ATE382084T1 - Bromelinbestandteil - Google Patents

Bromelinbestandteil

Info

Publication number
ATE382084T1
ATE382084T1 AT98907053T AT98907053T ATE382084T1 AT E382084 T1 ATE382084 T1 AT E382084T1 AT 98907053 T AT98907053 T AT 98907053T AT 98907053 T AT98907053 T AT 98907053T AT E382084 T1 ATE382084 T1 AT E382084T1
Authority
AT
Austria
Prior art keywords
component
bromelin
bromelain
map kinase
activation
Prior art date
Application number
AT98907053T
Other languages
English (en)
Inventor
Tracey Mynott
Christian Engwerda
Keith Cortecs Peek
Original Assignee
Sarantis Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9703850.9A external-priority patent/GB9703850D0/en
Priority claimed from GBGB9703827.7A external-priority patent/GB9703827D0/en
Priority claimed from GBGB9704252.7A external-priority patent/GB9704252D0/en
Priority claimed from GBGB9706119.6A external-priority patent/GB9706119D0/en
Application filed by Sarantis Pty Ltd filed Critical Sarantis Pty Ltd
Application granted granted Critical
Publication of ATE382084T1 publication Critical patent/ATE382084T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6472—Cysteine endopeptidases (3.4.22)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/63—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from plants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4873—Cysteine endopeptidases (3.4.22), e.g. stem bromelain, papain, ficin, cathepsin H
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55516—Proteins; Peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Communicable Diseases (AREA)
  • Botany (AREA)
  • Oncology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Saccharide Compounds (AREA)
AT98907053T 1997-02-25 1998-02-25 Bromelinbestandteil ATE382084T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9703850.9A GB9703850D0 (en) 1997-02-25 1997-02-25 Novel protein
GBGB9703827.7A GB9703827D0 (en) 1997-02-25 1997-02-25 Novel protein
GBGB9704252.7A GB9704252D0 (en) 1997-02-28 1997-02-28 Novel protein
GBGB9706119.6A GB9706119D0 (en) 1997-03-25 1997-03-25 Novel protein

Publications (1)

Publication Number Publication Date
ATE382084T1 true ATE382084T1 (de) 2008-01-15

Family

ID=27451608

Family Applications (3)

Application Number Title Priority Date Filing Date
AT98907054T ATE364700T1 (de) 1997-02-25 1998-02-25 Bestandteil von bromelain
AT07024577T ATE533842T1 (de) 1997-02-25 1998-02-25 Bromelainbestandteil
AT98907053T ATE382084T1 (de) 1997-02-25 1998-02-25 Bromelinbestandteil

Family Applications Before (2)

Application Number Title Priority Date Filing Date
AT98907054T ATE364700T1 (de) 1997-02-25 1998-02-25 Bestandteil von bromelain
AT07024577T ATE533842T1 (de) 1997-02-25 1998-02-25 Bromelainbestandteil

Country Status (8)

Country Link
EP (4) EP0996710B1 (de)
JP (3) JP4673454B2 (de)
CN (2) CN100400659C (de)
AT (3) ATE364700T1 (de)
AU (2) AU6303698A (de)
DE (2) DE69838909T2 (de)
ES (4) ES2288762T3 (de)
WO (2) WO1998038319A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1012305A1 (de) 1997-02-25 2000-06-28 Cortecs (UK) Limited Bestandteil von bromelain
US20020102253A1 (en) 1997-02-25 2002-08-01 Mynott Tracey Lehanne Component of bromelain
CA2333252C (en) * 1998-07-15 2008-11-25 Ursapharm Arzneimittel Gmbh Use of bromelain proteases for inhibiting blood coagulation
AU2845400A (en) * 1998-12-24 2000-07-31 Phairson Medical Inc. Treatment and prevention of immune rejection reactions
US6977245B2 (en) * 1999-04-12 2005-12-20 The United States Of America As Represented By The Department Of Health And Human Services Oligodeoxynucleotide and its use to induce an immune response
EP1208849B1 (de) * 2000-11-28 2015-10-28 URSAPHARM Arzneimittel GmbH Verwendung von Bromelain zur adjuvanten Therapie der Wundheilung
JP2004529906A (ja) * 2001-03-19 2004-09-30 イオマイ コーポレイシヨン 経皮的免疫賦活
CN108472341A (zh) * 2015-08-20 2018-08-31 安纳塔拉生命科学有限公司 具有抗炎活性的酶级分
KR20230005130A (ko) * 2020-03-20 2023-01-09 노벨 콘셉츠 메디컬 리미티드 비-악성 호흡기 질환을 치료 및 예방하기 위한 조성물 및 방법

