ES2171116A1 - Procedimiento para la obtencion de derivados de (((piridil sustituido)metil)tio)bencimidazol. - Google Patents

Procedimiento para la obtencion de derivados de (((piridil sustituido)metil)tio)bencimidazol.

Info

Publication number
ES2171116A1
ES2171116A1 ES200000989A ES200000989A ES2171116A1 ES 2171116 A1 ES2171116 A1 ES 2171116A1 ES 200000989 A ES200000989 A ES 200000989A ES 200000989 A ES200000989 A ES 200000989A ES 2171116 A1 ES2171116 A1 ES 2171116A1
Authority
ES
Spain
Prior art keywords
benzimidazol
thio
methyl
alkoxy
carbon atoms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES200000989A
Other languages
English (en)
Other versions
ES2171116B1 (es
Inventor
Laura Coppi
Maimo Ramon Berenguer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Esteve Quimica SA
Original Assignee
Esteve Quimica SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to ES200000989A priority Critical patent/ES2171116B1/es
Application filed by Esteve Quimica SA filed Critical Esteve Quimica SA
Priority to AU46551/01A priority patent/AU780314B2/en
Priority to ES01919463T priority patent/ES2284629T3/es
Priority to US10/204,604 priority patent/US6723852B2/en
Priority to DE60128736T priority patent/DE60128736T2/de
Priority to PCT/ES2001/000143 priority patent/WO2001079194A1/es
Priority to HU0300583A priority patent/HUP0300583A2/hu
Priority to CNB018088791A priority patent/CN1214027C/zh
Priority to CA2405304A priority patent/CA2405304C/en
Priority to KR1020027013675A priority patent/KR100757346B1/ko
Priority to PT01919463T priority patent/PT1411053E/pt
Priority to MXPA02010039A priority patent/MXPA02010039A/es
Priority to JP2001576794A priority patent/JP2003531144A/ja
Priority to SI200130741T priority patent/SI1411053T1/sl
Priority to DK01919463T priority patent/DK1411053T3/da
Priority to EP01919463A priority patent/EP1411053B1/en
Priority to NZ521930A priority patent/NZ521930A/en
Priority to AT01919463T priority patent/ATE363479T1/de
Publication of ES2171116A1 publication Critical patent/ES2171116A1/es
Priority to NO20024858A priority patent/NO323468B1/no
Application granted granted Critical
Publication of ES2171116B1 publication Critical patent/ES2171116B1/es
Priority to CY20071100725T priority patent/CY1106632T1/el
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)

Abstract

Procedimiento para la obtención de derivados de [[(piridil sustituido)metil]tio]bencimidazol. El procedimiento para la obtención de derivados de [[(piridil sustituido)metil]tio]bencimidazol (I), donde cada uno de R1, R3 y R4, independientemente entre sí, es hidrógeno, un grupo alquilo o un grupo alquiloxi de 1 a 6 átomos de carbono, y R2 es un grupo nitro, un grupo alquiloxi o un grupo alquiloxi fluorado de 1 a 6 átomos de carbono, comprende (a) hacer reaccionar un N-óxido de una metilpiridina con un anhídrido de ácido carboxílico activado o de ácido sulfónico, y (b) hacer reaccionar el intermedio formado en la etapa (a) con un mercaptobencimidazol correspondiente. Los compuestos (I) son útiles para la síntesis de derivados de [[(piridil sustituido)metil]sulfinil]bencimidazol, por ejemplo, omeprazol o lansopazol.
ES200000989A 2000-04-14 2000-04-14 Procedimiento para la obtencion de derivados de (((piridil sustituido)metil)tio)bencimidazol. Expired - Fee Related ES2171116B1 (es)

Priority Applications (20)

Application Number Priority Date Filing Date Title
ES200000989A ES2171116B1 (es) 2000-04-14 2000-04-14 Procedimiento para la obtencion de derivados de (((piridil sustituido)metil)tio)bencimidazol.
MXPA02010039A MXPA02010039A (es) 2000-04-14 2001-04-10 Procedimiento para la obtencion de derivados de 1[[piridil sustituido)metil]tio]bencimidazol.
US10/204,604 US6723852B2 (en) 2000-04-14 2001-04-10 Method for obtaining derivatives of [[(pyridil substituted)methyl]thio]benzomidazol
DE60128736T DE60128736T2 (de) 2000-04-14 2001-04-10 Methode zur darstellung von (pyridyl substituierten)methyl-thio-benzimidazol-derivaten
PCT/ES2001/000143 WO2001079194A1 (es) 2000-04-14 2001-04-10 Procedimiento para la obtención de derivados de [[(piridil sustituido)metil]tio]bencimidazol
HU0300583A HUP0300583A2 (hu) 2000-04-14 2001-04-10 Eljárás piridilcsoporttal helyettesített metiltiobenzimidazol-származékok előállítására
ES01919463T ES2284629T3 (es) 2000-04-14 2001-04-10 Procredimiento para la obtencion de derivados de (((piridil sustituido ) metil) tio) bencimidazol.
CA2405304A CA2405304C (en) 2000-04-14 2001-04-10 Method for obtaining derivatives of [[(pyridil substituted)methyl]thio]benzimidazole
KR1020027013675A KR100757346B1 (ko) 2000-04-14 2001-04-10 [[(피리딜 치환)메틸]티오]벤지미다졸 유도체의 제조 방법
PT01919463T PT1411053E (pt) 2000-04-14 2001-04-10 Processo para obter derivados de [[ (piridil substituído) metil] tio] benzimidazolo
AU46551/01A AU780314B2 (en) 2000-04-14 2001-04-10 Method for obtaining derivatives of (((pyridil substituted) methyl)thio)benzimidazol
CNB018088791A CN1214027C (zh) 2000-04-14 2001-04-10 [[(取代的吡啶基)甲基]硫基]苯并咪唑衍生物的制备方法
AT01919463T ATE363479T1 (de) 2000-04-14 2001-04-10 Methode zur darstellung von (pyridyl substituierten)methyl-thio-benzimidazol-derivat n
DK01919463T DK1411053T3 (da) 2000-04-14 2001-04-10 Fremgangsmåde til opnåelse af derivater af [[(pyridilsubstitueret)methyl]thio]benzimidazol
EP01919463A EP1411053B1 (en) 2000-04-14 2001-04-10 Method for obtaining derivatives of (pyridil substituted)methyl|thio|benzimidazol
NZ521930A NZ521930A (en) 2000-04-14 2001-04-10 Method for obtaining derivatives of [[(pyridil substituted)methyl]thio]benzimidazol
SI200130741T SI1411053T1 (sl) 2000-04-14 2001-04-10 Postopek pridobivanja derivatov (s piridilom substituiranega) metiltiobenzimidazola
JP2001576794A JP2003531144A (ja) 2000-04-14 2001-04-10 ［［（ピリジル置換）メチル］チオ］ベンズイミダゾールの誘導体を得る方法
NO20024858A NO323468B1 (no) 2000-04-14 2002-10-08 Fremgangsmate for fremstilling av derivater av [[(substituert pyridyl)metyl]tio]benzimidazol, et mellomprodukt samt en fremgangsmate for oppnaelse av mellomproduktet
CY20071100725T CY1106632T1 (el) 2000-04-14 2007-05-31 Μεθοδος ληψης παραγωγων [[(πυριδιλ υποκατεστημενου) μεθυλ] θειο] βενζιμιδαζολιου

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES200000989A ES2171116B1 (es) 2000-04-14 2000-04-14 Procedimiento para la obtencion de derivados de (((piridil sustituido)metil)tio)bencimidazol.

Publications (2)

Publication Number Publication Date
ES2171116A1 true ES2171116A1 (es) 2002-08-16
ES2171116B1 ES2171116B1 (es) 2003-08-01

Family

ID=8493207

Family Applications (2)

Application Number Title Priority Date Filing Date
ES200000989A Expired - Fee Related ES2171116B1 (es) 2000-04-14 2000-04-14 Procedimiento para la obtencion de derivados de (((piridil sustituido)metil)tio)bencimidazol.
ES01919463T Expired - Lifetime ES2284629T3 (es) 2000-04-14 2001-04-10 Procredimiento para la obtencion de derivados de (((piridil sustituido ) metil) tio) bencimidazol.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES01919463T Expired - Lifetime ES2284629T3 (es) 2000-04-14 2001-04-10 Procredimiento para la obtencion de derivados de (((piridil sustituido ) metil) tio) bencimidazol.

Country Status (18)

Country Link
US (1) US6723852B2 (es)
EP (1) EP1411053B1 (es)
JP (1) JP2003531144A (es)
KR (1) KR100757346B1 (es)
CN (1) CN1214027C (es)
AT (1) ATE363479T1 (es)
AU (1) AU780314B2 (es)
CA (1) CA2405304C (es)
CY (1) CY1106632T1 (es)
DE (1) DE60128736T2 (es)
DK (1) DK1411053T3 (es)
ES (2) ES2171116B1 (es)
HU (1) HUP0300583A2 (es)
MX (1) MXPA02010039A (es)
NO (1) NO323468B1 (es)
NZ (1) NZ521930A (es)
PT (1) PT1411053E (es)
WO (1) WO2001079194A1 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2185459B1 (es) 2000-10-02 2003-12-16 Dinamite Dipharma Spa Procedimiento para la obtencion de pantoprazol y compuestos intermedios para el mismo.
US7507829B2 (en) * 2002-12-19 2009-03-24 Teva Pharmaceuticals Industries, Ltd Solid states of pantoprazole sodium, processes for preparing them and processes for preparing known pantoprazole sodium hydrates
WO2004080961A2 (en) * 2003-03-12 2004-09-23 Teva Pharmaceutical Industries Ltd. Crystalline and amorphous solids of pantoprazole and processes for their preparation
US7683177B2 (en) * 2003-06-10 2010-03-23 Teva Pharmaceutical Industries Ltd Process for preparing 2-[(pyridinyl)methyl]sulfinyl-substituted benzimidazoles and novel chlorinated derivatives of pantoprazole
ITMI20031813A1 (it) * 2003-09-23 2005-03-24 Dinamite Dipharma S P A In Forma A Bbreviata Diph Procedimento per la preparazione di pantoprazolo e suoi sali.
KR100771659B1 (ko) * 2005-03-23 2007-10-30 주식회사 카이로제닉스 판토프라졸 및 그 중간체의 제조방법
AR054113A1 (es) * 2005-05-06 2007-06-06 Medichem Sa Forma cristalina solida de pantoprazol como acido libre, sales derivadas del mismo y proceso para su preparacion
ATE533757T1 (de) * 2006-03-10 2011-12-15 Arigen Pharmaceuticals Inc Neues pyridinderivat mit wirkung gegen helicobacter pylori
WO2008001392A2 (en) * 2006-06-30 2008-01-03 Msn Laboratories Limited An improved process for the preparation of pantoprazole and its pharmaceutically acceptable salts
CA2671949C (en) * 2006-12-18 2011-11-01 Arigen Pharmaceuticals, Inc. Helicobacter pylori eradicating agent having inhibitory activity on gastric acid secretion
EP2181106A1 (en) 2007-07-17 2010-05-05 Ranbaxy Laboratories Limited Process for the preparation op pantoprazole sodium and pantoprazole sodium sesquihydrate
US20090076089A1 (en) * 2007-09-17 2009-03-19 Protia, Llc Deuterium-enriched pantoprazole
CN102020637B (zh) * 2010-12-13 2014-09-10 浙江华义医药有限公司 5-二氟甲氧基-2-[[(3,4-二甲氧基-2-吡啶基)甲基]硫基]-1h-苯并咪唑制备法
CN103242297A (zh) * 2013-05-20 2013-08-14 湖北宜恒茶油产业科技有限责任公司 一种5-二氟甲氧基-2-[[(4-氯-3-甲氧基-2-吡啶基)甲基]硫代]-1h-苯并咪唑一水合物的制备方法
CN103664886A (zh) * 2013-12-06 2014-03-26 威海迪素制药有限公司 2-[[[4-(3-甲氧基丙氧基)-3-甲基吡啶-2-基]甲基]硫代]-1h-苯并咪唑的制备方法
CN105399729B (zh) * 2015-12-21 2018-04-17 山东金城医药化工有限公司 奥美拉唑的合成方法

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0103553A1 (en) * 1982-08-26 1984-03-21 Aktiebolaget Hässle Intermediates for the preparation of omeprazole
US4628098A (en) * 1984-08-16 1986-12-09 Takeda Chemical Industries, Ltd. 2-[2-pyridylmethylthio-(sulfinyl)]benzimidazoles
ES2003658A6 (es) * 1986-01-20 1988-11-01 Esteve Labor Dr Procedimiento de preparar derivaods de 2-alquilbenzimidazol.
ES2024357A6 (es) * 1990-12-05 1992-02-16 Genesis Para La Investigacion Procedimiento de obtencion de halohidrato de 2-halometil-3,5-dimetil-4-metoxipiri-dina.
ES2026761A6 (es) * 1990-10-31 1992-05-01 Genesis Para La Investigacion Procedimiento de obtencion del omeprazol.
EP0729957A1 (en) * 1993-10-29 1996-09-04 Yoshitomi Pharmaceutical Industries, Ltd. Pyridine compound and medicinal use thereof

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Publication number Priority date Publication date Assignee Title
HU195220B (en) * 1983-05-03 1988-04-28 Byk Gulden Lomberg Chem Fqb Process for production of new fluor-alkoxi-benzimidasole-derivatives and medical compositions containig them
ZA854287B (en) * 1984-06-16 1986-02-26 Byk Gulden Lomberg Chem Fab Dialkoxypyridines,process for their preparation,their use and medicaments containing them
JPH0674272B2 (ja) * 1986-11-13 1994-09-21 エーザイ株式会社 ピリジン誘導体及びそれを含有する潰瘍治療剤
ES2036948B1 (es) * 1991-11-21 1994-09-01 Genesis Para La Investigacion Procedimiento de obtencion de compuestos derivados de piridina.
JP3828648B2 (ja) * 1996-11-14 2006-10-04 武田薬品工業株式会社 ２−（２−ピリジルメチルスルフィニル）ベンズイミダゾール系化合物の結晶およびその製造法
ID18983A (id) * 1996-12-04 1998-05-28 Lilly Co Eli Pirazola sebagai inhibitor sekresi fosfolipase a2 non-pankreas pada manusia
GB9921578D0 (en) * 1999-09-13 1999-11-17 Cipla Limited Omeprazole synthesis

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0103553A1 (en) * 1982-08-26 1984-03-21 Aktiebolaget Hässle Intermediates for the preparation of omeprazole
US4628098A (en) * 1984-08-16 1986-12-09 Takeda Chemical Industries, Ltd. 2-[2-pyridylmethylthio-(sulfinyl)]benzimidazoles
ES2003658A6 (es) * 1986-01-20 1988-11-01 Esteve Labor Dr Procedimiento de preparar derivaods de 2-alquilbenzimidazol.
ES2026761A6 (es) * 1990-10-31 1992-05-01 Genesis Para La Investigacion Procedimiento de obtencion del omeprazol.
ES2024357A6 (es) * 1990-12-05 1992-02-16 Genesis Para La Investigacion Procedimiento de obtencion de halohidrato de 2-halometil-3,5-dimetil-4-metoxipiri-dina.
EP0729957A1 (en) * 1993-10-29 1996-09-04 Yoshitomi Pharmaceutical Industries, Ltd. Pyridine compound and medicinal use thereof

Non-Patent Citations (1)

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C. FONTENAS, E. BEJAN, H. AIET HADDOU, G.G.A. GALAVOINE, "The Boekelheide reaction: trifluoroacetic anhydride a convenient acylating agent". Synth. Commun., 1995, Vol. 25, No 5, paginas 629-633. *

Also Published As

Publication number Publication date
WO2001079194A9 (es) 2003-05-08
CN1427836A (zh) 2003-07-02
CA2405304C (en) 2011-01-18
DK1411053T3 (da) 2007-09-24
WO2001079194A1 (es) 2001-10-25
JP2003531144A (ja) 2003-10-21
EP1411053A1 (en) 2004-04-21
CY1106632T1 (el) 2012-01-25
DE60128736D1 (de) 2007-07-12
MXPA02010039A (es) 2004-08-19
NO323468B1 (no) 2007-05-21
DE60128736T2 (de) 2008-02-07
ES2284629T3 (es) 2007-11-16
US20030036656A1 (en) 2003-02-20
PT1411053E (pt) 2007-07-12
US6723852B2 (en) 2004-04-20
NO20024858L (no) 2002-12-06
ATE363479T1 (de) 2007-06-15
ES2171116B1 (es) 2003-08-01
CN1214027C (zh) 2005-08-10
NO20024858D0 (no) 2002-10-08
NZ521930A (en) 2004-07-30
EP1411053B1 (en) 2007-05-30
AU4655101A (en) 2001-10-30
HUP0300583A2 (hu) 2003-07-28
KR100757346B1 (ko) 2007-09-11
KR20030030990A (ko) 2003-04-18
AU780314B2 (en) 2005-03-17
CA2405304A1 (en) 2002-10-07

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