ATE363479T1 - Methode zur darstellung von (pyridyl substituierten)methyl-thio-benzimidazol-derivat n - Google Patents

Methode zur darstellung von (pyridyl substituierten)methyl-thio-benzimidazol-derivat n

Info

Publication number: ATE363479T1
Authority: AT; Austria
Prior art keywords: methyl; alkoxy; substituted; thio; carbon atoms
Prior art date: 2000-04-14

Application number

AT01919463T

Other languages

English (en)

Inventor

Laura Coppi

Maimo Ramon Berenguer

Original Assignee

Esteve Quimica Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-04-14

Filing date

2001-04-10

Publication date

2007-06-15

2001-04-10 Application filed by Esteve Quimica Sa filed Critical Esteve Quimica Sa

2007-06-15 Application granted granted Critical

2007-06-15 Publication of ATE363479T1 publication Critical patent/ATE363479T1/de

Links

238000000034 method Methods 0.000 title abstract 2
OCKJFOHZLXIAAT-UHFFFAOYSA-N 2-methylsulfanyl-1h-benzimidazole Chemical class C1=CC=C2NC(SC)=NC2=C1 OCKJFOHZLXIAAT-UHFFFAOYSA-N 0.000 title 1
125000003545 alkoxy group Chemical group 0.000 abstract 4
125000004432 carbon atom Chemical group C* 0.000 abstract 3
PIINXYKJQGMIOZ-UHFFFAOYSA-N 1,2-dipyridin-2-ylethane-1,2-dione Chemical group C=1C=CC=NC=1C(=O)C(=O)C1=CC=CC=N1 PIINXYKJQGMIOZ-UHFFFAOYSA-N 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 2
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
BSKHPKMHTQYZBB-UHFFFAOYSA-N 2-methylpyridine Chemical compound CC1=CC=CC=N1 BSKHPKMHTQYZBB-UHFFFAOYSA-N 0.000 abstract 1
LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 abstract 1
150000001204 N-oxides Chemical class 0.000 abstract 1
IQPSEEYGBUAQFF-UHFFFAOYSA-N Pantoprazole Chemical compound COC1=CC=NC(CS(=O)C=2NC3=CC=C(OC(F)F)C=C3N=2)=C1OC IQPSEEYGBUAQFF-UHFFFAOYSA-N 0.000 abstract 1
150000008064 anhydrides Chemical class 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical group 0.000 abstract 1
MJIHNNLFOKEZEW-UHFFFAOYSA-N lansoprazole Chemical compound CC1=C(OCC(F)(F)F)C=CN=C1CS(=O)C1=NC2=CC=CC=C2N1 MJIHNNLFOKEZEW-UHFFFAOYSA-N 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
YREYEVIYCVEVJK-UHFFFAOYSA-N rabeprazole Chemical compound COCCCOC1=CC=NC(CS(=O)C=2NC3=CC=CC=C3N=2)=C1C YREYEVIYCVEVJK-UHFFFAOYSA-N 0.000 abstract 1
125000000446 sulfanediyl group Chemical group *S* 0.000 abstract 1
125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Plural Heterocyclic Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyridine Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT01919463T 2000-04-14 2001-04-10 Methode zur darstellung von (pyridyl substituierten)methyl-thio-benzimidazol-derivat n ATE363479T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
ES200000989A ES2171116B1 (es)	2000-04-14	2000-04-14	Procedimiento para la obtencion de derivados de (((piridil sustituido)metil)tio)bencimidazol.

Publications (1)

Publication Number	Publication Date
ATE363479T1 true ATE363479T1 (de)	2007-06-15

Family

ID=8493207

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT01919463T ATE363479T1 (de)	2000-04-14	2001-04-10	Methode zur darstellung von (pyridyl substituierten)methyl-thio-benzimidazol-derivat n

Country Status (18)

Country	Link
US (1)	US6723852B2 (de)
EP (1)	EP1411053B1 (de)
JP (1)	JP2003531144A (de)
KR (1)	KR100757346B1 (de)
CN (1)	CN1214027C (de)
AT (1)	ATE363479T1 (de)
AU (1)	AU780314B2 (de)
CA (1)	CA2405304C (de)
CY (1)	CY1106632T1 (de)
DE (1)	DE60128736T2 (de)
DK (1)	DK1411053T3 (de)
ES (2)	ES2171116B1 (de)
HU (1)	HUP0300583A2 (de)
MX (1)	MXPA02010039A (de)
NO (1)	NO323468B1 (de)
NZ (1)	NZ521930A (de)
PT (1)	PT1411053E (de)
WO (1)	WO2001079194A1 (de)

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* Cited by examiner, † Cited by third party
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ES2185459B1 (es) *	2000-10-02	2003-12-16	Dinamite Dipharma Spa	Procedimiento para la obtencion de pantoprazol y compuestos intermedios para el mismo.
EP1572680A2 (de) *	2002-12-19	2005-09-14	Eva Pharmaceutical Industries Ltd.	Festkörper pantoprazol natrium,bekannte pantoprazol natrium hydraten, verfahren zu deren herstellungen.
EP1601667A2 (de) *	2003-03-12	2005-12-07	Teva Pharmaceutical Industries Limited	Kristalline und amorphe festformen von pantoprazol und vervahren zu ihrer herstellung
MXPA05013316A (es) *	2003-06-10	2006-03-17	Teva Pharma	Proceso para preparar bencimidazoles 2[-(piridinil)metil]sulfinil-sustituidos y derivados clorados novedosos de pantoprazol.
ITMI20031813A1 (it) *	2003-09-23	2005-03-24	Dinamite Dipharma S P A In Forma A Bbreviata Diph	Procedimento per la preparazione di pantoprazolo e suoi sali.
KR100771659B1 (ko) *	2005-03-23	2007-10-30	주식회사 카이로제닉스	판토프라졸 및 그 중간체의 제조방법
US20080262043A1 (en) *	2005-05-06	2008-10-23	Medichem, S.A.	Solid Crystalline Form of Pantoprazole Free Acid, Salts Derived Therefrom and Process for Their Preparation
DK2003130T3 (da) *	2006-03-10	2011-12-12	Arigen Pharmaceuticals Inc	Nyt pyridinderivat med anti-helicobacter pylori-aktivitet
WO2008001392A2 (en) *	2006-06-30	2008-01-03	Msn Laboratories Limited	An improved process for the preparation of pantoprazole and its pharmaceutically acceptable salts
ES2390611T3 (es) *	2006-12-18	2012-11-14	Arigen Pharmaceuticals, Inc.	Agente de erradicación de Helicobacter pylori que tiene actividad inhibidora sobre la secreción de ácido gástrico
EP2181106A1 (de)	2007-07-17	2010-05-05	Ranbaxy Laboratories Limited	Verfahren zur herstellung von pantoprazol-natrium und pantoprazol-natrium-sesquihydrat
US20090076089A1 (en) *	2007-09-17	2009-03-19	Protia, Llc	Deuterium-enriched pantoprazole
CN102020637B (zh) *	2010-12-13	2014-09-10	浙江华义医药有限公司	5-二氟甲氧基-2-[[(3,4-二甲氧基-2-吡啶基)甲基]硫基]-1h-苯并咪唑制备法
CN103242297A (zh) *	2013-05-20	2013-08-14	湖北宜恒茶油产业科技有限责任公司	一种5-二氟甲氧基-2-[[(4-氯-3-甲氧基-2-吡啶基)甲基]硫代]-1h-苯并咪唑一水合物的制备方法
CN103664886A (zh) *	2013-12-06	2014-03-26	威海迪素制药有限公司	2-[[[4-(3-甲氧基丙氧基)-3-甲基吡啶-2-基]甲基]硫代]-1h-苯并咪唑的制备方法
CN105399729B (zh) *	2015-12-21	2018-04-17	山东金城医药化工有限公司	奥美拉唑的合成方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE8204879D0 (sv) *	1982-08-26	1982-08-26	Haessle Ab	Novel chemical intermediates
HU195220B (en) *	1983-05-03	1988-04-28	Byk Gulden Lomberg Chem Fqb	Process for production of new fluor-alkoxi-benzimidasole-derivatives and medical compositions containig them
ZA854287B (en) *	1984-06-16	1986-02-26	Byk Gulden Lomberg Chem Fab	Dialkoxypyridines,process for their preparation,their use and medicaments containing them
JPS6150978A (ja) *	1984-08-16	1986-03-13	Takeda Chem Ind Ltd	ピリジン誘導体およびその製造法
FR2593178B1 (fr) *	1986-01-20	1988-04-29	Esteve Labor Dr	Derives de 2-benzimidazolylalkylthio (ou sulfinyle ou sulfonyle) leur preparation et leur application en tant que medicaments.
JPH0674272B2 (ja) *	1986-11-13	1994-09-21	エーザイ株式会社	ピリジン誘導体及びそれを含有する潰瘍治療剤
ES2026761A6 (es) *	1990-10-31	1992-05-01	Genesis Para La Investigacion	Procedimiento de obtencion del omeprazol.
ES2024357A6 (es) *	1990-12-05	1992-02-16	Genesis Para La Investigacion	Procedimiento de obtencion de halohidrato de 2-halometil-3,5-dimetil-4-metoxipiri-dina.
ES2036948B1 (es) *	1991-11-21	1994-09-01	Genesis Para La Investigacion	Procedimiento de obtencion de compuestos derivados de piridina.
CA2175235A1 (en) *	1993-10-29	1995-05-04	Takeshi Kawakita	Pyridine compound and medicinal use thereof
JP3828648B2 (ja) *	1996-11-14	2006-10-04	武田薬品工業株式会社	２−（２−ピリジルメチルスルフィニル）ベンズイミダゾール系化合物の結晶およびその製造法
ID18983A (id) *	1996-12-04	1998-05-28	Lilly Co Eli	Pirazola sebagai inhibitor sekresi fosfolipase a2 non-pankreas pada manusia
GB9921578D0 (en) *	1999-09-13	1999-11-17	Cipla Limited	Omeprazole synthesis

2000
- 2000-04-14 ES ES200000989A patent/ES2171116B1/es not_active Expired - Fee Related
2001
- 2001-04-10 WO PCT/ES2001/000143 patent/WO2001079194A1/es not_active Ceased
- 2001-04-10 HU HU0300583A patent/HUP0300583A2/hu unknown
- 2001-04-10 DE DE60128736T patent/DE60128736T2/de not_active Expired - Lifetime
- 2001-04-10 MX MXPA02010039A patent/MXPA02010039A/es active IP Right Grant
- 2001-04-10 KR KR1020027013675A patent/KR100757346B1/ko not_active Expired - Fee Related
- 2001-04-10 EP EP01919463A patent/EP1411053B1/de not_active Expired - Lifetime
- 2001-04-10 AU AU46551/01A patent/AU780314B2/en not_active Ceased
- 2001-04-10 AT AT01919463T patent/ATE363479T1/de not_active IP Right Cessation
- 2001-04-10 DK DK01919463T patent/DK1411053T3/da active
- 2001-04-10 CA CA2405304A patent/CA2405304C/en not_active Expired - Fee Related
- 2001-04-10 PT PT01919463T patent/PT1411053E/pt unknown
- 2001-04-10 JP JP2001576794A patent/JP2003531144A/ja active Pending
- 2001-04-10 CN CNB018088791A patent/CN1214027C/zh not_active Expired - Fee Related
- 2001-04-10 NZ NZ521930A patent/NZ521930A/en unknown
- 2001-04-10 ES ES01919463T patent/ES2284629T3/es not_active Expired - Lifetime
- 2001-04-10 US US10/204,604 patent/US6723852B2/en not_active Expired - Fee Related
2002
- 2002-10-08 NO NO20024858A patent/NO323468B1/no not_active IP Right Cessation
2007
- 2007-05-31 CY CY20071100725T patent/CY1106632T1/el unknown

Also Published As

Publication number	Publication date
MXPA02010039A (es)	2004-08-19
PT1411053E (pt)	2007-07-12
NO20024858D0 (no)	2002-10-08
WO2001079194A1 (es)	2001-10-25
WO2001079194A9 (es)	2003-05-08
NO20024858L (no)	2002-12-06
AU4655101A (en)	2001-10-30
ES2171116B1 (es)	2003-08-01
HUP0300583A2 (hu)	2003-07-28
NZ521930A (en)	2004-07-30
CY1106632T1 (el)	2012-01-25
JP2003531144A (ja)	2003-10-21
ES2171116A1 (es)	2002-08-16
CN1427836A (zh)	2003-07-02
CA2405304C (en)	2011-01-18
NO323468B1 (no)	2007-05-21
DK1411053T3 (da)	2007-09-24
AU780314B2 (en)	2005-03-17
US20030036656A1 (en)	2003-02-20
CA2405304A1 (en)	2002-10-07
US6723852B2 (en)	2004-04-20
EP1411053A1 (de)	2004-04-21
DE60128736D1 (de)	2007-07-12
KR20030030990A (ko)	2003-04-18
KR100757346B1 (ko)	2007-09-11
EP1411053B1 (de)	2007-05-30
CN1214027C (zh)	2005-08-10
DE60128736T2 (de)	2008-02-07
ES2284629T3 (es)	2007-11-16

Legal Events

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2007-10-15

UEP

Publication of translation of european patent specification

Ref document number: 1411053

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2012-01-15

REN

Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE60128736D1 (de)	2007-07-12	Methode zur darstellung von (pyridyl substituierten)methyl-thio-benzimidazol-derivaten
DE69719350D1 (de)	2003-04-03	2-pyrimidinamin derivaten und verfahrens zu deren herstellung
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ATE144770T1 (de)	1996-11-15	Dihydropyridinderivate und verfahren zu ihrer herstellung
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