ATE364700T1 - Bestandteil von bromelain - Google Patents

Bestandteil von bromelain

Info

Publication number
ATE364700T1
ATE364700T1 AT98907054T AT98907054T ATE364700T1 AT E364700 T1 ATE364700 T1 AT E364700T1 AT 98907054 T AT98907054 T AT 98907054T AT 98907054 T AT98907054 T AT 98907054T AT E364700 T1 ATE364700 T1 AT E364700T1
Authority
AT
Austria
Prior art keywords
bromelain
component
map kinase
activation
comosain
Prior art date
Application number
AT98907054T
Other languages
English (en)
Inventor
Tracey Mynott
Christian Engwerda
Keith Peek
Original Assignee
Sarantis Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9703827.7A external-priority patent/GB9703827D0/en
Priority claimed from GBGB9703850.9A external-priority patent/GB9703850D0/en
Priority claimed from GBGB9704252.7A external-priority patent/GB9704252D0/en
Priority claimed from GBGB9706119.6A external-priority patent/GB9706119D0/en
Application filed by Sarantis Pty Ltd filed Critical Sarantis Pty Ltd
Application granted granted Critical
Publication of ATE364700T1 publication Critical patent/ATE364700T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6472—Cysteine endopeptidases (3.4.22)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/63—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from plants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4873—Cysteine endopeptidases (3.4.22), e.g. stem bromelain, papain, ficin, cathepsin H
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55516—Proteins; Peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Botany (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Transplantation (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Saccharide Compounds (AREA)
AT98907054T 1997-02-25 1998-02-25 Bestandteil von bromelain ATE364700T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9703827.7A GB9703827D0 (en) 1997-02-25 1997-02-25 Novel protein
GBGB9703850.9A GB9703850D0 (en) 1997-02-25 1997-02-25 Novel protein
GBGB9704252.7A GB9704252D0 (en) 1997-02-28 1997-02-28 Novel protein
GBGB9706119.6A GB9706119D0 (en) 1997-03-25 1997-03-25 Novel protein

Publications (1)

Publication Number Publication Date
ATE364700T1 true ATE364700T1 (de) 2007-07-15

Family

ID=27451608

Family Applications (3)

Application Number Title Priority Date Filing Date
AT98907053T ATE382084T1 (de) 1997-02-25 1998-02-25 Bromelinbestandteil
AT98907054T ATE364700T1 (de) 1997-02-25 1998-02-25 Bestandteil von bromelain
AT07024577T ATE533842T1 (de) 1997-02-25 1998-02-25 Bromelainbestandteil

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT98907053T ATE382084T1 (de) 1997-02-25 1998-02-25 Bromelinbestandteil

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT07024577T ATE533842T1 (de) 1997-02-25 1998-02-25 Bromelainbestandteil

Country Status (8)

Country Link
EP (4) EP1012304B1 (de)
JP (3) JP4673454B2 (de)
CN (2) CN100400659C (de)
AT (3) ATE382084T1 (de)
AU (2) AU6303798A (de)
DE (2) DE69837923T2 (de)
ES (4) ES2403433T3 (de)
WO (2) WO1998038291A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6303898A (en) 1997-02-25 1998-09-18 Cortecs (Uk) Limited Component of bromelain
US20020102253A1 (en) 1997-02-25 2002-08-01 Mynott Tracey Lehanne Component of bromelain
ATE222121T1 (de) 1998-07-15 2002-08-15 Ursapharm Arzneimittel Gmbh Verwendung von bromelainproteasen zur hemmung der blutgerinnung
AU2845400A (en) * 1998-12-24 2000-07-31 Phairson Medical Inc. Treatment and prevention of immune rejection reactions
US6977245B2 (en) * 1999-04-12 2005-12-20 The United States Of America As Represented By The Department Of Health And Human Services Oligodeoxynucleotide and its use to induce an immune response
EP1208849B1 (de) * 2000-11-28 2015-10-28 URSAPHARM Arzneimittel GmbH Verwendung von Bromelain zur adjuvanten Therapie der Wundheilung
CA2441530A1 (en) * 2001-03-19 2002-09-26 Iomai Corporation Transcutaneous immunostimulation
CN108472341A (zh) * 2015-08-20 2018-08-31 安纳塔拉生命科学有限公司 具有抗炎活性的酶级分
US20230181665A1 (en) * 2020-03-20 2023-06-15 Novel Concepts Medical Ltd Treating or preventing inflammatory diseases including diabetes mellitus 10 type i and type ii and thyroid diseases

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8724728D0 (en) * 1987-10-22 1987-11-25 Genzyme Corp Cysteine proteinase
IL105699A0 (en) * 1992-06-26 1993-09-22 Genzyme Corp Hydrophilic creams for delivery of therapeutic agents
JPH08503691A (ja) * 1992-06-30 1996-04-23 コーテックス リミテッド 下痢の治療における酵素、特にブロメラインの使用
US5387517A (en) * 1994-03-23 1995-02-07 Ethicon, Inc. Thiol activated protease from stem bromelain for treating devitalized tissue
GB9412711D0 (en) * 1994-06-24 1994-08-17 Cortecs Ltd Medical use of bromelain

Also Published As

Publication number Publication date
ES2288762T3 (es) 2008-01-16
WO1998038291A1 (en) 1998-09-03
CN1249002A (zh) 2000-03-29
CN1204258C (zh) 2005-06-01
EP1908823A1 (de) 2008-04-09
JP2001513635A (ja) 2001-09-04
ATE533842T1 (de) 2011-12-15
EP1908823B1 (de) 2011-11-16
DE69838909T2 (de) 2009-01-08
JP2002512509A (ja) 2002-04-23
EP1865055A1 (de) 2007-12-12
EP0996710A1 (de) 2000-05-03
AU6303798A (en) 1998-09-18
AU6303698A (en) 1998-09-18
EP1865055B1 (de) 2012-12-05
JP2010143945A (ja) 2010-07-01
CN100400659C (zh) 2008-07-09
DE69837923D1 (de) 2007-07-26
DE69837923T2 (de) 2008-02-14
JP4673454B2 (ja) 2011-04-20
CN1252096A (zh) 2000-05-03
ES2297878T3 (es) 2008-05-01
EP1012304A1 (de) 2000-06-28
ES2403433T3 (es) 2013-05-17
EP0996710B1 (de) 2007-12-26
ES2377539T3 (es) 2012-03-28
EP1012304B1 (de) 2007-06-13
JP4651756B2 (ja) 2011-03-16
WO1998038319A1 (en) 1998-09-03
DE69838909D1 (de) 2008-02-07
ATE382084T1 (de) 2008-01-15

Similar Documents

Publication Publication Date Title
DE59911005D1 (de) Aminosäureester von arylsulfonamiden und analoga
PT1042305E (pt) Inibicao de quinase p38 utilizando difenilureias simetricas e assimetricas
DE69814618D1 (de) Behandlung von infarkten durch inhibierung von nf-kappab
BG99261A (en) Steroid glycosides for the treatment of hyperchlesterolemia
NO924229L (no) Trombin, samt fremstilling derav
DE59409200D1 (de) Pharmazeutisches Präparat enthaltend Glucosidase- und/oder Amylasehemmer und einen Lipasehemmer
DE69837295D1 (de) Probucolbernsteinsäureester zur Hemmung der Expression von VCAM-1
DK0971713T3 (da) Anvendelse af cholinesteraseinhibitorer til behandling af opmærksomhedsforstyrrelser
SE9504077L (sv) Absorberande artikel såsom en blöja med en skålformig absorpstionskropp uppvisande minst en urtagning i form av spår eller kompressionslinjer
DK0705100T3 (da) Terapeutiske substituerede guanidiner
DE69812784D1 (de) Zusammensetzung zur Vorbeugung und Beseitigung von Pflanzenkrankheiten
CA2264750A1 (en) Highly selective butyrylcholinesterase inhibitors for the treatment and diagnosis of alzheimer's disease and dementias
EP0656886A1 (de) N-(alkanoylamino-2-hydroxypropyl)-sulfonamide verwendbar als retrovirale proteaseninhibitoren.
DE69837923D1 (de) Bestandteil von bromelain
EE200000093A (et) Agrekanaasi ja maatriksmetalloproteinaaside uudsed inhibiitorid artriidi käitlemiseks
ES2059501T3 (es) Aminoacidos utiles en trastornos hepaticos.
FI956178L (fi) Varsibromelaiiniproteaasin lääkekäyttö
DE69022373D1 (de) Wiedergewinnung von tert.-Butyl-hydroperoxid und von tert.-Butyl-Alkohol.
DK226889A (da) Alkoholpeptidderivat samt anvendelse deraf til mindskning af blodkoagulation
DE60128009D1 (de) Verwendung von sarp-1 zur behandlung und/oder vorbeugung von scleroderma
ATE169618T1 (de) Piperidinylamide, sulfonamide und sulfoxamide als inhibitoren der cholesterin biosynthese
EP0705263A1 (de) Carbocyclische nucleozide mittel nützlich als selektive inhibitoren von proinflammatorischen cytokinen
ES2059666T3 (es) Utilizacion de enzimas catabolicas para el tratamiento de una infeccion vih.
TR200000954T2 (tr) Mikrodolaşım hastalıklarının tedavisi ve önlenmesi için madde.
DE68916377D1 (de) Reinigung von tertiären Hydroperoxiden die primäre und sekundäre Hydroperoxid-Verunreinigungen enthalten.

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties