ATE373235T1 - Fluoreszensanalyseelement mit der anwendung eines metallischen nanolochs und verfahren zur herstellung desselben - Google Patents

Fluoreszensanalyseelement mit der anwendung eines metallischen nanolochs und verfahren zur herstellung desselben

Info

Publication number
ATE373235T1
ATE373235T1 AT02715712T AT02715712T ATE373235T1 AT E373235 T1 ATE373235 T1 AT E373235T1 AT 02715712 T AT02715712 T AT 02715712T AT 02715712 T AT02715712 T AT 02715712T AT E373235 T1 ATE373235 T1 AT E373235T1
Authority
AT
Austria
Prior art keywords
fluorescence
producing
fluorescence analysis
same
analysis element
Prior art date
Application number
AT02715712T
Other languages
English (en)
Inventor
Akito Ishida
Original Assignee
Japan Science & Tech Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Japan Science & Tech Corp filed Critical Japan Science & Tech Corp
Application granted granted Critical
Publication of ATE373235T1 publication Critical patent/ATE373235T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5308—Immunoassay; Biospecific binding assay; Materials therefor for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/551—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic
    • G01N33/553—Metal or metal coated
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nanotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Medical Informatics (AREA)
  • Inorganic Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Optical Measuring Cells (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
AT02715712T 2001-01-12 2002-01-09 Fluoreszensanalyseelement mit der anwendung eines metallischen nanolochs und verfahren zur herstellung desselben ATE373235T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2001005041A JP3525142B2 (ja) 2001-01-12 2001-01-12 金属ナノウェルを用いた蛍光分析用素子及びその製造方法

Publications (1)

Publication Number Publication Date
ATE373235T1 true ATE373235T1 (de) 2007-09-15

Family

ID=18873135

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02715712T ATE373235T1 (de) 2001-01-12 2002-01-09 Fluoreszensanalyseelement mit der anwendung eines metallischen nanolochs und verfahren zur herstellung desselben

Country Status (6)

Country Link
US (1) US20040029152A1 (de)
EP (1) EP1353179B1 (de)
JP (1) JP3525142B2 (de)
AT (1) ATE373235T1 (de)
DE (1) DE60222378T2 (de)
WO (1) WO2002056012A1 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL1027031C2 (nl) * 2004-09-13 2006-03-14 Univ Delft Tech Titerplaat.
US9012207B2 (en) * 2005-08-02 2015-04-21 University Of Utah Research Foundation Biosensors including metallic nanocavities
US8535616B2 (en) * 2005-08-02 2013-09-17 Moxtek, Inc. Sub-wavelength metallic apertures as light enhancement devices
US20070148677A1 (en) * 2005-12-02 2007-06-28 Chagovetz Alexander M Methods and systems for acquiring real-time quantitative melt data
US7851028B2 (en) 2006-06-30 2010-12-14 The Invention Science Fund I, Llc Method of combing an elongated molecule
US7618771B2 (en) 2006-06-30 2009-11-17 Searete Llc Method of combing a nucleic acid
US7595150B2 (en) * 2006-06-30 2009-09-29 Searete Llc Method of applying an elongated molecule to a surface
JP2008051512A (ja) * 2006-08-22 2008-03-06 Fujifilm Corp 近接場光を用いたセンサおよびその作製方法
CA2677833C (en) * 2007-01-22 2016-05-03 Wafergen, Inc. Apparatus for high throughput chemical reactions
US8376013B2 (en) 2008-03-11 2013-02-19 Duke University Plasmonic assisted systems and methods for interior energy-activation from an exterior source
JP5222599B2 (ja) * 2007-07-20 2013-06-26 株式会社日立ハイテクノロジーズ 核酸分析デバイス及びそれを用いた核酸分析装置
ATE482171T1 (de) 2008-03-13 2010-10-15 Inst Ciencies Fotoniques Funda Verfahren zur herstellung von molekular plasmonischen nanostrukturen
US9518288B2 (en) 2008-04-11 2016-12-13 University Of Utah Research Foundation Methods and compositions related to quantitative, array based methylation analysis
JP4997181B2 (ja) * 2008-06-13 2012-08-08 株式会社日立ハイテクノロジーズ 核酸分析デバイス及び核酸分析装置
JP5066110B2 (ja) 2009-01-30 2012-11-07 株式会社日立ハイテクノロジーズ 蛍光分析装置、及び蛍光分析方法
JP5707030B2 (ja) * 2009-04-02 2015-04-22 株式会社日立ハイテクノロジーズ 核酸分析デバイス、及び核酸分析装置
FR2951271B1 (fr) * 2009-10-13 2012-11-16 Univ Troyes Technologie Support d'echantillon, procede et systeme d'imagerie par fonctionnalisation du substrat
US9459212B2 (en) * 2009-12-17 2016-10-04 University Of Maryland, Baltimore County Mixed-metal substrates for metal-enhanced fluorescence
KR20120010513A (ko) 2010-07-26 2012-02-03 삼성전자주식회사 바이오 물질 수용소자와 그 제조 및 동작방법
KR101663183B1 (ko) 2010-08-26 2016-10-06 삼성전자주식회사 열전재료, 이를 포함하는 열전모듈과 열전장치
JP5372876B2 (ja) * 2010-09-10 2013-12-18 株式会社日立ハイテクノロジーズ 核酸分析デバイス，核酸分析装置、及び核酸分析方法
CN102604140B (zh) * 2012-03-21 2013-12-11 陕西师范大学 含胆固醇的聚合物荧光传感薄膜的制备方法
CN103980884B (zh) * 2014-05-21 2016-09-21 南京理工大学 Al3+荧光传感器、合成方法及应用
JP2016012114A (ja) * 2014-06-02 2016-01-21 オリンパス株式会社 照明装置、これを有する顕微鏡装置及び顕微鏡観察方法

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8423204D0 (en) * 1984-09-14 1984-10-17 Comtech Res Unit Assay technique and equipment
CA2076709A1 (en) * 1992-08-24 1994-02-25 Ulrich J. Krull Amplified fluorescence emission for chemical transduction
US5690894A (en) * 1995-05-23 1997-11-25 The Regents Of The University Of California High density array fabrication and readout method for a fiber optic biosensor
US5776785A (en) * 1996-12-30 1998-07-07 Diagnostic Products Corporation Method and apparatus for immunoassay using fluorescent induced surface plasma emission
DE19715483A1 (de) * 1997-04-14 1998-10-15 Boehringer Mannheim Gmbh Methode zur gleichzeitigen Bestimmung von biomolekularen Wechselwirkungen mittels Plasmonenresonanz undFluoreszenzdetektion
JPH11332595A (ja) * 1997-07-09 1999-12-07 Masao Karube プローブｐｎａによるｄｎａの検出方法
US6210910B1 (en) * 1998-03-02 2001-04-03 Trustees Of Tufts College Optical fiber biosensor array comprising cell populations confined to microcavities
JP3647267B2 (ja) * 1998-05-29 2005-05-11 キヤノン株式会社 面発光レーザーを用いた表面プラズモン共鳴センサ装置
US6262216B1 (en) * 1998-10-13 2001-07-17 Affymetrix, Inc. Functionalized silicon compounds and methods for their synthesis and use
US6236033B1 (en) * 1998-12-09 2001-05-22 Nec Research Institute, Inc. Enhanced optical transmission apparatus utilizing metal films having apertures and periodic surface topography
US6429027B1 (en) * 1998-12-28 2002-08-06 Illumina, Inc. Composite arrays utilizing microspheres
JP3872227B2 (ja) * 1999-02-26 2007-01-24 北斗科学産業株式会社 新規の生物学的チップ及び分析方法
US6489102B2 (en) * 1999-08-05 2002-12-03 Wisconsin Alumni Research Foundation Biomolecule and/or cellular arrays on metal surfaces and product produced thereby
JP3249954B2 (ja) * 1999-07-07 2002-01-28 科学技術振興事業団 蛍光免疫分析方法及び装置
AU6504900A (en) * 1999-07-30 2001-02-19 Penn State Research Foundation, The Instruments, methods and reagents for surface plasmon resonance
US6395483B1 (en) * 1999-09-02 2002-05-28 3M Innovative Properties Company Arrays with mask layers
EP1305659B1 (de) * 2000-07-21 2004-12-08 Micro Managed Photons A/S Bandlücken strukturen für oberflächenplasmonenpolariton
CA2314398A1 (en) * 2000-08-10 2002-02-10 Edward Shipwash Microarrays and microsystems for amino acid analysis and protein sequencing
US6699665B1 (en) * 2000-11-08 2004-03-02 Surface Logix, Inc. Multiple array system for integrating bioarrays

