ATE370969T1 - Niedermolekulare peptidderivate als inhibitoren der laminin/nidogen wechselwirkung - Google Patents

Niedermolekulare peptidderivate als inhibitoren der laminin/nidogen wechselwirkung

Info

Publication number
ATE370969T1
ATE370969T1 AT00909221T AT00909221T ATE370969T1 AT E370969 T1 ATE370969 T1 AT E370969T1 AT 00909221 T AT00909221 T AT 00909221T AT 00909221 T AT00909221 T AT 00909221T AT E370969 T1 ATE370969 T1 AT E370969T1
Authority
AT
Austria
Prior art keywords
laminin
inhibitors
low molecular
peptide derivatives
nidogen
Prior art date
Application number
AT00909221T
Other languages
English (en)
Inventor
Hans Stilz
Martin Gerl
Gary Flynn
Magda Stankova
Robert Binnie
Original Assignee
Sanofi Aventis Deutschland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland
Application granted granted Critical
Publication of ATE370969T1 publication Critical patent/ATE370969T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Peptides Or Proteins (AREA)
AT00909221T 1999-03-01 2000-02-19 Niedermolekulare peptidderivate als inhibitoren der laminin/nidogen wechselwirkung ATE370969T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP99103869A EP1070727A1 (de) 1999-03-01 1999-03-01 Niedermolekulare Peptide als Inhibitoren der Laminin/Nidogen Wechselwirkung

Publications (1)

Publication Number Publication Date
ATE370969T1 true ATE370969T1 (de) 2007-09-15

Family

ID=8237658

Family Applications (2)

Application Number Title Priority Date Filing Date
AT00909221T ATE370969T1 (de) 1999-03-01 2000-02-19 Niedermolekulare peptidderivate als inhibitoren der laminin/nidogen wechselwirkung
AT07013872T ATE477271T1 (de) 1999-03-01 2000-02-19 Niedermolekulare peptide als inhibitoren der laminin/nidogen wechselwirkung

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT07013872T ATE477271T1 (de) 1999-03-01 2000-02-19 Niedermolekulare peptide als inhibitoren der laminin/nidogen wechselwirkung

Country Status (21)

Country Link
US (1) US6365572B1 (de)
EP (4) EP1070727A1 (de)
JP (1) JP4542272B2 (de)
CN (2) CN100441594C (de)
AT (2) ATE370969T1 (de)
AU (1) AU779779B2 (de)
BR (1) BR0008647A (de)
CA (1) CA2363958C (de)
CY (1) CY1106967T1 (de)
CZ (1) CZ300736B6 (de)
DE (2) DE60036087T2 (de)
DK (1) DK1157040T3 (de)
ES (1) ES2288844T3 (de)
HU (1) HU228993B1 (de)
ID (1) ID30183A (de)
PL (2) PL202887B1 (de)
PT (1) PT1157040E (de)
RU (2) RU2380371C2 (de)
TR (2) TR200800782T2 (de)
WO (1) WO2000052051A1 (de)
ZA (1) ZA200106972B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1070727A1 (de) * 1999-03-01 2001-01-24 Aventis Pharma Deutschland GmbH Niedermolekulare Peptide als Inhibitoren der Laminin/Nidogen Wechselwirkung
US20080241835A1 (en) * 1999-11-01 2008-10-02 Genentech, Inc. Differentially expressed genes involved in angiogenesis, the polypeptides encoded thereby, and methods of using the same
JP2003525595A (ja) * 1999-11-01 2003-09-02 キュラゲン コーポレイション 脈管形成に含まれる差動発現遺伝子、それにコードされるポリペプチド、及びそれを用いた方法
WO2004093892A2 (en) 2003-04-16 2004-11-04 Genentech, Inc. Stanniocalcin-1, variant or antagonists thereof for selective modulation of vascularization
FR2947452B1 (fr) * 2009-07-01 2012-04-20 Fabre Pierre Dermo Cosmetique L-serine et/ou l-asparagine et/ou l-valine pour prevenir et/ou au traiter des reactions inflammatoires de la peau.
RU2622018C1 (ru) * 2016-06-16 2017-06-08 федеральное государственное автономное образовательное учреждение высшего образования "Российский университет дружбы народов" (РУДН) Быстро растворяющаяся трансбуккальная плёнка для лечения депрессивных расстройств, тревоги и расстройств адаптации
CA3045887A1 (en) * 2016-12-09 2018-06-14 Celtaxsys, Inc. Pendant amines and derivatives as inhibitors of leukotriene a4 hydrolase

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8821785D0 (en) * 1988-09-16 1988-10-19 Nycomed As Peptide compounds
RU2145233C1 (ru) * 1990-07-02 2000-02-10 Дзе Аризона Борд оф Риджентс Неупорядоченная библиотека пептидов, способ ее получения и способ идентификации пептида, синтезированного твердофазным синтезом
US5493008A (en) * 1994-08-15 1996-02-20 The University Of Virginia Patent Foundation Two non-contiguous regions contribute to nidogen binding to a single EGF-like motif of the laminin γ1 chain
DE19622489A1 (de) * 1996-06-05 1997-12-11 Hoechst Ag Salze des 3-(2-(4-(4-(Amino-imino-methyl)-phenyl)-4- methyl-2,5-dioxo-imidazolidin-1-yl)-acetylamino)-3- phenyl-propionsäure-ethylesters
DE19701607A1 (de) 1997-01-17 1998-07-23 Hoechst Ag Anitkörper, die an die Nidogen-Bindungsdomäne des Laminins binden, deren Herstellung und Verwendung
EP1070727A1 (de) * 1999-03-01 2001-01-24 Aventis Pharma Deutschland GmbH Niedermolekulare Peptide als Inhibitoren der Laminin/Nidogen Wechselwirkung

Also Published As

Publication number Publication date
TR200102560T2 (tr) 2002-01-21
PL351483A1 (en) 2003-04-22
RU2262509C2 (ru) 2005-10-20
RU2380371C2 (ru) 2010-01-27
JP2002539092A (ja) 2002-11-19
ATE477271T1 (de) 2010-08-15
EP1157040B1 (de) 2007-08-22
CN1342167A (zh) 2002-03-27
HU228993B1 (en) 2013-07-29
CZ300736B6 (cs) 2009-07-29
DK1157040T3 (da) 2007-12-03
TR200800782T2 (tr) 2008-08-21
PL208356B1 (pl) 2011-04-29
CN1775801A (zh) 2006-05-24
WO2000052051A1 (en) 2000-09-08
ID30183A (id) 2001-11-08
AU779779B2 (en) 2005-02-10
US6365572B1 (en) 2002-04-02
DE60044832D1 (de) 2010-09-23
RU2005114905A (ru) 2006-11-20
HK1042499A1 (en) 2002-08-16
EP1157040A1 (de) 2001-11-28
ES2288844T3 (es) 2008-02-01
PT1157040E (pt) 2007-09-25
CA2363958A1 (en) 2000-09-08
PL202887B1 (pl) 2009-08-31
EP1845106A1 (de) 2007-10-17
DE60036087T2 (de) 2008-05-15
CZ20013063A3 (cs) 2001-11-14
HUP0200192A3 (en) 2002-09-30
CY1106967T1 (el) 2012-01-25
DE60036087D1 (de) 2007-10-04
EP1070727A1 (de) 2001-01-24
CA2363958C (en) 2012-04-17
AU3157700A (en) 2000-09-21
HUP0200192A2 (en) 2002-06-29
CN100441594C (zh) 2008-12-10
ZA200106972B (en) 2002-08-07
CN1237075C (zh) 2006-01-18
HK1087126A1 (zh) 2006-10-06
EP2239270A3 (de) 2011-01-12
JP4542272B2 (ja) 2010-09-08
BR0008647A (pt) 2002-01-22
EP1845106B1 (de) 2010-08-11
EP2239270A2 (de) 2010-10-13

Similar Documents

Publication Publication Date Title
DK0891325T3 (da) Para-substituerede phenylpropansyrederivater som integrinantagonister
ATE252080T1 (de) Indolin-2-one derivate, verfahren zu ihrer herstellung und dieseenthaltende arzneimittel
TR200200768T2 (tr) Yeni kuinüklidin türevleri ve bunu içeren ilaç bileşimleri
SE9904505D0 (sv) Novel compounds
EA200100774A1 (ru) Гетероциклические производные с функциональными группами (варианты), фармацевтическая композиция и комбинация, способ модулирования активности рецептора хемокина (варианты), способ профилактики инфицирования вич и лечения инфекции вич, замедления проявления спид и лечения спид, способ лечения воспалительных процессов
CY1112274T1 (el) Νεοι ολιγοσακχαριτες, η παρασκευh τους και οι φαρμακευτικες συνθεσεις οι οποιες τους περιεχουν
BR0016396A (pt) Novos antagonistas do receptor p2x7 para uso no tratamento de doenças inflamatórias, imunes ou cardiovasculares
ATE428729T1 (de) Kovalent verbrückte insulindimere
NO20015226L (no) Tri-aryl syrederivater som PPAR reseptor ligander, farmasoytisk sammensetning omfattende samme og anvendelse av samme for fremstilling av medikament.
ES2162676T3 (es) Derivados de fenileno sustituidos en meta y su uso como antagonistas o inhibidores de integrina alfav,beta3.
ATE254630T1 (de) Cyclosporine
TR200101412T2 (tr) Yeni bileşikler.
BRPI0110024B8 (pt) derivados de ecteinascidina antitumorais, composição farmacêutica que os compreende e uso dos mesmos
FR2764889B1 (fr) Nouveaux derives du 2-(iminomethyl)amino-phenyle, leur preparation, leur application a titre de medicaments et les compositions pharmaceutiques les contenant
ES2243579T3 (es) Derivados de pirazolopirideno.
CY1106967T1 (el) Παραγωγα πεπτιδιων χαμηλου μοριακου βαρους ως αναστολεις της αλληλεπιδρασης λαμινινης/εντακτινης
IL157540A (en) Pharmaceutical compositions comprising n-(aryl)-2-arylethenesulfonamides, some such novel compounds and process for their preparation
DE69720966D1 (de) Benzo[c]chinolizin derivate,deren herstellung und verwendung als 5-alfa-reduktase inhibitoren
EE04525B1 (et) Morfoliini derivaadid, nende valmistamismeetod janeid sisaldavad farmatseutilised kompositsioonid
NO20013878D0 (no) (1-fenacy-3-fenyl-3-piperidylety1)piperidin-derivater, fremgangsmate for fremstilling derav og farmasoytiske preparaterinneholdende de samme
NO20020914D0 (no) Alkoksy-substituerte benzimidazolforbindelser, preparater inneholdende slike samt anvendelser derav
ATE293635T1 (de) Streptograminderivate, ihre herstellung und sie enthaltende zubereitungen
EE200000336A (et) Ehhinokandiini derivaadid, nende valmistamismeetod, vaheühendid ja farmatseutilised kompositsioonid
MXPA05005340A (es) Nuevos derivados antagonistas del receptor de la vitronectina, sus procedimientos de preparacion, su aplicacion como medicamentos y los compuestos farmaceuticos que los contienen.
MXPA05006587A (es) Compuestos de tiazol como derivados de antagonistas del receptor de la integrina.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1157040

Country of ref document: EP