ATE369146T1 - Insulinpreparation mit mannitol - Google Patents

Insulinpreparation mit mannitol

Info

Publication number: ATE369146T1
Authority: AT; Austria
Prior art keywords: carbohydrate; mannitol; carbon atoms; insulin preparation; water
Prior art date: 1996-06-20

Application number

AT97927018T

Other languages

English (en)

Inventor

Lone Kimer

Per Balschmidt

Steen Jensen

Original Assignee

Novo Nordisk As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-06-20

Filing date

1997-06-19

Publication date

2007-08-15

1997-06-19 Application filed by Novo Nordisk As filed Critical Novo Nordisk As

2007-08-15 Application granted granted Critical

2007-08-15 Publication of ATE369146T1 publication Critical patent/ATE369146T1/de

Links

NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 4
102000004877 Insulin Human genes 0.000 title abstract 2
108090001061 Insulin Proteins 0.000 title abstract 2
229940125396 insulin Drugs 0.000 title abstract 2
238000002360 preparation method Methods 0.000 title abstract 2
FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 title 1
229930195725 Mannitol Natural products 0.000 title 1
235000010355 mannitol Nutrition 0.000 title 1
239000000594 mannitol Substances 0.000 title 1
150000001720 carbohydrates Chemical class 0.000 abstract 5
125000004432 carbon atom Chemical group C* 0.000 abstract 2
101000976075 Homo sapiens Insulin Proteins 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
150000002170 ethers Chemical class 0.000 abstract 1
PBGKTOXHQIOBKM-FHFVDXKLSA-N insulin (human) Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 PBGKTOXHQIOBKM-FHFVDXKLSA-N 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Diabetes (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Endocrinology (AREA)
Organic Chemistry (AREA)
Oil, Petroleum & Natural Gas (AREA)
Zoology (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Immunology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Hematology (AREA)
Obesity (AREA)
Emergency Medicine (AREA)
Dermatology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Medicinal Preparation (AREA)

AT97927018T 1996-06-20 1997-06-19 Insulinpreparation mit mannitol ATE369146T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DK68496		1996-06-20
DK89996		1996-08-27

Publications (1)

Publication Number	Publication Date
ATE369146T1 true ATE369146T1 (de)	2007-08-15

Family

ID=26064448

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT97927018T ATE369146T1 (de)	1996-06-20	1997-06-19	Insulinpreparation mit mannitol

Country Status (16)