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8724728D0 (en) * 1987-10-22 1987-11-25 Genzyme Corp Cysteine proteinase
IL105699A0 (en) * 1992-06-26 1993-09-22 Genzyme Corp Hydrophilic creams for delivery of therapeutic agents
DK0671943T3 (da) * 1992-06-30 2000-03-27 Cortecs Uk Ltd Anvendelse af enzymer, især bromelain, i behandlingen af ikke-infektiøs diarré
US5387517A (en) * 1994-03-23 1995-02-07 Ethicon, Inc. Thiol activated protease from stem bromelain for treating devitalized tissue
GB9412711D0 (en) * 1994-06-24 1994-08-17 Cortecs Ltd Medical use of bromelain

Also Published As

Publication number Publication date
ES2403433T3 (es) 2013-05-17
EP0996710A1 (de) 2000-05-03
CN1249002A (zh) 2000-03-29
ATE364700T1 (de) 2007-07-15
EP1908823A1 (de) 2008-04-09
EP1012304B1 (de) 2007-06-13
EP1012304A1 (de) 2000-06-28
JP4673454B2 (ja) 2011-04-20
CN1204258C (zh) 2005-06-01
ES2297878T3 (es) 2008-05-01
JP4651756B2 (ja) 2011-03-16
ATE533842T1 (de) 2011-12-15
DE69838909D1 (de) 2008-02-07
DE69837923D1 (de) 2007-07-26
JP2001513635A (ja) 2001-09-04
CN100400659C (zh) 2008-07-09
DE69837923T2 (de) 2008-02-14
DE69838909T2 (de) 2009-01-08
EP1865055B1 (de) 2012-12-05
EP1908823B1 (de) 2011-11-16
EP1865055A1 (de) 2007-12-12
EP0996710B1 (de) 2007-12-26
AU6303798A (en) 1998-09-18
JP2010143945A (ja) 2010-07-01
ES2288762T3 (es) 2008-01-16
AU6303698A (en) 1998-09-18
CN1252096A (zh) 2000-05-03
JP2002512509A (ja) 2002-04-23
WO1998038319A1 (en) 1998-09-03
ES2377539T3 (es) 2012-03-28
WO1998038291A1 (en) 1998-09-03

Similar Documents

Publication Publication Date Title
PT1042305E (pt) Inibicao de quinase p38 utilizando difenilureias simetricas e assimetricas
DE59911005D1 (de) Aminosäureester von arylsulfonamiden und analoga
DE60131262D1 (en) Ubiquitin-ligase-assay
SE9504077L (sv) Absorberande artikel såsom en blöja med en skålformig absorpstionskropp uppvisande minst en urtagning i form av spår eller kompressionslinjer
ID24838A (id) Penggunaan untuk beudesonid dan formoterol
DE59409200D1 (de) Pharmazeutisches Präparat enthaltend Glucosidase- und/oder Amylasehemmer und einen Lipasehemmer
CA2264750A1 (en) Highly selective butyrylcholinesterase inhibitors for the treatment and diagnosis of alzheimer's disease and dementias
NO924229D0 (no) Trombin, samt fremstilling derav
DE69812784D1 (de) Zusammensetzung zur Vorbeugung und Beseitigung von Pflanzenkrankheiten
BG99261A (en) Steroid glycosides for the treatment of hyperchlesterolemia
EE200000093A (et) Agrekanaasi ja maatriksmetalloproteinaaside uudsed inhibiitorid artriidi käitlemiseks
FI943231L (fi) Ihmisen Kunitz-tyyppisen proteaasiestäjän muunnoksia
DE3671021D1 (de) Peptid-derivate, pepstatin-analoga, renin- und saeureprotease hemmende mittel.
ATE382084T1 (de) Bromelinbestandteil
ES2059501T3 (es) Aminoacidos utiles en trastornos hepaticos.
FI935777A7 (fi) AIDSin hoitamisessa käyttökelpoiset HIV-proteaasin inhibiittorit
ATE277943T1 (de) Trypsininhibitoren
FI956178A7 (fi) Varsibromelaiiniproteaasin lääkekäyttö
DE69823339D1 (de) Atropisomere 3-heteroaryl-4(3h)-chinazolinone zur behandlung von neurodegenerativen und cns-trauma zuständen
DE69022373D1 (de) Wiedergewinnung von tert.-Butyl-hydroperoxid und von tert.-Butyl-Alkohol.
IL106237A0 (en) Piperidyl amides,sulfonamides and sulfoxamides as inhibitors of cholesterol biosynthesis
TR200000954T2 (tr) Mikrodolaşım hastalıklarının tedavisi ve önlenmesi için madde.
EP0705263A1 (de) Carbocyclische nucleozide mittel nützlich als selektive inhibitoren von proinflammatorischen cytokinen
DE68916377D1 (de) Reinigung von tertiären Hydroperoxiden die primäre und sekundäre Hydroperoxid-Verunreinigungen enthalten.
FI963263A7 (fi) Bromelaiinin lääkinnällinen käyttö

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties