ATE373635T1 - Verfahren zur herstellung von acylphenylalaninen - Google Patents

Verfahren zur herstellung von acylphenylalaninen

Info

Publication number: ATE373635T1
Authority: AT; Austria
Prior art keywords: producing; acylphenylalanines; solvent; acylphenylalanine; phenylalanine
Prior art date: 2000-10-18

Application number

AT01974874T

Other languages

English (en)

Inventor

Michito Sumikawa

Takao Ohgane

Original Assignee

Ajinomoto Kk

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-10-18

Filing date

2001-10-16

Publication date

2007-10-15

2001-10-16 Application filed by Ajinomoto Kk filed Critical Ajinomoto Kk

2007-10-15 Application granted granted Critical

2007-10-15 Publication of ATE373635T1 publication Critical patent/ATE373635T1/de

Links

238000004519 manufacturing process Methods 0.000 title abstract 2
KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 abstract 3
NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical compound CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 abstract 1
COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 abstract 1
239000003513 alkali Substances 0.000 abstract 1
239000012046 mixed solvent Substances 0.000 abstract 1
239000003960 organic solvent Substances 0.000 abstract 1
239000000825 pharmaceutical preparation Substances 0.000 abstract 1
229940127557 pharmaceutical product Drugs 0.000 abstract 1
COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 abstract 1
239000002994 raw material Substances 0.000 abstract 1
239000002904 solvent Substances 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)

AT01974874T 2000-10-18 2001-10-16 Verfahren zur herstellung von acylphenylalaninen ATE373635T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP2000317603		2000-10-18

Publications (1)

Publication Number	Publication Date
ATE373635T1 true ATE373635T1 (de)	2007-10-15

Family

ID=18796361

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT01974874T ATE373635T1 (de)	2000-10-18	2001-10-16	Verfahren zur herstellung von acylphenylalaninen

Country Status (18)

Country	Link
US (2)	US7030268B2 (de)
EP (1)	EP1334962B1 (de)
JP (1)	JP4158192B2 (de)
KR (1)	KR100783306B1 (de)
CN (1)	CN1273442C (de)
AT (1)	ATE373635T1 (de)
AU (1)	AU2001294264A1 (de)
BR (1)	BR0114728B1 (de)
CA (1)	CA2425533C (de)
CY (1)	CY1107502T1 (de)
DE (1)	DE60130575T2 (de)
DK (1)	DK1334962T3 (de)
ES (1)	ES2290173T3 (de)
MX (1)	MXPA03003483A (de)
PT (1)	PT1334962E (de)
RU (1)	RU2287520C2 (de)
TW (1)	TW575541B (de)
WO (1)	WO2002032853A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2403442A1 (en) *	2000-03-17	2002-09-17	Ajinomoto Co., Inc.	Use of nateglinide alone or in combination for the treatment or prevention of diabetic complications
ATE373635T1 (de) *	2000-10-18	2007-10-15	Ajinomoto Kk	Verfahren zur herstellung von acylphenylalaninen
KR100819358B1 (ko) *	2000-10-18	2008-04-04	아지노모토 가부시키가이샤	나테글리니드 결정의 제조방법
PT1334721E (pt) *	2000-10-24	2009-06-01	Ajinomoto Kk	Preparações de fármacos hidrofílicos contendo nateglinida
KR100810930B1 (ko) *	2000-10-24	2008-03-10	아지노모토 가부시키가이샤	나테글리니드 ｂ형 결정의 제조방법
ES2307653T3 (es) *	2000-10-24	2008-12-01	Ajinomoto Co., Inc.	Preparaciones que contienen nateglinida.
EP1535900B1 (de) *	2003-11-26	2006-12-27	A.M.S.A. ANONIMA MATERIE SINTETICHE E AFFINI S.p.A.	Verfahren zur Herstellung von Nateglinidin der B-Form
US7425648B2 (en)	2005-01-03	2008-09-16	A.M.S.A. Anonima Materie Sintetiche E. Affini S.P.A.	Process for the preparation of nateglinide, preferably in B-form
CN101111266A (zh) *	2005-01-31	2008-01-23	味之素株式会社	含有降血糖药的用于改善或治疗糖耐量异常、临界性糖尿病、胰岛素抵抗性和高胰岛素血症的药物组合物
EP2003113A4 (de)	2006-03-31	2012-07-18	Ajinomoto Kk	Verfahren zur produktion einer carbonsäurechloridverbindung
EP2580188A1 (de) *	2010-06-14	2013-04-17	Cilpa Limited	Verfahren für die zubereitung von nateglinid
CN115340857B (zh) *	2022-08-24	2024-03-26	宁波锋成先进能源材料研究院有限公司	一种原位自乳化纳米驱油剂及其制备方法和应用
WO2026145980A1 (en)	2025-01-02	2026-07-09	Syngenta Crop Protection Ag	Process for the preparation of pesticidally active cyclic amine compounds

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS58189121A (ja)	1982-04-30	1983-11-04	Ajinomoto Co Inc	インシユリン投与賦活剤
EP0093551B1 (de) *	1982-04-30	1991-01-16	Ajinomoto Co., Inc.	Pharmazeutische Zusammensetzung
JPS59190926A (ja)	1983-04-14	1984-10-29	Ajinomoto Co Inc	吸収性付与剤
AU567460B2 (en) *	1984-03-05	1987-11-19	Mitsui Toatsu Chemicals Inc.	Preparation process of n-acylphenylalanines
JPS6354321A (ja) *	1985-03-27	1988-03-08	Ajinomoto Co Inc	血糖降下剤
US4743547A (en) *	1985-04-09	1988-05-10	Kuraray Co., Ltd.	Method of producing L-phenylalanine
DE69217762T2 (de) *	1991-07-30	1997-10-09	Ajinomoto Kk	Kristalle von N-(Trans-4-isopropylcyclohexylcarbonyl)-D-phenylalanin und Verfahren zu ihrer Herstellung
JP2969397B2 (ja) *	1991-09-10	1999-11-02	花王株式会社	Ｎ−長鎖アシル−β−アラニンの製造方法
JP3025725B2 (ja) *	1992-11-24	2000-03-27	花王株式会社	Ｎ−長鎖アシルアミノ酸の分離法及び精製法
JPH06256276A (ja) *	1993-03-02	1994-09-13	Kao Corp	Ｎ−長鎖アシルアミノ酸塩の製造方法
JPH0717899A (ja) *	1993-07-01	1995-01-20	Ajinomoto Co Inc	カルボン酸クロリドの製造法
PT1586314E (pt)	1996-11-15	2011-07-01	Ajinomoto Kk	Composição de comprimidos de nateglinida
US6844006B1 (en) *	1999-07-09	2005-01-18	Pennfield Oil Company	Process and apparatus for the preparation of chlortetracycline-containing animal feed compositions
EP1616561B1 (de)	1999-12-28	2008-06-25	Ajinomoto Co., Inc.	Antidiabetes-Zubereitung zur oralen Verabreichung
CA2403442A1 (en)	2000-03-17	2002-09-17	Ajinomoto Co., Inc.	Use of nateglinide alone or in combination for the treatment or prevention of diabetic complications
ATE373635T1 (de)	2000-10-18	2007-10-15	Ajinomoto Kk	Verfahren zur herstellung von acylphenylalaninen
KR100819358B1 (ko)	2000-10-18	2008-04-04	아지노모토 가부시키가이샤	나테글리니드 결정의 제조방법
ES2307653T3 (es)	2000-10-24	2008-12-01	Ajinomoto Co., Inc.	Preparaciones que contienen nateglinida.
KR100810930B1 (ko)	2000-10-24	2008-03-10	아지노모토 가부시키가이샤	나테글리니드 ｂ형 결정의 제조방법

2001
- 2001-10-16 AT AT01974874T patent/ATE373635T1/de active
- 2001-10-16 WO PCT/JP2001/009068 patent/WO2002032853A1/ja not_active Ceased
- 2001-10-16 CN CNB018206727A patent/CN1273442C/zh not_active Expired - Fee Related
- 2001-10-16 CA CA2425533A patent/CA2425533C/en not_active Expired - Fee Related
- 2001-10-16 BR BRPI0114728-5A patent/BR0114728B1/pt not_active IP Right Cessation
- 2001-10-16 ES ES01974874T patent/ES2290173T3/es not_active Expired - Lifetime
- 2001-10-16 JP JP2002536037A patent/JP4158192B2/ja not_active Expired - Lifetime
- 2001-10-16 PT PT01974874T patent/PT1334962E/pt unknown
- 2001-10-16 DE DE60130575T patent/DE60130575T2/de not_active Expired - Lifetime
- 2001-10-16 MX MXPA03003483A patent/MXPA03003483A/es active IP Right Grant
- 2001-10-16 EP EP01974874A patent/EP1334962B1/de not_active Expired - Lifetime
- 2001-10-16 KR KR1020037005384A patent/KR100783306B1/ko not_active Expired - Fee Related
- 2001-10-16 AU AU2001294264A patent/AU2001294264A1/en not_active Abandoned
- 2001-10-16 DK DK01974874T patent/DK1334962T3/da active
- 2001-10-16 RU RU2003111012/04A patent/RU2287520C2/ru not_active IP Right Cessation
- 2001-10-17 TW TW090125695A patent/TW575541B/zh not_active IP Right Cessation
2003
- 2003-04-18 US US10/418,102 patent/US7030268B2/en not_active Expired - Fee Related
2005
- 2005-12-28 US US11/319,177 patent/US7659428B2/en not_active Expired - Fee Related
2007
- 2007-09-26 CY CY20071101237T patent/CY1107502T1/el unknown

Also Published As

Publication number	Publication date
US20060155143A1 (en)	2006-07-13
US7659428B2 (en)	2010-02-09
CN1481355A (zh)	2004-03-10
RU2287520C2 (ru)	2006-11-20
KR20030059202A (ko)	2003-07-07
EP1334962A4 (de)	2005-08-24
CA2425533A1 (en)	2003-04-10
BR0114728B1 (pt)	2014-01-14
EP1334962A1 (de)	2003-08-13
DE60130575T2 (de)	2008-04-30
DE60130575D1 (de)	2007-10-31
PT1334962E (pt)	2007-10-09
EP1334962B1 (de)	2007-09-19
US20040024219A1 (en)	2004-02-05
US7030268B2 (en)	2006-04-18
AU2001294264A1 (en)	2002-04-29
BR0114728A (pt)	2003-10-14
WO2002032853A1 (en)	2002-04-25
ES2290173T3 (es)	2008-02-16
JP4158192B2 (ja)	2008-10-01
DK1334962T3 (da)	2007-12-10
CY1107502T1 (el)	2013-03-13
CN1273442C (zh)	2006-09-06
MXPA03003483A (es)	2003-07-14
JPWO2002032853A1 (ja)	2004-02-26
TW575541B (en)	2004-02-11
KR100783306B1 (ko)	2007-12-10
CA2425533C (en)	2010-04-20

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2008-01-15

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