IL144127A0 - Pharmaceutical compositions containing a carboxylic acid secondary amide derivative - Google Patents
Pharmaceutical compositions containing a carboxylic acid secondary amide derivativeInfo
- Publication number
- IL144127A0 IL144127A0 IL14412799A IL14412799A IL144127A0 IL 144127 A0 IL144127 A0 IL 144127A0 IL 14412799 A IL14412799 A IL 14412799A IL 14412799 A IL14412799 A IL 14412799A IL 144127 A0 IL144127 A0 IL 144127A0
- Authority
- IL
- Israel
- Prior art keywords
- carboxylic acid
- pharmaceutical compositions
- compositions containing
- secondary amide
- amide derivative
- Prior art date
Links
- -1 carboxylic acid secondary amide Chemical class 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 abstract 2
- 125000000896 monocarboxylic acid group Chemical group 0.000 abstract 2
- 241001465754 Metazoa Species 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229960000905 indomethacin Drugs 0.000 abstract 1
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 abstract 1
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 abstract 1
- 150000003334 secondary amides Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Indole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/226,693 US6207700B1 (en) | 1999-01-07 | 1999-01-07 | Amide derivatives for antiangiogenic and/or antitumorigenic use |
| PCT/US1999/030220 WO2000040088A1 (en) | 1999-01-07 | 1999-12-16 | Amide derivatives for antiangiogenic and/or antitumorigenic use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL144127A0 true IL144127A0 (en) | 2002-05-23 |
Family
ID=22850011
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL14412799A IL144127A0 (en) | 1999-01-07 | 1999-12-16 | Pharmaceutical compositions containing a carboxylic acid secondary amide derivative |
| IL144127A IL144127A (en) | 1999-01-07 | 2001-07-03 | Pharmaceutical preparations containing a secondary rich history of carboxylic acid |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL144127A IL144127A (en) | 1999-01-07 | 2001-07-03 | Pharmaceutical preparations containing a secondary rich history of carboxylic acid |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US6207700B1 (de) |
| EP (1) | EP1146788B1 (de) |
| JP (1) | JP2002534362A (de) |
| CN (1) | CN1195515C (de) |
| AT (1) | ATE362758T1 (de) |
| AU (1) | AU760555B2 (de) |
| BR (1) | BR9916800A (de) |
| CA (1) | CA2358289C (de) |
| DE (1) | DE69936150T2 (de) |
| ES (1) | ES2288039T3 (de) |
| IL (2) | IL144127A0 (de) |
| WO (1) | WO2000040088A1 (de) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU1290700A (en) * | 1998-12-02 | 2000-06-19 | Pfizer Products Inc. | Methods and compositions for restoring conformational stability of a protein of the p53 family |
| ATE420201T1 (de) * | 2000-08-07 | 2009-01-15 | Univ Vanderbilt | Nachweis der cox-2 aktivität und von anandamid- metaboliten |
| AR030345A1 (es) * | 2000-08-14 | 2003-08-20 | Alcon Inc | Metodo de tratamiento de desordenes relacionados con angiogenesis |
| WO2002018324A2 (en) | 2000-08-29 | 2002-03-07 | Nobex Corporation | Immunoregulatory compounds, derivatives thereof and their use |
| US7157487B2 (en) * | 2000-12-28 | 2007-01-02 | Daiichi Pharmaceutical Co., Ltd. | Vla-4 inhibitors |
| US8048924B2 (en) * | 2001-08-29 | 2011-11-01 | Biocon Limited | Methods and compositions employing 4-aminophenylacetic acid compounds |
| AU2003217791A1 (en) | 2002-02-28 | 2003-09-16 | A And D Bioscience, Inc. | Glycuronamides, glycosides and orthoester glycosides of fluoxetine, analogs and uses thereof |
| WO2003079980A2 (en) * | 2002-03-19 | 2003-10-02 | A & D Bioscience, Inc. | Caboxylic acid glycuronides, glycosamides and glycosides of quinolones, penicillins, analogs, and uses thereof |
| US20050255038A1 (en) * | 2002-04-12 | 2005-11-17 | A And D Bioscience, Inc. | Conjugates comprising cancer cell specific ligands, a sugar and diagnostic agents and uses thereof |
| WO2003094842A2 (en) * | 2002-05-07 | 2003-11-20 | A & D Bioscience, Inc. | Conjugates comprising central nervous system active drug |
| US20050215487A1 (en) * | 2002-06-27 | 2005-09-29 | Holick Michael F | Conjugates comprising an nsaid and a sugar and uses thereof |
| US7414067B2 (en) | 2003-03-27 | 2008-08-19 | Merck & Co. Inc. | Ophthalmic compositions for treating ocular hypertension |
| US20050002859A1 (en) * | 2003-06-25 | 2005-01-06 | Vanderbilt University | COX-2-targeted imaging agents |
| EP1650205B1 (de) | 2003-07-24 | 2012-04-25 | Daiichi Sankyo Company, Limited | Cyclohexancarbonsäureverbindung |
| CA2563617A1 (en) * | 2004-04-20 | 2005-11-03 | Rnd Pharmaceuticals | Pharmaceutical compositions and methods of use of lipophilic, silicon-substituted, cyclooxygenase-2 selective non-steroidal anti-inflammatory drugs and derivatives |
| EP1744747A4 (de) * | 2004-04-26 | 2009-12-02 | Univ Vanderbilt | Indolessigsäure und indolessigsäurederivate als therapeutische wirkstoffe mit verminderter gastrointestinaler toxizität |
| JP2005343802A (ja) * | 2004-05-31 | 2005-12-15 | Norifumi Sakayama | 非ステロイド性消炎鎮痛剤の外用剤を用いた癌細胞の増殖を抑制する方法 |
| DK1773767T3 (en) | 2004-07-07 | 2016-03-21 | Biocon Ltd | Synthesis of azo bound in immune regulatory relations |
| BRPI0606515A2 (pt) * | 2005-01-04 | 2009-06-30 | Novartis Ag | estrutura de raios x de fpps humana e uso para selecionar compostos de ligação de fpps |
| US20090162316A1 (en) * | 2005-07-05 | 2009-06-25 | Harvard University | Liver targeted conjugates |
| US8044048B2 (en) * | 2006-01-04 | 2011-10-25 | Southern Research Institute | Derivatives of sulindac, use thereof and preparation thereof |
| US20080261911A1 (en) * | 2006-03-24 | 2008-10-23 | Safe Stephen H | Uses of diphenyl/diphenylamine carboxylic acids |
| WO2007112098A2 (en) * | 2006-03-24 | 2007-10-04 | The Texas A & M University System And Safe Et Al | Uses of diphenyl/diphenylamine carboxylic acids |
| US7736624B2 (en) * | 2006-06-19 | 2010-06-15 | Univ Vanderbilt | Methods and compositions for diagnostic and therapeutic targeting of COX-2 |
| WO2010019549A2 (en) * | 2008-08-12 | 2010-02-18 | Osteogenex Inc | Indoprofen derivatives for promoting bone growth |
| TWI450715B (zh) * | 2010-01-08 | 2014-09-01 | Nat Univ Tsing Hua | 治療癌症的芬布芬衍生物 |
| CN101897718A (zh) * | 2010-07-13 | 2010-12-01 | 山东省医学科学院基础医学研究所 | 一种肿瘤血管生长抑制剂 |
| US20120022116A1 (en) * | 2010-07-20 | 2012-01-26 | Huayun Deng | Compositions and methods for the treatment of pathological condition(s) related to gpr35 and/or gpr35-herg complex |
| WO2013059245A1 (en) | 2011-10-17 | 2013-04-25 | Vanderbilt University | Indomethacin analogs for the treatment of castrate-resistant prostate cancer |
| EP2623098B1 (de) * | 2012-02-03 | 2016-09-07 | King Saud University | Amid-Aminosäurenester von nichtsteroidalen entzündungshemmenden Arzneimitteln (NSAIDs) als potente Inhibitoren des Krebszellwachstums |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT290523B (de) | 1962-01-05 | 1971-06-11 | Merck & Co Inc | Verfahren zur Herstellung neuer α-(3-Indolyl)-carbonsäuren |
| US3285908A (en) | 1963-04-30 | 1966-11-15 | Merck & Co Inc | Indolyl acid amides |
| US3336194A (en) | 1963-04-30 | 1967-08-15 | Merck & Co Inc | Indolyl acid amides |
| US3654349A (en) | 1970-05-01 | 1972-04-04 | Merck & Co Inc | Substituted indenyl acetic acids |
| US3725548A (en) | 1970-05-01 | 1973-04-03 | Merck & Co Inc | Substituted indenyl acetic acids in the treatment of pain, fever or inflammation |
| FR2392008A1 (fr) | 1977-05-02 | 1978-12-22 | Fabre Sa Pierre | Nouvelles formes modulees de medicaments utilisant les n-hydroxy alcoyl pyridine carboxamides comme vecteurs |
| DE2735537A1 (de) | 1977-08-06 | 1979-02-22 | Troponwerke Gmbh & Co Kg | Indolacetoxyacetylaminosaeurederivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| JPS5490174A (en) | 1977-12-27 | 1979-07-17 | Kanebo Ltd | Novel indomethacin derivatives and their preparation |
| US4229447A (en) | 1979-06-04 | 1980-10-21 | American Home Products Corporation | Intraoral methods of using benzodiazepines |
| DE2926472A1 (de) | 1979-06-30 | 1981-01-15 | Thomae Gmbh Dr K | Neue benzoylderivate, deren herstellung und deren verwendung als arzneimittel |
| US4412994A (en) | 1980-04-24 | 1983-11-01 | Interx Research Corporation | Mannich-base hydroxamic acid prodrugs, compositions and use |
| US4381307A (en) | 1980-10-31 | 1983-04-26 | Merck & Co., Inc. | Soft tertiary amine esters of bio-affecting carboxylic acids |
| PL131389B1 (en) | 1980-11-13 | 1984-11-30 | Krakowskie Zaklady Pharma | Method of obtaining n-acyl derivatives of triptamines |
| DE3145465A1 (de) | 1981-11-16 | 1983-05-19 | Krakowskie Zakłady Farmaceutyczne "Polfa", Kraków | Verfahren zur herstellung von n-acylderivaten der tryptamine |
| CA1187488A (en) | 1982-02-02 | 1985-05-21 | Yoichiro Ogawa | Indoleacetic ester derivatives and process for preparing same |
| DE3206885A1 (de) | 1982-02-26 | 1983-09-15 | Troponwerke GmbH & Co KG, 5000 Köln | Indolderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| JPS58201763A (ja) | 1982-05-17 | 1983-11-24 | Kowa Co | インド−ルアセトキシ酢酸エステル |
| IL67445A (en) | 1982-12-09 | 1985-11-29 | Teva Pharma | Ethoxycarbonyloxy ethyl esters of non-steroidal anti-inflammatory carboxylic acids |
| JPS59161358A (ja) | 1983-03-04 | 1984-09-12 | Ss Pharmaceut Co Ltd | 新規なインド−ル酢酸エステル誘導体及びその製造法 |
| JPS60112760A (ja) | 1983-11-18 | 1985-06-19 | Green Cross Corp:The | インド−ル酢酸誘導体及びその脂肪乳剤 |
| JPS60214768A (ja) * | 1984-04-07 | 1985-10-28 | Fujisawa Pharmaceut Co Ltd | オリゴペプチド化合物 |
| JPS6160649A (ja) | 1984-08-31 | 1986-03-28 | Ss Pharmaceut Co Ltd | 新規なエステル誘導体及びその製造法 |
| US5016652A (en) | 1985-04-25 | 1991-05-21 | The Regents Of The University Of California | Method and apparatus for aiding in the reduction of incidence of tobacco smoking |
| JPS63196598A (ja) | 1987-02-09 | 1988-08-15 | Ss Pharmaceut Co Ltd | 新規なプレドニゾロンエステル誘導体 |
| JPS63275593A (ja) | 1987-05-08 | 1988-11-14 | Fujirebio Inc | β−アミノエチルリン酸エステル誘導体 |
| US5002935A (en) | 1987-12-30 | 1991-03-26 | University Of Florida | Improvements in redox systems for brain-targeted drug delivery |
| EP0335545B2 (de) | 1988-03-29 | 1998-09-23 | University Of Florida | Pharmazeutische Zusammensetzungen für die parenterale Anwendung |
| DE3811120A1 (de) | 1988-03-31 | 1989-10-12 | Merckle Gmbh | Neopentylesterderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| US4943587A (en) | 1988-05-19 | 1990-07-24 | Warner-Lambert Company | Hydroxamate derivatives of selected nonsteroidal antiinflammatory acyl residues and their use for cyclooxygenase and 5-lipoxygenase inhibition |
| US5504086A (en) | 1989-10-17 | 1996-04-02 | Ellinwood, Jr.; Everett H. | Intraoral dosing method of administering trifluorobenzodiazepines, propoxyphene, and nefazodone |
| US5032588A (en) | 1989-12-08 | 1991-07-16 | Abbott Laboratories | Thiazole lipoxygenase-inhibiting compounds derived from non-steroidal antiinflammatory carboxylic acids |
| US5681964A (en) | 1990-10-23 | 1997-10-28 | University Of Kentucky Research Foundation | Permeable, non-irritating prodrugs of nonsteroidal and steroidal agents |
| GB9200114D0 (en) * | 1992-01-04 | 1992-02-26 | Scras | Dual inhibitors of no synthase and cyclooxygenase |
| US6048850A (en) | 1992-09-22 | 2000-04-11 | Young; Donald A. | Method of inhibiting prostaglandin synthesis in a human host |
| US5436265A (en) | 1993-11-12 | 1995-07-25 | Merck Frosst Canada, Inc. | 1-aroyl-3-indolyl alkanoic acids and derivatives thereof useful as anti-inflammatory agents |
| CA2167818A1 (en) | 1993-08-02 | 1995-02-09 | Robert George Whittaker | Therapeutic compound - fatty acid conjugates |
| PT740650E (pt) | 1994-01-28 | 2004-10-29 | Univ Kentucky Res Found | Co-farmacos como um metodo de administracao controlada de farmacos |
| DK0746544T3 (da) * | 1994-02-22 | 1999-06-07 | Merrell Pharma Inc | Indolderivater til behandling af østrogenafhængige neoplasmer og sygdomme |
| US5643943A (en) | 1994-12-23 | 1997-07-01 | Alcon Laboratories, Inc. | Systemic administration of esters and amides of antioxidants which may be used as antioxidant prodrug therapy for oxidative and inflammatory pathogenesis |
| US5607966A (en) | 1994-12-23 | 1997-03-04 | Alcon Laboratories, Inc. | Esters and amides of non-steroidal anti-inflammatory carboxylic acids which may be used as anti-oxidants, 5-lipoxygenase inhibitors and non-steroidal anti-inflammatory prodrugs |
| US5510368A (en) * | 1995-05-22 | 1996-04-23 | Merck Frosst Canada, Inc. | N-benzyl-3-indoleacetic acids as antiinflammatory drugs |
| GB2321455A (en) * | 1997-01-24 | 1998-07-29 | Norsk Hydro As | Lipophilic derivatives of biologically active compounds |
-
1999
- 1999-01-07 US US09/226,693 patent/US6207700B1/en not_active Expired - Lifetime
- 1999-12-16 EP EP99967417A patent/EP1146788B1/de not_active Expired - Lifetime
- 1999-12-16 AU AU23698/00A patent/AU760555B2/en not_active Ceased
- 1999-12-16 AT AT99967417T patent/ATE362758T1/de not_active IP Right Cessation
- 1999-12-16 DE DE69936150T patent/DE69936150T2/de not_active Expired - Lifetime
- 1999-12-16 ES ES99967417T patent/ES2288039T3/es not_active Expired - Lifetime
- 1999-12-16 JP JP2000591862A patent/JP2002534362A/ja active Pending
- 1999-12-16 CA CA002358289A patent/CA2358289C/en not_active Expired - Fee Related
- 1999-12-16 BR BR9916800-6A patent/BR9916800A/pt not_active Application Discontinuation
- 1999-12-16 CN CNB998164259A patent/CN1195515C/zh not_active Expired - Fee Related
- 1999-12-16 WO PCT/US1999/030220 patent/WO2000040088A1/en not_active Ceased
- 1999-12-16 IL IL14412799A patent/IL144127A0/xx active IP Right Grant
-
2001
- 2001-03-27 US US09/818,201 patent/US6399647B2/en not_active Expired - Fee Related
- 2001-07-03 IL IL144127A patent/IL144127A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2358289A1 (en) | 2000-07-13 |
| WO2000040088A1 (en) | 2000-07-13 |
| EP1146788A1 (de) | 2001-10-24 |
| US6207700B1 (en) | 2001-03-27 |
| CN1337850A (zh) | 2002-02-27 |
| DE69936150T2 (de) | 2008-01-31 |
| BR9916800A (pt) | 2001-10-23 |
| AU760555B2 (en) | 2003-05-15 |
| IL144127A (en) | 2006-12-10 |
| ES2288039T3 (es) | 2007-12-16 |
| DE69936150D1 (de) | 2007-07-05 |
| EP1146788B1 (de) | 2007-05-23 |
| US6399647B2 (en) | 2002-06-04 |
| US20010034361A1 (en) | 2001-10-25 |
| CN1195515C (zh) | 2005-04-06 |
| AU2369800A (en) | 2000-07-24 |
| JP2002534362A (ja) | 2002-10-15 |
| ATE362758T1 (de) | 2007-06-15 |
| EP1146788A4 (de) | 2003-09-10 |
| CA2358289C (en) | 2009-12-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed |