ATE362758T1 - Indomethacin-amidderivate zur antiangiogenen und/oder antitumorigen verwendung - Google Patents
Indomethacin-amidderivate zur antiangiogenen und/oder antitumorigen verwendungInfo
- Publication number
- ATE362758T1 ATE362758T1 AT99967417T AT99967417T ATE362758T1 AT E362758 T1 ATE362758 T1 AT E362758T1 AT 99967417 T AT99967417 T AT 99967417T AT 99967417 T AT99967417 T AT 99967417T AT E362758 T1 ATE362758 T1 AT E362758T1
- Authority
- AT
- Austria
- Prior art keywords
- amide derivatives
- antitumorous
- antiangiogenic
- indomethacin
- indomethacin amide
- Prior art date
Links
- CGIGDMFJXJATDK-UHFFFAOYSA-N Indomethacin Natural products CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 title abstract 3
- 229960000905 indomethacin Drugs 0.000 title abstract 2
- -1 INDOMETHACIN AMIDE Chemical class 0.000 title 1
- 230000001772 anti-angiogenic effect Effects 0.000 title 1
- 230000000259 anti-tumor effect Effects 0.000 title 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 abstract 2
- 241001465754 Metazoa Species 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 abstract 1
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 abstract 1
- 150000003334 secondary amides Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Indole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/226,693 US6207700B1 (en) | 1999-01-07 | 1999-01-07 | Amide derivatives for antiangiogenic and/or antitumorigenic use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE362758T1 true ATE362758T1 (de) | 2007-06-15 |
Family
ID=22850011
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99967417T ATE362758T1 (de) | 1999-01-07 | 1999-12-16 | Indomethacin-amidderivate zur antiangiogenen und/oder antitumorigen verwendung |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US6207700B1 (de) |
| EP (1) | EP1146788B1 (de) |
| JP (1) | JP2002534362A (de) |
| CN (1) | CN1195515C (de) |
| AT (1) | ATE362758T1 (de) |
| AU (1) | AU760555B2 (de) |
| BR (1) | BR9916800A (de) |
| CA (1) | CA2358289C (de) |
| DE (1) | DE69936150T2 (de) |
| ES (1) | ES2288039T3 (de) |
| IL (2) | IL144127A0 (de) |
| WO (1) | WO2000040088A1 (de) |
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| EE200100302A (et) * | 1998-12-02 | 2002-08-15 | Pfizer Products Inc. | Meetodid ja kompositsioonid p53 perekonna valgu konformatsioonilise stabiilsuse taastamiseks |
| EP1307585B1 (de) * | 2000-08-07 | 2009-01-21 | Vanderbilt University | Zusammensetzungen und verfahren zum nachweis und zur quantifizierung von cox-2-aktivität und 2-arachidonylglycerin-metaboliten |
| AR030345A1 (es) * | 2000-08-14 | 2003-08-20 | Alcon Inc | Metodo de tratamiento de desordenes relacionados con angiogenesis |
| EP1313697B1 (de) | 2000-08-29 | 2005-11-30 | Nobex Corporation | Immunoregulierende verbindungen, deren derivate und ihre verwendung |
| WO2002053534A1 (en) * | 2000-12-28 | 2002-07-11 | Daiichi Pharmaceutical Co., Ltd. | Vla-4 inhibitors |
| US8048924B2 (en) * | 2001-08-29 | 2011-11-01 | Biocon Limited | Methods and compositions employing 4-aminophenylacetic acid compounds |
| WO2003073988A2 (en) | 2002-02-28 | 2003-09-12 | A & D Bioscience, Inc. | Glycuronamides, glycosides and orthoester glycosides of fluoxetine, analogs and uses thereof |
| WO2003079980A2 (en) * | 2002-03-19 | 2003-10-02 | A & D Bioscience, Inc. | Caboxylic acid glycuronides, glycosamides and glycosides of quinolones, penicillins, analogs, and uses thereof |
| WO2003086475A1 (en) * | 2002-04-12 | 2003-10-23 | A & D Bioscience, Inc. | Conjugates comprising cancer cell specific ligands, a sugar and diagnostic agents, and uses thereof |
| WO2003094842A2 (en) * | 2002-05-07 | 2003-11-20 | A & D Bioscience, Inc. | Conjugates comprising central nervous system active drug |
| US20050215487A1 (en) * | 2002-06-27 | 2005-09-29 | Holick Michael F | Conjugates comprising an nsaid and a sugar and uses thereof |
| JP2006524239A (ja) * | 2003-03-27 | 2006-10-26 | メルク エンド カムパニー インコーポレーテッド | 高眼圧症を治療するための眼用組成物 |
| WO2005002293A2 (en) * | 2003-06-25 | 2005-01-06 | Vanderbilt University | Cox-2-targeted imaging agents |
| CA2528586A1 (en) | 2003-07-24 | 2005-02-03 | Daiichi Pharmaceutical Co., Ltd. | Cyclohexanecarboxylic acid compound |
| CA2563617A1 (en) * | 2004-04-20 | 2005-11-03 | Rnd Pharmaceuticals | Pharmaceutical compositions and methods of use of lipophilic, silicon-substituted, cyclooxygenase-2 selective non-steroidal anti-inflammatory drugs and derivatives |
| US7491744B2 (en) * | 2004-04-26 | 2009-02-17 | Vanderbilt University | Indoleacetic acid and indenacetic acid derivatives as therapeutic agents with reduced gastrointestinal toxicity |
| JP2005343802A (ja) * | 2004-05-31 | 2005-12-15 | Norifumi Sakayama | 非ステロイド性消炎鎮痛剤の外用剤を用いた癌細胞の増殖を抑制する方法 |
| EP1773767B1 (de) | 2004-07-07 | 2016-03-09 | Biocon Limited | Synthese von azogebundenen, das immunsystem regulierenden verbindungen |
| AU2006204523A1 (en) * | 2005-01-04 | 2006-07-13 | Novartis Ag | X-ray structure of human FPPS and use for selecting FPPS binding compounds |
| WO2007005941A2 (en) | 2005-07-05 | 2007-01-11 | President And Fellows Of Harvard College | Liver targeted conjugates |
| AU2007205208B2 (en) * | 2006-01-04 | 2012-11-01 | Southern Research Institute | Derivatives of sulindac, use thereof and preparation thereof |
| US20070259829A1 (en) * | 2006-03-24 | 2007-11-08 | Maen Abdelrahim | Uses of diphenyl/diphenylamine carboxylic acids |
| US20080261911A1 (en) * | 2006-03-24 | 2008-10-23 | Safe Stephen H | Uses of diphenyl/diphenylamine carboxylic acids |
| EP2040699A4 (de) * | 2006-06-19 | 2013-03-13 | Vanderbilt University Medical Ct | Verfahren und zusammensetzungen für diagnostisches und therapeutisches cox-2-targeting |
| WO2010019549A2 (en) * | 2008-08-12 | 2010-02-18 | Osteogenex Inc | Indoprofen derivatives for promoting bone growth |
| TWI450715B (zh) * | 2010-01-08 | 2014-09-01 | Nat Univ Tsing Hua | 治療癌症的芬布芬衍生物 |
| CN101897718A (zh) * | 2010-07-13 | 2010-12-01 | 山东省医学科学院基础医学研究所 | 一种肿瘤血管生长抑制剂 |
| US20120022116A1 (en) * | 2010-07-20 | 2012-01-26 | Huayun Deng | Compositions and methods for the treatment of pathological condition(s) related to gpr35 and/or gpr35-herg complex |
| US9346803B2 (en) | 2011-10-17 | 2016-05-24 | Vanderbilt University | Indomethacin analogs for the treatment of castrate-resistant prostate cancer |
| EP2623098B1 (de) * | 2012-02-03 | 2016-09-07 | King Saud University | Amid-Aminosäurenester von nichtsteroidalen entzündungshemmenden Arzneimitteln (NSAIDs) als potente Inhibitoren des Krebszellwachstums |
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| AT290523B (de) | 1962-01-05 | 1971-06-11 | Merck & Co Inc | Verfahren zur Herstellung neuer α-(3-Indolyl)-carbonsäuren |
| US3336194A (en) | 1963-04-30 | 1967-08-15 | Merck & Co Inc | Indolyl acid amides |
| US3285908A (en) | 1963-04-30 | 1966-11-15 | Merck & Co Inc | Indolyl acid amides |
| US3654349A (en) | 1970-05-01 | 1972-04-04 | Merck & Co Inc | Substituted indenyl acetic acids |
| US3725548A (en) | 1970-05-01 | 1973-04-03 | Merck & Co Inc | Substituted indenyl acetic acids in the treatment of pain, fever or inflammation |
| FR2392008A1 (fr) | 1977-05-02 | 1978-12-22 | Fabre Sa Pierre | Nouvelles formes modulees de medicaments utilisant les n-hydroxy alcoyl pyridine carboxamides comme vecteurs |
| DE2735537A1 (de) | 1977-08-06 | 1979-02-22 | Troponwerke Gmbh & Co Kg | Indolacetoxyacetylaminosaeurederivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| JPS5490174A (en) | 1977-12-27 | 1979-07-17 | Kanebo Ltd | Novel indomethacin derivatives and their preparation |
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| US4412994A (en) | 1980-04-24 | 1983-11-01 | Interx Research Corporation | Mannich-base hydroxamic acid prodrugs, compositions and use |
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| DE3145465A1 (de) | 1981-11-16 | 1983-05-19 | Krakowskie Zakłady Farmaceutyczne "Polfa", Kraków | Verfahren zur herstellung von n-acylderivaten der tryptamine |
| CA1187488A (en) | 1982-02-02 | 1985-05-21 | Yoichiro Ogawa | Indoleacetic ester derivatives and process for preparing same |
| DE3206885A1 (de) | 1982-02-26 | 1983-09-15 | Troponwerke GmbH & Co KG, 5000 Köln | Indolderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
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| IL67445A (en) | 1982-12-09 | 1985-11-29 | Teva Pharma | Ethoxycarbonyloxy ethyl esters of non-steroidal anti-inflammatory carboxylic acids |
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| JPS63275593A (ja) | 1987-05-08 | 1988-11-14 | Fujirebio Inc | β−アミノエチルリン酸エステル誘導体 |
| US5002935A (en) | 1987-12-30 | 1991-03-26 | University Of Florida | Improvements in redox systems for brain-targeted drug delivery |
| DE68906942T3 (de) | 1988-03-29 | 1999-05-12 | University Of Florida, Gainesville, Fla. | Pharmazeutische Zusammensetzungen für die parenterale Anwendung. |
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-
1999
- 1999-01-07 US US09/226,693 patent/US6207700B1/en not_active Expired - Lifetime
- 1999-12-16 WO PCT/US1999/030220 patent/WO2000040088A1/en not_active Ceased
- 1999-12-16 ES ES99967417T patent/ES2288039T3/es not_active Expired - Lifetime
- 1999-12-16 AU AU23698/00A patent/AU760555B2/en not_active Ceased
- 1999-12-16 DE DE69936150T patent/DE69936150T2/de not_active Expired - Lifetime
- 1999-12-16 AT AT99967417T patent/ATE362758T1/de not_active IP Right Cessation
- 1999-12-16 EP EP99967417A patent/EP1146788B1/de not_active Expired - Lifetime
- 1999-12-16 JP JP2000591862A patent/JP2002534362A/ja active Pending
- 1999-12-16 BR BR9916800-6A patent/BR9916800A/pt not_active Application Discontinuation
- 1999-12-16 CA CA002358289A patent/CA2358289C/en not_active Expired - Fee Related
- 1999-12-16 IL IL14412799A patent/IL144127A0/xx active IP Right Grant
- 1999-12-16 CN CNB998164259A patent/CN1195515C/zh not_active Expired - Fee Related
-
2001
- 2001-03-27 US US09/818,201 patent/US6399647B2/en not_active Expired - Fee Related
- 2001-07-03 IL IL144127A patent/IL144127A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| US6207700B1 (en) | 2001-03-27 |
| EP1146788A1 (de) | 2001-10-24 |
| EP1146788B1 (de) | 2007-05-23 |
| DE69936150D1 (de) | 2007-07-05 |
| DE69936150T2 (de) | 2008-01-31 |
| AU760555B2 (en) | 2003-05-15 |
| CA2358289C (en) | 2009-12-08 |
| CN1195515C (zh) | 2005-04-06 |
| IL144127A0 (en) | 2002-05-23 |
| IL144127A (en) | 2006-12-10 |
| US6399647B2 (en) | 2002-06-04 |
| CA2358289A1 (en) | 2000-07-13 |
| EP1146788A4 (de) | 2003-09-10 |
| AU2369800A (en) | 2000-07-24 |
| CN1337850A (zh) | 2002-02-27 |
| BR9916800A (pt) | 2001-10-23 |
| ES2288039T3 (es) | 2007-12-16 |
| JP2002534362A (ja) | 2002-10-15 |
| WO2000040088A1 (en) | 2000-07-13 |
| US20010034361A1 (en) | 2001-10-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |