NO323468B1 - Fremgangsmate for fremstilling av derivater av [[(substituert pyridyl)metyl]tio]benzimidazol, et mellomprodukt samt en fremgangsmate for oppnaelse av mellomproduktet - Google Patents

Fremgangsmate for fremstilling av derivater av [[(substituert pyridyl)metyl]tio]benzimidazol, et mellomprodukt samt en fremgangsmate for oppnaelse av mellomproduktet

Info

Publication number: NO323468B1
Authority: NO; Norway
Prior art keywords: methyl; derivatives; thio; alkoxy; obtaining
Prior art date: 2000-04-14

Application number

NO20024858A

Other languages

English (en)

Norwegian (no)

Other versions

NO20024858D0 (no

NO20024858L (no

Inventor

Ramon Berenguer Maimo

Laura Coppi

Original Assignee

Esteve Quimica Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-04-14

Filing date

2002-10-08

Publication date

2007-05-21

2002-10-08 Application filed by Esteve Quimica Sa filed Critical Esteve Quimica Sa

2002-10-08 Publication of NO20024858D0 publication Critical patent/NO20024858D0/no

2002-12-06 Publication of NO20024858L publication Critical patent/NO20024858L/no

2007-05-21 Publication of NO323468B1 publication Critical patent/NO323468B1/no

Links

238000000034 method Methods 0.000 title abstract 3
-1 [[(substituted pyridyl) methyl] thio] benzimidazole Chemical class 0.000 title 1
125000003545 alkoxy group Chemical group 0.000 abstract 4
125000004432 carbon atom Chemical group C* 0.000 abstract 3
PIINXYKJQGMIOZ-UHFFFAOYSA-N 1,2-dipyridin-2-ylethane-1,2-dione Chemical group C=1C=CC=NC=1C(=O)C(=O)C1=CC=CC=N1 PIINXYKJQGMIOZ-UHFFFAOYSA-N 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 2
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
BSKHPKMHTQYZBB-UHFFFAOYSA-N 2-methylpyridine Chemical compound CC1=CC=CC=N1 BSKHPKMHTQYZBB-UHFFFAOYSA-N 0.000 abstract 1
LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 abstract 1
150000001204 N-oxides Chemical class 0.000 abstract 1
IQPSEEYGBUAQFF-UHFFFAOYSA-N Pantoprazole Chemical compound COC1=CC=NC(CS(=O)C=2NC3=CC=C(OC(F)F)C=C3N=2)=C1OC IQPSEEYGBUAQFF-UHFFFAOYSA-N 0.000 abstract 1
150000008064 anhydrides Chemical class 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical group 0.000 abstract 1
MJIHNNLFOKEZEW-UHFFFAOYSA-N lansoprazole Chemical compound CC1=C(OCC(F)(F)F)C=CN=C1CS(=O)C1=NC2=CC=CC=C2N1 MJIHNNLFOKEZEW-UHFFFAOYSA-N 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
YREYEVIYCVEVJK-UHFFFAOYSA-N rabeprazole Chemical compound COCCCOC1=CC=NC(CS(=O)C=2NC3=CC=CC=C3N=2)=C1C YREYEVIYCVEVJK-UHFFFAOYSA-N 0.000 abstract 1
125000000446 sulfanediyl group Chemical group *S* 0.000 abstract 1
125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Plural Heterocyclic Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pyridine Compounds (AREA)

NO20024858A 2000-04-14 2002-10-08 Fremgangsmate for fremstilling av derivater av [[(substituert pyridyl)metyl]tio]benzimidazol, et mellomprodukt samt en fremgangsmate for oppnaelse av mellomproduktet NO323468B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
ES200000989A ES2171116B1 (es)	2000-04-14	2000-04-14	Procedimiento para la obtencion de derivados de (((piridil sustituido)metil)tio)bencimidazol.
PCT/ES2001/000143 WO2001079194A1 (es)	2000-04-14	2001-04-10	Procedimiento para la obtención de derivados de [[(piridil sustituido)metil]tio]bencimidazol

Publications (3)

Publication Number	Publication Date
NO20024858D0 NO20024858D0 (no)	2002-10-08
NO20024858L NO20024858L (no)	2002-12-06
NO323468B1 true NO323468B1 (no)	2007-05-21

Family

ID=8493207

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20024858A NO323468B1 (no)	2000-04-14	2002-10-08	Fremgangsmate for fremstilling av derivater av [[(substituert pyridyl)metyl]tio]benzimidazol, et mellomprodukt samt en fremgangsmate for oppnaelse av mellomproduktet

Country Status (18)

Country	Link
US (1)	US6723852B2 (de)
EP (1)	EP1411053B1 (de)
JP (1)	JP2003531144A (de)
KR (1)	KR100757346B1 (de)
CN (1)	CN1214027C (de)
AT (1)	ATE363479T1 (de)
AU (1)	AU780314B2 (de)
CA (1)	CA2405304C (de)
CY (1)	CY1106632T1 (de)
DE (1)	DE60128736T2 (de)
DK (1)	DK1411053T3 (de)
ES (2)	ES2171116B1 (de)
HU (1)	HUP0300583A2 (de)
MX (1)	MXPA02010039A (de)
NO (1)	NO323468B1 (de)
NZ (1)	NZ521930A (de)
PT (1)	PT1411053E (de)
WO (1)	WO2001079194A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2185459B1 (es) *	2000-10-02	2003-12-16	Dinamite Dipharma Spa	Procedimiento para la obtencion de pantoprazol y compuestos intermedios para el mismo.
US7507829B2 (en) *	2002-12-19	2009-03-24	Teva Pharmaceuticals Industries, Ltd	Solid states of pantoprazole sodium, processes for preparing them and processes for preparing known pantoprazole sodium hydrates
ES2245277T1 (es) *	2003-03-12	2006-01-01	Teva Pharmaceutical Industries Limited	Solidos cristalinos y amorfos de pantoprazol y procedimientos para su preparacion.
MXPA05013316A (es) *	2003-06-10	2006-03-17	Teva Pharma	Proceso para preparar bencimidazoles 2[-(piridinil)metil]sulfinil-sustituidos y derivados clorados novedosos de pantoprazol.
ITMI20031813A1 (it) *	2003-09-23	2005-03-24	Dinamite Dipharma S P A In Forma A Bbreviata Diph	Procedimento per la preparazione di pantoprazolo e suoi sali.
KR100771659B1 (ko) *	2005-03-23	2007-10-30	주식회사 카이로제닉스	판토프라졸 및 그 중간체의 제조방법
EP1893602A2 (de) *	2005-05-06	2008-03-05	Medichem, S.A.	Pantoprazole free acid form iii
PL2003130T3 (pl) *	2006-03-10	2012-04-30	Link Genomics Inc	Nowa pochodna pirydyny o aktywności przeciwko helicobacter pylori
WO2008001392A2 (en) *	2006-06-30	2008-01-03	Msn Laboratories Limited	An improved process for the preparation of pantoprazole and its pharmaceutically acceptable salts
DK2103608T3 (da) *	2006-12-18	2012-09-17	Arigen Pharmaceuticals Inc	Helicobacter pylori eradikerende middel med inhiberende virkning på mavesyresekretion
EP2181106A1 (de) *	2007-07-17	2010-05-05	Ranbaxy Laboratories Limited	Verfahren zur herstellung von pantoprazol-natrium und pantoprazol-natrium-sesquihydrat
US20090076089A1 (en) *	2007-09-17	2009-03-19	Protia, Llc	Deuterium-enriched pantoprazole
CN102020637B (zh) *	2010-12-13	2014-09-10	浙江华义医药有限公司	5-二氟甲氧基-2-[[(3,4-二甲氧基-2-吡啶基)甲基]硫基]-1h-苯并咪唑制备法
CN103242297A (zh) *	2013-05-20	2013-08-14	湖北宜恒茶油产业科技有限责任公司	一种5-二氟甲氧基-2-[[(4-氯-3-甲氧基-2-吡啶基)甲基]硫代]-1h-苯并咪唑一水合物的制备方法
CN103664886A (zh) *	2013-12-06	2014-03-26	威海迪素制药有限公司	2-[[[4-(3-甲氧基丙氧基)-3-甲基吡啶-2-基]甲基]硫代]-1h-苯并咪唑的制备方法
CN105399729B (zh) *	2015-12-21	2018-04-17	山东金城医药化工有限公司	奥美拉唑的合成方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE8204879D0 (sv) *	1982-08-26	1982-08-26	Haessle Ab	Novel chemical intermediates
HU195220B (en) *	1983-05-03	1988-04-28	Byk Gulden Lomberg Chem Fqb	Process for production of new fluor-alkoxi-benzimidasole-derivatives and medical compositions containig them
ZA854287B (en) *	1984-06-16	1986-02-26	Byk Gulden Lomberg Chem Fab	Dialkoxypyridines,process for their preparation,their use and medicaments containing them
JPS6150978A (ja) *	1984-08-16	1986-03-13	Takeda Chem Ind Ltd	ピリジン誘導体およびその製造法
FR2593178B1 (fr) *	1986-01-20	1988-04-29	Esteve Labor Dr	Derives de 2-benzimidazolylalkylthio (ou sulfinyle ou sulfonyle) leur preparation et leur application en tant que medicaments.
JPH0674272B2 (ja) *	1986-11-13	1994-09-21	エーザイ株式会社	ピリジン誘導体及びそれを含有する潰瘍治療剤
ES2026761A6 (es) *	1990-10-31	1992-05-01	Genesis Para La Investigacion	Procedimiento de obtencion del omeprazol.
ES2024357A6 (es) *	1990-12-05	1992-02-16	Genesis Para La Investigacion	Procedimiento de obtencion de halohidrato de 2-halometil-3,5-dimetil-4-metoxipiri-dina.
ES2036948B1 (es) *	1991-11-21	1994-09-01	Genesis Para La Investigacion	Procedimiento de obtencion de compuestos derivados de piridina.
EP0729957A4 (de) *	1993-10-29	1996-12-27	Yoshitomi Pharmaceutical	Pyridinderivate und ihre medizinische verwendung
JP3828648B2 (ja) *	1996-11-14	2006-10-04	武田薬品工業株式会社	２−（２−ピリジルメチルスルフィニル）ベンズイミダゾール系化合物の結晶およびその製造法
ID18983A (id) *	1996-12-04	1998-05-28	Lilly Co Eli	Pirazola sebagai inhibitor sekresi fosfolipase a2 non-pankreas pada manusia
GB9921578D0 (en) *	1999-09-13	1999-11-17	Cipla Limited	Omeprazole synthesis

