BRPI0510109A - derivados quirais de heptina para preparação de epotilonas e processos para sua preparação - Google Patents
derivados quirais de heptina para preparação de epotilonas e processos para sua preparaçãoInfo
- Publication number
- BRPI0510109A BRPI0510109A BRPI0510109-3A BRPI0510109A BRPI0510109A BR PI0510109 A BRPI0510109 A BR PI0510109A BR PI0510109 A BRPI0510109 A BR PI0510109A BR PI0510109 A BRPI0510109 A BR PI0510109A
- Authority
- BR
- Brazil
- Prior art keywords
- preparation
- epothilones
- derivatives
- heptin
- chiral
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 229930013356 epothilone Natural products 0.000 title abstract 2
- HESCAJZNRMSMJG-KKQRBIROSA-N epothilone A Chemical class C/C([C@@H]1C[C@@H]2O[C@@H]2CCC[C@@H]([C@@H]([C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O1)O)C)=C\C1=CSC(C)=N1 HESCAJZNRMSMJG-KKQRBIROSA-N 0.000 title abstract 2
- VSRBKQFNFZQRBM-UHFFFAOYSA-N tuaminoheptane Chemical class CCCCCC(C)N VSRBKQFNFZQRBM-UHFFFAOYSA-N 0.000 title 1
- 239000000543 intermediate Substances 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 150000003883 epothilone derivatives Chemical class 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
- C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrane Compounds (AREA)
Abstract
DERIVADOS QUIRAIS DE HEPTINA PARA PREPARAçãO DE EPOTILONAS E PROCESSOS PARA SUA PREPARAçãO. A presente invenção refere-se a um novo processo sintético para a produção de intermediários-chave úteis na síntese de epotilonas ou derivados de epotilonas, a certos compostos usados para produzir estes intermediários-chave e a um processo para produzir os referidos compostos. Os intermediários usados são representados por fórmulas II e III, em que R é selecionado entre H, alquila, e alquila substituída e X¬ 1¬ é um grupo protetor de oxigênio.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04090157A EP1589011A1 (en) | 2004-04-22 | 2004-04-22 | Novel chiral heptyne derivates for the preparation of epothilones and processes for their preparation |
| US56584904P | 2004-04-28 | 2004-04-28 | |
| PCT/EP2005/004492 WO2005101950A1 (en) | 2004-04-22 | 2005-04-21 | Chiral heptyne derivatives for the preparation of epothilones and processes for their preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0510109A true BRPI0510109A (pt) | 2007-10-30 |
Family
ID=34928801
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0510109-3A BRPI0510109A (pt) | 2004-04-22 | 2005-04-21 | derivados quirais de heptina para preparação de epotilonas e processos para sua preparação |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US7326798B2 (pt) |
| EP (2) | EP1589011A1 (pt) |
| JP (1) | JP2007533700A (pt) |
| CN (1) | CN1942462B (pt) |
| AT (1) | ATE374758T1 (pt) |
| AU (1) | AU2005235376A1 (pt) |
| BR (1) | BRPI0510109A (pt) |
| CA (1) | CA2560455A1 (pt) |
| DE (1) | DE602005002750T2 (pt) |
| DK (1) | DK1758875T3 (pt) |
| ES (1) | ES2293574T3 (pt) |
| MX (1) | MXPA06012212A (pt) |
| PL (1) | PL1758875T3 (pt) |
| PT (1) | PT1758875E (pt) |
| RU (1) | RU2006140967A (pt) |
| SI (1) | SI1758875T1 (pt) |
| WO (1) | WO2005101950A1 (pt) |
| ZA (1) | ZA200609677B (pt) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2003211A4 (en) | 2006-03-28 | 2010-12-01 | Sumitomo Chemical Co | PROCESS FOR THE PREPARATION OF OPTICALLY ACTIVE (S) -7-HYDROXY-6-METHYL-HEPTAN-2-ON AND A PREVENTION THEREOF |
| CN104758089B (zh) | 2014-01-08 | 2018-03-30 | 库克医学技术有限责任公司 | 用于塞住经皮心脏瓣膜泄漏的ecm条带 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6320045B1 (en) * | 1997-12-04 | 2001-11-20 | Bristol-Myers Squibb Company | Process for the reduction of oxiranyl epothilones to olefinic epothilones |
| GB9810659D0 (en) | 1998-05-18 | 1998-07-15 | Ciba Geigy Ag | Organic compounds |
| HK1044946A1 (zh) * | 1999-02-11 | 2002-11-08 | 舍林股份公司 | 依泊昔酮衍生物、其製備方法及藥物用途 |
| US6593115B2 (en) | 2000-03-24 | 2003-07-15 | Bristol-Myers Squibb Co. | Preparation of epothilone intermediates |
-
2004
- 2004-04-22 EP EP04090157A patent/EP1589011A1/en not_active Withdrawn
-
2005
- 2005-04-21 CA CA002560455A patent/CA2560455A1/en not_active Abandoned
- 2005-04-21 AU AU2005235376A patent/AU2005235376A1/en not_active Abandoned
- 2005-04-21 RU RU2006140967/04A patent/RU2006140967A/ru not_active Application Discontinuation
- 2005-04-21 EP EP05740374A patent/EP1758875B1/en not_active Expired - Lifetime
- 2005-04-21 CN CN2005800116115A patent/CN1942462B/zh not_active Expired - Fee Related
- 2005-04-21 ES ES05740374T patent/ES2293574T3/es not_active Expired - Lifetime
- 2005-04-21 WO PCT/EP2005/004492 patent/WO2005101950A1/en not_active Ceased
- 2005-04-21 JP JP2007508870A patent/JP2007533700A/ja active Pending
- 2005-04-21 SI SI200530107T patent/SI1758875T1/sl unknown
- 2005-04-21 AT AT05740374T patent/ATE374758T1/de not_active IP Right Cessation
- 2005-04-21 PL PL05740374T patent/PL1758875T3/pl unknown
- 2005-04-21 BR BRPI0510109-3A patent/BRPI0510109A/pt not_active IP Right Cessation
- 2005-04-21 DK DK05740374T patent/DK1758875T3/da active
- 2005-04-21 DE DE602005002750T patent/DE602005002750T2/de not_active Expired - Lifetime
- 2005-04-21 PT PT05740374T patent/PT1758875E/pt unknown
- 2005-04-21 US US11/110,959 patent/US7326798B2/en not_active Expired - Fee Related
- 2005-04-21 MX MXPA06012212A patent/MXPA06012212A/es not_active Application Discontinuation
-
2006
- 2006-11-21 ZA ZA200609677A patent/ZA200609677B/en unknown
-
2007
- 2007-12-12 US US11/954,348 patent/US20080108838A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA06012212A (es) | 2007-04-17 |
| ES2293574T3 (es) | 2008-03-16 |
| DK1758875T3 (da) | 2008-01-21 |
| EP1758875B1 (en) | 2007-10-03 |
| CA2560455A1 (en) | 2005-11-03 |
| DE602005002750D1 (de) | 2007-11-15 |
| US20080108838A1 (en) | 2008-05-08 |
| ZA200609677B (en) | 2008-01-30 |
| PT1758875E (pt) | 2007-12-14 |
| JP2007533700A (ja) | 2007-11-22 |
| EP1758875A1 (en) | 2007-03-07 |
| AU2005235376A1 (en) | 2005-11-03 |
| CN1942462A (zh) | 2007-04-04 |
| ATE374758T1 (de) | 2007-10-15 |
| EP1589011A1 (en) | 2005-10-26 |
| WO2005101950A1 (en) | 2005-11-03 |
| DE602005002750T2 (de) | 2008-07-17 |
| RU2006140967A (ru) | 2008-05-27 |
| SI1758875T1 (sl) | 2008-02-29 |
| US7326798B2 (en) | 2008-02-05 |
| PL1758875T3 (pl) | 2008-02-29 |
| CN1942462B (zh) | 2011-05-25 |
| US20060100442A1 (en) | 2006-05-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 5A,6A,7A E 8A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2204 DE 02/04/2013. |