2007-08-15 | Genentech, Inc. | Konjugate von 1,8-bis-naphthalimiden mit einem antikörper |
| CA2698541C (en) * | 2007-10-19 | 2018-01-09 | Genentech, Inc. | Cysteine engineered anti-tenb2 antibodies and antibody drug conjugates |
| CA2739608A1 (en) * | 2008-10-07 | 2010-04-15 | The Regents Of The University Of California | Recombinant nell protein production |
| CA2809819A1 (en) | 2009-09-09 | 2011-03-17 | Centrose, Llc | Extracellular targeted drug conjugates |
| WO2011130598A1 (en) | 2010-04-15 | 2011-10-20 | Spirogen Limited | Pyrrolobenzodiazepines and conjugates thereof |
| MX336540B (es) | 2010-06-08 | 2016-01-22 | Genentech Inc | Conjugados y anticuerpos manipulados geneticamente con cisteina. |
| ES2544608T3 (es) | 2010-11-17 | 2015-09-02 | Genentech, Inc. | Conjugados de anticuerpo y de alaninil-maitansinol |
| MX2013013054A (es) | 2011-05-12 | 2014-02-20 | Genentech Inc | Metodo de monitoreo de lc-ms/ms de reaccion multiple para detectar anticuerpos terapeuticos en muestras de animales utilizando peptidos de firma de estructura. |
| WO2013055987A1 (en) | 2011-10-14 | 2013-04-18 | Spirogen Sàrl | Pyrrolobenzodiazepines and conjugates thereof |
| WO2013130093A1 (en) | 2012-03-02 | 2013-09-06 | Genentech, Inc. | Biomarkers for treatment with anti-tubulin chemotherapeutic compounds |
| WO2014057117A1 (en) | 2012-10-12 | 2014-04-17 | Adc Therapeutics Sàrl | Pyrrolobenzodiazepine-antibody conjugates |
| KR101645905B1 (ko) | 2012-10-12 | 2016-08-04 | 스피로즌 살 | 피롤로벤조디아제핀 및 그의 컨주게이트 |
| PL2906251T3 (pl) | 2012-10-12 | 2018-02-28 | Adc Therapeutics Sa | Koniugaty pirolobenzodiazepina-przeciwciało anty-CD22 |
| WO2014057120A1 (en) | 2012-10-12 | 2014-04-17 | Adc Therapeutics Sàrl | Pyrrolobenzodiazepine-antibody conjugates |
| ES2680153T3 (es) | 2012-10-12 | 2018-09-04 | Adc Therapeutics Sa | Conjugados de anticuerpos anti-PSMA-pirrolobenzodiazepinas |
| HRP20181646T2 (hr) | 2012-10-12 | 2019-08-09 | Adc Therapeutics Sa | Konjugati pirolobenzodiazepin - anti-psma protutijela |
| MX364328B (es) | 2012-10-12 | 2019-04-23 | Medimmune Ltd | Conjugados del anticuerpo pirrolobenzodiazepina. |
| AU2013366493B2 (en) | 2012-12-21 | 2017-08-24 | Medimmune Limited | Pyrrolobenzodiazepines and conjugates thereof |
| CN105246894A (zh) | 2012-12-21 | 2016-01-13 | 斯皮罗根有限公司 | 用于治疗增殖性和自身免疫疾病的非对称吡咯并苯并二氮杂卓二聚物 |
| WO2014140862A2 (en) | 2013-03-13 | 2014-09-18 | Spirogen Sarl | Pyrrolobenzodiazepines and conjugates thereof |
| EP2968585B1 (de) | 2013-03-13 | 2018-07-18 | Medimmune Limited | Pyrrolobenzodiazepine und konjugate davon |
| JP6445519B2 (ja) | 2013-03-13 | 2018-12-26 | メドイミューン・リミテッドMedImmune Limited | ピロロベンゾジアゼピン及びそのコンジュゲート |
| US10442836B2 (en) | 2013-08-12 | 2019-10-15 | Genentech, Inc. | 1-(chloromethyl)-2,3-dihydro-1H-benzo[E]indole dimer antibody-drug conjugate compounds, and methods of use and treatment |
| EP3054986B1 (de) | 2013-10-11 | 2019-03-20 | Medimmune Limited | Pyrrolobenzodiazepin-antikörper-konjugate |
