ATE369146T1 - Insulinpreparation mit mannitol - Google Patents

Insulinpreparation mit mannitol

Info

Publication number: ATE369146T1
Authority: AT; Austria
Prior art keywords: carbohydrate; mannitol; carbon atoms; insulin preparation; water
Prior art date: 1996-06-20

Application number

AT97927018T

Other languages

English (en)

Inventor

Lone Kimer

Per Balschmidt

Steen Jensen

Original Assignee

Novo Nordisk As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-06-20

Filing date

1997-06-19

Publication date

2007-08-15

1997-06-19 Application filed by Novo Nordisk As filed Critical Novo Nordisk As

2007-08-15 Application granted granted Critical

2007-08-15 Publication of ATE369146T1 publication Critical patent/ATE369146T1/de

Links

NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 4
102000004877 Insulin Human genes 0.000 title abstract 2
108090001061 Insulin Proteins 0.000 title abstract 2
229940125396 insulin Drugs 0.000 title abstract 2
238000002360 preparation method Methods 0.000 title abstract 2
FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 title 1
229930195725 Mannitol Natural products 0.000 title 1
235000010355 mannitol Nutrition 0.000 title 1
239000000594 mannitol Substances 0.000 title 1
150000001720 carbohydrates Chemical class 0.000 abstract 5
125000004432 carbon atom Chemical group C* 0.000 abstract 2
101000976075 Homo sapiens Insulin Proteins 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
150000002170 ethers Chemical class 0.000 abstract 1
PBGKTOXHQIOBKM-FHFVDXKLSA-N insulin (human) Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 PBGKTOXHQIOBKM-FHFVDXKLSA-N 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Diabetes (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Endocrinology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Oil, Petroleum & Natural Gas (AREA)
Gastroenterology & Hepatology (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Immunology (AREA)
Zoology (AREA)
Dermatology (AREA)
Emergency Medicine (AREA)
Hematology (AREA)
Obesity (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Medicinal Preparation (AREA)

AT97927018T 1996-06-20 1997-06-19 Insulinpreparation mit mannitol ATE369146T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DK68496		1996-06-20
DK89996		1996-08-27

Publications (1)

Publication Number	Publication Date
ATE369146T1 true ATE369146T1 (de)	2007-08-15

Family

ID=26064448

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT97927018T ATE369146T1 (de)	1996-06-20	1997-06-19	Insulinpreparation mit mannitol

Country Status (16)

Country	Link
EP (1)	EP0910402B1 (de)
JP (2)	JP4472027B2 (de)
KR (1)	KR20000022030A (de)
CN (1)	CN1198643C (de)
AT (1)	ATE369146T1 (de)
AU (1)	AU719361B2 (de)
BR (1)	BR9709844A (de)
CA (1)	CA2258099A1 (de)
CZ (1)	CZ297682B6 (de)
DE (1)	DE69737995T2 (de)
ES (1)	ES2292189T3 (de)
HU (1)	HUP9904156A3 (de)
IL (1)	IL127365A0 (de)
NO (1)	NO324276B1 (de)
PL (1)	PL188736B1 (de)
WO (1)	WO1997048413A1 (de)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2001521004A (ja)	1997-10-24	2001-11-06	イーライ・リリー・アンド・カンパニー	脂肪酸−アシル化インスリン類似体
ZA989644B (en) *	1997-10-24	2000-04-25	Lilly Co Eli	Insoluble insulen compositions.
EP1396272A1 (de) *	1997-12-23	2004-03-10	Eli Lilly & Company	Unlöslische Insulin Zusammensetzungen zur Regelung der Blutglukose
CO4970787A1 (es) *	1997-12-23	2000-11-07	Lilly Co Eli	Composiciones insolubles de insulina y derivados de insulina que controlan la glucosa sanguinea
WO1999048520A1 (en) *	1998-03-24	1999-09-30	Joergensen Klavs Holger	Novel preparation of protracted acting human insulin
GB9806462D0 (en) *	1998-03-26	1998-05-27	Glaxo Group Ltd	Improved compositions for inhalation
US6635617B1 (en)	1998-10-16	2003-10-21	Novo Nordisk A/S	Insulin preparations for pulmonary delivery containing menthol
DE69920767T2 (de) *	1998-10-16	2006-02-02	Novo Nordisk A/S	Stabile konzentrierte Insulin Präparationen zur pulmonaren Verabreichung
US6211144B1 (en)	1998-10-16	2001-04-03	Novo Nordisk A/S	Stable concentrated insulin preparations for pulmonary delivery
UA67798C2 (uk) *	1998-10-16	2004-07-15	Ново Нордіск А/С	Препарати інсуліну, які містять ментол, для доставки через легені
ATE390126T1 (de) *	2003-05-01	2008-04-15	Ltt Bio Pharma Co Ltd	Zubereitungen mit verzögerter freigabe enthaltend zink, und herstellung derselben
AU2005291233B2 (en) *	2004-10-05	2011-02-03	Novo Nordisk A/S	A pharmaceutical formulation comprising crystalline insulin and dissolved insulin
CN101060856B (zh) *	2004-11-22	2011-01-19	诺和诺德公司	可溶、稳定的含胰岛素制剂
CN1931360B (zh) *	2006-09-22	2013-02-13	江苏万邦生化医药股份有限公司	双时相精蛋白锌胰岛素注射液(30%)及其制备方法
AU2009203809B2 (en)	2008-01-09	2013-07-25	Sanofi-Aventis Deutschland Gmbh	Novel insulin derivatives having an extremely delayed time-action profile
PT3228320T (pt)	2008-10-17	2020-03-26	Sanofi Aventis Deutschland	Combinação de uma insulina e de um agonista do glp-1
KR101853606B1 (ko)	2009-07-06	2018-05-03	사노피-아벤티스 도이칠란트 게엠베하	메티오닌을 함유하는 수성 인슐린 제제
DK2498802T3 (en)	2009-11-13	2015-04-13	Sanofi Aventis Deutschland	Pharmaceutical composition comprising a GLP-1 agonist, insulin and a methionine
KR101337322B1 (ko)	2009-11-13	2013-12-06	사노피-아벤티스 도이칠란트 게엠베하	Ｇｌｐ-1 효능제 및 메티오닌을 포함하는 약제학적 조성물
ES2606554T3 (es)	2010-08-30	2017-03-24	Sanofi-Aventis Deutschland Gmbh	Uso de AVE0010 para la fabricación de un medicamento para el tratamiento de la diabetes mellitus de tipo 2
US9821032B2 (en)	2011-05-13	2017-11-21	Sanofi-Aventis Deutschland Gmbh	Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
PL2750699T3 (pl)	2011-08-29	2015-12-31	Sanofi Aventis Deutschland	Kombinacja farmaceutyczna do stosowania w kontroli glikemii u pacjentów z cukrzycą typu 2
AR087744A1 (es)	2011-09-01	2014-04-16	Sanofi Aventis Deutschland	Composicion farmaceutica para uso en el tratamiento de una enfermedad neurodegenerativa
TWI641381B (zh)	2013-02-04	2018-11-21	法商賽諾菲公司	胰島素類似物及／或胰島素衍生物之穩定化醫藥調配物
SG11201604706TA (en) *	2014-01-09	2016-07-28	Sanofi Sa	Stabilized pharmaceutical formulations of insulin aspart
JP2020143105A (ja) *	2014-01-09	2020-09-10	サノフイＳａｎｏｆｉ	インスリンアスパルトの安定化された医薬製剤
EP3091965A1 (de) *	2014-01-09	2016-11-16	Sanofi	Stabilisierte glycerinfreie pharmazeutische formulierungen von insulinanaloga und/oder insulinderivaten
JP2020114861A (ja) *	2014-01-09	2020-07-30	サノフイＳａｎｏｆｉ	インスリンアナログおよび／またはインスリン誘導体の、グリセリンを含まない安定化された医薬製剤
JP7173953B2 (ja) *	2014-01-09	2022-11-16	サノフイ	インスリンアナログおよび／またはインスリン誘導体の安定化された医薬製剤
CN112957455A (zh)	2014-01-09	2021-06-15	赛诺菲	胰岛素类似物和/或胰岛素衍生物的稳定化药物制剂
AU2015359376B2 (en)	2014-12-12	2021-09-09	Sanofi-Aventis Deutschland Gmbh	Insulin glargine/lixisenatide fixed ratio formulation
TWI748945B (zh)	2015-03-13	2021-12-11	德商賽諾菲阿凡提斯德意志有限公司	第２型糖尿病病患治療
TW201705975A (zh)	2015-03-18	2017-02-16	賽諾菲阿凡提斯德意志有限公司	第２型糖尿病病患之治療
WO2017163159A1 (en) *	2016-03-21	2017-09-28	Wockhardt Limited	Biphasic pharmaceutical composition of insulin human

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4439181A (en) *	1981-01-26	1984-03-27	Regents Of The University Of Minnesota	Polyol-hormone mixture for use in chronic parenteral hormone administration
US4839341A (en) *	1984-05-29	1989-06-13	Eli Lilly And Company	Stabilized insulin formulations
US4876241A (en) *	1987-05-22	1989-10-24	Armour Pharmaceutical Company	Stabilization of biological and pharmaceutical products during thermal inactivation of viral and bacterial contaminants
DE122006000015I1 (de) *	1993-06-21	2006-06-29	Novo Nordisk As	Asp-B28-Insulinkristalle

1997
- 1997-06-19 AT AT97927018T patent/ATE369146T1/de not_active IP Right Cessation
- 1997-06-19 EP EP97927018A patent/EP0910402B1/de not_active Expired - Lifetime
- 1997-06-19 ES ES97927018T patent/ES2292189T3/es not_active Expired - Lifetime
- 1997-06-19 AU AU31665/97A patent/AU719361B2/en not_active Ceased
- 1997-06-19 WO PCT/DK1997/000267 patent/WO1997048413A1/en not_active Ceased
- 1997-06-19 PL PL97330828A patent/PL188736B1/pl not_active IP Right Cessation
- 1997-06-19 CN CNB971956642A patent/CN1198643C/zh not_active Expired - Fee Related
- 1997-06-19 IL IL12736597A patent/IL127365A0/xx active IP Right Grant
- 1997-06-19 JP JP50212898A patent/JP4472027B2/ja not_active Expired - Lifetime
- 1997-06-19 CA CA002258099A patent/CA2258099A1/en not_active Abandoned
- 1997-06-19 DE DE69737995T patent/DE69737995T2/de not_active Expired - Lifetime
- 1997-06-19 BR BR9709844A patent/BR9709844A/pt not_active IP Right Cessation
- 1997-06-19 CZ CZ0395798A patent/CZ297682B6/cs not_active IP Right Cessation
- 1997-06-19 KR KR1019980710428A patent/KR20000022030A/ko not_active Ceased
- 1997-06-19 HU HU9904156A patent/HUP9904156A3/hu unknown
1998
- 1998-12-18 NO NO19985978A patent/NO324276B1/no unknown
2009
- 2009-05-07 JP JP2009112968A patent/JP2009242400A/ja not_active Withdrawn

Also Published As

Publication number	Publication date
HUP9904156A3 (en)	2000-07-28
WO1997048413A1 (en)	1997-12-24
EP0910402B1 (de)	2007-08-08
CN1198643C (zh)	2005-04-27
IL127365A0 (en)	1999-10-28
PL330828A1 (en)	1999-06-07
DE69737995T2 (de)	2008-04-24
NO985978D0 (no)	1998-12-18
HUP9904156A2 (hu)	2000-06-28
AU3166597A (en)	1998-01-07
CN1222084A (zh)	1999-07-07
NO324276B1 (no)	2007-09-17
PL188736B1 (pl)	2005-04-29
NO985978L (no)	1999-02-19
ES2292189T3 (es)	2008-03-01
JP4472027B2 (ja)	2010-06-02
JP2009242400A (ja)	2009-10-22
JP2000513343A (ja)	2000-10-10
CZ395798A3 (cs)	1999-05-12
DE69737995D1 (de)	2007-09-20
EP0910402A1 (de)	1999-04-28
BR9709844A (pt)	1999-08-10
CA2258099A1 (en)	1997-12-24
KR20000022030A (ko)	2000-04-25
CZ297682B6 (cs)	2007-03-07
AU719361B2 (en)	2000-05-04

Legal Events

Date	Code	Title	Description
2008-02-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE69737995D1 (de)	2007-09-20	INSULINPREPARATION MIT MAnnitol
ZA975470B (en)	1997-12-22	Insulin preparations containing naci.
AU7928891A (en)	1992-01-02	Mixtures of low molecular weight polysaccharides, and their preparation and use
EP1736147A3 (de)	2007-10-17	Fluorchlorkohlenwasserstofffreie Aerosolformulierungen
GB9806632D0 (en)	1998-05-27	Peptide factor
DE68906161D1 (de)	1993-05-27	Ballon fuer medizinische einrichtung und dessen herstellung.
IT8919730A0 (it)	1989-03-10	Derivati xantinici ad attivita' broncodilatatrice e loro applicazioni terapeutiche.
DE59009354D1 (de)	1995-08-03	Zahnärztlicher Patientenstuhl.
USD285630S (en)	1986-09-16	Adjustable lounge chair
PT1058544E (pt)	2005-04-29	Inibicao da actividade do tnf
BR9106372A (pt)	1993-04-27	Derivados 1,5-benzotiazepinona,suas preparacoes e uso farmaceutico
IT8820113A0 (it)	1988-04-07	Derivati peptidici del3_aminodiidrotiofen_2_one, loro preparazione e impiego terapeutico.
IT8820245A0 (it)	1988-04-19	Palmitoil_fruttosio_1,6_difosfato, suo uso terapeutico e relativi metodi di preparazione.
IT1249060B (it)	1995-02-11	Composizione farmaceutica ad uso topico per il trattamento di cicatrizzazione e riepitelizzazione di ulcere flebostatiche croniche.
Sharpe	1990	Bilingualism in the administration of justice in New Brunswick from 1963 to 1989.
ES1009379U (es)	1990-01-01	Tumbona anatomica y basculante.
AU3062189A (en)	1989-08-25	Wheeled invalid chairs
李国林	1988	The Other Side of Midnight
AU110641S (en)	1991-03-21	A set of office chairs including a high backed chair a high backed chair with arms a low backed chair and a low backed chair with arms.
BR7001057U (pt)	1991-12-17	Mesa com cadeira conjugadas
FR2665443B1 (fr)	1992-11-06	Derives d'amino-4-methyl-1-tetralines, leur preparation et leur application en therapeutique.
KR900002434U (ko)	1990-02-06	의자의 회전 변환식 머리받침구
IT8834038V0 (it)	1988-08-01	Dispositivo di sostegno, posizionamento e bloccaggio della prolunga aggiuntiva inseribile nei tavoli prolungabili, dedispositivo di sostegno, posizionamento e bloccaggio della prolunga aggiuntiva inseribile nei tavoli prolungabili, denominato ricel 88. nominato ricel 88.
IT9022315A1 (it)	1992-06-07	Composti ad attivita' antiradicalica, procedimento per la loro prepara zione e loro impieghi.
SE8701326L (sv)	1988-10-01	Ergodynamisk sittmoebel