ATE533842T1 - Bromelainbestandteil - Google Patents

Bromelainbestandteil

Info

Publication number: ATE533842T1
Authority: AT; Austria
Prior art keywords: bromelain; component; map kinase; activation; bromelain component
Prior art date: 1997-02-25

Application number

AT07024577T

Other languages

English (en)

Inventor

Tracey Lehanne Mynott

Christian Engwerda

Keith Peek

Original Assignee

Sarantis Pty Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-02-25

Filing date

1998-02-25

Publication date

2011-12-15

1997-02-25 Priority claimed from GBGB9703850.9A external-priority patent/GB9703850D0/en

1997-02-25 Priority claimed from GBGB9703827.7A external-priority patent/GB9703827D0/en

1997-02-28 Priority claimed from GBGB9704252.7A external-priority patent/GB9704252D0/en

1997-03-25 Priority claimed from GBGB9706119.6A external-priority patent/GB9706119D0/en

1998-02-25 Application filed by Sarantis Pty Ltd filed Critical Sarantis Pty Ltd

2011-12-15 Application granted granted Critical

2011-12-15 Publication of ATE533842T1 publication Critical patent/ATE533842T1/de

Links

108010004032 Bromelains Proteins 0.000 title abstract 3
239000004365 Protease Substances 0.000 title abstract 3
235000019835 bromelain Nutrition 0.000 title abstract 3
UNMLVGNWZDHBRA-UHFFFAOYSA-N N-[2-[5-acetamido-6-hydroxy-2-(hydroxymethyl)-4-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyoxan-3-yl]oxy-5-[4,5-dihydroxy-6-[[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]-3-(3,4,5-trihydroxyoxan-2-yl)oxyoxan-2-yl]oxy-4-hydroxy-6-(hydroxymethyl)oxan-3-yl]acetamide Chemical compound OC1C(O)C(O)C(C)OC1OC1C(OC2C(C(O)C(OC3C(C(O)C(O)C(COC4C(C(O)C(O)C(CO)O4)O)O3)OC3C(C(O)C(O)CO3)O)C(CO)O2)NC(C)=O)C(CO)OC(O)C1NC(C)=O UNMLVGNWZDHBRA-UHFFFAOYSA-N 0.000 title 1
102000043136 MAP kinase family Human genes 0.000 abstract 2
108091054455 MAP kinase family Proteins 0.000 abstract 2
108090000886 Ananain Proteins 0.000 abstract 1
230000006044 T cell activation Effects 0.000 abstract 1
230000004913 activation Effects 0.000 abstract 1
108010033856 comosain Proteins 0.000 abstract 1
230000006806 disease prevention Effects 0.000 abstract 1
230000001404 mediated effect Effects 0.000 abstract 1
230000037361 pathway Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6472—Cysteine endopeptidases (3.4.22)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/63—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from plants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/4873—Cysteine endopeptidases (3.4.22), e.g. stem bromelain, papain, ficin, cathepsin H
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55516—Proteins; Peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Immunology (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Genetics & Genomics (AREA)
Biomedical Technology (AREA)
General Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Microbiology (AREA)
Communicable Diseases (AREA)
Botany (AREA)
Oncology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Rheumatology (AREA)
Pulmonology (AREA)
Gastroenterology & Hepatology (AREA)
Toxicology (AREA)
Epidemiology (AREA)
Pain & Pain Management (AREA)
Transplantation (AREA)
Tropical Medicine & Parasitology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Enzymes And Modification Thereof (AREA)
Saccharide Compounds (AREA)

AT07024577T 1997-02-25 1998-02-25 Bromelainbestandteil ATE533842T1 (de)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
GBGB9703850.9A GB9703850D0 (en)	1997-02-25	1997-02-25	Novel protein
GBGB9703827.7A GB9703827D0 (en)	1997-02-25	1997-02-25	Novel protein
GBGB9704252.7A GB9704252D0 (en)	1997-02-28	1997-02-28	Novel protein
GBGB9706119.6A GB9706119D0 (en)	1997-03-25	1997-03-25	Novel protein

Publications (1)

Publication Number	Publication Date
ATE533842T1 true ATE533842T1 (de)	2011-12-15

Family

ID=27451608

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
AT98907054T ATE364700T1 (de)	1997-02-25	1998-02-25	Bestandteil von bromelain
AT07024577T ATE533842T1 (de)	1997-02-25	1998-02-25	Bromelainbestandteil
AT98907053T ATE382084T1 (de)	1997-02-25	1998-02-25	Bromelinbestandteil

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
AT98907054T ATE364700T1 (de)	1997-02-25	1998-02-25	Bestandteil von bromelain

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
AT98907053T ATE382084T1 (de)	1997-02-25	1998-02-25	Bromelinbestandteil

Country Status (8)

Country	Link
EP (4)	EP0996710B1 (de)
JP (3)	JP4673454B2 (de)
CN (2)	CN100400659C (de)
AT (3)	ATE364700T1 (de)
AU (2)	AU6303698A (de)
DE (2)	DE69838909T2 (de)
ES (4)	ES2288762T3 (de)
WO (2)	WO1998038319A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1012305A1 (de)	1997-02-25	2000-06-28	Cortecs (UK) Limited	Bestandteil von bromelain
US20020102253A1 (en)	1997-02-25	2002-08-01	Mynott Tracey Lehanne	Component of bromelain
CA2333252C (en) *	1998-07-15	2008-11-25	Ursapharm Arzneimittel Gmbh	Use of bromelain proteases for inhibiting blood coagulation
AU2845400A (en) *	1998-12-24	2000-07-31	Phairson Medical Inc.	Treatment and prevention of immune rejection reactions
US6977245B2 (en) *	1999-04-12	2005-12-20	The United States Of America As Represented By The Department Of Health And Human Services	Oligodeoxynucleotide and its use to induce an immune response
EP1208849B1 (de) *	2000-11-28	2015-10-28	URSAPHARM Arzneimittel GmbH	Verwendung von Bromelain zur adjuvanten Therapie der Wundheilung
JP2004529906A (ja) *	2001-03-19	2004-09-30	イオマイコーポレイシヨン	経皮的免疫賦活
CN108472341A (zh) *	2015-08-20	2018-08-31	安纳塔拉生命科学有限公司	具有抗炎活性的酶级分
KR20230005130A (ko) *	2020-03-20	2023-01-09	노벨 콘셉츠 메디컬 리미티드	비-악성 호흡기 질환을 치료 및 예방하기 위한 조성물 및 방법

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8724728D0 (en) *	1987-10-22	1987-11-25	Genzyme Corp	Cysteine proteinase
IL105699A0 (en) *	1992-06-26	1993-09-22	Genzyme Corp	Hydrophilic creams for delivery of therapeutic agents
DK0671943T3 (da) *	1992-06-30	2000-03-27	Cortecs Uk Ltd	Anvendelse af enzymer, især bromelain, i behandlingen af ikke-infektiøs diarré
US5387517A (en) *	1994-03-23	1995-02-07	Ethicon, Inc.	Thiol activated protease from stem bromelain for treating devitalized tissue
GB9412711D0 (en) *	1994-06-24	1994-08-17	Cortecs Ltd	Medical use of bromelain

1998
- 1998-02-25 WO PCT/GB1998/000591 patent/WO1998038319A1/en not_active Ceased
- 1998-02-25 EP EP98907053A patent/EP0996710B1/de not_active Expired - Lifetime
- 1998-02-25 DE DE69838909T patent/DE69838909T2/de not_active Expired - Lifetime
- 1998-02-25 ES ES98907054T patent/ES2288762T3/es not_active Expired - Lifetime
- 1998-02-25 AT AT98907054T patent/ATE364700T1/de not_active IP Right Cessation
- 1998-02-25 CN CNB98803901XA patent/CN100400659C/zh not_active Expired - Fee Related
- 1998-02-25 JP JP53742398A patent/JP4673454B2/ja not_active Expired - Fee Related
- 1998-02-25 AT AT07024577T patent/ATE533842T1/de active
- 1998-02-25 ES ES98907053T patent/ES2297878T3/es not_active Expired - Lifetime
- 1998-02-25 DE DE69837923T patent/DE69837923T2/de not_active Expired - Lifetime
- 1998-02-25 WO PCT/GB1998/000590 patent/WO1998038291A1/en not_active Ceased
- 1998-02-25 EP EP07024577A patent/EP1908823B1/de not_active Expired - Lifetime
- 1998-02-25 ES ES07011287T patent/ES2403433T3/es not_active Expired - Lifetime
- 1998-02-25 AU AU63036/98A patent/AU6303698A/en not_active Abandoned
- 1998-02-25 CN CNB988028255A patent/CN1204258C/zh not_active Expired - Fee Related
- 1998-02-25 AU AU63037/98A patent/AU6303798A/en not_active Abandoned
- 1998-02-25 EP EP07011287A patent/EP1865055B1/de not_active Expired - Lifetime
- 1998-02-25 EP EP98907054A patent/EP1012304B1/de not_active Expired - Lifetime
- 1998-02-25 JP JP53742498A patent/JP4651756B2/ja not_active Expired - Fee Related
- 1998-02-25 AT AT98907053T patent/ATE382084T1/de not_active IP Right Cessation
- 1998-02-25 ES ES07024577T patent/ES2377539T3/es not_active Expired - Lifetime
2010
- 2010-02-23 JP JP2010037537A patent/JP2010143945A/ja active Pending

Also Published As

Publication number	Publication date
ES2403433T3 (es)	2013-05-17
EP0996710A1 (de)	2000-05-03
CN1249002A (zh)	2000-03-29
ATE364700T1 (de)	2007-07-15
EP1908823A1 (de)	2008-04-09
EP1012304B1 (de)	2007-06-13
EP1012304A1 (de)	2000-06-28
JP4673454B2 (ja)	2011-04-20
CN1204258C (zh)	2005-06-01
ES2297878T3 (es)	2008-05-01
ATE382084T1 (de)	2008-01-15
JP4651756B2 (ja)	2011-03-16
DE69838909D1 (de)	2008-02-07
DE69837923D1 (de)	2007-07-26
JP2001513635A (ja)	2001-09-04
CN100400659C (zh)	2008-07-09
DE69837923T2 (de)	2008-02-14
DE69838909T2 (de)	2009-01-08
EP1865055B1 (de)	2012-12-05
EP1908823B1 (de)	2011-11-16
EP1865055A1 (de)	2007-12-12
EP0996710B1 (de)	2007-12-26
AU6303798A (en)	1998-09-18
JP2010143945A (ja)	2010-07-01
ES2288762T3 (es)	2008-01-16
AU6303698A (en)	1998-09-18
CN1252096A (zh)	2000-05-03
JP2002512509A (ja)	2002-04-23
WO1998038319A1 (en)	1998-09-03
ES2377539T3 (es)	2012-03-28
WO1998038291A1 (en)	1998-09-03

Publication	Publication Date	Title
PT1042305E (pt)	2005-10-31	Inibicao de quinase p38 utilizando difenilureias simetricas e assimetricas
DE59911005D1 (de)	2004-12-09	Aminosäureester von arylsulfonamiden und analoga
CA2264750A1 (en)	1999-01-21	Highly selective butyrylcholinesterase inhibitors for the treatment and diagnosis of alzheimer's disease and dementias
DE59409200D1 (de)	2000-04-20	Pharmazeutisches Präparat enthaltend Glucosidase- und/oder Amylasehemmer und einen Lipasehemmer
BG99261A (en)	1995-06-30	Steroid glycosides for the treatment of hyperchlesterolemia
DK0971713T3 (da)	2003-09-22	Anvendelse af cholinesteraseinhibitorer til behandling af opmærksomhedsforstyrrelser
DE69812784D1 (de)	2003-05-08	Zusammensetzung zur Vorbeugung und Beseitigung von Pflanzenkrankheiten
SE9504077L (sv)	1997-02-10	Absorberande artikel såsom en blöja med en skålformig absorpstionskropp uppvisande minst en urtagning i form av spår eller kompressionslinjer
EP0935963A3 (de)	2000-10-04	Verwendung von selektive MMP-13-hemmer zur behandlung von osteoarthrose und sonstige von matrix metalloproteinase vermittelte erkrankungen
DE69837295D1 (de)	2007-04-19	Probucolbernsteinsäureester zur Hemmung der Expression von VCAM-1
ID24838A (id)	2000-08-24	Penggunaan untuk beudesonid dan formoterol
NO924229D0 (no)	1992-11-03	Trombin, samt fremstilling derav
DK0705100T3 (da)	2003-11-17	Terapeutiske substituerede guanidiner
NO20005032D0 (no)	2000-10-06	Behandling av parasittsykdommer ved inhibering av cysteinproteaser av papainsuperfamilien
DE69413051D1 (de)	1998-10-08	Waschmittelzusammensetzungen enthaltend mittel zur verhinderung des anlaufens von silber
FI943231L (fi)	1994-07-06	Ihmisen Kunitz-tyyppisen proteaasiestäjän muunnoksia
EE200000093A (et)	2000-12-15	Agrekanaasi ja maatriksmetalloproteinaaside uudsed inhibiitorid artriidi käitlemiseks
ATE533842T1 (de)	2011-12-15	Bromelainbestandteil
ES2059501T3 (es)	1994-11-16	Aminoacidos utiles en trastornos hepaticos.
MXPA94009086A (es)	2006-02-14	Guanidinas sustituidas terapeuticas.
FI956178L (fi)	1996-02-21	Varsibromelaiiniproteaasin lääkekäyttö
WO2003105753A3 (en)	2005-04-21	METHODS AND COMPOSITIONS FOR GRAFTING FUNCTIONAL LOOPS INTO A PROTEIN
ATE359808T1 (de)	2007-05-15	Verwendung von sarp-1 zur behandlung und/oder vorbeugung von scleroderma
TR200000954T2 (tr)	2000-07-21	Mikrodolaşım hastalıklarının tedavisi ve önlenmesi için madde.
ATE92331T1 (de)	1993-08-15	Verwendung katabolischer enzyme zur bekaempfung einer hiv-erst-infektion.