ATE363292T1 - Hydrogelzusammensetzungen mit kontrollierter freigabe von wachstumsfaktoren - Google Patents
Hydrogelzusammensetzungen mit kontrollierter freigabe von wachstumsfaktorenInfo
- Publication number
- ATE363292T1 ATE363292T1 AT99946759T AT99946759T ATE363292T1 AT E363292 T1 ATE363292 T1 AT E363292T1 AT 99946759 T AT99946759 T AT 99946759T AT 99946759 T AT99946759 T AT 99946759T AT E363292 T1 ATE363292 T1 AT E363292T1
- Authority
- AT
- Austria
- Prior art keywords
- controlled release
- growth factors
- hydrogel compositions
- compositions
- physiologically acceptable
- Prior art date
Links
- 239000003102 growth factor Substances 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 3
- 238000013270 controlled release Methods 0.000 title abstract 2
- 239000000017 hydrogel Substances 0.000 title abstract 2
- 229920001184 polypeptide Polymers 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 229920006318 anionic polymer Polymers 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1825—Fibroblast growth factor [FGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1858—Platelet-derived growth factor [PDGF]
- A61K38/1866—Vascular endothelial growth factor [VEGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Inorganic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dermatology (AREA)
- Vascular Medicine (AREA)
- Organic Chemistry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Urology & Nephrology (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9916898P | 1998-09-04 | 1998-09-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE363292T1 true ATE363292T1 (de) | 2007-06-15 |
Family
ID=22273280
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99946759T ATE363292T1 (de) | 1998-09-04 | 1999-09-03 | Hydrogelzusammensetzungen mit kontrollierter freigabe von wachstumsfaktoren |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US6331309B1 (de) |
| EP (1) | EP1107791B8 (de) |
| JP (2) | JP2002524425A (de) |
| AT (1) | ATE363292T1 (de) |
| AU (1) | AU758178B2 (de) |
| CA (1) | CA2341410C (de) |
| CY (1) | CY1107704T1 (de) |
| DE (1) | DE69936212T2 (de) |
| DK (1) | DK1107791T3 (de) |
| ES (1) | ES2288024T3 (de) |
| IL (2) | IL141688A0 (de) |
| PT (1) | PT1107791E (de) |
| WO (1) | WO2000013710A2 (de) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2255257T3 (es) * | 1999-04-22 | 2006-06-16 | Eidgenossische Technische Hochschule (Eth) | Liberacion controlada de factores de crecimiento a partir de matrices que contienen heparina. |
| US20020013261A1 (en) * | 2000-05-18 | 2002-01-31 | Robert Pawliuk | Methods and compositions for promoting angiogenesis using polyethylene glycol (PEG) polymers |
| AR034517A1 (es) * | 2001-06-21 | 2004-02-25 | Astrazeneca Ab | Formulacion farmaceutica |
| US6818613B2 (en) * | 2001-11-07 | 2004-11-16 | Ortho-Mcneil Pharmaceutical, Inc. | Aqueous sustained-release formulations of proteins |
| US7491690B2 (en) | 2001-11-14 | 2009-02-17 | Northwestern University | Self-assembly and mineralization of peptide-amphiphile nanofibers |
| US8608661B1 (en) | 2001-11-30 | 2013-12-17 | Advanced Cardiovascular Systems, Inc. | Method for intravascular delivery of a treatment agent beyond a blood vessel wall |
| JP2003238439A (ja) * | 2002-02-13 | 2003-08-27 | Yasuhiko Tabata | 虚血治療剤 |
| WO2003070749A2 (en) | 2002-02-15 | 2003-08-28 | Northwestern University | Self-assembly of peptide-amphiphile nanofibers under physiological conditions |
| US20030203032A1 (en) * | 2002-04-25 | 2003-10-30 | Schultz Clyde L. | Growth factor delivery system for the healing of wounds and the prevention of inflammation and disease |
| AU2003222668A1 (en) * | 2002-04-25 | 2003-11-10 | Rapidheal, Inc. | Growth factor delivery system for the healing of wounds and the prevention of inflammation and disease |
| SE0201659D0 (sv) | 2002-05-31 | 2002-05-31 | Astrazeneca Ab | Modified release pharmaceutical formulation |
| SE0201661D0 (sv) | 2002-05-31 | 2002-05-31 | Astrazeneca Ab | New salts |
| US7361368B2 (en) | 2002-06-28 | 2008-04-22 | Advanced Cardiovascular Systems, Inc. | Device and method for combining a treatment agent and a gel |
| AU2003262760A1 (en) | 2002-08-21 | 2004-03-11 | Northwestern University | Charged peptide-amphiphile solutions and self-assembled peptide nanofiber networks formed therefrom |
| JP2004115413A (ja) * | 2002-09-25 | 2004-04-15 | Yasuhiko Tabata | 冠状動脈狭窄または閉塞治療用徐放性製剤 |
| US7554021B2 (en) | 2002-11-12 | 2009-06-30 | Northwestern University | Composition and method for self-assembly and mineralization of peptide amphiphiles |
| AU2003298647A1 (en) | 2002-11-14 | 2004-06-15 | Claussen, Randal, C. | Synthesis and self-assembly of abc triblock bola peptide |
| EP1606065A4 (de) | 2003-02-11 | 2010-09-29 | Univ Northwestern | Verfahren und materialien für nanokristalline oberflächenbeschichtungen und befestigung von amphiphilen peptid-nanofasern daran |
| US20050255144A1 (en) * | 2003-04-09 | 2005-11-17 | Directcontact Llc | Methods and articles for the delivery of medicaments to the eye for the treatment of posterior segment diseases |
| US20050074497A1 (en) * | 2003-04-09 | 2005-04-07 | Schultz Clyde L. | Hydrogels used to deliver medicaments to the eye for the treatment of posterior segment diseases |
| US9216106B2 (en) | 2003-04-09 | 2015-12-22 | Directcontact Llc | Device and method for the delivery of drugs for the treatment of posterior segment disease |
| US8038991B1 (en) | 2003-04-15 | 2011-10-18 | Abbott Cardiovascular Systems Inc. | High-viscosity hyaluronic acid compositions to treat myocardial conditions |
| US8821473B2 (en) | 2003-04-15 | 2014-09-02 | Abbott Cardiovascular Systems Inc. | Methods and compositions to treat myocardial conditions |
| US8383158B2 (en) | 2003-04-15 | 2013-02-26 | Abbott Cardiovascular Systems Inc. | Methods and compositions to treat myocardial conditions |
| EP1696944A4 (de) | 2003-12-05 | 2008-11-05 | Univ Northwestern | Verzweigte peptid-amphiphile, verwandte epitope verbindungen und selbst zusammengesetzte strukturen davon |
| US7544661B2 (en) | 2003-12-05 | 2009-06-09 | Northwestern University | Self-assembling peptide amphiphiles and related methods for growth factor delivery |
| MX2007006214A (es) * | 2004-11-24 | 2008-04-16 | Therakine Ltd | Un implante para suministro de farmaco intraocular. |
| WO2006096614A2 (en) | 2005-03-04 | 2006-09-14 | Northwestern University | Angiogenic heparin binding peptide amphiphiles |
| US9539410B2 (en) | 2005-04-19 | 2017-01-10 | Abbott Cardiovascular Systems Inc. | Methods and compositions for treating post-cardial infarction damage |
| US8828433B2 (en) | 2005-04-19 | 2014-09-09 | Advanced Cardiovascular Systems, Inc. | Hydrogel bioscaffoldings and biomedical device coatings |
| US20080125745A1 (en) | 2005-04-19 | 2008-05-29 | Shubhayu Basu | Methods and compositions for treating post-cardial infarction damage |
| US7732190B2 (en) | 2006-07-31 | 2010-06-08 | Advanced Cardiovascular Systems, Inc. | Modified two-component gelation systems, methods of use and methods of manufacture |
| US9242005B1 (en) | 2006-08-21 | 2016-01-26 | Abbott Cardiovascular Systems Inc. | Pro-healing agent formulation compositions, methods and treatments |
| US8741326B2 (en) | 2006-11-17 | 2014-06-03 | Abbott Cardiovascular Systems Inc. | Modified two-component gelation systems, methods of use and methods of manufacture |
| US9005672B2 (en) | 2006-11-17 | 2015-04-14 | Abbott Cardiovascular Systems Inc. | Methods of modifying myocardial infarction expansion |
| US8192760B2 (en) | 2006-12-04 | 2012-06-05 | Abbott Cardiovascular Systems Inc. | Methods and compositions for treating tissue using silk proteins |
| US8076295B2 (en) | 2007-04-17 | 2011-12-13 | Nanotope, Inc. | Peptide amphiphiles having improved solubility and methods of using same |
| US11969501B2 (en) | 2008-04-21 | 2024-04-30 | Dompé Farmaceutici S.P.A. | Auris formulations for treating otic diseases and conditions |
| EP2278999B1 (de) | 2008-04-21 | 2025-01-29 | Dompé farmaceutici S.p.A. | Ohrbehandlungsformulierungen zur behandlung von ohrenerkrankungen und -leiden |
| US8496957B2 (en) | 2008-07-21 | 2013-07-30 | Otonomy, Inc | Controlled release auris sensory cell modulator compositions and methods for the treatment of otic disorders |
| US9248159B2 (en) | 2008-10-14 | 2016-02-02 | Robert Stanley Berman | MRSA bactericidal topical gel |
| KR101101321B1 (ko) * | 2008-11-03 | 2012-01-02 | 주식회사 엠씨티티 | 상처 치유를 위한 하이드로 겔 형태의 세포전달용 비히클 및 그 제조방법 |
| KR101163171B1 (ko) * | 2009-01-20 | 2012-07-19 | (주)케어젠 | 노긴?유래 펩타이드 및 그의 용도 |
| MX2011010780A (es) | 2009-04-13 | 2011-10-28 | Univ Northwestern | Andamios novedosos basados en peptido para la regeneracion de cartilagos y metodos para su uso. |
| WO2014145016A2 (en) | 2013-03-15 | 2014-09-18 | Genentech, Inc. | Il-22 polypeptides and il-22 fc fusion proteins and methods of use |
| EP3079668A1 (de) | 2013-12-09 | 2016-10-19 | Durect Corporation | Pharmazeutisch aktive wirkstoffkomplexe, polymerkomplexe und zusammensetzungen und verfahren damit |
| CN108025017A (zh) * | 2015-09-22 | 2018-05-11 | 米拉根医疗股份有限公司 | MiR-19调节剂及其用途 |
| CA3007084A1 (en) * | 2015-12-04 | 2017-07-06 | President And Fellows Of Harvard College | Devices, methods, and compositions for restricting cell position and stabilizing cells in culture systems |
| CR20200327A (es) | 2018-01-26 | 2020-11-05 | Genentech Inc | Proteínas de fusión fc il-22 y métodos de uso |
| CN112020365A (zh) | 2018-01-26 | 2020-12-01 | 豪夫迈·罗氏有限公司 | 组合物和使用方法 |
| KR20200123118A (ko) | 2018-02-21 | 2020-10-28 | 제넨테크, 인크. | IL-22 Fc 융합 단백질로 치료를 위한 투약 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4100271A (en) | 1976-02-26 | 1978-07-11 | Cooper Laboratories, Inc. | Clear, water-miscible, liquid pharmaceutical vehicles and compositions which gel at body temperature for drug delivery to mucous membranes |
| NZ226171A (en) * | 1987-09-18 | 1990-06-26 | Ethicon Inc | Gel formulation containing polypeptide growth factor |
| US5705485A (en) | 1987-09-18 | 1998-01-06 | Ethicon, Inc. | Gel formulations containing growth factors |
| US5457093A (en) | 1987-09-18 | 1995-10-10 | Ethicon, Inc. | Gel formulations containing growth factors |
| US5100668A (en) * | 1988-06-14 | 1992-03-31 | Massachusetts Institute Of Technology | Controlled release systems containing heparin and growth factors |
| US5013769A (en) * | 1988-08-22 | 1991-05-07 | Medipro Sciences Limited | Method of making a hydrogel-forming wound dressing or skin coating material |
| US5470829A (en) | 1988-11-17 | 1995-11-28 | Prisell; Per | Pharmaceutical preparation |
| FR2644066B1 (fr) * | 1989-03-09 | 1994-05-13 | Therapeutiques Substitutives | Compositions stabilisees comprenant des fgfs, leur procede d'obtention et leurs applications therapeutiques, chirurgicales et cosmetologiques |
| US5271943A (en) * | 1989-10-27 | 1993-12-21 | Scott Health Care | Wound gel compositions containing sodium chloride and method of using them |
| US5591709A (en) * | 1991-08-30 | 1997-01-07 | Life Medical Sciences, Inc. | Compositions and methods for treating wounds |
| EP0551626A1 (de) * | 1991-12-19 | 1993-07-21 | LEK, tovarna farmacevtskih in kemicnih izdelkov, d.d. | Thermoreversible Gel als pharmazeutische Grundmasse für eine galenische Form |
| US5952006A (en) * | 1995-09-29 | 1999-09-14 | L.A.M. Pharmaceuticals, Llc | Drug preparations for treating impotency |
| FR2740678B1 (fr) * | 1995-11-06 | 1999-05-14 | Oreal | Utilisation en cosmetique d'une composition solide ayant une matrice gelifiee et compositions cosmetiques ou dermatologiques mises en oeuvre |
| DE69735622T2 (de) * | 1996-08-16 | 2007-04-12 | MCW Research Foundation, Inc., Milwaukee | Knochen morphogenetisches protein und fibroblasten wachstumsfaktor enthaltende zusammensetzungen und methoden zur induzierung der kardiogenese |
| US6103266A (en) * | 1998-04-22 | 2000-08-15 | Tapolsky; Gilles H. | Pharmaceutical gel preparation applicable to mucosal surfaces and body tissues |
-
1999
- 1999-09-03 IL IL14168899A patent/IL141688A0/xx active IP Right Grant
- 1999-09-03 US US09/390,164 patent/US6331309B1/en not_active Expired - Lifetime
- 1999-09-03 AT AT99946759T patent/ATE363292T1/de active
- 1999-09-03 EP EP99946759A patent/EP1107791B8/de not_active Expired - Lifetime
- 1999-09-03 DE DE69936212T patent/DE69936212T2/de not_active Expired - Lifetime
- 1999-09-03 CA CA002341410A patent/CA2341410C/en not_active Expired - Lifetime
- 1999-09-03 ES ES99946759T patent/ES2288024T3/es not_active Expired - Lifetime
- 1999-09-03 WO PCT/US1999/020382 patent/WO2000013710A2/en not_active Ceased
- 1999-09-03 JP JP2000568516A patent/JP2002524425A/ja active Pending
- 1999-09-03 AU AU59095/99A patent/AU758178B2/en not_active Expired
- 1999-09-03 DK DK99946759T patent/DK1107791T3/da active
- 1999-09-03 PT PT99946759T patent/PT1107791E/pt unknown
-
2001
- 2001-02-27 IL IL141688A patent/IL141688A/en not_active IP Right Cessation
-
2007
- 2007-08-02 CY CY20071101034T patent/CY1107704T1/el unknown
-
2010
- 2010-11-05 JP JP2010249223A patent/JP5576772B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| AU758178B2 (en) | 2003-03-20 |
| EP1107791B8 (de) | 2007-11-07 |
| EP1107791B1 (de) | 2007-05-30 |
| WO2000013710A3 (en) | 2000-06-02 |
| CA2341410C (en) | 2007-11-20 |
| DE69936212D1 (de) | 2007-07-12 |
| CY1107704T1 (el) | 2013-04-18 |
| DE69936212T2 (de) | 2008-01-24 |
| JP2002524425A (ja) | 2002-08-06 |
| IL141688A (en) | 2006-07-05 |
| CA2341410A1 (en) | 2000-03-16 |
| ES2288024T3 (es) | 2007-12-16 |
| JP2011021045A (ja) | 2011-02-03 |
| US6331309B1 (en) | 2001-12-18 |
| DK1107791T3 (da) | 2007-09-03 |
| JP5576772B2 (ja) | 2014-08-20 |
| WO2000013710A2 (en) | 2000-03-16 |
| IL141688A0 (en) | 2002-03-10 |
| PT1107791E (pt) | 2007-07-06 |
| EP1107791A2 (de) | 2001-06-20 |
| AU5909599A (en) | 2000-03-27 |
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Legal Events
| Date | Code | Title | Description |
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