ATE374758T1 - Chirale heptinderivate zur herstellung von epothilonen und verfahren zu deren herstellung - Google Patents

Chirale heptinderivate zur herstellung von epothilonen und verfahren zu deren herstellung

Info

Publication number
ATE374758T1
ATE374758T1 AT05740374T AT05740374T ATE374758T1 AT E374758 T1 ATE374758 T1 AT E374758T1 AT 05740374 T AT05740374 T AT 05740374T AT 05740374 T AT05740374 T AT 05740374T AT E374758 T1 ATE374758 T1 AT E374758T1
Authority
AT
Austria
Prior art keywords
production
derivatives
heptin
chiral
epothilones
Prior art date
Application number
AT05740374T
Other languages
English (en)
Inventor
Johannes Platzek
Orlin Petrov
Marc Willuhn
Klaus-Dieter Graske
Werner Skuballa
Original Assignee
Bayer Schering Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Schering Pharma Ag filed Critical Bayer Schering Pharma Ag
Application granted granted Critical
Publication of ATE374758T1 publication Critical patent/ATE374758T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)
AT05740374T 2004-04-22 2005-04-21 Chirale heptinderivate zur herstellung von epothilonen und verfahren zu deren herstellung ATE374758T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04090157A EP1589011A1 (de) 2004-04-22 2004-04-22 Neue chirale Heptin Derivate zur Herstellung von Epothilonen und Verfahren zu deren Herstellung
US56584904P 2004-04-28 2004-04-28

Publications (1)

Publication Number Publication Date
ATE374758T1 true ATE374758T1 (de) 2007-10-15

Family

ID=34928801

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05740374T ATE374758T1 (de) 2004-04-22 2005-04-21 Chirale heptinderivate zur herstellung von epothilonen und verfahren zu deren herstellung

Country Status (18)

Country Link
US (2) US7326798B2 (de)
EP (2) EP1589011A1 (de)
JP (1) JP2007533700A (de)
CN (1) CN1942462B (de)
AT (1) ATE374758T1 (de)
AU (1) AU2005235376A1 (de)
BR (1) BRPI0510109A (de)
CA (1) CA2560455A1 (de)
DE (1) DE602005002750T2 (de)
DK (1) DK1758875T3 (de)
ES (1) ES2293574T3 (de)
MX (1) MXPA06012212A (de)
PL (1) PL1758875T3 (de)
PT (1) PT1758875E (de)
RU (1) RU2006140967A (de)
SI (1) SI1758875T1 (de)
WO (1) WO2005101950A1 (de)
ZA (1) ZA200609677B (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2003211A4 (de) 2006-03-28 2010-12-01 Sumitomo Chemical Co Verfahren zur herstellung von optisch aktivem (s)-7-hydroxy-6-methylheptan-2-on und einer vorstufe davon
CN104758089B (zh) 2014-01-08 2018-03-30 库克医学技术有限责任公司 用于塞住经皮心脏瓣膜泄漏的ecm条带

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6320045B1 (en) * 1997-12-04 2001-11-20 Bristol-Myers Squibb Company Process for the reduction of oxiranyl epothilones to olefinic epothilones
GB9810659D0 (en) 1998-05-18 1998-07-15 Ciba Geigy Ag Organic compounds
HK1044946A1 (zh) * 1999-02-11 2002-11-08 舍林股份公司 依泊昔酮衍生物、其製備方法及藥物用途
US6593115B2 (en) 2000-03-24 2003-07-15 Bristol-Myers Squibb Co. Preparation of epothilone intermediates

Also Published As

Publication number Publication date
MXPA06012212A (es) 2007-04-17
ES2293574T3 (es) 2008-03-16
DK1758875T3 (da) 2008-01-21
EP1758875B1 (de) 2007-10-03
CA2560455A1 (en) 2005-11-03
DE602005002750D1 (de) 2007-11-15
US20080108838A1 (en) 2008-05-08
ZA200609677B (en) 2008-01-30
PT1758875E (pt) 2007-12-14
JP2007533700A (ja) 2007-11-22
EP1758875A1 (de) 2007-03-07
AU2005235376A1 (en) 2005-11-03
CN1942462A (zh) 2007-04-04
BRPI0510109A (pt) 2007-10-30
EP1589011A1 (de) 2005-10-26
WO2005101950A1 (en) 2005-11-03
DE602005002750T2 (de) 2008-07-17
RU2006140967A (ru) 2008-05-27
SI1758875T1 (sl) 2008-02-29
US7326798B2 (en) 2008-02-05
PL1758875T3 (pl) 2008-02-29
CN1942462B (zh) 2011-05-25
US20060100442A1 (en) 2006-05-11

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