Also Published As

Publication number Publication date
EP1353179A4 (de) 2004-05-19
JP3525142B2 (ja) 2004-05-10
EP1353179B1 (de) 2007-09-12
WO2002056012A1 (en) 2002-07-18
US20040029152A1 (en) 2004-02-12
EP1353179A1 (de) 2003-10-15
DE60222378T2 (de) 2008-06-12
JP2002214142A (ja) 2002-07-31
DE60222378D1 (de) 2007-10-25

Similar Documents

Publication Publication Date Title
ATE373235T1 (de) Fluoreszensanalyseelement mit der anwendung eines metallischen nanolochs und verfahren zur herstellung desselben
Kang et al. One‐step modification of superhydrophobic surfaces by a mussel‐inspired polymer coating
Michel et al. Selective molecular assembly patterning: a new approach to micro-and nanochemical patterning of surfaces for biological applications
US10656149B2 (en) Analyte detection enhancement by targeted immobilization, surface amplification, and pixelated reading and analysis
DE60042738D1 (de) Verfahren zum nachweis von analyten mit hilfe von halbleiternanokrystallen
ATE502117T1 (de) Nanopartikel mit gebundenen oligonukleotiden und deren verwendungen
ATE543092T1 (de) Biosensor
DE69522176D1 (de) Verfahren zur Dämpfung der Fluoreszenz von Fluoreszenzmarkierten Oligonukleotiden in Lösung
ATE516492T1 (de) Vorrichtung und verfahren zur multianalytbestimmung
ATE401390T1 (de) Zytokin (zcytor17-ligand)
DE60026337D1 (de) Verfahren zur diagnose von leberkrankheit unter verwendung von biochemischen merkmalen
DE60207978T2 (de) Biochip mit Kohlenstoff-Nanoröhrchen sowie Verfahren zur Trennung von Proben unter Verwendung dieses Biochips
DE60143888D1 (de) Methode um die sensitivität einer luminesenz assay zu erhöhen
DE50102190D1 (de) Optischer Sensor zur Bestimmung eines Analyten und Verfahren zu dessen Herstellung
DE69401717D1 (de) Verfahren zur Aktivierung von polyanionischen,fluoreszierenden Farbstoffen in schwach dielektrischen Medien mit quaternären Oniumverbindungen
DE60209537D1 (de) Neue kristalline formen von meloxicam, deren herstellung und verfahren zu deren umwandlung ineinander
WO2003008634A1 (en) Microbe examining device and method
ATE276980T1 (de) Verfahren zur erhaltung einer oberflächenaktivierung eines festen trägers zur bildung von biochips mikroanordnungen
ATE422671T1 (de) Verfahren zur diagnose von morbus alzheimer
ATE525462T1 (de) Proteomanalyseverfahren für phosphoryliertes protein
DE69800312D1 (de) Verfahren zur Herstellung von Acrylsäuren aus Acrolein durch Redox-Reaktion
CN107858403A (zh) 一种基于单分子荧光传感的痕量目标物检测方法
ATE482283T1 (de) Verfahren, biosensoren und kits zum nachweis und zur identifizierung von pilzen
EP1881471A3 (de) Etikettband mit Identifizierungscode
EP0802408A3 (de) Verfahren zur Konzentrationsbestimmung mittels Kontinuums-Atomabsorptionsspektroskopie

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties