ATE369384T1 - Expression und export von interferon-alpha proteinen als fc fusionsproteine - Google Patents
Expression und export von interferon-alpha proteinen als fc fusionsproteineInfo
- Publication number
- ATE369384T1 ATE369384T1 AT00932622T AT00932622T ATE369384T1 AT E369384 T1 ATE369384 T1 AT E369384T1 AT 00932622 T AT00932622 T AT 00932622T AT 00932622 T AT00932622 T AT 00932622T AT E369384 T1 ATE369384 T1 AT E369384T1
- Authority
- AT
- Austria
- Prior art keywords
- interferon
- alpha
- proteins
- nucleic acid
- expression
- Prior art date
Links
- 102000006992 Interferon-alpha Human genes 0.000 title abstract 2
- 108010047761 Interferon-alpha Proteins 0.000 title abstract 2
- 108091006020 Fc-tagged proteins Proteins 0.000 title 1
- 150000007523 nucleic acids Chemical group 0.000 abstract 4
- 102000037865 fusion proteins Human genes 0.000 abstract 3
- 108020001507 fusion proteins Proteins 0.000 abstract 3
- 108060003951 Immunoglobulin Proteins 0.000 abstract 2
- 102000018358 immunoglobulin Human genes 0.000 abstract 2
- 239000013604 expression vector Substances 0.000 abstract 1
- 208000006454 hepatitis Diseases 0.000 abstract 1
- 231100000283 hepatitis Toxicity 0.000 abstract 1
- 210000004962 mammalian cell Anatomy 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/56—IFN-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Virology (AREA)
- Toxicology (AREA)
- General Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Oncology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Communicable Diseases (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13489599P | 1999-05-19 | 1999-05-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE369384T1 true ATE369384T1 (de) | 2007-08-15 |
Family
ID=22465500
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00932622T ATE369384T1 (de) | 1999-05-19 | 2000-05-19 | Expression und export von interferon-alpha proteinen als fc fusionsproteine |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US20020081664A1 (de) |
| EP (1) | EP1187852B1 (de) |
| JP (1) | JP2003530070A (de) |
| KR (1) | KR20020018197A (de) |
| CN (1) | CN1361793A (de) |
| AT (1) | ATE369384T1 (de) |
| AU (1) | AU777963B2 (de) |
| BR (1) | BR0010725A (de) |
| CA (1) | CA2372400C (de) |
| CZ (1) | CZ20014123A3 (de) |
| DE (1) | DE60035871T2 (de) |
| DK (1) | DK1187852T3 (de) |
| ES (1) | ES2291205T3 (de) |
| HK (1) | HK1046694A1 (de) |
| HU (1) | HUP0201474A3 (de) |
| MX (1) | MXPA01011845A (de) |
| NO (1) | NO20015587L (de) |
| PL (1) | PL352332A1 (de) |
| PT (1) | PT1187852E (de) |
| RU (1) | RU2262510C9 (de) |
| WO (1) | WO2000069913A1 (de) |
| ZA (1) | ZA200109227B (de) |
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| KR20020018197A (ko) * | 1999-05-19 | 2002-03-07 | 추후보정 | Ｆｃ 융합 단백질로서의 인터페론-알파 단백질의 발현 및분비 |
| US7067110B1 (en) | 1999-07-21 | 2006-06-27 | Emd Lexigen Research Center Corp. | Fc fusion proteins for enhancing the immunogenicity of protein and peptide antigens |
| SK782002A3 (en) * | 1999-07-21 | 2003-08-05 | Lexigen Pharm Corp | FC fusion proteins for enhancing the immunogenicity of protein and peptide antigens |
| BR0013231A (pt) | 1999-08-09 | 2002-07-23 | Lexigen Pharm Corp | Complexos citocina-anticorpo múltiplos |
| US20050202538A1 (en) * | 1999-11-12 | 2005-09-15 | Merck Patent Gmbh | Fc-erythropoietin fusion protein with improved pharmacokinetics |
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| JP5179689B2 (ja) | 2000-02-11 | 2013-04-10 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | 抗体ベース融合タンパク質の循環系内半減期の増強 |
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| JP5390055B2 (ja) | 2000-06-29 | 2014-01-15 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | 免疫サイトカインの取り込み増強剤との併用治療による抗体−サイトカイン融合タンパク質媒介免疫応答の増強 |
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| US20030065148A1 (en) * | 2001-05-02 | 2003-04-03 | Villarete Lorelie H. | Method for expression of human interferon alpha 1 in Pichia pastoris |
| KR100900166B1 (ko) | 2001-05-03 | 2009-06-02 | 메르크 파텐트 게엠베하 | 재조합 종양 특이적 항체 및 이들의 용도 |
| ATE542137T1 (de) | 2001-12-04 | 2012-02-15 | Merck Patent Gmbh | Immunocytokine mit modulierter selektivität |
| PT1463751E (pt) | 2001-12-21 | 2013-08-26 | Human Genome Sciences Inc | Proteínas de fusão de albumina |
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| RU2764787C1 (ru) * | 2020-12-08 | 2022-01-21 | Федеральное государственное бюджетное научное учреждение "Федеральный исследовательский центр фундаментальной и трансляционной медицины" (ФИЦ ФТМ) | Рекомбинантная плазмидная ДНК, кодирующая химерный интерферон alpha2b, рекомбинантный штамм дрожжей P. pastoris X33 - продуцент химерного интерферона alpha2b и способ получения указанного белка |
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2000
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- 2000-05-19 PL PL00352332A patent/PL352332A1/xx unknown
- 2000-05-19 CN CN00810671A patent/CN1361793A/zh active Pending
- 2000-05-19 CZ CZ20014123A patent/CZ20014123A3/cs unknown
- 2000-05-19 AT AT00932622T patent/ATE369384T1/de active
- 2000-05-19 DE DE60035871T patent/DE60035871T2/de not_active Expired - Lifetime
- 2000-05-19 BR BR0010725-5A patent/BR0010725A/pt not_active IP Right Cessation
- 2000-05-19 EP EP00932622A patent/EP1187852B1/de not_active Expired - Lifetime
- 2000-05-19 WO PCT/US2000/013827 patent/WO2000069913A1/en not_active Ceased
- 2000-05-19 HU HU0201474A patent/HUP0201474A3/hu unknown
- 2000-05-19 RU RU2001130984/13A patent/RU2262510C9/ru not_active IP Right Cessation
- 2000-05-19 MX MXPA01011845A patent/MXPA01011845A/es unknown
- 2000-05-19 HK HK02108255.1A patent/HK1046694A1/zh unknown
- 2000-05-19 PT PT00932622T patent/PT1187852E/pt unknown
- 2000-05-19 JP JP2000618329A patent/JP2003530070A/ja active Pending
- 2000-05-19 ES ES00932622T patent/ES2291205T3/es not_active Expired - Lifetime
- 2000-05-19 CA CA2372400A patent/CA2372400C/en not_active Expired - Lifetime
- 2000-05-19 AU AU50318/00A patent/AU777963B2/en not_active Expired
- 2000-05-19 DK DK00932622T patent/DK1187852T3/da active
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2001
- 2001-10-11 US US09/977,034 patent/US20020081664A1/en not_active Abandoned
- 2001-11-08 ZA ZA200109227A patent/ZA200109227B/en unknown
- 2001-11-15 NO NO20015587A patent/NO20015587L/no not_active Application Discontinuation
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Also Published As
| Publication number | Publication date |
|---|---|
| NO20015587L (no) | 2002-01-16 |
| JP2003530070A (ja) | 2003-10-14 |
| CN1361793A (zh) | 2002-07-31 |
| ZA200109227B (en) | 2003-02-03 |
| NO20015587D0 (no) | 2001-11-15 |
| KR20020018197A (ko) | 2002-03-07 |
| AU5031800A (en) | 2000-12-05 |
| RU2262510C9 (ru) | 2006-04-20 |
| BR0010725A (pt) | 2002-02-19 |
| DE60035871T2 (de) | 2008-06-05 |
| DK1187852T3 (da) | 2007-11-26 |
| CA2372400C (en) | 2010-04-27 |
| PT1187852E (pt) | 2007-11-14 |
| DE60035871D1 (de) | 2007-09-20 |
| HK1046694A1 (zh) | 2003-01-24 |
| EP1187852A1 (de) | 2002-03-20 |
| CZ20014123A3 (cs) | 2002-06-12 |
| HUP0201474A2 (en) | 2002-08-28 |
| RU2262510C2 (ru) | 2005-10-20 |
| US20050042729A1 (en) | 2005-02-24 |
| EP1187852B1 (de) | 2007-08-08 |
| AU777963B2 (en) | 2004-11-04 |
| US20020081664A1 (en) | 2002-06-27 |
| WO2000069913A1 (en) | 2000-11-23 |
| HUP0201474A3 (en) | 2002-11-28 |
| MXPA01011845A (es) | 2002-06-21 |
| CA2372400A1 (en) | 2000-11-23 |
| PL352332A1 (en) | 2003-08-11 |
| ES2291205T3 (es) | 2008-03-01 |
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