2000
- 2000-04-14 ES ES200000989A patent/ES2171116B1/es not_active Expired - Fee Related
2001
- 2001-04-10 DE DE60128736T patent/DE60128736T2/de not_active Expired - Lifetime
- 2001-04-10 JP JP2001576794A patent/JP2003531144A/ja active Pending
- 2001-04-10 DK DK01919463T patent/DK1411053T3/da active
- 2001-04-10 AU AU46551/01A patent/AU780314B2/en not_active Ceased
- 2001-04-10 ES ES01919463T patent/ES2284629T3/es not_active Expired - Lifetime
- 2001-04-10 CN CNB018088791A patent/CN1214027C/zh not_active Expired - Fee Related
- 2001-04-10 US US10/204,604 patent/US6723852B2/en not_active Expired - Fee Related
- 2001-04-10 WO PCT/ES2001/000143 patent/WO2001079194A1/es not_active Ceased
- 2001-04-10 MX MXPA02010039A patent/MXPA02010039A/es active IP Right Grant
- 2001-04-10 PT PT01919463T patent/PT1411053E/pt unknown
- 2001-04-10 EP EP01919463A patent/EP1411053B1/de not_active Expired - Lifetime
- 2001-04-10 KR KR1020027013675A patent/KR100757346B1/ko not_active Expired - Fee Related
- 2001-04-10 HU HU0300583A patent/HUP0300583A2/hu unknown
- 2001-04-10 NZ NZ521930A patent/NZ521930A/en unknown
- 2001-04-10 AT AT01919463T patent/ATE363479T1/de not_active IP Right Cessation
- 2001-04-10 CA CA2405304A patent/CA2405304C/en not_active Expired - Fee Related
2002
- 2002-10-08 NO NO20024858A patent/NO323468B1/no not_active IP Right Cessation
2007
- 2007-05-31 CY CY20071100725T patent/CY1106632T1/el unknown

Also Published As

Publication number	Publication date
PT1411053E (pt)	2007-07-12
MXPA02010039A (es)	2004-08-19
KR20030030990A (ko)	2003-04-18
DK1411053T3 (da)	2007-09-24
CN1427836A (zh)	2003-07-02
JP2003531144A (ja)	2003-10-21
ES2284629T3 (es)	2007-11-16
CY1106632T1 (el)	2012-01-25
DE60128736D1 (de)	2007-07-12
NO20024858D0 (no)	2002-10-08
US20030036656A1 (en)	2003-02-20
NZ521930A (en)	2004-07-30
KR100757346B1 (ko)	2007-09-11
CN1214027C (zh)	2005-08-10
AU4655101A (en)	2001-10-30
EP1411053A1 (de)	2004-04-21
AU780314B2 (en)	2005-03-17
WO2001079194A9 (es)	2003-05-08
US6723852B2 (en)	2004-04-20
ATE363479T1 (de)	2007-06-15
DE60128736T2 (de)	2008-02-07
ES2171116A1 (es)	2002-08-16
HUP0300583A2 (hu)	2003-07-28
WO2001079194A1 (es)	2001-10-25
NO20024858L (no)	2002-12-06
ES2171116B1 (es)	2003-08-01
EP1411053B1 (de)	2007-05-30
CA2405304C (en)	2011-01-18
CA2405304A1 (en)	2002-10-07

Legal Events

Date	Code	Title	Description
2011-11-28	MM1K	Lapsed by not paying the annual fees

Publication	Publication Date	Title
NO20024858L (no)	2002-12-06	Fremgangsmåte for fremstilling av derivater av [[(substituert pyridyl)metyl]tio]benzimidazol
TR199901055T2 (xx)	1999-07-21	Benzimidazol t�revlerinin kristalleri ve bunlar�n �retimi.
NO20016087D0 (no)	2001-12-13	Benzimidazolforbindelsekrystall
ATE105285T1 (de)	1994-05-15	Salicylaldehyd- und salicylsaeurederivate sowie deren schwefelanaloge, verfahren zu ihrer herstellung und ihre verwendung als herbizide und bioregulatoren.
ATE158574T1 (de)	1997-10-15	N-(aminoalkyl)piperidin-verbindungen und ihre enantiomere als neurokinine-receptoren antagonisten, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen
EA200100755A1 (ru)	2001-12-24	4-оксо-1,4-дигидро-3-хинолинкарбоксамиды как антивирусные агенты
YU48213B (sh)	1997-08-22	Postupak za izradu derivata aril (ili heteroaril) piperazinilbutilazola
PT887344E (pt)	2004-02-27	Quinolinas e quinazolinas uteis em terapia
HUP9903836A2 (hu)	2001-05-28	Új eljárás Cox-2 inhibítor hatású fenil-szubsztituált 2(5H)-furanonok előállítására
YU46547B (sh)	1993-11-16	1,4-dihidropiridini i postupak za njihovo dobijanje
RU1833371C (ru)	1993-08-07	Cпocoб пoлучehия amидoпpoизboдhыx 4-фehил-3-буtehoboй kиcлotы
DE3474022D1 (de)	1988-10-20	Quinazoline and isoquinoline derivatives
EA199901096A1 (ru)	2000-08-28	Цианогуанидины в качестве ингибиторов пролиферации клеток
ES2056835T3 (es)	1994-10-16	Derivados de pirido(2,3-d)pirimidina.
DE3264253D1 (de)	1985-07-25	Pyridine derivatives as histamine h2 antagonists
DE3785076D1 (de)	1993-05-06	Pyrido(4,3-d)pyrimidin-derivate.
FI914971A0 (fi)	1991-10-22	4-(4- eller 6-(trifluormetyl-2 -pyridinyl))-1-piperazinylalkylsubstituerade laktamer.
FI971177A0 (fi)	1997-03-20	Bisyklisiä karboksiamideja 5-HT1A-antagonisteina
ATE191911T1 (de)	2000-05-15	Neue chinoloncarbonsäurederivate
ATE500241T1 (de)	2011-03-15	Phenyl- und pyridyl-piperidine mit tnf-wirkung
TH43782B (th)	2015-04-17	ผลึกของอนุพันธ์ของเบนซิมิเดโซลและการผลิตของมัน
IT1271703B (it)	1997-06-04	"derivati 6-o 7-sostituiti del 4-aminoandrostadienone e procedimento per la loro preparazione"