ATE370131T1 - Verfahren zur herstellung von 5-(1,3-oxazol-2- yl)benzoesäurederivaten - Google Patents

Verfahren zur herstellung von 5-(1,3-oxazol-2- yl)benzoesäurederivaten

Info

Publication number: ATE370131T1
Authority: AT; Austria
Prior art keywords: sub; oxazole; producing; benzoic acid; acid derivatives
Prior art date: 2002-06-20

Application number

AT03761206T

Other languages

English (en)

Inventor

Michael Reeder

Rick Imbordino

Original Assignee

Pharmacia & Upjohn Co Llc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-06-20

Filing date

2003-06-20

Publication date

2007-09-15

2003-06-20 Application filed by Pharmacia & Upjohn Co Llc filed Critical Pharmacia & Upjohn Co Llc

2007-09-15 Application granted granted Critical

2007-09-15 Publication of ATE370131T1 publication Critical patent/ATE370131T1/de

Links

IMAITKPPSLYKDS-UHFFFAOYSA-N 3-(1,3-oxazol-2-yl)benzoic acid Chemical class OC(=O)C1=CC=CC(C=2OC=CN=2)=C1 IMAITKPPSLYKDS-UHFFFAOYSA-N 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 5
238000000034 method Methods 0.000 abstract 2
JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical group [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 abstract 2
208000024827 Alzheimer disease Diseases 0.000 abstract 1
150000002916 oxazoles Chemical class 0.000 abstract 1
235000005074 zinc chloride Nutrition 0.000 abstract 1
239000011592 zinc chloride Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Neurosurgery (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Hospice & Palliative Care (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Psychiatry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Catalysts (AREA)

AT03761206T 2002-06-20 2003-06-20 Verfahren zur herstellung von 5-(1,3-oxazol-2- yl)benzoesäurederivaten ATE370131T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US39028502P	2002-06-20	2002-06-20
US45047803P	2003-02-27	2003-02-27

Publications (1)

Publication Number	Publication Date
ATE370131T1 true ATE370131T1 (de)	2007-09-15

Family

ID=30003150

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT03761206T ATE370131T1 (de)	2002-06-20	2003-06-20	Verfahren zur herstellung von 5-(1,3-oxazol-2- yl)benzoesäurederivaten

Country Status (17)

Country	Link
US (2)	US7115747B2 (de)
EP (1)	EP1532123B1 (de)
JP (1)	JP2005533811A (de)
CN (1)	CN1324017C (de)
AT (1)	ATE370131T1 (de)
AU (1)	AU2003249344A1 (de)
BR (1)	BR0312439A (de)
CA (1)	CA2489988A1 (de)
CO (1)	CO5670350A2 (de)
DE (1)	DE60315664D1 (de)
EA (1)	EA008389B1 (de)
IL (1)	IL165763A0 (de)
MX (1)	MXPA04012630A (de)
NO (1)	NO20045497L (de)
NZ (1)	NZ537390A (de)
PL (1)	PL374999A1 (de)
WO (1)	WO2004000821A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2507484A1 (en) *	2002-11-27	2004-06-17	Elan Pharmaceuticals, Inc.	Substituted ureas and carbamates
TW200738701A (en)	2005-07-26	2007-10-16	Du Pont	Fungicidal carboxamides
WO2007061670A1 (en)	2005-11-21	2007-05-31	Amgen Inc.	Beta-secretase modulators and methods of use
US7872009B2 (en) *	2005-11-21	2011-01-18	Amgen Inc.	Beta-Secretase modulators and methods of use
US7745484B2 (en)	2005-11-21	2010-06-29	Amgen Inc.	Beta-secretase modulators and methods of use
US7838676B2 (en)	2005-11-21	2010-11-23	Amgen Inc.	Beta-secretase modulators and methods of use
WO2008137954A2 (en) *	2007-05-07	2008-11-13	Environmental Packaging Technologies Limited	Universal shipping container
CL2008001500A1 (es)	2007-05-25	2008-12-26	Amgen Inc	Compuestos derivados de hidroxietil amina sustituidas, moduladores de betasecretasa; proceso de preparacion de dichos c ompuestos; composicion farmaceutica que los comprende; y su uso para tratar un trastorno neurologico, tal como alzheimer, sindrome de down, demencia degenerativa, entre otros.
WO2008147544A1 (en)	2007-05-25	2008-12-04	Amgen Inc.	Substituted hydroxyethyl amine compounds as beta-secretase modulators and methods of use
US7803809B2 (en)	2008-11-12	2010-09-28	Amgen Inc.	Substituted pyrano [2,3-b] pyridinamine compounds as beta-secretase modulators and methods of use
MY148558A (en)	2008-09-11	2013-04-30	Amgen Inc	Spiro-tetracyclic ring compounds as betasecretase modulators and methods of use
EP2504330A1 (de)	2009-11-23	2012-10-03	Amgen Inc.	Aminoheteroarylverbindungen als beta-sekretase-modulatoren und verwendungsverfahren dafür
WO2011063233A1 (en)	2009-11-23	2011-05-26	Amgen Inc.	Amino heteroaryl compounds as beta-secretase modulators and methods of use
CA2788363A1 (en)	2010-01-19	2011-07-28	Amgen Inc.	Amino heteroaryl compounds as beta-secretase modulators and methods of use
US8497264B2 (en)	2010-03-15	2013-07-30	Amgen Inc.	Amino-oxazines and amino-dihydrothiazine compounds as beta-secretase modulators and methods of use
EP2547685A1 (de)	2010-03-15	2013-01-23	Amgen Inc.	Spiro-tetracyclische ringverbindungen als beta-sekretase-modulatoren
US9346827B2 (en)	2011-02-07	2016-05-24	Amgen Inc.	5-amino-oxazepine and 5-amino-thiazepane compounds as beta secretase antagonists and methods of use
WO2013044092A1 (en)	2011-09-21	2013-03-28	Amgen Inc.	Amino-oxazines and amino-dihydrothiazine compounds as beta-secretase modulators and methods of use
WO2014078314A1 (en)	2012-11-15	2014-05-22	Amgen Inc.	Amino-oxazine and amino-dihydrothiazine compounds as beta-secretase modulators and methods of use
US9462841B1 (en)	2016-03-01	2016-10-11	William Popejoy	Protective headgear and shoulder pad apparatus and methods
US11272751B2 (en)	2016-03-01	2022-03-15	Nicholas Popejoy	Protective headgear, impact diffusing systems and methods

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PE20020276A1 (es) *	2000-06-30	2002-04-06	Elan Pharm Inc	COMPUESTOS DE AMINA SUSTITUIDA COMO INHIBIDORES DE ß-SECRETASA PARA EL TRATAMIENTO DE ALZHEIMER
EP1432674A2 (de) *	2001-10-04	2004-06-30	Elan Pharmaceuticals, Inc.	Hydroxypropylamine
AU2002359376B2 (en) *	2001-11-08	2008-01-10	Elan Pharmaceuticals, Inc.	N, N'-substituted-1,3-diamino-2-hydroxypropane derivatives
GB0325830D0 (en) *	2003-11-05	2003-12-10	Novartis Ag	Organic compounds

2003
- 2003-06-20 EA EA200401510A patent/EA008389B1/ru unknown
- 2003-06-20 CN CNB038144476A patent/CN1324017C/zh not_active Expired - Fee Related
- 2003-06-20 US US10/600,100 patent/US7115747B2/en not_active Expired - Fee Related
- 2003-06-20 AU AU2003249344A patent/AU2003249344A1/en not_active Abandoned
- 2003-06-20 DE DE60315664T patent/DE60315664D1/de not_active Expired - Lifetime
- 2003-06-20 JP JP2004516055A patent/JP2005533811A/ja active Pending
- 2003-06-20 WO PCT/US2003/019585 patent/WO2004000821A1/en not_active Ceased
- 2003-06-20 BR BR0312439-8A patent/BR0312439A/pt not_active IP Right Cessation
- 2003-06-20 NZ NZ537390A patent/NZ537390A/en unknown
- 2003-06-20 EP EP03761206A patent/EP1532123B1/de not_active Expired - Lifetime
- 2003-06-20 PL PL03374999A patent/PL374999A1/xx unknown
- 2003-06-20 AT AT03761206T patent/ATE370131T1/de not_active IP Right Cessation
- 2003-06-20 MX MXPA04012630A patent/MXPA04012630A/es active IP Right Grant
- 2003-06-20 CA CA002489988A patent/CA2489988A1/en not_active Abandoned
2004
- 2004-12-14 IL IL16576304A patent/IL165763A0/xx unknown
- 2004-12-16 NO NO20045497A patent/NO20045497L/no not_active Application Discontinuation
2005
- 2005-01-20 CO CO05004558A patent/CO5670350A2/es not_active Application Discontinuation
2006
- 2006-10-03 US US11/538,155 patent/US20070105921A1/en not_active Abandoned

Also Published As

Publication number	Publication date
NO20045497L (no)	2005-03-07
NO20045497D0 (no)	2004-12-16
EA200401510A1 (ru)	2005-06-30
EA008389B1 (ru)	2007-04-27
HK1081543A1 (zh)	2006-05-19
IL165763A0 (en)	2006-01-15
MXPA04012630A (es)	2005-09-30
US7115747B2 (en)	2006-10-03
EP1532123A1 (de)	2005-05-25
NZ537390A (en)	2006-07-28
CO5670350A2 (es)	2006-08-31
AU2003249344A1 (en)	2004-01-06
US20040063965A1 (en)	2004-04-01
CN1324017C (zh)	2007-07-04
WO2004000821A1 (en)	2003-12-31
EP1532123B1 (de)	2007-08-15
CN1662510A (zh)	2005-08-31
CA2489988A1 (en)	2003-12-31
PL374999A1 (en)	2005-11-14
US20070105921A1 (en)	2007-05-10
JP2005533811A (ja)	2005-11-10
BR0312439A (pt)	2005-05-10
DE60315664D1 (de)	2007-09-27

Legal Events

Date	Code	Title	Description
2008-02-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE370131T1 (de)	2007-09-15	Verfahren zur herstellung von 5-(1,3-oxazol-2- yl)benzoesäurederivaten
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