ATE353911T1 - Verfahren zur rekombinanten herstellung von antifusogenikpeptide - Google Patents

Verfahren zur rekombinanten herstellung von antifusogenikpeptide

Info

Publication number
ATE353911T1
ATE353911T1 AT03026521T AT03026521T ATE353911T1 AT E353911 T1 ATE353911 T1 AT E353911T1 AT 03026521 T AT03026521 T AT 03026521T AT 03026521 T AT03026521 T AT 03026521T AT E353911 T1 ATE353911 T1 AT E353911T1
Authority
AT
Austria
Prior art keywords
peptide
antifusogenic
inclusion bodies
recombinant production
repeat
Prior art date
Application number
AT03026521T
Other languages
English (en)
Inventor
Alexandra Kaczmarek
Erhard Kopetzki
Christian Schantz
Stefan Seeber
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE353911T1 publication Critical patent/ATE353911T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Pulmonology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT03026521T 2002-11-19 2003-11-18 Verfahren zur rekombinanten herstellung von antifusogenikpeptide ATE353911T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02025618 2002-11-19
EP03000988 2003-01-17

Publications (1)

Publication Number Publication Date
ATE353911T1 true ATE353911T1 (de) 2007-03-15

Family

ID=32510122

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03026521T ATE353911T1 (de) 2002-11-19 2003-11-18 Verfahren zur rekombinanten herstellung von antifusogenikpeptide

Country Status (11)

Country Link
US (1) US20050191729A1 (de)
EP (1) EP1422237B1 (de)
JP (1) JP3904553B2 (de)
KR (1) KR100553510B1 (de)
CN (1) CN1254542C (de)
AT (1) ATE353911T1 (de)
CA (1) CA2443365C (de)
DE (1) DE60311731T2 (de)
DK (1) DK1422237T3 (de)
ES (1) ES2280673T3 (de)
MX (1) MXPA03010433A (de)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5148989B2 (ja) * 2007-12-27 2013-02-20 イーストマン コダック カンパニー 撮像装置
US8730351B2 (en) 2008-12-18 2014-05-20 Intellectual Ventures Fund 83 Llc Method for deleting data files in an electronic device
US8432461B2 (en) * 2008-12-18 2013-04-30 Apple Inc. Wireless camera with automatic wake-up and transfer capability and transfer status display
US20110205397A1 (en) * 2010-02-24 2011-08-25 John Christopher Hahn Portable imaging device having display with improved visibility under adverse conditions
US8957981B2 (en) 2010-03-03 2015-02-17 Intellectual Ventures Fund 83 Llc Imaging device for capturing self-portrait images
US20110228074A1 (en) * 2010-03-22 2011-09-22 Parulski Kenneth A Underwater camera with presssure sensor
US20110228075A1 (en) * 2010-03-22 2011-09-22 Madden Thomas E Digital camera with underwater capture mode
US8665340B2 (en) 2010-04-29 2014-03-04 Intellectual Ventures Fund 83 Llc Indoor/outdoor scene detection using GPS
US8605221B2 (en) 2010-05-25 2013-12-10 Intellectual Ventures Fund 83 Llc Determining key video snippets using selection criteria to form a video summary
US8446490B2 (en) 2010-05-25 2013-05-21 Intellectual Ventures Fund 83 Llc Video capture system producing a video summary
US8599316B2 (en) 2010-05-25 2013-12-03 Intellectual Ventures Fund 83 Llc Method for determining key video frames
US8520088B2 (en) 2010-05-25 2013-08-27 Intellectual Ventures Fund 83 Llc Storing a video summary as metadata
US8432965B2 (en) 2010-05-25 2013-04-30 Intellectual Ventures Fund 83 Llc Efficient method for assembling key video snippets to form a video summary
US8619150B2 (en) 2010-05-25 2013-12-31 Intellectual Ventures Fund 83 Llc Ranking key video frames using camera fixation
US8432456B2 (en) 2010-06-18 2013-04-30 Apple Inc. Digital camera for sharing digital images
US8970720B2 (en) 2010-07-26 2015-03-03 Apple Inc. Automatic digital camera photography mode selection
WO2012028523A2 (en) 2010-08-30 2012-03-08 F. Hoffmann-La Roche Ag Prokaryotic expression construct
ES2558751T3 (es) 2010-08-30 2016-02-08 F. Hoffmann-La Roche Ag Alimento alcalino
JP5860052B2 (ja) 2010-08-30 2016-02-16 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ テトラネクチン−アポリポタンパク質ａ−ｉ、それを含有する脂質粒子及びその使用
JP2013544488A (ja) 2010-08-30 2013-12-19 エフ．ホフマン−ラ ロシュ アーゲー テトラネクチン−アポリポタンパク質ａ−ｉ脂質粒子を産生するための方法、脂質粒子自体、及びその使用
KR20130117760A (ko) 2010-08-30 2013-10-28 에프. 호프만-라 로슈 아게 테트라넥틴-아포지단백질 a-i 입자의 제조 방법, 이에 의해 제조된 지질 입자 및 이의 용도
JP5757639B2 (ja) 2010-09-14 2015-07-29 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ セルピンフィンガー融合ポリペプチド
US8494301B2 (en) 2010-09-16 2013-07-23 Eastman Kodak Company Refocusing images using scene captured images
US8643734B2 (en) 2010-11-10 2014-02-04 Apple Inc. Automatic engagement of image stabilization
US9013602B2 (en) 2011-01-03 2015-04-21 Intellectual Ventures Fund 83 Llc Digital camera system having a retail mode
US8379934B2 (en) 2011-02-04 2013-02-19 Eastman Kodak Company Estimating subject motion between image frames
US8428308B2 (en) 2011-02-04 2013-04-23 Apple Inc. Estimating subject motion for capture setting determination
US8736697B2 (en) 2011-03-25 2014-05-27 Apple Inc. Digital camera having burst image capture mode
US8736704B2 (en) 2011-03-25 2014-05-27 Apple Inc. Digital camera for capturing an image sequence
US8736716B2 (en) 2011-04-06 2014-05-27 Apple Inc. Digital camera having variable duration burst mode
BR112013033562A2 (pt) 2011-08-25 2017-02-14 Hoffmann La Roche proteína de fusão de tetranectina-apolipoproteína a-i encurtada, uma partícula de lipídio que a contém e uso das mesmas
WO2013127700A1 (en) 2012-02-29 2013-09-06 F. Hoffmann-La Roche Ag Method for reduction of 1->2 reading frame shifts
CN114107352A (zh) 2012-04-17 2022-03-01 弗·哈夫曼-拉罗切有限公司 使用修饰的核酸表达多肽的方法
EP2959006B1 (de) 2013-02-22 2018-07-18 F.Hoffmann-La Roche Ag Verwendung eines aminosäuren-auxotrophiegeheilten prokaryoten stammes für die rekombinante herstellung eines polypeptids
CN111303245B (zh) * 2020-02-21 2023-06-27 成都奥达生物科技有限公司 一种抗合胞病毒膜融合抑制剂
CN113004375B (zh) * 2021-03-15 2022-07-01 华南农业大学 一种高效介导重组多肽形成包涵体的小分子蛋白

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5064943A (en) * 1988-12-16 1991-11-12 American Cyanamid Company Method for solubilization and naturation of somatotropin
US5614192A (en) * 1989-07-19 1997-03-25 Connective Therapeutics, Inc. T cell receptor peptides as therapeutics for immune-related disease
US5371386A (en) * 1992-04-28 1994-12-06 Mitsubishi Denki Kabushiki Kaisha Semiconductor device and method of assembling the same
DE69332377T2 (de) * 1992-07-13 2003-07-03 Bionebraska, Inc. Verfahren zur modifizierung rekombinanter polypeptide
US5656456A (en) * 1992-07-13 1997-08-12 Bionebraska, Inc. Chemical method for selective modification of the N- and/or C-terminal amino acid α-carbon reactive group of a recombinant polypeptide or a portion thereof
AU688733B2 (en) * 1992-07-20 1998-03-19 Duke University Compounds which inhibit HIV replication
US6479055B1 (en) * 1993-06-07 2002-11-12 Trimeris, Inc. Methods for inhibition of membrane fusion-associated events, including respiratory syncytial virus transmission
US5464933A (en) * 1993-06-07 1995-11-07 Duke University Synthetic peptide inhibitors of HIV transmission
US6017536A (en) * 1993-06-07 2000-01-25 Trimeris, Inc. Simian immunodeficiency virus peptides with antifusogenic and antiviral activities
US6291245B1 (en) * 1998-07-15 2001-09-18 Roche Diagnostics Gmbh Host-vector system
BR0010757A (pt) * 1999-05-17 2002-02-19 Conjuchem Inc Inibidores de peptìdeo de fusão de longa duração de infecção viral
CA2395291C (en) * 1999-12-16 2012-09-11 Whitehead Institute For Biomedical Research Five-helix protein
CA2450548C (en) * 2001-06-15 2012-05-01 F. Hoffmann-La Roche Ag Method for the recombinant production of peptidic antiviral fusion inhibitors, and acetylation of gb41 fragments

Also Published As

Publication number Publication date
JP3904553B2 (ja) 2007-04-11
DE60311731T2 (de) 2007-10-31
KR100553510B1 (ko) 2006-02-20
CN1502698A (zh) 2004-06-09
DE60311731D1 (de) 2007-03-29
US20050191729A1 (en) 2005-09-01
KR20040044372A (ko) 2004-05-28
CN1254542C (zh) 2006-05-03
EP1422237B1 (de) 2007-02-14
CA2443365C (en) 2010-01-12
EP1422237A2 (de) 2004-05-26
JP2004166703A (ja) 2004-06-17
DK1422237T3 (da) 2007-06-11
CA2443365A1 (en) 2004-05-19
ES2280673T3 (es) 2007-09-16
EP1422237A3 (de) 2004-10-06
MXPA03010433A (es) 2004-10-15

Similar Documents

Publication Publication Date Title
DE60311731D1 (de) Verfahren zur rekombinanten Herstellung von Antifusogenikpeptide
ATE299942T1 (de) Verfahren zur herstellung von natürlich gefalteten proteinen durch co-sekretion von molekularen chaperonen
ATE414162T1 (de) Verfahren und materialien zur herstellung von glucosamin
ATE372383T1 (de) Verfahren zur herstellung von l-aminosäuren
ATE375393T1 (de) Verfahren zur herstellung eines peptids mittels eines hilfspeptids
DE502004005166D1 (de) Expressionsvektor zur antibiotikafreien expression
BRPI0713252B8 (pt) processo para a recuperação de fator de crescimento endotelial vascular (vegf) recombinante reenovelado
ATE415469T1 (de) Verfahren zur gewinnung von heterologen polypeptiden aus bakterienzellen
DK1874932T3 (da) Produktion af rekombinante proteiner ved autoproteolytisk spaltning af et fusionsprotein
ATE397061T1 (de) Verfahren zur herstellung von proteinen
ATE493497T1 (de) Verfahren zur herstellung von oligopeptiden
BR0309401A (pt) polinucleotìdeo isolado, vetor de expressão, célula cultivada, método para produzir polipeptìdeos, e um anticorpo para um polipeptìdeo, e, anticorpo
ATE533851T1 (de) Prozess zur herstellung eines plastidgerichteten proteins in pflanzenzellen
DE60037508D1 (de) Verfahren zur herstellung von rekombinantem insulin durch fusionsproteine
ATE312939T1 (de) Verfahren zur rekombinanten herstellung von polypeptiden
DE60219361D1 (de) Verfahren zur rekombinanten herstellung von plazenta wachstumsfaktor
ATE445009T1 (de) Signalpeptid zur herstellung eines polypeptids
ATE522604T1 (de) Verfahren zur herstellung von proteinen durch elektropulsierung
ATE261985T1 (de) Verfahren zur herstellung von richtig gefaltetem, biologisch aktivem, rekombinantem protein
JO2429B1 (en) Ways to produce recombinant peptides of antigen - merger
ATE319837T1 (de) Verfahren zur herstellung von rekombinantem trypsin
ATE303400T1 (de) Vefahren zur herstellung von peptiduntereinheiten aus polymer-proteinen
DE60040789D1 (de) Verfahren zur aufreinigung heterologer proteine
DE69930118D1 (de) Verfahren zur herstellung von proteinen in transformierten hefezellen
EP1788075A4 (de) Grosstechnisch geeigneter mikroorganismus

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1422237

Country of ref document: EP