Country	Link
EP (1)	EP0910402B1 (de)
JP (2)	JP4472027B2 (de)
KR (1)	KR20000022030A (de)
CN (1)	CN1198643C (de)
AT (1)	ATE369146T1 (de)
AU (1)	AU719361B2 (de)
BR (1)	BR9709844A (de)
CA (1)	CA2258099A1 (de)
CZ (1)	CZ297682B6 (de)
DE (1)	DE69737995T2 (de)
ES (1)	ES2292189T3 (de)
HU (1)	HUP9904156A3 (de)
IL (1)	IL127365A0 (de)
NO (1)	NO324276B1 (de)
PL (1)	PL188736B1 (de)
WO (1)	WO1997048413A1 (de)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ZA989644B (en) *	1997-10-24	2000-04-25	Lilly Co Eli	Insoluble insulen compositions.
AR020047A1 (es)	1997-10-24	2002-04-10	Lilly Co Eli	Composiciones insolubles de insulina, formulaciones en suspension que incluyen dicha composicion insoluble de insulina; y el uso de dicha composicionpara preparar medicamentos y procedimiento para preparar dichas composiciones insolubles.
EP1396272A1 (de) *	1997-12-23	2004-03-10	Eli Lilly & Company	Unlöslische Insulin Zusammensetzungen zur Regelung der Blutglukose
CO4970787A1 (es)	1997-12-23	2000-11-07	Lilly Co Eli	Composiciones insolubles de insulina y derivados de insulina que controlan la glucosa sanguinea
AU2827199A (en) *	1998-03-24	1999-10-18	Klavs Holger Jorgensen	Novel preparation of protracted acting human insulin
GB9806462D0 (en) *	1998-03-26	1998-05-27	Glaxo Group Ltd	Improved compositions for inhalation
US6211144B1 (en)	1998-10-16	2001-04-03	Novo Nordisk A/S	Stable concentrated insulin preparations for pulmonary delivery
AU758146B2 (en) *	1998-10-16	2003-03-13	Novo Nordisk A/S	Stable concentrated insulin preparations for pulmonary delivery
HUP0103606A3 (en) *	1998-10-16	2002-05-28	Novo Nordisk As	Insulin preparations for pulmonary delivery containing menthol
US6635617B1 (en)	1998-10-16	2003-10-21	Novo Nordisk A/S	Insulin preparations for pulmonary delivery containing menthol
JP4567668B2 (ja) *	2003-05-01	2010-10-20	株式会社Ｌｔｔバイオファーマ	亜鉛含有徐放性組成物，その製剤およびその製造方法
LT2918286T (lt) *	2004-10-05	2020-04-10	Novo Nordisk A/S	Farmacinis preparatas, kurio sudėtyje yra kristalinės ir taip pat ištirpintos formos insulino
US8263551B2 (en)	2004-11-22	2012-09-11	Novo Nordisk A/S	Soluble, stable insulin-containing formulations with a protamine salt
CN1931360B (zh) *	2006-09-22	2013-02-13	江苏万邦生化医药股份有限公司	双时相精蛋白锌胰岛素注射液(30%)及其制备方法
CA2711749A1 (en)	2008-01-09	2009-07-16	Sanofi-Aventis Deutschland Gmbh	Novel insulin derivatives having an extremely delayed time-action profile
RS59913B1 (sr)	2008-10-17	2020-03-31	Sanofi Aventis Deutschland	Kombinacija insulina i glp-1-agonista
SG10201403840VA (en)	2009-07-06	2014-10-30	Sanofi Aventis Deutschland	Aqueous insulin preparations containing methionine
SI2498802T1 (sl)	2009-11-13	2015-05-29	Sanofi-Aventis Deutschland Gmbh	Farmacevtski sestavek, ki vsebuje agonist GLP-1, inzulin in metionin
PL2498801T3 (pl)	2009-11-13	2018-08-31	Sanofi Aventis Deutschland	Kompozycja farmaceutyczna zawierająca desPro<sup>36</sup>eksendyno-4(1-39)-Lys6-NH2 i metioninę
BR112013004756B1 (pt)	2010-08-30	2020-04-28	Sanofi Aventis Deutschland	uso de ave0010 para a fabricação de um medicamento para o tratamento da diabetes melito tipo 2
US9821032B2 (en)	2011-05-13	2017-11-21	Sanofi-Aventis Deutschland Gmbh	Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
CA2846413C (en)	2011-08-29	2021-11-02	Sanofi-Aventis Deutschland Gmbh	Pharmaceutical combination for use in glycemic control in diabetes type 2 patients
TWI559929B (en)	2011-09-01	2016-12-01	Sanofi Aventis Deutschland	Pharmaceutical composition for use in the treatment of a neurodegenerative disease
TWI641381B (zh)	2013-02-04	2018-11-21	法商賽諾菲公司	胰島素類似物及／或胰島素衍生物之穩定化醫藥調配物
CA2932877A1 (en) *	2014-01-09	2015-07-16	Sanofi	Stabilized pharmaceutical formulations of insulin analogues and/or insulin derivatives
JP7173953B2 (ja) *	2014-01-09	2022-11-16	サノフイ	インスリンアナログおよび／またはインスリン誘導体の安定化された医薬製剤
JP2020143105A (ja) *	2014-01-09	2020-09-10	サノフイＳａｎｏｆｉ	インスリンアスパルトの安定化された医薬製剤
JP2020114861A (ja) *	2014-01-09	2020-07-30	サノフイＳａｎｏｆｉ	インスリンアナログおよび／またはインスリン誘導体の、グリセリンを含まない安定化された医薬製剤
RU2016132340A (ru) *	2014-01-09	2018-02-14	Санофи	Стабилизированные фармацевтические составы на основе инсулина аспарта
EP3091965A1 (de)	2014-01-09	2016-11-16	Sanofi	Stabilisierte glycerinfreie pharmazeutische formulierungen von insulinanaloga und/oder insulinderivaten
TWI758239B (zh)	2014-12-12	2022-03-21	德商賽諾菲阿凡提斯德意志有限公司	甘精胰島素/利司那肽固定比率配製劑
TWI748945B (zh)	2015-03-13	2021-12-11	德商賽諾菲阿凡提斯德意志有限公司	第２型糖尿病病患治療
TW201705975A (zh)	2015-03-18	2017-02-16	賽諾菲阿凡提斯德意志有限公司	第２型糖尿病病患之治療
WO2017163159A1 (en) *	2016-03-21	2017-09-28	Wockhardt Limited	Biphasic pharmaceutical composition of insulin human

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4439181A (en) *	1981-01-26	1984-03-27	Regents Of The University Of Minnesota	Polyol-hormone mixture for use in chronic parenteral hormone administration
US4839341A (en) *	1984-05-29	1989-06-13	Eli Lilly And Company	Stabilized insulin formulations
US4876241A (en) *	1987-05-22	1989-10-24	Armour Pharmaceutical Company	Stabilization of biological and pharmaceutical products during thermal inactivation of viral and bacterial contaminants
DE122006000017I1 (de) *	1993-06-21	2006-06-29	Novo Nordisk As	ASP-B28-Insulinkristalle

1997
- 1997-06-19 PL PL97330828A patent/PL188736B1/pl not_active IP Right Cessation
- 1997-06-19 ES ES97927018T patent/ES2292189T3/es not_active Expired - Lifetime
- 1997-06-19 JP JP50212898A patent/JP4472027B2/ja not_active Expired - Lifetime
- 1997-06-19 AT AT97927018T patent/ATE369146T1/de not_active IP Right Cessation
- 1997-06-19 AU AU31665/97A patent/AU719361B2/en not_active Ceased
- 1997-06-19 KR KR1019980710428A patent/KR20000022030A/ko not_active Ceased
- 1997-06-19 BR BR9709844A patent/BR9709844A/pt not_active IP Right Cessation
- 1997-06-19 CA CA002258099A patent/CA2258099A1/en not_active Abandoned
- 1997-06-19 CZ CZ0395798A patent/CZ297682B6/cs not_active IP Right Cessation
- 1997-06-19 EP EP97927018A patent/EP0910402B1/de not_active Expired - Lifetime
- 1997-06-19 DE DE69737995T patent/DE69737995T2/de not_active Expired - Lifetime
- 1997-06-19 HU HU9904156A patent/HUP9904156A3/hu unknown
- 1997-06-19 WO PCT/DK1997/000267 patent/WO1997048413A1/en not_active Ceased
- 1997-06-19 IL IL12736597A patent/IL127365A0/xx active IP Right Grant
- 1997-06-19 CN CNB971956642A patent/CN1198643C/zh not_active Expired - Fee Related
1998
- 1998-12-18 NO NO19985978A patent/NO324276B1/no unknown
2009
- 2009-05-07 JP JP2009112968A patent/JP2009242400A/ja not_active Withdrawn

Also Published As

Publication number	Publication date
PL330828A1 (en)	1999-06-07
PL188736B1 (pl)	2005-04-29
CZ395798A3 (cs)	1999-05-12
EP0910402B1 (de)	2007-08-08
CN1198643C (zh)	2005-04-27
IL127365A0 (en)	1999-10-28
JP2000513343A (ja)	2000-10-10
NO985978D0 (no)	1998-12-18
ES2292189T3 (es)	2008-03-01
WO1997048413A1 (en)	1997-12-24
AU719361B2 (en)	2000-05-04
NO985978L (no)	1999-02-19
CA2258099A1 (en)	1997-12-24
JP2009242400A (ja)	2009-10-22
DE69737995T2 (de)	2008-04-24
EP0910402A1 (de)	1999-04-28
AU3166597A (en)	1998-01-07
HUP9904156A3 (en)	2000-07-28
JP4472027B2 (ja)	2010-06-02
HUP9904156A2 (hu)	2000-06-28
DE69737995D1 (de)	2007-09-20
CN1222084A (zh)	1999-07-07
CZ297682B6 (cs)	2007-03-07
KR20000022030A (ko)	2000-04-25
BR9709844A (pt)	1999-08-10
NO324276B1 (no)	2007-09-17

Legal Events

Date	Code	Title	Description
2008-02-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE369146T1 (de)	2007-08-15	Insulinpreparation mit mannitol
DE69708121D1 (de)	2001-12-13	Halogenid-enthaltende insulinzubereitungen
DK0725648T3 (da)	2007-08-20	Leverspecifikke farmaceutiske aktivstoffer
AU7928891A (en)	1992-01-02	Mixtures of low molecular weight polysaccharides, and their preparation and use
EP1736147A3 (de)	2007-10-17	Fluorchlorkohlenwasserstofffreie Aerosolformulierungen
IL138665A0 (en)	2001-10-31	Peptide factor
IT8919730A0 (it)	1989-03-10	Derivati xantinici ad attivita' broncodilatatrice e loro applicazioni terapeutiche.
USD285630S (en)	1986-09-16	Adjustable lounge chair
PT1058544E (pt)	2005-04-29	Inibicao da actividade do tnf
BR9106372A (pt)	1993-04-27	Derivados 1,5-benzotiazepinona,suas preparacoes e uso farmaceutico
IT8820113A0 (it)	1988-04-07	Derivati peptidici del3_aminodiidrotiofen_2_one, loro preparazione e impiego terapeutico.
FR2672594B1 (fr)	1994-07-01	Derives d'ethers de phenols, leur preparation et leur application en therapeutique.
Sharpe	1990	Bilingualism in the administration of justice in New Brunswick from 1963 to 1989.
ES1009379U (es)	1990-01-01	Tumbona anatomica y basculante.
AU3062189A (en)	1989-08-25	Wheeled invalid chairs
李国林	1988	The Other Side of Midnight
Greer	1989	Effects of NaCl on tobacco callus cultures
AU110641S (en)	1991-03-21	A set of office chairs including a high backed chair a high backed chair with arms a low backed chair and a low backed chair with arms.
BR7001057U (pt)	1991-12-17	Mesa com cadeira conjugadas
KR900002434U (ko)	1990-02-06	의자의 회전 변환식 머리받침구
IT8834038V0 (it)	1988-08-01	Dispositivo di sostegno, posizionamento e bloccaggio della prolunga aggiuntiva inseribile nei tavoli prolungabili, dedispositivo di sostegno, posizionamento e bloccaggio della prolunga aggiuntiva inseribile nei tavoli prolungabili, denominato ricel 88. nominato ricel 88.
KR930022878U (ko)	1993-11-25	가구의 고저수평 조절구
KR900019813U (ko)	1990-12-12	의자용 캐스터
IT9022315A1 (it)	1992-06-07	Composti ad attivita' antiradicalica, procedimento per la loro prepara zione e loro impieghi.
SE8701326L (sv)	1988-10-01	Ergodynamisk sittmoebel