ATE380543T1 - Stabilisierung von festen schilddrüsenhormonzusammensetzungen - Google Patents

Stabilisierung von festen schilddrüsenhormonzusammensetzungen

Info

Publication number: ATE380543T1
Authority: AT; Austria
Prior art keywords: stabilization; thyroid hormone; forms; excipients; moisture
Prior art date: 2000-10-03

Application number

AT01971348T

Other languages

English (en)

Inventor

Spiridon Spireas

Original Assignee

Sigmapharm Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-10-03

Filing date

2001-09-26

Publication date

2007-12-15

2001-09-26 Application filed by Sigmapharm Inc filed Critical Sigmapharm Inc

2007-12-15 Application granted granted Critical

2007-12-15 Publication of ATE380543T1 publication Critical patent/ATE380543T1/de

Links

239000000203 mixture Substances 0.000 title abstract 3
AUYYCJSJGJYCDS-LBPRGKRZSA-N Thyrolar Chemical class IC1=CC(C[C@H](N)C(O)=O)=CC(I)=C1OC1=CC=C(O)C(I)=C1 AUYYCJSJGJYCDS-LBPRGKRZSA-N 0.000 title 1
239000007787 solid Substances 0.000 title 1
230000006641 stabilisation Effects 0.000 title 1
238000011105 stabilization Methods 0.000 title 1
239000005495 thyroid hormone Substances 0.000 title 1
229940036555 thyroid hormone Drugs 0.000 title 1
230000015556 catabolic process Effects 0.000 abstract 2
238000006731 degradation reaction Methods 0.000 abstract 2
239000002552 dosage form Substances 0.000 abstract 2
239000003814 drug Substances 0.000 abstract 2
229940079593 drug Drugs 0.000 abstract 2
238000009472 formulation Methods 0.000 abstract 2
239000000546 pharmaceutical excipient Substances 0.000 abstract 2
238000007906 compression Methods 0.000 abstract 1
230000006835 compression Effects 0.000 abstract 1
230000002209 hydrophobic effect Effects 0.000 abstract 1
239000000346 nonvolatile oil Substances 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
239000000843 powder Substances 0.000 abstract 1
210000001685 thyroid gland Anatomy 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/485—Inorganic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Epidemiology (AREA)
Inorganic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AT01971348T 2000-10-03 2001-09-26 Stabilisierung von festen schilddrüsenhormonzusammensetzungen ATE380543T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US23744200P	2000-10-03	2000-10-03
US09/690,973 US6855333B1 (en)	2000-10-03	2000-10-18	Stabilization of solid thyroid drug formulations

Publications (1)

Publication Number	Publication Date
ATE380543T1 true ATE380543T1 (de)	2007-12-15

Family

ID=26930677

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT01971348T ATE380543T1 (de)	2000-10-03	2001-09-26	Stabilisierung von festen schilddrüsenhormonzusammensetzungen

Country Status (13)

Country	Link
US (1)	US6855333B1 (de)
EP (1)	EP1322294B1 (de)
CN (1)	CN1543341A (de)
AT (1)	ATE380543T1 (de)
AU (2)	AU9124401A (de)
CA (4)	CA2641575C (de)
CY (1)	CY1107295T1 (de)
DE (1)	DE60131863T2 (de)
ES (1)	ES2298262T3 (de)
MX (1)	MXPA03002809A (de)
NZ (1)	NZ524567A (de)
PT (1)	PT1322294E (de)
WO (1)	WO2002028364A2 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6979462B1 (en) *	2000-10-03	2005-12-27	Mutual Pharmaceutical Co., Inc.	Stabilization of solid drug formulations
US6555581B1 (en)	2001-02-15	2003-04-29	Jones Pharma, Inc.	Levothyroxine compositions and methods
JP2004525109A (ja)	2001-02-15	2004-08-19	キング・ファーマシューティカルズ・インコーポレイティッド	安定化された甲状腺ホルモン医薬組成物、及びその製法
WO2002072069A1 (en) *	2001-03-12	2002-09-19	Novo Nordisk A/S	Novel tablets and capsules and a process for its preparation
US7101569B2 (en)	2001-08-14	2006-09-05	Franz G Andrew	Methods of administering levothyroxine pharmaceutical compositions
US20030099699A1 (en) *	2001-11-13	2003-05-29	Hanshew Dwight D.	Storage stable thyroxine active drug formulations and methods for their production
US6645526B2 (en)	2001-11-13	2003-11-11	Mylan Pharmaceuticals, Inc.	Storage stable thyroxine active drug formulations and methods for their production
ITMI20022394A1 (it)	2002-11-13	2004-05-14	Bracco Spa	Uso di triiodotironina 3-solfato come farmaco ad attivita' tireomimetica e relative formulazioni farmaceutiche.
ITMI20110713A1 (it)	2011-04-29	2012-10-30	Bracco Imaging Spa	Processo per la preparazione di un derivato solfatato di3,5-diiodo-o-[3-iodofenil]-l-tirosina
US10231931B1 (en)	2018-03-23	2019-03-19	Genus Lifesciences Inc.	Thyroid hormone oral dosage forms and methods of using the same

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4001211A (en) *	1974-12-02	1977-01-04	The Dow Chemical Company	Pharmaceutical capsules from improved thermogelling methyl cellulose ethers
US4389393A (en) *	1982-03-26	1983-06-21	Forest Laboratories, Inc.	Sustained release therapeutic compositions based on high molecular weight hydroxypropylmethylcellulose
US4755386A (en)	1986-01-22	1988-07-05	Schering Corporation	Buccal formulation
US5051406A (en)	1987-03-04	1991-09-24	Nippon Hypox Laboratories Incorporated	Pharmaceutical composition using albumin as a carrier and process for producing the same
US4983399A (en) *	1989-10-18	1991-01-08	Eastman Kodak Company	Direct compression carrier composition
US5225204A (en) *	1991-11-05	1993-07-06	Chen Jivn Ren	Stable dosage of levothyroxine sodium and process of production
DE4318577A1 (de)	1993-06-04	1994-12-08	Merck Patent Gmbh	Schmiermittelfreie, arzneimittelhaltige Tabletten
WO1995013794A1 (en)	1993-11-18	1995-05-26	Nippon Shinyaku Co., Ltd.	Process for producing stable medicinal composition, and pharmaceutical preparation
GB9401892D0 (en)	1994-02-01	1994-03-30	Boots Co Plc	Therapeutic agents
IL115445A (en)	1994-10-17	1999-08-17	Akzo Nobel Nv	Solid pharmaceutical compositions comprising low dosage active ingredient oil and excipient capable of binding water and their preparation
US5756123A (en) *	1994-12-01	1998-05-26	Japan Elanco Co., Ltd.	Capsule shell
DE19541128C2 (de)	1995-10-27	1997-11-27	Henning Berlin Gmbh & Co	Stabilisierte schilddrüsenhormonhaltige Arzneimittel
US5635209A (en)	1995-10-31	1997-06-03	Vintage Pharmaceuticals, Inc.	Stabilized composition of levothyroxine sodium medication and method for its production
AU712217B2 (en)	1995-11-14	1999-11-04	Abbott Gmbh & Co. Kg	Stabilized thyroid hormone preparations and methods of making same
IL126580A (en)	1996-04-16	2001-08-08	Bayer Ag	D- Manitol and its preparation
US5800834A (en)	1996-06-10	1998-09-01	Spireas; Spiridon	Liquisolid systems and methods of preparing same
US6399101B1 (en)	2000-03-30	2002-06-04	Mova Pharmaceutical Corp.	Stable thyroid hormone preparations and method of making same

2000
- 2000-10-18 US US09/690,973 patent/US6855333B1/en not_active Expired - Lifetime
2001
- 2001-09-26 WO PCT/US2001/029986 patent/WO2002028364A2/en not_active Ceased
- 2001-09-26 EP EP01971348A patent/EP1322294B1/de not_active Expired - Lifetime
- 2001-09-26 AT AT01971348T patent/ATE380543T1/de active
- 2001-09-26 PT PT01971348T patent/PT1322294E/pt unknown
- 2001-09-26 MX MXPA03002809A patent/MXPA03002809A/es active IP Right Grant
- 2001-09-26 DE DE60131863T patent/DE60131863T2/de not_active Expired - Lifetime
- 2001-09-26 ES ES01971348T patent/ES2298262T3/es not_active Expired - Lifetime
- 2001-09-26 NZ NZ524567A patent/NZ524567A/xx not_active IP Right Cessation
- 2001-09-26 CA CA2641575A patent/CA2641575C/en not_active Expired - Lifetime
- 2001-09-26 CA CA002423572A patent/CA2423572C/en not_active Expired - Lifetime
- 2001-09-26 AU AU9124401A patent/AU9124401A/xx active Pending
- 2001-09-26 CA CA2641570A patent/CA2641570C/en not_active Expired - Lifetime
- 2001-09-26 AU AU2001291244A patent/AU2001291244B2/en not_active Ceased
- 2001-09-26 CA CA2641581A patent/CA2641581C/en not_active Expired - Lifetime
- 2001-09-26 CN CNA018165931A patent/CN1543341A/zh active Pending
2008
- 2008-03-05 CY CY20081100254T patent/CY1107295T1/el unknown

Also Published As

Publication number	Publication date
CA2423572A1 (en)	2002-04-11
CA2641570C (en)	2014-04-22
AU9124401A (en)	2002-04-15
CN1543341A (zh)	2004-11-03
CA2641570A1 (en)	2002-04-11
CA2641581C (en)	2011-11-29
MXPA03002809A (es)	2004-09-10
HK1055260A1 (en)	2004-01-02
DE60131863D1 (de)	2008-01-24
CA2641575A1 (en)	2002-04-11
WO2002028364A3 (en)	2002-06-06
NZ524567A (en)	2004-12-24
CA2423572C (en)	2009-01-06
CA2641581A1 (en)	2002-04-11
PT1322294E (pt)	2008-02-28
EP1322294A2 (de)	2003-07-02
DE60131863T2 (de)	2008-12-11
EP1322294B1 (de)	2007-12-12
CA2641575C (en)	2014-04-08
ES2298262T3 (es)	2008-05-16
AU2001291244B2 (en)	2006-09-21
WO2002028364A2 (en)	2002-04-11
CY1107295T1 (el)	2012-11-21
US6855333B1 (en)	2005-02-15

Legal Events

Date

Code

Title

Description

2008-08-15

UEP

Publication of translation of european patent specification

Ref document number: 1322294

Country of ref document: EP

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