ATE370131T1 - Verfahren zur herstellung von 5-(1,3-oxazol-2- yl)benzoesäurederivaten - Google Patents
Verfahren zur herstellung von 5-(1,3-oxazol-2- yl)benzoesäurederivatenInfo
- Publication number
- ATE370131T1 ATE370131T1 AT03761206T AT03761206T ATE370131T1 AT E370131 T1 ATE370131 T1 AT E370131T1 AT 03761206 T AT03761206 T AT 03761206T AT 03761206 T AT03761206 T AT 03761206T AT E370131 T1 ATE370131 T1 AT E370131T1
- Authority
- AT
- Austria
- Prior art keywords
- sub
- oxazole
- producing
- benzoic acid
- acid derivatives
- Prior art date
Links
- IMAITKPPSLYKDS-UHFFFAOYSA-N 3-(1,3-oxazol-2-yl)benzoic acid Chemical class OC(=O)C1=CC=CC(C=2OC=CN=2)=C1 IMAITKPPSLYKDS-UHFFFAOYSA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 5
- 238000000034 method Methods 0.000 abstract 2
- JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical group [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 150000002916 oxazoles Chemical class 0.000 abstract 1
- 235000005074 zinc chloride Nutrition 0.000 abstract 1
- 239000011592 zinc chloride Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39028502P | 2002-06-20 | 2002-06-20 | |
| US45047803P | 2003-02-27 | 2003-02-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE370131T1 true ATE370131T1 (de) | 2007-09-15 |
Family
ID=30003150
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03761206T ATE370131T1 (de) | 2002-06-20 | 2003-06-20 | Verfahren zur herstellung von 5-(1,3-oxazol-2- yl)benzoesäurederivaten |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US7115747B2 (de) |
| EP (1) | EP1532123B1 (de) |
| JP (1) | JP2005533811A (de) |
| CN (1) | CN1324017C (de) |
| AT (1) | ATE370131T1 (de) |
| AU (1) | AU2003249344A1 (de) |
| BR (1) | BR0312439A (de) |
| CA (1) | CA2489988A1 (de) |
| CO (1) | CO5670350A2 (de) |
| DE (1) | DE60315664D1 (de) |
| EA (1) | EA008389B1 (de) |
| IL (1) | IL165763A0 (de) |
| MX (1) | MXPA04012630A (de) |
| NO (1) | NO20045497L (de) |
| NZ (1) | NZ537390A (de) |
| PL (1) | PL374999A1 (de) |
| WO (1) | WO2004000821A1 (de) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004050609A1 (en) * | 2002-11-27 | 2004-06-17 | Elan Pharmaceutical, Inc. | Substituted ureas and carbamates |
| TW200738701A (en) | 2005-07-26 | 2007-10-16 | Du Pont | Fungicidal carboxamides |
| JP5274258B2 (ja) | 2005-11-21 | 2013-08-28 | アムジエン・インコーポレーテツド | β−セクレターゼ調節物質及び使用方法 |
| US7838676B2 (en) | 2005-11-21 | 2010-11-23 | Amgen Inc. | Beta-secretase modulators and methods of use |
| US7745484B2 (en) * | 2005-11-21 | 2010-06-29 | Amgen Inc. | Beta-secretase modulators and methods of use |
| US7872009B2 (en) * | 2005-11-21 | 2011-01-18 | Amgen Inc. | Beta-Secretase modulators and methods of use |
| WO2008137954A2 (en) * | 2007-05-07 | 2008-11-13 | Environmental Packaging Technologies Limited | Universal shipping container |
| EP2167471B1 (de) * | 2007-05-25 | 2013-10-16 | Amgen Inc. | Substituierte hydroxyethylaminverbindungen als modulatoren von beta-sekretase und anwendungsverfahren |
| WO2008147547A1 (en) | 2007-05-25 | 2008-12-04 | Amgen Inc. | Substituted hydroxyethyl amine compounds as beta-secretase modulators and methods of use |
| US7803809B2 (en) | 2008-11-12 | 2010-09-28 | Amgen Inc. | Substituted pyrano [2,3-b] pyridinamine compounds as beta-secretase modulators and methods of use |
| US8426447B2 (en) | 2008-09-11 | 2013-04-23 | Amgen Inc. | Spiro-tricyclic ring compounds as beta-secretase modulators and methods of use |
| EP2504330A1 (de) | 2009-11-23 | 2012-10-03 | Amgen Inc. | Aminoheteroarylverbindungen als beta-sekretase-modulatoren und verwendungsverfahren dafür |
| EP2504315A1 (de) | 2009-11-23 | 2012-10-03 | Amgen Inc. | Aminoheteroarylverbindungen als beta-sekretase-modulatoren und verwendungsverfahren dafür |
| CA2788363A1 (en) | 2010-01-19 | 2011-07-28 | Amgen Inc. | Amino heteroaryl compounds as beta-secretase modulators and methods of use |
| JP5584352B2 (ja) | 2010-03-15 | 2014-09-03 | アムジエン・インコーポレーテツド | β−セクレターゼ調節剤としてのアミノ−ジヒドロオキサジン系およびアミノ−ジヒドロチアジン系スピロ化合物ならびにそれらの医学的用途 |
| US8883782B2 (en) | 2010-03-15 | 2014-11-11 | Amgen Inc. | Spiro-tetracyclic ring compounds as beta-secretase modulators and methods of use |
| US9346827B2 (en) | 2011-02-07 | 2016-05-24 | Amgen Inc. | 5-amino-oxazepine and 5-amino-thiazepane compounds as beta secretase antagonists and methods of use |
| JP2014526560A (ja) | 2011-09-21 | 2014-10-06 | アムジエン・インコーポレーテツド | β‐セクレターゼ調節因子としてのアミノオキサジン化合物およびアミノジヒドロチアジン化合物および使用方法 |
| WO2014078314A1 (en) | 2012-11-15 | 2014-05-22 | Amgen Inc. | Amino-oxazine and amino-dihydrothiazine compounds as beta-secretase modulators and methods of use |
| US9462841B1 (en) | 2016-03-01 | 2016-10-11 | William Popejoy | Protective headgear and shoulder pad apparatus and methods |
| US11272751B2 (en) | 2016-03-01 | 2022-03-15 | Nicholas Popejoy | Protective headgear, impact diffusing systems and methods |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20020276A1 (es) * | 2000-06-30 | 2002-04-06 | Elan Pharm Inc | COMPUESTOS DE AMINA SUSTITUIDA COMO INHIBIDORES DE ß-SECRETASA PARA EL TRATAMIENTO DE ALZHEIMER |
| BR0213139A (pt) | 2001-10-04 | 2004-08-10 | Elan Pharm Inc | Composto, método de tratamento ou prevenção de doenças e de preparação de um composto, uso de um composto e composição farmacêutica |
| EP1453789A2 (de) * | 2001-11-08 | 2004-09-08 | Elan Pharmaceuticals, Inc. | N,n'-substituierte 1,3-diamino-2-hydroxypropanderivate |
| GB0325830D0 (en) * | 2003-11-05 | 2003-12-10 | Novartis Ag | Organic compounds |
-
2003
- 2003-06-20 WO PCT/US2003/019585 patent/WO2004000821A1/en not_active Ceased
- 2003-06-20 DE DE60315664T patent/DE60315664D1/de not_active Expired - Lifetime
- 2003-06-20 CA CA002489988A patent/CA2489988A1/en not_active Abandoned
- 2003-06-20 MX MXPA04012630A patent/MXPA04012630A/es active IP Right Grant
- 2003-06-20 NZ NZ537390A patent/NZ537390A/en unknown
- 2003-06-20 US US10/600,100 patent/US7115747B2/en not_active Expired - Fee Related
- 2003-06-20 BR BR0312439-8A patent/BR0312439A/pt not_active IP Right Cessation
- 2003-06-20 EA EA200401510A patent/EA008389B1/ru unknown
- 2003-06-20 JP JP2004516055A patent/JP2005533811A/ja active Pending
- 2003-06-20 CN CNB038144476A patent/CN1324017C/zh not_active Expired - Fee Related
- 2003-06-20 AU AU2003249344A patent/AU2003249344A1/en not_active Abandoned
- 2003-06-20 AT AT03761206T patent/ATE370131T1/de not_active IP Right Cessation
- 2003-06-20 PL PL03374999A patent/PL374999A1/xx unknown
- 2003-06-20 EP EP03761206A patent/EP1532123B1/de not_active Expired - Lifetime
-
2004
- 2004-12-14 IL IL16576304A patent/IL165763A0/xx unknown
- 2004-12-16 NO NO20045497A patent/NO20045497L/no not_active Application Discontinuation
-
2005
- 2005-01-20 CO CO05004558A patent/CO5670350A2/es not_active Application Discontinuation
-
2006
- 2006-10-03 US US11/538,155 patent/US20070105921A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1532123A1 (de) | 2005-05-25 |
| US7115747B2 (en) | 2006-10-03 |
| AU2003249344A1 (en) | 2004-01-06 |
| US20040063965A1 (en) | 2004-04-01 |
| MXPA04012630A (es) | 2005-09-30 |
| EA200401510A1 (ru) | 2005-06-30 |
| EP1532123B1 (de) | 2007-08-15 |
| DE60315664D1 (de) | 2007-09-27 |
| JP2005533811A (ja) | 2005-11-10 |
| CO5670350A2 (es) | 2006-08-31 |
| EA008389B1 (ru) | 2007-04-27 |
| US20070105921A1 (en) | 2007-05-10 |
| BR0312439A (pt) | 2005-05-10 |
| CN1662510A (zh) | 2005-08-31 |
| HK1081543A1 (zh) | 2006-05-19 |
| NO20045497D0 (no) | 2004-12-16 |
| IL165763A0 (en) | 2006-01-15 |
| CA2489988A1 (en) | 2003-12-31 |
| CN1324017C (zh) | 2007-07-04 |
| PL374999A1 (en) | 2005-11-14 |
| WO2004000821A1 (en) | 2003-12-31 |
| NZ537390A (en) | 2006-07-28 |
| NO20045497L (no) | 2005-03-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |