DK1334962T3 - Fremgangsmåder til fremstilling af acylphenylalanin - Google Patents
Fremgangsmåder til fremstilling af acylphenylalaninInfo
- Publication number
- DK1334962T3 DK1334962T3 DK01974874T DK01974874T DK1334962T3 DK 1334962 T3 DK1334962 T3 DK 1334962T3 DK 01974874 T DK01974874 T DK 01974874T DK 01974874 T DK01974874 T DK 01974874T DK 1334962 T3 DK1334962 T3 DK 1334962T3
- Authority
- DK
- Denmark
- Prior art keywords
- acylphenylalanine
- preparing
- methods
- solvent
- phenylalanine
- Prior art date
Links
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 abstract 3
- NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical compound CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 abstract 1
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 abstract 1
- 239000003513 alkali Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000012046 mixed solvent Substances 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 229940127557 pharmaceutical product Drugs 0.000 abstract 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 abstract 1
- 239000002994 raw material Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2000317603 | 2000-10-18 | ||
| PCT/JP2001/009068 WO2002032853A1 (en) | 2000-10-18 | 2001-10-16 | Process for the preparation of acylphenylalanines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1334962T3 true DK1334962T3 (da) | 2007-12-10 |
Family
ID=18796361
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK01974874T DK1334962T3 (da) | 2000-10-18 | 2001-10-16 | Fremgangsmåder til fremstilling af acylphenylalanin |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US7030268B2 (da) |
| EP (1) | EP1334962B1 (da) |
| JP (1) | JP4158192B2 (da) |
| KR (1) | KR100783306B1 (da) |
| CN (1) | CN1273442C (da) |
| AT (1) | ATE373635T1 (da) |
| AU (1) | AU2001294264A1 (da) |
| BR (1) | BR0114728B1 (da) |
| CA (1) | CA2425533C (da) |
| CY (1) | CY1107502T1 (da) |
| DE (1) | DE60130575T2 (da) |
| DK (1) | DK1334962T3 (da) |
| ES (1) | ES2290173T3 (da) |
| MX (1) | MXPA03003483A (da) |
| PT (1) | PT1334962E (da) |
| RU (1) | RU2287520C2 (da) |
| TW (1) | TW575541B (da) |
| WO (1) | WO2002032853A1 (da) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU4116801A (en) * | 2000-03-17 | 2001-09-24 | Ajinomoto Kk | Drugs for complications of diabetes and neuropathy and utilization thereof |
| JP4114200B2 (ja) * | 2000-10-18 | 2008-07-09 | 味の素株式会社 | ナテグリニド結晶の製造方法 |
| ES2290173T3 (es) * | 2000-10-18 | 2008-02-16 | Ajinomoto Co., Inc. | Procedimiento para la preparacion de acilfenilalaninas. |
| BR0114896A (pt) * | 2000-10-24 | 2003-08-12 | Ajinomoto Kk | Preparação contendo nateglinida, e, método para produzir a mesma |
| DE60130014T2 (de) * | 2000-10-24 | 2008-05-08 | Ajinomoto Co., Inc. | Verfahren zur herstellung der b-form von nateglinid-kristallen |
| AU2001296000A1 (en) * | 2000-10-24 | 2002-05-27 | Ajinomoto Co., Inc. | Nateglinide-containing hydrophilic drug preparations |
| ES2279921T3 (es) * | 2003-11-26 | 2007-09-01 | A.M.S.A. Anonima Materie Sintetiche E Affini S.P.A. | Procedimiento para la preparacion de nateglinida preferentemente en forma b. |
| US7425648B2 (en) | 2005-01-03 | 2008-09-16 | A.M.S.A. Anonima Materie Sintetiche E. Affini S.P.A. | Process for the preparation of nateglinide, preferably in B-form |
| CN101111266A (zh) * | 2005-01-31 | 2008-01-23 | 味之素株式会社 | 含有降血糖药的用于改善或治疗糖耐量异常、临界性糖尿病、胰岛素抵抗性和高胰岛素血症的药物组合物 |
| WO2007119580A1 (ja) | 2006-03-31 | 2007-10-25 | Ajinomoto Co., Inc. | カルボン酸クロリド化合物の製造方法 |
| US9150499B2 (en) | 2010-06-14 | 2015-10-06 | Cipla Limited | Process for the preparation of nateglinide |
| CN115340857B (zh) * | 2022-08-24 | 2024-03-26 | 宁波锋成先进能源材料研究院有限公司 | 一种原位自乳化纳米驱油剂及其制备方法和应用 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0093551B1 (en) * | 1982-04-30 | 1991-01-16 | Ajinomoto Co., Inc. | Pharmaceutical composition |
| JPS59190926A (ja) | 1983-04-14 | 1984-10-29 | Ajinomoto Co Inc | 吸収性付与剤 |
| JPS58189121A (ja) | 1982-04-30 | 1983-11-04 | Ajinomoto Co Inc | インシユリン投与賦活剤 |
| DE3590085C2 (da) * | 1984-03-05 | 1990-11-29 | Mitsui Toatsu Chemicals, Inc., Tokio/Tokyo, Jp | |
| JPS6354321A (ja) * | 1985-03-27 | 1988-03-08 | Ajinomoto Co Inc | 血糖降下剤 |
| US4743547A (en) * | 1985-04-09 | 1988-05-10 | Kuraray Co., Ltd. | Method of producing L-phenylalanine |
| DE10199058I2 (de) * | 1991-07-30 | 2006-04-27 | Alcm Co | Kristalle von N-(trans-4-isopropylcyclohexylcarbonyl)-D-phenylalanin und Verfahren zu ihrer Herstellung |
| JP2969397B2 (ja) * | 1991-09-10 | 1999-11-02 | 花王株式会社 | Ｎ−長鎖アシル−β−アラニンの製造方法 |
| JP3025725B2 (ja) * | 1992-11-24 | 2000-03-27 | 花王株式会社 | Ｎ−長鎖アシルアミノ酸の分離法及び精製法 |
| JPH06256276A (ja) * | 1993-03-02 | 1994-09-13 | Kao Corp | Ｎ−長鎖アシルアミノ酸塩の製造方法 |
| JPH0717899A (ja) * | 1993-07-01 | 1995-01-20 | Ajinomoto Co Inc | カルボン酸クロリドの製造法 |
| PT1586314E (pt) | 1996-11-15 | 2011-07-01 | Ajinomoto Kk | Composição de comprimidos de nateglinida |
| US6844006B1 (en) * | 1999-07-09 | 2005-01-18 | Pennfield Oil Company | Process and apparatus for the preparation of chlortetracycline-containing animal feed compositions |
| PT1616561E (pt) | 1999-12-28 | 2008-07-09 | Ajinomoto Kk | Preparação antidiabética para administração oral |
| AU4116801A (en) | 2000-03-17 | 2001-09-24 | Ajinomoto Kk | Drugs for complications of diabetes and neuropathy and utilization thereof |
| JP4114200B2 (ja) | 2000-10-18 | 2008-07-09 | 味の素株式会社 | ナテグリニド結晶の製造方法 |
| ES2290173T3 (es) * | 2000-10-18 | 2008-02-16 | Ajinomoto Co., Inc. | Procedimiento para la preparacion de acilfenilalaninas. |
| DE60130014T2 (de) | 2000-10-24 | 2008-05-08 | Ajinomoto Co., Inc. | Verfahren zur herstellung der b-form von nateglinid-kristallen |
| BR0114896A (pt) | 2000-10-24 | 2003-08-12 | Ajinomoto Kk | Preparação contendo nateglinida, e, método para produzir a mesma |
-
2001
- 2001-10-16 ES ES01974874T patent/ES2290173T3/es not_active Expired - Lifetime
- 2001-10-16 AT AT01974874T patent/ATE373635T1/de active
- 2001-10-16 DE DE60130575T patent/DE60130575T2/de not_active Expired - Lifetime
- 2001-10-16 EP EP01974874A patent/EP1334962B1/en not_active Expired - Lifetime
- 2001-10-16 WO PCT/JP2001/009068 patent/WO2002032853A1/ja not_active Ceased
- 2001-10-16 MX MXPA03003483A patent/MXPA03003483A/es active IP Right Grant
- 2001-10-16 DK DK01974874T patent/DK1334962T3/da active
- 2001-10-16 CN CNB018206727A patent/CN1273442C/zh not_active Expired - Fee Related
- 2001-10-16 PT PT01974874T patent/PT1334962E/pt unknown
- 2001-10-16 AU AU2001294264A patent/AU2001294264A1/en not_active Abandoned
- 2001-10-16 BR BRPI0114728-5A patent/BR0114728B1/pt not_active IP Right Cessation
- 2001-10-16 KR KR1020037005384A patent/KR100783306B1/ko not_active Expired - Fee Related
- 2001-10-16 JP JP2002536037A patent/JP4158192B2/ja not_active Expired - Lifetime
- 2001-10-16 RU RU2003111012/04A patent/RU2287520C2/ru not_active IP Right Cessation
- 2001-10-16 CA CA2425533A patent/CA2425533C/en not_active Expired - Fee Related
- 2001-10-17 TW TW090125695A patent/TW575541B/zh not_active IP Right Cessation
-
2003
- 2003-04-18 US US10/418,102 patent/US7030268B2/en not_active Expired - Fee Related
-
2005
- 2005-12-28 US US11/319,177 patent/US7659428B2/en not_active Expired - Fee Related
-
2007
- 2007-09-26 CY CY20071101237T patent/CY1107502T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ATE373635T1 (de) | 2007-10-15 |
| WO2002032853A1 (en) | 2002-04-25 |
| ES2290173T3 (es) | 2008-02-16 |
| CN1481355A (zh) | 2004-03-10 |
| KR100783306B1 (ko) | 2007-12-10 |
| EP1334962B1 (en) | 2007-09-19 |
| AU2001294264A1 (en) | 2002-04-29 |
| PT1334962E (pt) | 2007-10-09 |
| DE60130575T2 (de) | 2008-04-30 |
| KR20030059202A (ko) | 2003-07-07 |
| BR0114728A (pt) | 2003-10-14 |
| RU2287520C2 (ru) | 2006-11-20 |
| EP1334962A1 (en) | 2003-08-13 |
| US20040024219A1 (en) | 2004-02-05 |
| CA2425533A1 (en) | 2003-04-10 |
| CA2425533C (en) | 2010-04-20 |
| MXPA03003483A (es) | 2003-07-14 |
| JPWO2002032853A1 (ja) | 2004-02-26 |
| TW575541B (en) | 2004-02-11 |
| DE60130575D1 (de) | 2007-10-31 |
| CY1107502T1 (el) | 2013-03-13 |
| US7659428B2 (en) | 2010-02-09 |
| US20060155143A1 (en) | 2006-07-13 |
| EP1334962A4 (en) | 2005-08-24 |
| CN1273442C (zh) | 2006-09-06 |
| US7030268B2 (en) | 2006-04-18 |
| JP4158192B2 (ja) | 2008-10-01 |
| BR0114728B1 (pt) | 2014-01-14 |
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