| US9950078B2 (en) | 2013-10-11 | 2018-04-24 | Medimmune Limited | Pyrrolobenzodiazepine-antibody conjugates |
| GB201317982D0 (en) | 2013-10-11 | 2013-11-27 | Spirogen Sarl | Pyrrolobenzodiazepines and conjugates thereof |
| US10010624B2 (en) | 2013-10-11 | 2018-07-03 | Medimmune Limited | Pyrrolobenzodiazepine-antibody conjugates |
| CA2928952A1 (en) | 2013-12-16 | 2015-06-25 | Genentech, Inc. | Peptidomimetic compounds and antibody-drug conjugates thereof |
| JP6895254B2 (ja) | 2013-12-16 | 2021-06-30 | ジェネンテック, インコーポレイテッド | ペプチド模倣化合物及びその抗体−薬物コンジュゲート |
| BR112016013258A2 (pt) | 2013-12-16 | 2018-01-16 | Genentech Inc | composto conjugado anticorpo-droga, composição farmacêutica, método para tratar câncer e kit |
| CN104189884A (zh) * | 2014-08-19 | 2014-12-10 | 承德医学院 | Urantide的应用 |
| WO2016037644A1 (en) | 2014-09-10 | 2016-03-17 | Medimmune Limited | Pyrrolobenzodiazepines and conjugates thereof |
| GB201416112D0 (en) | 2014-09-12 | 2014-10-29 | Medimmune Ltd | Pyrrolobenzodiazepines and conjugates thereof |
| US10149913B2 (en) | 2014-09-12 | 2018-12-11 | Genentech, Inc. | Anthracycline disulfide intermediates, antibody-drug conjugates and methods |
| US10077318B2 (en) | 2014-09-12 | 2018-09-18 | Genentech, Inc. | Cysteine engineered antibodies and conjugates |
| JP2017533887A (ja) | 2014-09-17 | 2017-11-16 | ジェネンテック, インコーポレイテッド | ピロロベンゾジアゼピン類及びその抗体ジスルフィドコンジュゲート |
| US10780096B2 (en) | 2014-11-25 | 2020-09-22 | Adc Therapeutics Sa | Pyrrolobenzodiazepine-antibody conjugates |
| CA2969689A1 (en) | 2014-12-03 | 2016-06-09 | Genentech, Inc. | Quaternary amine compounds and antibody-drug conjugates thereof |
| GB201506402D0 (en) | 2015-04-15 | 2015-05-27 | Berkel Patricius H C Van And Howard Philip W | Site-specific antibody-drug conjugates |
| GB201506411D0 (en) | 2015-04-15 | 2015-05-27 | Bergenbio As | Humanized anti-axl antibodies |
| NZ741261A (en) | 2015-10-02 | 2019-11-29 | Genentech Inc | Pyrrolobenzodiazepine antibody drug conjugates and methods of use |
| MA43354A (fr) | 2015-10-16 | 2018-08-22 | Genentech Inc | Conjugués médicamenteux à pont disulfure encombré |
| EP3365025B1 (de) | 2015-10-20 | 2020-07-15 | Genentech, Inc. | Calicheamicin-antikörper-arzneimittelkonjugate und verfahren zur verwendung |
| GB201601431D0 (en) | 2016-01-26 | 2016-03-09 | Medimmune Ltd | Pyrrolobenzodiazepines |
| GB201602359D0 (en) | 2016-02-10 | 2016-03-23 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
| GB201602356D0 (en) | 2016-02-10 | 2016-03-23 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
| EP3433621A1 (de) | 2016-03-25 | 2019-01-30 | H. Hoffnabb-La Roche Ag | Multiplex-gesamtantikörper- und antikörper-konjugierter arzneimittelquantifizierungstest |
| GB201607478D0 (en) | 2016-04-29 | 2016-06-15 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
| CN118436801A (zh) | 2016-05-20 | 2024-08-06 | 豪夫迈·罗氏有限公司 | Protac抗体缀合物及其使用方法 |
| US20170370906A1 (en) | 2016-05-27 | 2017-12-28 | Genentech, Inc. | Bioanalytical analysis of site-specific antibody drug conjugates |
| EP3464280B1 (de) | 2016-06-06 | 2021-10-06 | F. Hoffmann-La Roche AG | Silvestrol-antikörper-arzneimittelkonjugate und verfahren zur verwendung |
| WO2018031662A1 (en) | 2016-08-11 | 2018-02-15 | Genentech, Inc. | Pyrrolobenzodiazepine prodrugs and antibody conjugates thereof |
| JP7050770B2 (ja) | 2016-10-05 | 2022-04-08 | エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト | 抗体薬物コンジュゲートの調製方法 |
| GB201617466D0 (en) | 2016-10-14 | 2016-11-30 | Medimmune Ltd | Pyrrolobenzodiazepine conjugates |
| UA125198C2 (uk) | 2017-02-08 | 2022-01-26 | Ейдісі Терапьютікс Са | Кон'югати піролобензодіазепін-антитіло |
| GB201702031D0 (en) | 2017-02-08 | 2017-03-22 | Medlmmune Ltd | Pyrrolobenzodiazepine-antibody conjugates |
| SI3612537T1 (sl) | 2017-04-18 | 2022-10-28 | Medimmune Limited | Konjugati pirolobenzodiazepina |
| WO2018193102A1 (en) | 2017-04-20 | 2018-10-25 | Adc Therapeutics Sa | Combination therapy with an anti-axl antibody-drug conjugate |
| JP7145891B2 (ja) | 2017-06-14 | 2022-10-03 | アーデーセー セラピューティクス ソシエテ アノニム | 抗cd19 adcを投与するための投与レジメ |
| BR112020003003A2 (pt) | 2017-08-18 | 2020-08-11 | Medimmune Limited | conjugados de pirrolobenzodiazepina |
| AU2018337815A1 (en) | 2017-09-20 | 2020-03-12 | Ph Pharma Co., Ltd. | Thailanstatin analogs |
| GB201803342D0 (en) | 2018-03-01 | 2018-04-18 | Medimmune Ltd | Methods |
| GB201806022D0 (en) | 2018-04-12 | 2018-05-30 | Medimmune Ltd | Pyrrolobenzodiazepines and conjugates thereof |
| GB201814281D0 (en) | 2018-09-03 | 2018-10-17 | Femtogenix Ltd | Cytotoxic agents |
| WO2020086858A1 (en) | 2018-10-24 | 2020-04-30 | Genentech, Inc. | Conjugated chemical inducers of degradation and methods of use |
| EP3894427A1 (de) | 2018-12-10 | 2021-10-20 | Genentech, Inc. | Photovernetzende peptide zur stellenspezifischen konjugation an fc-haltige proteine |
| GB201901197D0 (en) | 2019-01-29 | 2019-03-20 | Femtogenix Ltd | G-A Crosslinking cytotoxic agents |
| MX2021010477A (es) | 2019-03-15 | 2021-10-01 | Medimmune Ltd | Dimeros de azetidobenzodiazepina y conjugados que los comprenden para uso en el tratamiento de cancer. |
| GB2597532A (en) | 2020-07-28 | 2022-02-02 | Femtogenix Ltd | Cytotoxic compounds |
| WO2022078524A2 (en) | 2021-11-03 | 2022-04-21 | Hangzhou Dac Biotech Co., Ltd. | Specific conjugation of an antibody |
| JP2026502860A (ja) | 2022-12-23 | 2026-01-27 | ジェネンテック, インコーポレイテッド | セレブロン分解剤コンジュゲートおよびその使用 |
| CN121263210A (zh) | 2023-04-17 | 2026-01-02 | 沛科生物公司 | 抗体和抗体-药物偶联物以及使用方法和合成工艺及中间体 |
| WO2026006689A2 (en) | 2024-06-28 | 2026-01-02 | Firefly Bio, Inc. | Bcl-xl degrader antibody conjugates and uses thereof |
| WO2026006688A2 (en) | 2024-06-28 | 2026-01-02 | Firefly Bio, Inc. | Degrader antibody conjugates and uses thereof |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH05268957A (ja) | 1992-03-27 | 1993-10-19 | Bio Material Kenkyusho:Kk | ラット多機能プロテアーゼ構成因子およびそのdna |
| JP3125235B2 (ja) | 1992-04-22 | 2001-01-15 | 株式会社バイオマテリアル研究所 | ヒト26sプロテアソーム |
| JPH05317059A (ja) | 1992-05-22 | 1993-12-03 | Bio Material Kenkyusho:Kk | ラットプロテアソームのコンポーネントおよび そのdna |
| US5470577A (en) * | 1993-07-07 | 1995-11-28 | Trustees Of Boston University | Stimulation of tanning by DNA fragments or single-stranded DNA |
| WO1996036709A1 (en) * | 1995-05-19 | 1996-11-21 | Human Genome Sciences, Inc. | Transforming growth factor alpha hii |
| US5863779A (en) * | 1997-08-21 | 1999-01-26 | Incyte Pharmaceuticals, Inc. | UBC7-like ubiquitin-conjugating enzyme |
| EP1594889B1 (de) * | 2003-02-07 | 2011-04-06 | The Regents of The University of California | Nell-peptidexpressionssysteme und knochenbildende aktivität des nell-peptids |
-
1997
- 1997-03-05 JP JP06916397A patent/JP3646191B2/ja not_active Expired - Fee Related
- 1997-03-19 EP EP97104842A patent/EP0796913A3/de not_active Ceased
- 1997-03-19 US US08/820,170 patent/US5831058A/en not_active Expired - Lifetime
- 1997-03-19 AT AT02026841T patent/ATE362536T1/de active
- 1997-03-19 CA CA2641565A patent/CA2641565C/en not_active Expired - Fee Related
- 1997-03-19 EP EP10182760A patent/EP2272960A1/de not_active Withdrawn
- 1997-03-19 DK DK02026841T patent/DK1295944T3/da active
- 1997-03-19 ES ES02026841T patent/ES2284770T3/es not_active Expired - Lifetime
- 1997-03-19 DE DE69737740T patent/DE69737740T2/de not_active Expired - Lifetime
- 1997-03-19 EP EP07014998A patent/EP1860189A1/de not_active Withdrawn
- 1997-03-19 EP EP04004141A patent/EP1439230A3/de not_active Withdrawn
- 1997-03-19 EP EP10185775A patent/EP2361982A1/de not_active Withdrawn
- 1997-03-19 EP EP02026841A patent/EP1295944B1/de not_active Expired - Lifetime
- 1997-03-19 CA CA002200371A patent/CA2200371C/en not_active Expired - Fee Related
-
2004
- 2004-02-20 US US10/781,841 patent/US20060134634A1/en not_active Abandoned
-
2006
- 2006-11-07 US US11/593,525 patent/US7674889B2/en not_active Expired - Fee Related
-
2007
- 2007-07-06 US US11/774,330 patent/US7592438B2/en not_active Expired - Fee Related
-
2009
- 2009-07-27 US US12/510,074 patent/US7858754B2/en not_active Expired - Fee Related
-
2010
- 2010-01-19 US US12/689,917 patent/US8048995B2/en not_active Expired - Fee Related
- 2010-12-23 US US12/977,497 patent/US8106171B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2641565A1 (en) | 1997-09-19 |
| CA2200371C (en) | 2007-07-10 |
| US20100160611A1 (en) | 2010-06-24 |
| US8048995B2 (en) | 2011-11-01 |
| ES2284770T3 (es) | 2007-11-16 |
| US7592438B2 (en) | 2009-09-22 |
| EP1295944A3 (de) | 2004-04-21 |
| JPH09308492A (ja) | 1997-12-02 |
| DE69737740D1 (de) | 2007-06-28 |
| EP1860189A1 (de) | 2007-11-28 |
| US7858754B2 (en) | 2010-12-28 |
| EP1295944B1 (de) | 2007-05-16 |
| EP0796913A2 (de) | 1997-09-24 |
| US20100048878A1 (en) | 2010-02-25 |
| US20080032337A1 (en) | 2008-02-07 |
| EP1439230A3 (de) | 2004-09-22 |
| EP2361982A1 (de) | 2011-08-31 |
| US20110105718A1 (en) | 2011-05-05 |
| US5831058A (en) | 1998-11-03 |
| US8106171B2 (en) | 2012-01-31 |
| JP3646191B2 (ja) | 2005-05-11 |
| US20060134634A1 (en) | 2006-06-22 |
| EP0796913A3 (de) | 2001-01-31 |
| DK1295944T3 (da) | 2007-09-17 |
| EP2272960A1 (de) | 2011-01-12 |
| EP1295944A2 (de) | 2003-03-26 |
| DE69737740T2 (de) | 2008-01-31 |
| US7674889B2 (en) | 2010-03-09 |
| CA2641565C (en) | 2012-11-13 |
| US20070111285A1 (en) | 2007-05-17 |
| EP1439230A2 (de) | 2004-07-21 |
| CA2200371A1 (en) | 1997-09-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE362536T1 (de) | Gdp-dissoziation stimulierendes protein, gehirnspezifisches nucleosomfügungsprotein, skelettmuskel-spezifisches ubiquitin- conjugationsenzym, zellproliferationsprotein, phosphatidylinositolkinase, nel verwandte proteine | |
| DE69833784D1 (de) | Polypeptide mit aminopeptidaseaktivität und für diese kodierende nukleinsäuren | |
| ATE432983T1 (de) | Mage-3 peptide, die durch hla-klasse-ii molecule presentiert werden | |
| BG109433A (en) | RET (RetL) Lead for Stimulating Nerve and Rat Growth | |
| ATE310090T1 (de) | Gereinigte coprinus laccasen und nukleinsäuren welche dafür kodieren | |
| DK1005540T3 (da) | IKK-beta-proteiner, nukleinsyrer og fremgangsmåder | |
| TR200700740T2 (tr) | Nogo genlerinin nükleotid ve protein dizileri ve bunlar bazında yöntemler | |
| ATE450603T1 (de) | Polypeptide mit verzweigungsenzym-aktivität und für diese kodierende nukleinsäuren | |
| AU1724795A (en) | Human tissue inhibitor of metalloproteinase-4 | |
| WO1998014596A3 (en) | Disease associated protein tyrosine phosphatases | |
| AU9291198A (en) | Apoptosis-related compounds and their use | |
| EP0947583A3 (de) | Expressionsaktivierende Nukleinsäurefragmente des Melanom-inhibierenden Proteins (MIA) | |
| WO1999027098A3 (en) | A-33 related antigens and their pharmacological uses | |
| DE69837475D1 (de) | Polypeptide mit aminopeptidaseaktivität und dafür kodierende nukleinsäuren | |
| DE69839178D1 (de) | Gene, die für proteine mit transglykolysierungsaktivität kodieren. | |
| Hou et al. | Molecular dissection of a transfer RNA and the basis for its identity | |
| ATE334195T1 (de) | Proteine mit zellulase-aktivitäten und prozess für ihre herstellung | |
| WO2000008157A3 (en) | Human anion transporter genes atnov | |
| EP0261403A3 (de) | Polypeptide des Rhinovirusstammes HRV89 sowie die hierfür codierenden DNA-Moleküle | |
| DE69837265D1 (de) | Polypeptide zur regenerierung des nervensystems | |
| ATE288491T1 (de) | Polypeptide mit 5-aminolevulinsäure synthaseaktivität und deren nukleinsäuren | |
| PT914417E (pt) | Dnase ii humana | |
| Prickril | Physical and biochemical studies of rubrerythrin from Desulfovibrio vulgaris (Hildenborough) | |
| EP1428833A3 (de) | 207 menschliche sekretierte Proteine |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1295944 Country of ref document: EP |